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Evolution Characteristics of Government-Industry-University-Research Cooperative Innovation Network for China＇s Agriculture and Influ- encing Factors： Illustrated According to Agricultural Patent Case

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Chinese Geographical Science 2018年第1期28卷 137-152页

作者： li Erling yao Fei xi Jiaxin GUO Chunyang Key Research Institute of Yellow River Civilization and Sustainable Development/Henan Collaborative Innovation Center for the Yellow River Civilization Heritage and Modern Civilization Construction/College of Environment and Planning Henan University Kaifeng 475001 China Collaborative Innovation Center of Urban-Rural Coordinated Development Henan Province Kaifeng 475004 China Gemmological Institute China University of Geosciences (Wuhan) Wuhan 430074 China

Under the special background of China, the cooperative innovation between different government-industry-university-research institutes plays an increasingly important role in the agricultural field. However, the existing literature has paid little attention to it. Considering the cooperation patents, published in the agriculture field stemming from the Full-text Database of China Patents as the study object, the spatial and institutional attribute of the authors as the data source, and by combining the social network and spatial econometrics analysis, this paper analyzes the structure evolution characteristics of cooperative innovation networks of agricultural government-industry-university-research institute in the city level of China in 1985–2014, based on the triple helix theory, with the influence factors discussed. This shows that, 1) since 1985, China's agricultural innovation level has been substantially increased, but the development degree of the cooperative innovation network is low, and the patent cooperation mainly relies on authors in the same unit; 2) enterprises play a leading role in the agricultural cooperative innovation. The effect of the government and hybrid organizations driven by the government is not obvious; 3) the cooperative innovation in the province and city dominates, and a multi-pole pattern has been formed. The cooperative innovation network structure evolves from a single helix empty core and double helix multi core to a double helix hierarchical network; 4) the city's science, education funding and personnel investment are key factors determining the agricultural cooperative innovation, while the agricultural development of the city presents slight negative impacts on it. The spatial mismatch of supply and demand is present in the technical cooperative innovation of China's agriculture. Therefore, the science enhancement and education investment to big agricultural provinces should be promptly implemented.

关键词： cooperation innovation networks government-industry-university-research institute China's agricultural patent SocialNetwork Analysis (SNA)

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Numerical Simulation of Radiation Transport to Improve Microalgae Cultivation in an Air-lift Photobioreactor

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Journal of Thermal Science 2025年第1期34卷 62-76页

作者： ZHANG xianbin li Mingjia HUNG Tzuchen ZHANG Zixun Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi'an Jiaotong University School of Mechanical Engineering Beijing Institute of Technology Department of Mechanical Engineering Taipei University of Technology

A comprehensive numerical model is developed to simulate the growth of microalgae under light/dark cycling *** purpose of this study is to predict the growth rate of Chlorella vulgaris cultivated in photobioreactors(PBRs) in order to improve the light conditions for microalgae and enhance the photosynthetic *** fluid dynamics(CFD) is used to simulate its internal hydrodynamic *** Lagrangian method is employed to track the movement of microalgae *** radiative transfer equation(RTE)is used to obtain light intensity *** combination of light radiation field and microalgae cell motions is used to construct the light history and they are integrated into the model of the photosynthetic units(PSU) to calculate the microalgae growth *** numerical results demonstrate that enhanced light/dark cycling frequency with ordered mixing can promote efficient microalgae *** effect of the vortex flow field generated by the baffles in an air-lift PBR is analyzed for increasing microalgae growth *** using the 1:1 baffle spacing,the biomass production of microalgae is increased by 41.8% compared to the original PBR.

关键词： light distribution particle tracking photobioreactor structure optimization

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Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia Zhang Jiayi li Jingli Yang Zisheng Huang Zhijun Wu Baitao liu Hongjie Huang Haijun Wang Yongjian Wang Dingge liu Zhihua Zhang Kaiping liu Gang Yang xi Gong Hui Dai Yingjia li Erdan Dong xin Zhang Yan Zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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Joint user pairing and power allocation in uplink virtual MIMO with imperfect CSI

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The Journal of China Universities of Posts and Telecommunications 2013年第3期20卷 32-36页

作者： yao li-ping XU Quan-sheng li xi JI Hong School of Telecommunication Engineering Beijing University of Posts and Telecommunications

User pairing strategy for virtual multi-input multi-output （VMIMO） has been widely studied to improve system throughput, but most studies are based on perfect channel state information （CSI） and uniform power allocation. However, perfect CSI is very difficult or even impossible to obtain in practical system. Moreover power allocation has significant impact on algorithm performance. Therefore, in this paper, a low-complex joint user pairing and power allocation algorithm based on aggressive discrete stochastic optimization and Lagrangian dual solution is proposed for uplink VMIMO with imperfect CSI. Simulation results show that the proposed algorithm can achieve desirable throughput performance, and restrict inter-user interference （IUI） efficiently.

