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Effect and mechanism of salvianolic acid B on the myocardial ischemiareperfusion injury in rats

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 280-284页

作者： Ling Xue Zhen Wu xiao-Ping Ji xia-qing gao Yan-Hua Guo Department of Cardiovascular Medicine Qilu HospitalShandong University Department of Cardiovascular Medicine Third Affiliated Hospital of Liaoning Medical College

Objective:To investigate the effect of salvianolic acid B on rats with myocardial ischemiareperfusion ***:SD rats were randomly divided into five groups(n=10 in each group):A sham operation group,B ischemic reperfusion group model group,C low dose salvianolic acid B group,D median dose salvianolic acid B group,E high dose salvianolic acid B *** hour after establishment of the myocardial ischemia-reperfusion model,the concentration and the apoptotic index of the plasma level of myocardial enzymes(CTnⅠ,CKMB),SOD,MDA,NO,ET were,*** tissues were obtained and micro-structural changes were ***:Compared the model group,the plasma CTnⅠ,CK-MB,MDA and ET contents were significantly increased,NO,T-SOD contents were decreased in the treatment group(group C,D,and E)(P<0.05);compared with group E,the plasma CTnⅠ,CKMB,MDA and ET levels were increased,the NO,T-SOD levels were decreased in groups C and D(P<0.05).Infarct size was significantly reduced,and the myocardial ultrastructural changes were improved significantly in treatment ***:Salvianolic acid B has a significant protective effect on myocardial ischemia-reperfusion *** can alleviate oxidative stress,reduce calcium overload,improve endothelial function and so on.

关键词： Ischemia-reperfusion injury Myocardial infarction Salvianolic acid B Inflammatory response

Nitrogen and phosphorus removal under intermittent aeration conditions

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Journal of Environmental Sciences 2002年第4期14卷 541-546页

作者： xia Si\|qing, gao Ting\|yao, ZHOU Zeng\|yan (State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai 200092, China.) Tongji University State Key Laboratory of Pollution Control and Resource Reuse 上海 200092 Tongji University State Key Laboratory of Pollution Control and Resource Reuse 上海 200092

A practice wastewater treatment plant was operated using intermittent aeration activated sludge process to enhance biological nitrogen and phosphorus removal. When the influent concentrations of COD Cr , BOD 5, TN, TP, NH 3\|N, TKN, and SS varied in a range of 207.5—1640 mg/L, 61.8—637 mg/L, 28.5—75.6 mg/L, 4.38—20.2 mg/L, 13.6—31.9 mg/L, 28.5—75.6 mg/L, and 111—1208 mg/L, the effluent means were less than 50 mg/L, 20 mg/L, 5 mg/L, 1.0 mg/L, 5 mg/L, 10 mg/L, and 20 mg/L, respectively. Based on a long time of operating results, this process is very suitable for nutrient biological removal for treating the municipal wastewater those water characteristics are similar as that of the Songjiang Municipal Waste Water Treatment Plant(SJMWTP).

关键词： intermittent aeration process high concentration activated sludge nitrogen removal phosphorus removal

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu gao Dayong Wang qing xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei xia Yue Ma Mingtong gao Shuai Hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

氮肥后移对强筋小麦氮素积累转运及籽粒产量与品质的影响

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水土保持学报 2018年第3期32卷 289-294页

作者：代新俊夏清杨珍平高志强山西农业大学农学院山西太谷030801

为探索强筋小麦施用氮肥的合理基追比模式,在山西中部麦区水地小麦田,研究了氮肥基施、拔节期追施和孕穗期追施的不同比例(10∶0∶0,7∶3∶0,7∶2∶1,6∶4∶0,6∶2∶2,5∶5∶0,5∶3∶2)对强筋小麦CA0547氮素积累转运及籽粒产量与品质的... 详细信息

为探索强筋小麦施用氮肥的合理基追比模式,在山西中部麦区水地小麦田,研究了氮肥基施、拔节期追施和孕穗期追施的不同比例(10∶0∶0,7∶3∶0,7∶2∶1,6∶4∶0,6∶2∶2,5∶5∶0,5∶3∶2)对强筋小麦CA0547氮素积累转运及籽粒产量与品质的影响。结果表明:(1)适当追氮对强筋小麦CA0547氮素与干物质积累转运及产量品质有显著的调节效应。(2)追氮能显著提高小麦拔节期后的含氮量,提高花前氮素转运量和花后氮素积累量,促进氮素向籽粒中的累积,同时增加花前干物质转运量和花后干物质积累量,为产量提高提供了物质基础。(3)籽粒氮素中约有68.38%~75.18%是来自花前氮素转运,籽粒产量中约有55.12%~70.04%是来自花后干物质积累。追氮通过显著增加穗数和穗粒数来提高产量,并提高氮素吸收效率和氮素生产效率。(4)追氮可提高籽粒醇溶蛋白、谷蛋白、总蛋白质和湿面筋含量,提高面筋指数和淀粉含量,改善谷醇比和直/支比,进而改善籽粒品质。相关分析亦表明,提高干物质花后积累量与花前氮素转运量可以改善小麦品质。(5)拔节期和孕穗期2次施氮效果不如拔节期1次追施。综合分析得出,在本试验条件下,施氮量150kg/hm^2时,基肥、拔节肥、孕穗肥比例为6∶4∶0能较好的协调产量品质之间的关系。

