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Influence of transcatheter arterial embolization on symptom distress and fatigue in liver cancer patients

World Journal of Gastrointestinal Oncology 2024年第3期16卷 810-818页

作者： Xu-Min Yang Xu-Yan Yang Xin-Yu Wang Yue-xia Gu Department of Nursing The First Affiliated Hospital of Naval Medical University(Changhai Hospital)Shanghai 200433China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent malignancy,and transcatheter arterial embolization(TAE)has emerged as a pivotal therapeutic ***-ever,TAE may induce symptom distress and fatigue,adversely affecting the quality of life of *** To investigate symptom distress,fatigue,and associated factors in HCC patients undergoing *** We used a cross-sectional design and purposive sampling to enroll HCC patients who underwent TAE at our institution from January to December ***-naires were utilized to collect data on symptom distress and fatigue scores from the first to the third day after *** Our study revealed a significant reduction in fatigue and symptom distress among patients after ***,fatigue,insomnia,fever and abdominal dis-tension were the most common symptoms troubling patients during the first 3 d *** status,presence of family support,physical functional status,age,and symptom distress were identified as predictors of fatigue in *** Healthcare professionals should educate HCC patients on symptom distress and INTRODUCTION Hepatocellular carcinoma(HCC)ranks as the fifth most prevalent cancer and the third leading cause of cancer-related mortality *** intervention remains the cornerstone of HCC treatment;however,due to the challenges associated with early diagnosis and the lack of specific diagnostic markers,a considerable proportion of patients are diagnosed at advanced stages,rendering them ineligible for surgical *** arterial embolization(TAE)is an interventional therapeutic approach involving the insertion of a fine catheter via the femoral artery to reach the vasculature near the tumor *** aims to obstruct the arterial supply to the tumor by deploying embolic agents,thereby inducing necrosis in cancer *** procedure is suitable for patients with good liver function and overall health,particularly those with large HCCs that ha

关键词： Transcatheter arterial embolization Fatigue Symptom distress Hepatocellular carcinoma Influencing factors

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Overstory functional groups indicate the legacy of land use in a secondary tropical forest in southwestern China

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Journal of Forestry Research 2024年第5期35卷 91-105页

作者： Yun Deng Wenfu Zhang Min Cao Jinlong Dong Hui Chen xiaobao Deng Jiajia Liu xiaoyang Song Shangwen xia Liqing Sha Shengdong Yuan Luxiang Lin CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303People’s Republic of China Center for Plant Ecology Core Botanical GardensChinese Academy of SciencesMengla 666303People’s Republic of China National Forest Ecosystem Research Station at Xishuangbanna Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303People’s Republic of China Department of Life Sciences Fudan UniversityShanghai 570228People’s Republic of China Department of Life Sciences University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

Anthropogenic disturbances are widespread in tropical forests and influence the species composition in the ***,the impacts of historical disturbance on tropical forest overstory recovery are unclear due to a lack of disturbance data,and previous studies have focused on understory *** this study,the purpose was to deter-mine the influence of historical disturbance on the diver-sity,composition and regeneration of overstory species in present *** the 20-ha Xishuangbanna tropical sea-sonal rainforest dynamics plot in southwestern China,the historical disturbance boundaries were delineated based on panchromatic photographs from *** that drove species clustering in the overstory layer(DBH≥40 cm)were analyzed and the abundance,richness and composition of these species were compared among different tree groups based on multiple regression tree *** coefficient of variation of the brightness value in historical panchro-matic photographs from 1965 was the primary driver of spe-cies clustering in the overstory *** abundance and richness of overstory species throughout the regeneration process were similar,but species composition was always *** the proportion of large-seeded and vigorous-sprouting species showed no significant differ-ence between disturbed and undisturbed forests in the tree-let layer(DBHhat historical disturbances have strong legacy effects on functional group composition in the overstory and the recovery of overstory species was *** group composi-tion can better indicate the dynamics of overstory species replacement during secondary succession.

