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Bipolar hip arthroplasty using conjoined tendon preserving posterior lateral approach in treatment of displaced femoral neck fractures

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World Journal of Clinical Cases 2024年第6期12卷 1076-1083页

作者： Ting-xin yan Sheng-Jie Dong Bo Ning Yu-Chi Zhao Department of Joint Surgery Yantaishan HospitalYantai 264003Shandong ProvinceChina Department of Joint Surgery Dongying People's HospitalDongying 257091Shandong ProvinceChina

BACKGROUND Hip fractures account for 23.8%of all fractures in patients over the age of 75 *** than half of these patients are older than 80 *** hemiarthroplasty(BHA)was established as an effective management option for these *** approaches can be used for the BHA ***,there is a high risk of postoperative *** conjoined tendon-preserving posterior(CPP)lateral approach was introduced to reduce postoperative dislocation *** To evaluate the effectiveness and safety of the CPP lateral approach for BHA in elderly *** We retrospectively analyzed medical data from 80 patients with displaced femoral neck fractures who underwent *** patients were followed up for at least 1 *** the 80 patients,57(71.3%)were *** time to operation averaged 2.3 d(range:1-5 d).The mean age was 80.5 years(range:67-90 years),and the mean body mass index was 24.9 kg/m^(2)(range:17-36 kg/m^(2)).According to the Garden classification,42.5%of patients were typeⅢand 57.5%of patients were typeⅣ.Uncemented bipolar hip prostheses were used for all *** conjoined tendons,dislocations,and adverse complications during and after surgery were *** The mean postoperative follow-up time was 15.3 months(range:12-18 months).The average surgery time was 52 min(range:40-70 min)with an average blood loss of 120 mL(range:80-320 mL).The transfusion rate was 10%(8 of 80 patients).The gemellus inferior was torn in 4 patients(5%),while it was difficult to identify in 2 patients(2.5%)during *** posterior capsule was punctured by the fractured femoral neck in 3 patients,but the conjoined tendon and the piriformis tendon remained *** patients had stem varus greater than 3 degrees or femoral *** were no patients with stem subsidence more than 5 mm at the last *** postoperative dislocations were observed throughout the follow-up *** significance was found between preoperative an

关键词： Conjoined tendon preserving Bipolar hip arthroplasty Femoral neck fractures Postoperative dislocation Posterolateral approach

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Current and Potential Roles of Ferroptosis in Bladder Cancer

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Current Medical Science 2024年第1期44卷 51-63页

作者： Wen-xin AN Radheshyam Gupta Kun ZHAI Ya-ru WANG Wan-hai XU yan CUI Department of Urology Harbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer

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Clinical application of eight-zone laparoscopic dissection strategy for rectal cancer:Experience and discussion

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World Journal of Gastroenterology 2024年第30期30卷 3574-3583页

作者： Chang Chen xiang Zhang xin Li yan-Lei Wang Department of General Surgery Rongchang People's HospitalChongqing 250012China Department of Colorectal Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Huantai Branch of Qilu Hospital of Shandong UniversityZibo 255000Shandong ProvinceChina

BACKGROUND The incidence of rectal cancer is increasing worldwide,and surgery remains the primary treatment *** the advent of total mesorectal excision(TME)technique,the probability of tumor recurrence post-surgery has significantly ***'focus has gradually shifted towards minimizing the impact of surgery on urinary and sexual *** these concerns,the optimal dissection of the rectal lateral ligaments and preservation of the pelvic floor neuro-vascular bundle have become *** explore the optimal surgical technique for TME and establish a standardized surgical protocol to minimize the impact on urinary and sexual functions,we propose the eight-zone dissection strategy for pelvic floor *** To compare the differences in surgical specimen integrity and postoperative quality of life satisfaction between the traditional pelvic floor dissection strategy and the innovative eight-zone dissection *** We analyzed the perioperative data of patients who underwent laparoscopic radical resection of rectal cancer at Qilu Hospital of Shandong University between January 1,2021 and December 1,*** study included a total of 218 patients undergoing laparoscopic radical surgery for rectal cancer,among whom 109 patients underwent traditional pelvic floor dissection strategy,and 109 patients received the eight-zone dissection *** There were no significant differences in general characteristics between the two *** in the eight-zone dissection group had higher postoperative specimen integrity(88.1%vs 78.0%,P=0.047).At the 3-month followup,patients in the eight-zone surgery group had better scores in urinary issues(6.8±3.3 vs 5.3±2.5,P=0.045)and male sexual desire(2.2±0.6 vs 2.5±0.5,P=0.047)compared to the traditional surgery strategy *** This study demonstrates that the eight-zone dissection strategy for laparoscopic lateral ligament dissection of rectal cancer is safe and ***

关键词： Eight-zone dissection strategy Rectal cancer Lateral ligament dissection Nerve injury Total mesorectal excision surgery

