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Enzyme-driven Nanorobots Walking Along Predesigned Tracks on the DNA Origami for Cargo Transport and Catalysis

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Chemical Research in Chinese Universities 2024年第2期40卷 333-342页

作者： NIE Cunpeng MA Tianran CHEN Tingting chu xia State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082P.R.China

In molecular engineering,designing and synthesizing molecular machines with capable of performing complex tasks,remains a formidable *** is an excellent candidate for building molecular robots because it is highly ***,we present an artificial nanorobot,in which a DNA cube serves as the inert‘body’,and nucleic acid catalysts based on an enzymatic nicking reaction act as the‘legs’for *** nanorobot can execute a series of actions,such as‘start’,‘turn’,and‘stop’when it walks along a predefined *** performance could be confirmed and monitored by using an atomic force microscope(AFM)and fluorescence *** by biological machines,we artificially designed a series of specialized tasks that combined walking with control of cargo transport and ***-time fluorescence kinetics curves provide monitoring signals for cargo transport and catalytic *** work can enrich the toolbox of DNA machinery and has great potential for engineering molecular nanofactories.

关键词： DNA origami DNA nanorobot Controlled cargo transport DNAzyme catalysis

论习近平总书记关于党的建设的重要思想守正创新的理论品格

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理论视野 2024年第7期293卷 25-31页

作者：储霞朱佩佩东北大学马克思主义学院

守正创新是习近平总书记关于党的建设的重要思想的鲜明品格,其生成源于马克思主义世界观与方法论的本质规定、中国共产党推进党的建设的历史总结、解决大党独有难题和建设强大的马克思主义执政党的时代要求;其内容突出体现在党的领导、... 详细信息

守正创新是习近平总书记关于党的建设的重要思想的鲜明品格,其生成源于马克思主义世界观与方法论的本质规定、中国共产党推进党的建设的历史总结、解决大党独有难题和建设强大的马克思主义执政党的时代要求;其内容突出体现在党的领导、以及党的建设总体布局、主题主线、规律探求等方面;其方法凸显了理论与实践的紧密结合、变与不变的辩证统一、传统与现代的互动交融。

关键词：习近平党的建设守正创新

地方应用型本科院校金融学一流专业建设探索与实践——以广州应用科技学院为例

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山东纺织经济 2024年第7期41卷 51-55页

作者：褚霞广州应用科技学院经济与管理学院广东广州511370

教育部启动的“双万计划”,将是地方应用型本科院校发展的重点和落脚点。广州应用科技学院以金融学一流专业建设为契机,在培养方案、教师团队、教学资源等方面,推进专业内涵发展。然而,目前学校金融学专业存在培养目标不精准、课程内容... 详细信息

教育部启动的“双万计划”,将是地方应用型本科院校发展的重点和落脚点。广州应用科技学院以金融学一流专业建设为契机,在培养方案、教师团队、教学资源等方面,推进专业内涵发展。然而,目前学校金融学专业存在培养目标不精准、课程内容未完善、教学手段不丰富等问题。因此,学校应坚持特色发展、内容优化、教学创新与能力提升,并在OBE教育理念的引领下,加快推进金融学一流专业建设,提高应用型金融人才培养质量。

关键词：应用型本科院校金融学一流专业实践探索

SAR images classification method based on Dempster-Shafer theory and kernel estimate

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Journal of Systems Engineering and Electronics 2007年第2期18卷 210-216页

作者： He chu xia Guisong Sun Hong Electronic Information School Wuhan Univ. Wuhan 430079 P.R. China

To study the scene classification in the Synthetic Aperture Radar （SAR） image, a novel method based on kernel estimate, with the Maxkov context and Dempster-Shafer evidence theory is proposed. Initially, a nonpaxametric Probability Density Function （PDF） estimate method is introduced, to describe the scene of SAR images. And then under the Maxkov context, both the determinate PDF and the kernel estimate method axe adopted respectively, to form a primary classification. Next, the primary classification results are fused using the evidence theory in an unsupervised way to get the scene classification. Finally, a regularization step is used, in which an iterated maximum selecting approach is introduced to control the fragments and modify the errors of the classification. Use of the kernel estimate and evidence theory can describe the complicated scenes with little prior knowledge and eliminate the ambiguities of the primary classification results. Experimental results on real SAR images illustrate a rather impressive performance.