关键词： Historical disturbance Legacy effects Secondary forests Overstory species Functional groups

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Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG Ying QU Jin-yu GUO Hua ZHOU hai-ying RUAN xia PENG Ying-chun SHEN Xue-fang XIONG Jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(ha),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

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Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis

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Chinese Chemical Letters 2024年第3期35卷 406-414页

作者： haili Hu Weiwei Zhang Lei Lei Fan Tong Huilin Zhang Yiwei Zhang Wenqin Yang Yilu Tang Ruyi Lin Xue xia Jiamei Li Shiyong Song Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Pharmacy Henan UniversityKaifeng 475004China Department of Public Health Chengdu Medical CollegeChengdu 610500China

The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photothermal agents,uneven photothermal distribution,and heat endurance of cancer *** still,despite PTT enhances immunogenicity,the anti-tumor immune efficacy is still unsatisfactory due to the inefficient immunogenic cell death(ICD)induction and poor infiltration of immune *** solve the above problems of PTT,we developed hyaluronic acid(ha)modified hollow copper sulfide nanoparticles encapsulating diethyldithiocarbamate(DDTC)to construct a breast tumor targeting and near infrared(NIR)photo-responsive drug delivery system(D-HCuS@ha),which further combined with losartan to improve the accumulation and penetration in the tumor *** irradiation,D-HCuS@ha realized enhanced PTT and released cytotoxic Cu(DDTC)_(2)to eliminate heat endurance tumor cells,thereby enhancing antitumor effect and inducing effective ***,the combination with losartan could remodel the tumor microenvironment,allowing more T cells to infiltrate into the tumor,and significantly inhibiting the occurrence and development of metastatic *** vitro/vivo results revealed the great potential of D-HCuS@ha combined with losartan,which provides a new paradigm for anti-tumor and anti-metastases.

关键词： Targeted drug delivery system Hollow copper sulfide nanoparticles Photothermal therapy Hyaluronic acid Breast cancer Anti-metastasis

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Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway

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Traditional Medicine Research 2024年第8期9卷 11-22页

作者： Kuok-Tong Lei Yun-xia Wu Yun Lu Zi-Shan Wang Thi-Huong Nguyen Qiu-Ying Cai Wen Zhu Yue Wang First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210000China Faculty of Traditional Medicine Phenikaa UniversityHa Noi 100803Vietnam Department of Rheumatology and Immunology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000China

Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 *** its action mechanism is still *** study is aimed to reveal the potential mechanism of ZT treated pSS and discover its active compounds of ZT and therapeutic target for ***:Firstly,the potential pathways of ZT for pSS treatment were predicted through network pharmacology and GO and KEGG enrichment ***,the inter-structural relationships between active compounds of ZT and target proteins were visualized using molecular docking ***,efficacy and mechanism were conducted through in vivo experiments,such as water intake,spleen index,hematoxylin-eosin staining pathological changes,ELISA,Western Blot analysis,and immunofluorescence ***:Nine active compounds were extracted from network pharmacology,including quercitrin,luteolin,kaempferol,β-sitosterol,isorhamnetin,galangin,hederagenin,diosmetin and gibberellin *** disease targets were identified:RELA,TP53,AKT1,interleukin(IL)6,MAPK1,ESR1,IL10;with RELA being the most core *** and GO enrichment analysis indicated that ZT may act through the TLR/NF-κB/RELA inflammatory mechanism *** results of molecular docking showed that ZT’s active compounds bind well to the RELA(p65)*** vivo results demonstrated that a high dose of ZT significantly improved water intake and reduced lymphocytes infiltration in submandibular gland pathology in NOD *** expression content of AQP5 and vasoactive intestinal peptide in the submaxillary gland was significantly increased,while levels of inflammatory factors such as tumor necrosis factor-α,IL-6,and IL-1βalong with protein expressions including toll-like receptor4,p-p65 and p-IKKα/βin NF-κB pathway were ***:The ZT treatment exhibits a promising efficacy in mitigating dryness symptoms of pSS,potentially attr

关键词： traditional Chinese medicine primary Sjogren’s syndrome NF-κB RELA

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SW220/430LV在不同温度下热-力压缩行为研究和表征建模

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复合材料学报 2024年第1期41卷 521-532页

作者：陈国涛梅志远夏奕海军工程大学舰船与海洋学院武汉430033 中国人民解放军92728部队上海200040

对S2/430LV进行热-力联合作用下压缩性能试验研究,重点揭示S2/430LV在20~180℃压缩损伤失效机制及强度/模量随温度变化规律;提出一种基于ha-Springer模型的分段曲线拟合方法,并对强度/模量随温度变化规律进行预报。研究表明:在热-力联... 详细信息

