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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

NUMERICAL ANALYSIS OF THE UNSTEADY FORCE IN INSECT FORWARD FLIgHT

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Journal of Hydrodynamics 2006年第2期18卷 143-147页

作者： zha xiong-quan LU xi-yun YIN xie-zhen Department of Mechanics and Mechanical Engineering University of Science and Technology of China Hefei 230026 China

The objective of this study is to get into physical insights to the unsteady force and the relevant mechanisms in forward flight of insects. Unsteady force in the forward flight was studied, based on a virtual model problem of a foil with oscillating translation and rotation in a uniform flow, by solving the two-dimensional incompressible Navier-Stokes equations with a finite element method. The effects of typical parameters, including the advance ratio, the inclined angle of stroke plane, the stroke amplitude, and the amplitude of pitching angle of attack, on the forces and the flow structures were analyzed.

关键词： unsteady flow vortex dynamics thrust and lift,flapping motion biomechanics

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Numerical simulation of rock-breaking and influence laws of dynamic load parameters during axial-torsional coupled impact drilling with a single PDC cutter

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Petroleum Science 2023年第3期20卷 1806-1827页

作者： Yan xi Hao-Yu Wang Chun-Qing zha Jun Li gong-Hui Liu Bo-Yun guo Beijing University of Technology Bejing100124China China University of Petroleum-Bejing Beijing102249China China University of Petroleum-Beijing at Karamay KaramayXinjiang834000China University of Louisiana at Lafayett Lafayette70504USA

Axial and torsional impact drilling technology is used to improve the drilling efficiency of hard rock formation in the deep ***,the corresponding theory is not mature,and there are few correlative research reports on the rock-breaking mechanism of axial and torsional coupled impact drilling *** the influence of the impact hammer geometry and movement on the dynamic load parameters(i.e.,wavelength,amplitude,frequency,and phase difference),a numerical model that includes a hard formation and single polycrystalline diamond compact cutter was *** Riedel-Hiermaier-Thoma model,which considers the dynamic damage and strength behavior of rocks,was adopted to analyze the rock damage under axial and torsional impact *** numerical simu-lation results were verified by the experimental *** was found that compared with conventional drilling,the penetration depths of axial,torsional,and axial-torsional coupled impact drilling increased by 31.3%,5.6%,and 34.7%,*** the wavelength and amplitude of the axial impact stress wave improved the penetration *** the bit rotation speed remained unchanged,increasing the frequency in the axial and circumferential directions had little effect on the penetration ***,as the frequency increased,the cutting surface became increasingly smooth,which reduced the occurrence of bit *** the phase difference between the axial and circumfer-ential stress waves was 25%,the penetration depth significantly *** addition,the bit vibration problem can be effectively ***,the adjustment of engineering and tool structure parameters is proposed to optimize the efficiency of the axial-torsional coupled impact drilling tool.

关键词： Axial-torsional coupled impact drilling tool Rock-breaking PDC cutter RHT model

Production of anthocyanins in metabolically engineered microorganisms:Current status and perspectives

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Synthetic and Systems Biotechnology 2017年第4期2卷 259-266页

作者： Jian zha Mattheos A.g.Koffas Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA Department of Biological Sciences Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA

Microbial production of plant-derived natural products by engineered microorganisms has achieved great success thanks to large extend to metabolic engineering and synthetic ***,the water-soluble colored pigments found in terrestrial plants that are responsible for the red,blue and purple coloration of many flowers and fruits,are extensively used in food and cosmetics industry;however,their current supply heavily relies on complex extraction from plant-based materials.A promising alternative is their sustainable production in metabolically engineered ***,we review the recent progress on anthocyanin biosynthesis in engineered bacteria,with a special focus on the systematic engineering modifications such as selection and engineering of biosynthetic enzymes,engineering of transportation,regulation of UDP-glucose supply,as well as process *** promising engineering strategies will facilitate successful microbial production of anthocyanins in industry in the near future.