关键词： Image classification Synthetic aperture Radar (SAR) Dempster-Shafer theory Kernel estimate.

酶抑制剂及其构效优化在阿尔茨海默病中的应用

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生物化学与生物物理进展 2024年第7期51卷 1510-1529页

作者：储超扬肖彪单江晖陈是燏张楚霞周钰愉方甜园林志成谢凯徐淑君李丽萍宁波大学医学部生理与病理学科宁波315211 宁波大学附属第一医院康复科宁波315211

阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变,而临床上缺乏有效治疗AD的药物。近些年来研究发现,多种酶抑制剂如胆碱酯酶抑制剂、单胺氧化酶抑制剂、分泌酶抑制剂等能... 详细信息

阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知功能障碍和行为损害为特征的中枢神经系统退行性病变,而临床上缺乏有效治疗AD的药物。近些年来研究发现,多种酶抑制剂如胆碱酯酶抑制剂、单胺氧化酶抑制剂、分泌酶抑制剂等能改善胆碱能系统的障碍、Aβ的产生和沉积、Tau蛋白的过度磷酸化、氧化应激损伤、突触可塑性下降等AD发生发展的不同环节,从而改善AD症状和认知功能。本文综述了近年来酶抑制剂或抑制剂构效优化靶向调节胆碱酯酶、单胺氧化酶、分泌酶等在AD治疗中的研究进展,以期为AD的治疗和药物研发提供新思路。

关键词：阿尔茨海默病乙酰胆碱酯酶抑制剂单胺氧化酶抑制剂 β分泌酶抑制剂 γ分泌酶抑制剂糖原合成酶激酶抑制剂抑制剂构效优化

Modulation of Electrochemical Oscillations by Specific Adsorption of Cl- during the Electrooxidation of Methanol on Pt Electrode

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Chinese Chemical Letters 2002年第3期13卷 277-278页

作者： Ze Lin LI Ji Hua HUANG xiao Ming xiaO Yue ZENG xia chu Department of Chemistry Hunan Normal UniversityChangsha 410081

Potential oscillation during the electrocatalytic oxidation of methanol can be modulated by the specific adsorption of Cl- on the platinum electrode, which suppresses the electrocatalytic oxidation of methanol, and makes the cross cycle in the cyclic voltammogram become smaller and finally disappear with the increase of Cl- concentration. The method is also applicable to the electrocatalytic oxidation of other small organic molecules.

关键词： Methanol chloride ions specific adsorption potential oscillation modulation.

Application of iron and silicon fertilizers reduces arsenic accumulation by two Ipomoea aquatica varities

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Journal of Integrative Agriculture 2016年第11期15卷 2613-2619页

作者： YU Tian-hong PENG Yang-yang LIN chu-xia QIN Jun-hao LI Hua-shou Key Laboratory of Tropical Agro-Environment Ministry of Agriculture/South China Agricultural University School of Environment and Life Science University of Salford

A 45 d pot experiment was conducted to examine the effects of silicon fertilizer or iron fertilizer on the growth of two typical Ipomoea aquatica cultivars（Daye and Liuye） and arsenic（As） accumuation of Daye and Liuye grown in As-contaminated soils at different As dosage levels. The results showed that the application of these two fertilizers generally enhanced the growth of the plants, which may be partly attributable to the reduction in As toxicity. The addition of these two fertilizers also significantly reduced the uptake of As by the plants though the iron fertilizer was more effective, as compared to the silicon fertilizer. The accumulation of As in shoot portion was weaker for Daye than for Liuye. The research findings obtained from this study have implications for developing cost-effective management strategies to minimize human health impacts from consumption of As-containing I. aquatica.