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A novel regio-and stereo-specific hydrohalogenation reaction of 2-alkynoic acids and their derivatives

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Chinese Journal of Chemistry 1993年第3期11卷 267-271页

作者： LU,xi-yan ZHU,Guo-xin MA,Sheng-Ming Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032 Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

The nucleophilic hydrohalogenation of 2-alkynoic acids anti their derivatives by heating with lithium halides iu HOAc afforded the thermodynamically unfavorable 3-halo-2 (Z)- alkenoic acids and their derivatives stere... 详细信息

关键词： A novel regio-and stereo-specific hydrohalogenation reaction of 2-alkynoic acids and their derivatives

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Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 106-114,I0002-I0005页

作者： Wei Luo Yi Lu Jun-Hua Deng Peng Liu yan Huang Wan-xi Liu Chun-Li Huang Laboratory of the Atherosclerosis and Ischemic Cardiovascular Diseases Department of CardiologyAffiliated Hospital of Youjiang Medical University for NationalitiesYoujiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Respiratory and Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Postgraduate School of Youjiang Medical University for Nationalities BaiseGuangxi 533000China Department of Neonatology Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Nephrology People’s Hospital of PubeiQinzhouGuangxi 535300China Urban Community Health Service Center of Youjiang District BaiseGuangxi 533000China

Objective:To explore the mechanism by which icariin alleviates viral ***:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on cell viability,inflammation,and ***,the effects of icariin on ferroptosis and TLR4 signaling were *** AC16 cells were transfected with TLR4 overexpression plasmids,the role of TLR4 in mediating the regulatory effect of icariin in viral myocarditis was ***:Icariin significantly elevated cell viability and reduced inflammatory factors TNF-α,IL-1β,IL-6,and *** cytometry revealed that icariin decreased apoptosis rate,and the protein expression of Bax and cleaved caspase 3 and 9 in CVB3-induced ***,it suppressed ferroptosis including lipid peroxidation and ferrous ion,as well as the TLR4 ***,TLR4 overexpression abrogated the modulatory effects of ***:Icariin mitigates CVB3-induced myocardial injury by inhibiting TLR4-mediated *** animal study is needed to verify its efficacy.

关键词： Viral myocarditis CVB3 TLR4 Ferroptosis Icariin

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Analysis on characteristics of extreme precipitation indices and atmospheric circulation in Northern Shanxi

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Research in Cold and Arid Regions 2024年第2期16卷 84-97页

作者： xia Cai yan Song Lin Cai xin Su GuiHua Liang yanMing Xu Shuozhou Meteorological Bureau of Shanxi Province ShuozhouShanxi 036002China China Meteorological Administration Training Center Beijing 100081China Heze University of Shandong Province HezeShandong 274000China Huafeng Meteorological Media Group Beijing 100081China Shuocheng Meteorological Bureau ShuozhouShanxi 036002China

This article utilizes daily precipitation data from 28 national meteorological stations in northern Shanxi Province spanning from 1972 to 2020,and the US NCEP/NCAR monthly average reanalysis and ERA5 monthly average reanalysis *** study employs techniques such as empirical orthogonal function(EOF)decomposition,MannKendall mutation and other methods to investigate the spatiotemporal distribution of extreme precipitation index in northern Shanxi and their correlation with atmospheric *** research results show that:the absolute index,relative index,intensity index and sustained dry period index(CDD)in the continuous index appear from southwest to *** spatial distribution characteristics of the central region decrease,while the continuous wet period(CWD)decreases from the central to the east and *** three indices Rx1day,Rx5day,and CWD mutated in 1978,1975,and 1983 respectively,and other extreme precipitation indices all appeared in a sudden change from a low-value period to a high-value period occurred around *** the high-value years of the summer extreme precipitation index,there is a significant negative anomaly in the height field in the mid-high latitude regions of *** Shanxi is controlled by a broad low-pressure trough in the Lake Baikal *** vapor transported via the east,west,and south routes converges in the northern Shanxi region and encounters cold air from the *** is a strong upward motion anomaly at 500 hPa in the troposphere,and the dynamic conditions of upper-level divergence and lower-level convergence lead to more summer extreme precipitation in the northern Shanxi ***,in the low-value years of the summer extreme precipitation index,northern Shanxi is affected by a strong high-pressure ridge north of Lake *** is a downward motion anomaly at 500 hPa,and the northern Shanxi region lacks water *** cold and warm air cannot converge,and both the water vapor conditions

关键词： Northern Shanxi Extreme precipitation indices Spatio-temporal distribution and evolution Mutations Atmospheric circulation anomaly

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Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(Science & Applications) 2024年第6期13卷 1140-1158页

作者： xinzhu Xu Wenyi Wang Liang Qiao Yunzhe Fu xichuan Ge Kun Zhao Karl Zhanghao Meiling Guan xin Chen Meiqi Li Dayong Jin Peng xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

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Exploring the Lagged Correlation Between Baidu Index and Influenza-Like Illness-China,2014-2019