对S2/430LV进行热-力联合作用下压缩性能试验研究,重点揭示S2/430LV在20~180℃压缩损伤失效机制及强度/模量随温度变化规律;提出一种基于ha-Springer模型的分段曲线拟合方法,并对强度/模量随温度变化规律进行预报。研究表明:在热-力联合作用下,压缩强度和模量随着温度升高而降低,但模量保留率高于强度;随着温度增加,试样最终失效模式发生改变,在100℃之前,试样呈整体剪切失效模式,纤维束发生扭结,并伴随纤维断裂和损伤路径出现断口;但在100℃以后,最终失效模式表现为树脂基体剪切损伤,而纤维织物形态基本不变;强度和模量随温度变化规律呈“S”形趋势,其中强度-温度曲线在20~80℃为凸曲线,80~180℃则为凹曲线;模量-温度曲线在20~100℃为凸曲线,100~180℃为凹曲线;提出了一种基于ha-Springer模型的分段曲线拟合方法,并利用Origin软件对强度/模量随温度变化规律进行预报,预报结果与试验结果高度吻合,且吻合程度优于Mahieux模型。

关键词：热-力联合压缩性能失效机制 Origin ha-Springer模型 Mahieux模型

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基于新灰色关联法分析某医院冠心病患者DRG超支病例用药情况

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药学与临床研究 2024年第4期32卷 371-375页

作者：夏蕾哈维超李梦媛郜苏苏南京医科大学药学院南京210000 南京医科大学第二附属医院药学部南京210011

目的:探究按疾病诊断相关分组(DRG)付费方式政策实施后,冠心病住院患者药品费用超支情况及各因素之间的关联性。方法:收集2022年1月-2023年3月南京医科大学第二附属医院冠心病住院患者基本费用信息和用药情况,应用新灰色关联法分析总药... 详细信息

目的:探究按疾病诊断相关分组(DRG)付费方式政策实施后,冠心病住院患者药品费用超支情况及各因素之间的关联性。方法:收集2022年1月-2023年3月南京医科大学第二附属医院冠心病住院患者基本费用信息和用药情况,应用新灰色关联法分析总药品费用与各类药品金额之间的关联性。结果:共纳入病例数为1421例,超支病例占总病例数的47.15%,其中有53.73%的病例超支主要原因为西药。药品费用关联度前三位的药品分类分别是消化道和代谢方面药物、心血管系统药物、血液和造血器官药物;依诺肝素和辅助用药烟酰胺、丹参酮ⅡA磺酸钠注射液的费用是影响住院患者总药品费用的主要因素。结论:DRG政策下冠心病住院患者的药品费用虽得到一定的合理管控,但辅助用药的使用仍需重点监控。

关键词： DRG付费新灰色关联法冠心病药品费用

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复合上转换纳米材料的制备及其性能研究的综合实验设计

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应用化工 2024年第5期53卷 1058-1062,1066页

作者：贾承政胡云霞周泰宇梁夏毓上海理工大学材料与化学学院上海200093

基于水热法制备高分散纳米粒子NaYF_(4)∶Yb,Er纳米粒子,在其外层包覆介孔二氧化硅(MSN),并进一步修饰了聚多巴胺(PDA)和透明质酸(ha),制备出复合纳米微球UCNPs@MSN@PDA-ha,通过透射电镜(TEM)观测其结构和形貌。通过红外分析仪(FITR)和... 详细信息

基于水热法制备高分散纳米粒子NaYF_(4)∶Yb,Er纳米粒子,在其外层包覆介孔二氧化硅(MSN),并进一步修饰了聚多巴胺(PDA)和透明质酸(ha),制备出复合纳米微球UCNPs@MSN@PDA-ha,通过透射电镜(TEM)观测其结构和形貌。通过红外分析仪(FITR)和荧光光谱仪检测其组成和发光性能。结果表明,复合纳米微球具有良好的分散性和介孔结构,通过修饰不同材料后,仍具有良好的上转换发光效果。