关键词： arsenic silicon fertilizer iron fertilizer arsenic species I aquatica

Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland-immunophenotypic and genetic features: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3895-3903页

作者： Chang-Song Wang xia chu Di Yang Lei Ren Nian-Long Meng Xue-xia Lv Tian Yun Yan-Sha Cao Department of Pathology 989th Hospital of PLALuoyang 471000Henan ProvinceChina Department of Pathology 988^th Hospital of PLAZhengzhou 450042Henan ProvinceChina Department of Pathology Sanmenxia center HospitalSanmenxia 472000Henan ProvinceChina Department of Pathology Luoyang First People’s HospitalLuoyang 471000Henan ProvinceChina

BACKGROUND Warthin’s tumor(WT)is composed of several cysts that are lined with tall,bilayered oncocytic columnar cells and lymphoid *** WT,the two components rarely transform into carcinoma or lymphoma,and when it does,carcinoma is the most common *** 28 cases of lymphoma with WT have been reported,most of which were non-Hodgkin lymphomas,and only a few cases were Hodgkin *** the present report,we studied a case of diffuse large B cell lymphoma(DLBCL)arising from follicular lymphoma(FL)with WT in the parotid gland and its immunophenotypic and genetic *** SUMMARY A 67-year-old man presented with a slowly enlarging right cheek mass for 12 years,and the mass began to change in size over a 2-mo time *** time,the patient felt mild local pain and right cheek *** medical history included a hepatitis B virus infection for 20 years and 30 years of *** examination of the excised specimen showed a gray-red and gray-white appearance and a soft texture lobulated external surface neoplasm that measured 9 cm×8 cm×7 cm and was well circumscribed by relative normal parotid gland *** cross section,the cut surfaces of the neoplasm were multicystic and had a homogeneous scaly appearance.A small fluid was discovered in the *** oxyphilic,cuboidal or polygonal epithelium cells and lymphoid intraparenchymal components were *** medium-to large-sized lymphoid cells were observed diffusely in part of the neoplasm,and a few secondary lymphoid follicles were observed at the center or edge of the *** staining showed that the columnar oncocytic cells were positive for AE1/AE3;neoplastic cells located in coarctate follicular were positive for CD20,Pax-5,bcl-2 and bcl-6;and the adjacent diffusely medium-to large-sized lymphoid cells were positive for Pax-5,bcl-6,CD20,MUM-1,bcl-2 and *** bcl-6(3q27)break-apart rearrangement was observed,and an Epstein Barr virus test was

关键词： Diffuse large B cell lymphoma Warthin’s tumor Parotid gland Follicularlymphoma Case report Genetic feature

Generating long-wavelength absorption bands with enhanced deep red fluorescence and photothermal performance in fused carbon dots aggregates

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Aggregate

Aggregate 2021年第6期2卷 116-123页

作者： Jun Wu Josh Haipeng Lei Bingchen He chu-xia Deng Zikang Tang Songnan Qu Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoTaipaP.R.China Cancer Center Faculty of Health SciencesUniversity of MacaoTaipaP.R.China MOE Frontier Science Centre for Precision Oncology University of MacaoTaipaP.R.China

Carbon dots(CDs)with long-wavelength absorptions and emissions are highly desired for biological ***,we report a new supra-CDs strategy to construct long-wavelength absorption bands based on fused CDs aggregates(f-CDAs)through a concentration-induced interparticle dehydration process among green emissive CDs(r-CDs)under solvothermal *** obtained fused f-CDAs exhibit an obvious absorption band in 550-700 nm and significantly enhanced deep red fluorescence in N,N-dimethylformamide with photoluminescence quantum yields of 15.6% and high photothermal conversion efficiency up to 26.1%in *** from the high photothermal performance,in vivo tumor photothermal therapy has been realized via intratumoral injection of f-CDAs under 655 nm laser irradiated at 0.5 W/cm^(2).

关键词： aggregates bandgap controlling carbon dots deep red emission photothermal therapy