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Unlocking the potential of transdermal drug delivery

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International Journal of Smart and Nano Materials 2024年第3期15卷 432-468页

作者： Shuang Li Jianhao Wu xiangjun Peng xi-qiao feng Institute of Biomechanics and Medical Engineering Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijingChina

Transdermal drug delivery(TDD)has gained clinical approval over several decades,with extensive research dedicated to novel drug and device *** notable research progress,the mar-ket adoption of TDD devices has not met anticipated levels,with oral administration and injection remaining predominant delivery *** maximize the potential of TDD,we identify bottlenecks hinder-ing its widespread clinical application and propose promising research *** begin by analyzing stringent demands necessary to truly benefit patients,addressing significant challenges in biomechanics,nanomedicine,and flexible ***,we delve into skin anatomy,enhancement strategies,nano-carriers,and their under-lining mechanisms,highlighting the importance and framework of quantitative *** on these discussions,we highlight the core strength of TDD,such as automatic precise administration based on feedback and high delivery efficiencies,especially applicable to localized conditions(e.g.,central nervous system diseases,tumors).Finally,we envision the future of intelligent TDD device and its opera-tion scenario,aiming to steer research efforts toward faster translation of laboratory innovations into widely used products for sufferers.

关键词： Transdermal drug delivery biomechanics nanomedicine flexible electronics

Spinodal surface instability of soft elastic thin films

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Acta Mechanica Sinica 2008年第3期24卷 289-296页

作者： Shi Qing Huang xi qiao feng Department of Engineering Mechanics Tsinghua University Beijing 100084 China

When the thicknesses of thin films reduce to microns or even nanometers, surface energy and surface interaction often play a significant role in their deformation behavior and surface morphology. The spinodal surface instability induced by the van der Waals force in a soft elastic thin film perfectly bonded to a rigid substrate is investigated theoretically using the bifurcation theory of elastic structures. The analytical solution is derived for the critical condition of spinodal surface morphology instability by accounting for the competition of the van der Waals interaction energy, elastic strain energy and surface energy. Detailed examinations on the effect of surface energy, thickness and elastic properties of the film show that the characteristic wavelength of the deformation bifurcation mode depends on the film thickness via an exponential relation, with the power index in the range from 0.749 to 1.0. The theoretical solution has a good agreement with relevant experiment results.

关键词： Thin film Surface instability Surface energy van der Waals force

Two-dimensional model of vesicle adhesion on curved substrates

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Acta Mechanica Sinica 2006年第6期22卷 529-535页

作者： Wendong Shi xi qiao feng Huajian Gao Department of Engineering Mechanics Tsinghua University Beijing 100084 China Division of Engineering Brown University 182 Hope Street Providence RI 02912 USA

We develop a two dimensional model of a vesicle adhered on a curved substrate via long-range molecular interactions while subjected to a detachment force. The relationship between the force and displacement of the vesicle is investigated as a function of the substrate shape. It is shown that both the force- displacement relationship and the maximum force at pull-off are significantly dependent on the substrate shape. The results suggest that probes with different tip shapes may be designed for cell manipulation. For example, we demonstrate that a vesicle can be pulled off a fiat surface using a probe with a curved tip.

关键词： Biomechanics Cell adhesion-Vesicle Adhesive contact Cell manipulation

About the special topic of mechanics and biomimetics of biomaterials and animal locomotion

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Acta Mechanica Sinica 2010年第1期26卷 3-4页

作者： xi qiao feng Mao Sun Institute of Biomechanics and Medical Engineering Department of Engineering Mechanics Tsinghua University 100084 Institute of Fluid Mechanics Beihang University 100083 Beijing China

Scientists have increasingly been turning their attentions to searching for inspirations from the splendid living world in order to solve various challenging problems of technologically importance. Rapid advances in observation techniques and computational ability will make it a reality to understand, at different time and space scales, the functions,

关键词： locomotion challenging swimming reality searching striking running flying advances kinematics

Controllable Nanostructural Transitions in Grafted Nanoparticle-Block Copolymer Composites

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Nano Research 2010年第5期3卷 356-362页

作者： Guang-Kui Xu xi-qiao feng Shou-Wen Yu Institute of Biomechanics and Medical Engineering Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

We report a theoretical investigation of self-assembled nanostructures of polymer-grafted nanoparticles in a block copolymer and explore underlying physical mechanisms by employing the self-consistent field method. By varying the particle concentration or the chain length and density of the grafted polymer, one can not only create various ordered morphologies (e.g., lamellar or hexagonally packed patterns) but also control the positions of nanoparticles either at the copolymer interfaces or in the center of one-block domains. The nanostructural transitions we here report are mainly attributed to the competition between entropy and enthalpy.