关键词： VMIMO user pairing power allocation I151

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Resource allocation algorithm in LTE uplink SC-FDMA system for time-varying channel with imperfect channel state information

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The Journal of China Universities of Posts and Telecommunications 2013年第2期20卷 7-11页

作者： XU Quan-sheng li xi JI Hong yao li-ping Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications

In long term evolution （LTE） uplink single carrier frequency division multiple access （SC-FDMA） system, the restriction that multiple resource blocks （RBs） allocated to a user should be adjacent, makes the resource allocation problem hard to solve. Moreover, with the practical constraint that perfect channel state information （CSI） cannot be obtained in time-varying channel, the resource allocation problem will become more difficult. In this paper, an efficient resource allocation algorithm is proposed in LTE uplink SC-FDMA system with imperfect CSI assumption. Firstly, the resource allocation problem is formulated as a mixed integer programming problem. Then an efficient algorithm based on discrete stochastic optimization is proposed to solve the problem. Finally, simulation results show that the proposed algorithm has desirable system performance.

关键词： SC-FDMA resource allocation imperfect channel state information discrete stochastic optimization time-varying channel

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Systematic energy-balanced cooperative transmission scheme in wireless sensor networks

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The Journal of China Universities of Posts and Telecommunications 2012年第6期19卷 14-18页

作者： yao li-ping li xi JI Hong XU Quan-sheng School of Telecommunication Engineering Beijing University of Posts and Telecommunications

Energy efficiency is a critical issue in wireless sensor networks （WSNs）. In order to minimize energy consumption and balance energy dissipation throughout the whole network, a systematic energy-balanced cooperative transmission scheme in WSNs is proposed in this paper. This scheme studies energy efficiency in systematic view. For three main steps, namely nodes clustering, data aggregation and cooperative transmission, corresponding measures are put forward to save energy. These measures are well designed and tightly coupled to achieve optimal performance. A half-controlled dynamic clustering method is proposed to avoid concentrated distribution of cluster heads caused by selecting cluster heads randomly and to get high spatial correlation between cluster nodes. Based on clusters built, data aggregation, with the adoption of dynamic data compression, is performed by cluster heads to get better use of data correlation. Cooperative multiple input multiple output （CMIMO） with an energy-balanced cooperative cluster heads selection method is proposed to transmit data to sink node. System model of this scheme is also given in this paper. And simulation results show that, compared with other traditional schemes, the proposed scheme can efficiently distribute the energy dissipation evenly throughout the network and achieve higher energy efficiency, which leads to longer network lifetime span. By adopting orthogonal space time block code （STBC）, the optimal number of the cooperative transmission nodes varying with the percentage of cluster heads is also concluded, which can help to improve energy efficiency by choosing the optimal number of cooperative nodes and making the most use of CMIMO.

关键词： energy efficiency dynamic clustering cooperative MIMO data aggregation wireless sensor networks

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Aggregate Engineering in Supramolecular Polymers via Extensive Non-covalent Networks

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Chinese Journal of Polymer Science 2021年第10期39卷 1310-1318,I0007页

作者： xin Huang Dong Lv li-Qing Ai Shuk Han Cheng xi yao Department of Biomedical Sciences City University of Hong KongHong Kong 999077China City University of Hong Kong Shenzhen Research InstituteShenzhen 518075China

Aggregate engineering of non-covalent networks endows supramolecular polymers with thermo-mechanical versatility,stimuli-responsive phase transitions and intrinsic damage-healing ***,most non-covalent networks are vulnerable at elevated temperatures,which suppresses the robustness of supramolecular ***,ureidocytosine(UCy)motifs,which are capable of forming extensive non-covalent networks and thus robust molecular aggregates via multivalent hydrogen bonds and aromatic stackings,are proposed to enable precise programming of the thermo-mechanical *** simulations reveal that the enthalpic contributions from the UCy aggregates play dominant roles to compensate the entropic loss from the redistributions of polymeric spacers and stabilize the non-covalent networks over wide temperature *** aggregate-level strategy offers prospects for applications which require thermo-mechanical versatility of supramolecular polymers,such as 3D printing,microfabrication and damage-healing coating.