关键词：上转换纳米粒子荧光光热转换

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双耳双模式干预者言语情感识别研究

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听力学及言语疾病杂志 2024年第3期32卷 211-215页

作者：夏雨奇魏朝刚刘玉和北京大学第一医院耳鼻咽喉头颈外科北京100034 首都医科大学附属北京友谊医院耳鼻咽喉头颈外科

目的研究双耳双模式干预者言语情感识别能力及特点,为单侧人工耳蜗植入(CI)者的听觉言语康复提供参考。方法招募17例双模式干预语后聋成人参与研究,20例正常听力成人及18例单侧CI语后聋成人作为对照组,采用自编的情感识别测试软件对三... 详细信息

目的研究双耳双模式干预者言语情感识别能力及特点,为单侧人工耳蜗植入(CI)者的听觉言语康复提供参考。方法招募17例双模式干预语后聋成人参与研究,20例正常听力成人及18例单侧CI语后聋成人作为对照组,采用自编的情感识别测试软件对三组言语情感识别能力进行测试。结果①相较于正常听力者,双模式干预者和单侧CI者情感识别的正确率降低,反应时间延长(P0.05),但双模式干预者的反应时间比单侧CI者缩短(Pha可以改善情感识别能力。

关键词：双模式人工耳蜗植入助听器言语情感

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基于网络药理学和动物实验探讨柠檬苦素抗肝纤维化的作用机制

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中国现代应用药学 2024年第4期41卷 460-468页

作者：肖玉洪安祯祥王芳王锦雯邵霞袁颖贵州中医药大学第一临床医学院贵阳550001 达州市达川区中医医院四川达州635000 贵州中医药大学第一附属医院贵阳550001

目的通过网络药理学方法探讨柠檬苦素治疗肝纤维化的作用机制,并运用分子对接和动物实验进行验证。方法首先,利用SwissTargetPrediction、GeneCards和DisGeNet等数据库筛选柠檬苦素和肝纤维化的靶点,并运用微生信网站获得柠檬苦素与肝... 详细信息

目的通过网络药理学方法探讨柠檬苦素治疗肝纤维化的作用机制,并运用分子对接和动物实验进行验证。方法首先,利用SwissTargetPrediction、GeneCards和DisGeNet等数据库筛选柠檬苦素和肝纤维化的靶点,并运用微生信网站获得柠檬苦素与肝纤维化的共同靶点。然后运用STRING数据库和Cytoscape软件构建共同靶点的蛋白质相互作用网络,并利用CytoNCA插件筛选核心靶点;使用Metascape数据库对共同靶点进行GO功能注释和KEGG通路富集分析,以预测其可能的作用机制。最后运用AutoDock Vina软件对柠檬苦素与核心靶蛋白进行分子对接验证,并将网络药理学预测结果进行动物实验验证。结果预测结果表明柠檬苦素可能作用于AKT1、VEGFA、HIF1A等86个靶点,参与激素应答、蛋白磷酸化、血管生成等生物过程和PI3K/AKT通路、HIF-1通路、VEGF通路等与肝纤维化相关的信号通路。蛋白质相互作用分析结果显示核心靶点包括AKT1、VEGFA、HIF1A、PIK3CA等11个靶点。分子对接结果表明柠檬苦素与AKT1、VEGFA、HIF1A 3个核心靶蛋白具有较强的结合活性和稳定的结合构象。动物实验显示,与模型组比较,柠檬苦素高剂量(high-dose group of limonin,LH)组、柠檬苦素低剂量(low-dose group of limonin,LL)组中血清透明质酸(hyaluronidase,ha)、层黏连蛋白(laminin,LN)含量(LL组中LN除外)均下降(P<0.01或P<0.05),肝组织炎症和纤维化程度均减轻;Western blotting和实时荧光定量PCR(qPCR)检测显示LH、LL组肝组织中AKT、HIF-1α、VEGF蛋白和mRNA表达水平(LL组中VEGF除外)均下调(P<0.01或P<0.05)。结论柠檬苦素主要作用于AKT1、VEGFA、HIF1A等核心靶点来干预肝纤维化血管新生,其机制可能与其抑制AKT/HIF-1α/VEGF信号通路有关。

关键词：网络药理学分子对接柠檬苦素肝纤维化血管新生

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