关键词： Anthocyanin Enzyme engineering Metabolic engineering Microbial production

Minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas

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World Journal of Clinical Cases 2021年第35期9卷 10919-10926页

作者： Duo-Ji Suo Lang Yang-Zhen Ci Ren zha-xi Bian Ba Department of general Surgery People’s Hospital of Tibet Autonomous RegionLasa 850000Tibet Autonomous RegionChina Department of Internal Medicine The Tibet Autonomous Region Centers for Disease Control and PreventionLasa 850000Tibet Autonomous RegionChina

BACKgROUND Colon cancer is associated with a higher incidence among residents in highaltitude *** environment at high altitudes inhibits the phagocytic and oxygen-dependent killing function of phagocytes,thereby increasing the inflammatory factors,inhibiting the body’s innate immunity and increasing the risk of colon *** To examine the effect of minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude *** Ninety-two patients with colon cancer in our hospital from January 2019 to February 2021 were selected and divided into the minimally invasive surgery and laparotomy groups using the random number table method,with 46 patients in each *** invasive surgery was performed in the minimally invasive group and laparotomy in the laparotomy *** conditions,inflammatory index pre-and post-surgery,immune function index and complication probability were *** Operative duration was significantly longer and intraoperative blood loss and recovery time of gastrointestinal function were significantly less(all Pgroup than in the laparotomy *** number of lymph nodes dissected was not significantly *** surgery,there were no significant differences in serum C-reactive protein,interleukin-6 and tumor necrosis factor-αlevels between the groups,whereas after surgery,the levels were significantly higher in the minimally invasive group(26.98±6.91 mg/L,146.38±11.23 ng/mL and 83.51±8.69 pg/mL vs 41.15±8.39 mg/L,186.79±15.36 ng/mL and 110.65±12.84 pg/mL,respectively,Pgery,there were no significant differences in CD3+,CD4+and CD4+/CD8+levels between the groups,whereas after surgery,the levels decreased in both groups,being significantly higher in the minimally invasive group(55.61%±4.39%,35.45%±3.67%and 1.30±0.35 vs 49.68%±5.33%,31.21%±3.25%and 1.13±0.30,respectively,Pgnificant

关键词： Minimally invasive surgery Laparotomy High-altitude area Colon cancer Surgical trauma Immune dysfunction

Secure quantum report with authentication based on six-particle cluster state and entanglement swapping

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Science China(Information Sciences) 2012年第12期55卷 2881-2887页

作者： LI Ning ,zha xinWei & LAN Qian School of Science,xi’an University of Posts and Telecommunications,xi’an 710061,China 1. School of Science Xi’an University of Posts and Telecommunications Xi’an 710061 China

A novel high-efficient secure quantum report with authentication based on six-particle cluster state and entanglement swapping is *** our protocol,using N groups of six-particle cluster state,the legitimate users Bob and Charlie send their secret reports to their boss(Alice),who operates sixteen kinds of unitary operations after receiving the ***,entanglement swapping of cluster states and maximum entanglement state measurement are employed by the *** has been proved that our protocol has high level guarantees and honesty,and the scheme is secure not only against the intercept-and-resend attack but also against disturbance attack.

关键词： six-particle cluster state quantum authentication entanglement swapping Bell measurement

Dissecting the hypothalamic pathways that underlie innate behaviors

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Neuroscience Bulletin 2015年第6期31卷 629-648页

作者： xi zha xiaohong Xu Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of Sciences University of the Chinese Academy of Sciences

Many complex behaviors that do not require learning are displayed and are termed innate. Although traditionally the subject matter of ethology, innate behaviors offer a unique entry point for neuroscientists to dissect the physiological mechanisms governing complex behaviors. Since the last century, converging evidence has implicated the hypothalamus as the central brain area that controls innate behaviors. Recent studies using cutting-edge tools have revealed that genetically-defined populations of neurons residing in distinct hypothalamic nuclei and their associated neural pathways regulate the initiation and maintenance of diverse behaviors including feeding, sleep, aggression, and parental care. Here, we review the newly-defined hypothalamic pathways that regulate each innate behavior. In addition, emerging general principles of the neural control of complex behaviors are discussed.

关键词： hypothalamus innate behaviors neural circuit optogenetics neural network

HOMOMORPHISMS BETWEEN CHEVALLEY gROUPS OF TYPES C_nAND g_2 OVER FINITE FIELDS

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Chinese Annals of Mathematics,Series B 1997年第2期18卷 167-172页

作者： zha JIANgUO Department of Applied Mathematics Tongji UniversityShanghai 200092China

It is known that there exists an isogeny sort of Chevalley groups g (Σ, F) associated to any indecomposable root system Σ and any field F . In this paper the author determines all nontrivial homomorphisms from g(Σ, k) to g(Σ, K) when the root system Σ is of type C n or g 2 , and the fields k and K are finite fields of characteristic p .

关键词： Chevalley group Homomorphism Finite field