关键词： Aggregate engineering Damage-healing Extensive non-covalent network Ureidocytosine Supramolecular polymers

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Defective g-C_(3)N_(4)supported Ru_(3)single-cluster catalyst for ammonia synthesis through parallel reaction pathways

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Nano Research 2023年第2期16卷 3580-3587页

作者： Yining Zhang Sha li Chao Sun xiaorou Cao xi Wang Jiannian yao Institute of Molecular Plus Tianjin UniversityTianjin 300072China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515031China Department of Physics School of Physical Science and EngineeringBeijing Jiaotong UniversityBeijing 100044China Key Laboratory of Photochemistry Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of ScienceBeijing 100190China

Designing catalyst to achieve ammonia synthesis at mild conditions is a meaningful challenge in catalysis *** g-C_(3)N_(4)nanosheet supported single-cluster ruthenium and iron catalysts were investigated for their ammonia synthesis *** on density functional theory(DFT)calculations and microkinetic simulations,Ru_(3)single-cluster anchored on defective g-C3N4 nanosheet(Ru_(3)/Nv-g-C_(3)N_(4))has a turnover frequency(TOF)5.8 times higher than the Ru(0001)step surface at industrial reaction conditions of 673 K and 100 bar for ammonia *** other words,similar TOFs could be achieved on Ru_(3)/Nv-g-C_(3)N_(4)at much milder conditions(623 K,30 bar)than on Ru(0001)(673 K,100 bar).Our computations reveal the reaction proceeds parallelly on Ru_(3)/Nv-g-C_(3)N_(4)through both dissociative and alternative associative mechanisms at typical reaction conditions(600–700 K,10–100 bar);N–N bond cleavage of*N2 and*NNH from the two respective pathways controls the reaction *** increasing temperatures or decreasing pressures,the dissociative mechanism gradually prevails and associative mechanism *** comparison,Fe_(3)/Nv-g-C_(3)N_(4)catalyst shows a much lower catalytic activity than Ru3/Nv-g-C_(3)N_(4)by two orders of magnitude and the reaction occurs solely through the dissociative *** finding provides a prospective candidate and deepens the mechanistic understanding for ammonia synthesis catalyzed by single-cluster catalysts(SCCs).

关键词： Ru_(3)cluster ammonia synthesis parallel reaction pathways density functional theory microkinetic simulations

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Recent advances in nickel-catalyzed reductive hydroalkylation and hydroarylation of electronically unbiased alkenes

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Science China Chemistry 2020年第11期63卷 1586-1600页

作者： xiao-Xu Wang xi Lu Yan li Jia-Wang Wang yao Fu Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyiChEMUniversity of Science and Technology of ChinaHefei 230026China

The use of simple and easily available feedstock to quickly and efficiently obtain compounds with complex molecular structures through the transition-metal-catalyzed construction of C(sp3)–C bonds has important *** traditional C(sp3)–C coupling reagents,alkylmetallic reagents often have limitations such as air and moisture sensitivity and difficulties in ***-catalyzed reductive olefin hydrocarbonation reactions use alkenes to replace organometallic reagents,reduce the synthesis steps,improve the functional group compatibility,and expand the substrate *** minireview discusses important progress in the hydroalkylation and hydroarylation of electronically unbiased alkenes in recent years and describes the key mechanism and applications.

关键词： nickel electronically unbiased alkenes C-C bond formation reductive hydroalkylation reductive hydroarylation

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Recent Advances in Cobalt-Catalyzed Regio-or Stereoselective Hydrofunctionalization of Alkenes and Alkynes

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CCS Chemistry 2024年第5期6卷 1130-1156页

作者： Yan li xi Lu yao Fu Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Urban Pollutant ConversionAnhui Province Key Laboratory of Biomass Clean EnergyUniversity of Science and Technology of ChinaHefei 230026 Key Laboratory of Precision and Intelligent Chemistry Department of Applied ChemistrySchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026

Hydrofunctionalization of alkenes and alkynes is increasingly important in preparing and modifying carbon-centered organic molecules such as pharmaceuticals,agrochemicals,andmaterial *** development of transition-metal-catalysts has revolutionized the hydrofunctionalization of unsaturated hydrocarbons,greatly improving the synthetic efficiency and selectivity of these *** recent years,notable progress has been achieved in low-cost metal-catalyzed alkene and alkyne hydrofunctionalization reactions following the utilization of traditional precious metal catalysts,including palladium,platinum,and ***-abundant cobalt catalysts,which are low in toxicity and exhibit unique reactivity and selectivity,are widely implemented in academic and industrial *** this review,we highlight recent examples of cobalt-catalyzed hydrofunctionalization of alkenes and alkynes to provide an overview of hydrofunctionalization methods,particularly hydroalkylation *** reactions greatly expand the scope and utility of cobalt-catalyzed couplings of carbon—carbon *** also highlight the mechanistic considerations and selective determinants *** hope our discussion will be informative for future developments in cobalt catalysis and hydrofunctionalization reactions.

关键词： hydrofunctionalization cobalt-catalysis alkene alkyne regioselectivity stereoselectivity

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