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China CDC weekly 2024年第26期6卷 629-634页

作者： Xuan Han Jiao yang yan Luo Dazhu Huo Xuya Yu Xuancheng Hu Ling xin Liuyang yang Hualei xin Ting Zhang Zhongjie Li Weizhong yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijingChina School of Health Policy and Management Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of management science and information system Faculty of Management and EconomicsKunming University of Science and TechnologyKunming CityYunnan ProvinceChina

Introduction:This study investigated the lagged correlation between Baidu Index for influenza-related keywords and influenza-like illness percentage(ILI%)across regions in *** aim is to establish a scientific foundation for utilizing Baidu Index as an early warning tool for influenza-like illness ***:In this study,data on ILI%and Baidu Index were collected from 30 provincial-level administrative divisions(PLADs)spanning April 2014 to March *** Baidu Index was categorized into Overall Index,Ordinary Index,Prevention Index,Symptom Index,and Treatment Index based on search query *** lagged correlation between the Baidu Index and ILI%was examined through the cross-correlation function(CCF)***:Correlating the Baidu Overall Index of 30 PLADs with ILI%revealed CCF values ranging from 0.46 to 0.86,with a median lag of 0.5 *** analysis indicated that the Prevention Index and Symptom Index exhibited quicker responses to ILI%,with median lags of−9 and−0.5 days,respectively,compared to 0 and 3 days for the Ordinary and Treatment *** median lag days between the Baidu Index and the ILI%were earlier in the northern PLADs compared to the southern ***:The Prevention and Symptom Indexes show promising predictive capabilities for influenzalike illness epidemics.

关键词： utilizing illness Baidu

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Mobile genetic elements facilitate the transmission of antibiotic resistance genes in multidrug-resistant Enterobacteriaceae from duck farms

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Food Science and Human Wellness 2024年第2期13卷 729-735页

作者： xin’er Zheng Dingting Xu Jinchang yan Min Qian Peng Wang Davood Zaeim Jianzhong Han Daofeng Qu School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310035China The Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 311100China Agricultural and rural Bureau of Wangdian Town Xiuzhou DistrictJiaxing 314011China

Multidrug-resistant(MDR)Enterobacteriaceae critically threaten duck farming and public *** phenotypes,genotypes,and associated mobile genetic elements(MGEs)of MDR Enterobacteriaceae isolated from 6 duck farms in Zhejiang Province,China,were investigated.A total of 215 isolates were identified as Escherichia coli(64.65%),Klebsiella pneumoniae(12.09%),Proteus mirabilis(10.23%),Salmonella(8.84%),and Enterobacter cloacae(4.19%).Meanwhile,all isolates were resistant to at least two *** isolates carried tet(A)(85.12%),blaTEM(78.60%)and sul1(67.44%)resistance *** co-occurrence analysis showed that the resistance genes were associated with IS26 and integrons.A conjugative IncFII plasmid pSDM004 containing all the above MGEs was detected in Proteus mirabilis isolate *** isolate was resistant to 18 antibiotics and carried the blaNDM-5 ***,especially plasmids,are the primary antibiotic resistance gene transmission route in duck *** findings provide a theoretical basis for the rational use of antibiotics in farms which are substantial for evaluating public health and food safety.

关键词： Duck farm Mobile genetic element Antibiotic resistance gene Plasmid Food safety

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Highly Transparent Fire-resistant Coatings with Intumescent Three-source Integration

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Chinese Journal of Polymer Science 2024年第7期42卷 907-915,I0005页

作者： xiao-Liang Zeng xin-Sheng Lan yan Wang Lin Zhang De-Ming Guo Hai-Bo Zhao State Grid Sichuan Electric Power Research Institute Chengdu610041China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(Ministry of Education) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)State Key Laboratory of Polymer Materials EngineeringCollege of ChemistrySichuan UniversityChengdu610064China

Wood,a readily available and sustainable natural resource,has found widespread use in construction and ***,its inherent flammability poses a potential fire *** intumescent fire-retardant coatings effectively mitigate this risk,achieving high transparency in such coatings presents a significant *** our approach,we employed a cross-linked network of phytic acid anion and N-[3-(trimethoxysilyl)propyl]-N,N,N-trimethylammonium cation to create a transparent"three-in-one"intumescent *** collaborative P/N/Si flame-retardant effect markedly improved the intumescent char-forming capability,preventing the wood from rapid *** resulted in a substantial reduction in heat release(13.9%decrease in THR)and an increased limiting oxygen index(LOI)value of 35.5%.Crucially,the high transparency of the coating ensured minimal impact on the wood's appearance,allowing the natural wood grains to remain clearly *** innovative approach provides a straightforward method for developing transparent intumescent flame-retardant coatings suitable for wooden *** potential applications extend to preserving ancient buildings and heritage conservation efforts.

关键词： Fire-resistant coating Flame retardancy Wood Transparency

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