关键词：氮肥后移氮素转运干物质积累产量品质

负载重组人骨形态发生蛋白2的纳米羟基磷灰石/丝素蛋白复合材料重建脊柱稳定性

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中国组织工程研究 2017年第18期21卷 2802-2807页

作者：陈晓敏马霄邵南齐代永霞高青付金芳郑州澍青医学高等专科学校河南省郑州市450064

背景:随着骨修复支架在医学领域的广泛应用,具有良好生物学性能的纳米羟基磷灰石和丝素蛋白成为近年来的研究热点。目的:探讨负载重组人骨形态发生蛋白2的纳米羟基磷灰石/丝素蛋白复合材料重建兔脊柱节段初始稳定性的可行性。方法:将36... 详细信息

背景:随着骨修复支架在医学领域的广泛应用,具有良好生物学性能的纳米羟基磷灰石和丝素蛋白成为近年来的研究热点。目的:探讨负载重组人骨形态发生蛋白2的纳米羟基磷灰石/丝素蛋白复合材料重建兔脊柱节段初始稳定性的可行性。方法:将36只雄性新西兰兔随机分为3组,均制备脊柱失稳模型。自体骨组在L4、L5椎间植入自体髂骨,n HA/SF组将纳米羟基磷灰石/丝素蛋白复合材料植入椎间隙进行椎间融合,rhB MP-2/nH A/SF组将负载重组人骨形态发生蛋白2的纳米羟基磷灰石/丝素蛋白复合材料植入椎间隙进行椎间融合。术后12周,X射线观察手术节段的融合情况,然后处死实验动物进行大体观察。使用电子拉力机测试融合节段的稳定性。组织学观察手术部位的植骨融合情况。结果与结论:(1)术后各组标本融合部位质地均较硬。自体骨组融合迹象明显,rhB MP-2/nH A/SF组次之,n HA/SF组未见融合迹象;(2)自体骨组椎体与髂骨植骨块分界处有大量骨小梁长入,nH A/SF组分界处有少量骨小梁长入,rh BMP-2/nH A/SF组分界处骨小梁较多。经X射线评估分别有10只、3只和9只符合融合标准;(3)rh BMP-2/n HA/SF组脊柱活动度与自体骨组间比较差异无显著性意义,rh BMP-2/nH A/SF组脊柱活动度优于nH A/SF组,差异有显著性意义(P<0.05);(4)自体骨组髂骨周边可见骨性连接,n HA/SF组材料周边可见骨性连接,未见成熟骨组织,rh BMP-2/nH A/SF组周边有大量新生毛细血管,并渗入组织内部;(5)结果表明,负载重组人骨形态发生蛋白2的纳米羟基磷灰石/丝素蛋白复合材料具有良好的生物相容性、力学性能和骨诱导能力,能在较短时间内重建兔脊柱稳定性。

关键词：生物材料骨组织工程重组人骨形态发生蛋白2 支架材料纳米羟基磷灰石丝素蛋白脊柱融合兔生物相容性

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网络环境下的书次号新论

四川图书馆学报 2004年第1期 47-49页

作者：夏青高博暨南大学珠海学院图书馆广东珠海519001

利用搜索引擎近期对网上图书馆进行了一次分类统计,调查结果显示,著者号正以种次号无法企及的优越性和强大的生命力不断改写着"在全国图书情报机构中,采用种次号的约占80%,而采用著者号的仅占10%"这一比例。

关键词：图书馆图书分类书次号著者号种次号网络环境

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan gao xia Li Wen-Yuan gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

Simultaneous nitrogen and phosphorus removal under low dissolved oxygen conditions

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Journal of Environmental Sciences 2001年第1期13卷 46-50页

作者： xia Si-qing gao Ting-yao ZHOU Zeng-yuan School of Environmental Science and Engineering Tongji UniversityShanghai 200092China

A full-scale test was operated by using low dissolved oxygen activated sludge process to enhance biological nitrogen and phosphorus removal. When the influent concentrations of CODCr, TN and TP varied in a range of 352.9 mg/L-1338.2 mg/L, 34.4 mg/L-96.3 mg/L, and 2.21 mg/L-24.0 mg/L, the average removal efficiencies were 94.9%, 86.7% and 93.0%, respectively. During the test period of two months, effluent meas of CODCr,, BOD5, NH3-N, TN and TP were below 50 mg/L, 25 mg/L, 10 mg/L and 1.0 mg/L respectively. The low dissolved oxygen activated sludge process has a simple flow sheet, fewer facilities and high N and P removal efficiency. It is very convenient to retrofit the conventional activated sludge process with the above process.

关键词： high concentration activated sludge low dissolved oxygen process nitrogen removal phosphorus removal