关键词： Block copolymer nanocomposite pattern formation self-assembly self-consistent field theory

A dynamic cellular vertex model of growing epithelial tissues

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Acta Mechanica Sinica 2017年第2期33卷 250-259页

作者： Shao-Zhen Lin Bo Li xi-qiao feng Institute of Biomechanics and Medical Engineering AMLDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084China

Intercellular interactions play a significant role in a wide range of biological functions and processes at both the cellular and tissue scales, for example, embryogenesis, organogenesis, and cancer invasion. In this paper, a dynamic cellular vertex model is presented to study the morphomechanics of a growing epithelial monolayer. The regulating role of stresses in soft tissue growth is revealed. It is found that the cells originating from the same parent cell in the monolayer can orchestrate into clustering patterns as the tissue grows. Collective cell migration exhibits a feature of spatial correlation across multiple cells. Dynamic intercellular interactions can engender a variety of distinct tissue behaviors in a social context. Uniform cell proliferation may render high and heterogeneous residual compressive stresses, while stress-regulated proliferation can effectively release the stresses, reducing the stress heterogeneity in the tissue. The results highlight the critical role of mechanical factors in the growth and morphogenesis of epithelial tissues and help understand the development and invasion of epithelial tumors.

关键词： Soft tissue Cellular vertex model Cell Morphogenesis

Tuning frictional properties of molecularly thin erucamide films through controlled self-assembling

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Acta Mechanica Sinica 2021年第7期37卷 1041-1049,I0001页

作者： Youyu Di Shuai Zhang xi-qiao feng Qunyang Li Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua UniversityBeijing 100084China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

Self-assembled films(SAFs)have been proposed to be a promising candidate for molecularly thin ***,the frictional performance of SAFs is sensitively dependent on their molecular structures that are susceptible to external *** erucamide,a fatty amide widely used as a macroscale slip additive,as an example,we demonstrate that SAFs can be readily formed on various substrates,including silicon oxide,sapphire,copper,and *** high-resolution topography and friction measurements,two types of erucamide SAFs are *** first type is atomically flat and exhibits clear atomic stick–slip friction behavior and ultra-low frictional dissipation;while the second type has a stripe-like nanoscale pattern and shows much higher(8 times higher)frictional *** sharp contrast between these two types of SAFs is attributed to their distinct molecular structures originating from different interactions between erucamide molecules and *** further demonstrate that,by proper surface functionalization,we can actively and reliably control the molecular structures of SAFs through guided self-assembling,achieving rational friction tuning with patterning capability.

关键词： Friction Lubrication Erucamide Two-dimensional organic film Self-assembly

Morphology of liquid drops and thin films on a solid surface with sinusoidal microstructures

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Acta Mechanica Sinica 2006年第4期22卷 315-322页

作者： Jian Lin Liu xi qiao feng Shou Wen Yu Department of Engineering Mechanics Tsinghua University Beijing 100084 China

Surface microstructures of solid materials play a significant role in various wetting and dewetting phenomena. In the present paper, the effect of micro- and nano-structures of a substrate surface on the morphology and evolution of liquid droplets and thin films is examined. The governing equations satisfied by droplets and films on a sinusoidal surface are derived by considering van der Waals force, surface tension, gravity and hydrostatic pressure. The morphologies of both liquid droplets and thin films are numerically simulated under various characteristic sizes of roughness. It is found that the droplet shapes show a significant dependence upon the characteristic sizes of substrate microstructures. A thin liquid film on a hydrophilic substrate may have a horizontal surface or replicate the substrate morphology, depending on the wavelength of roughness.

关键词： Microstructure Roughness Wetting Thin film Droplet

On elastocapillarity:A review

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Acta Mechanica Sinica 2012年第4期28卷 928-940页

作者： Jian-Lin Liu xi-qiao feng School of Pipeline and Civil Engineering China University of Petroleum266555 QingdaoChina Institute of Biomechanics and Medical Engineering Department of Engineering MechanicsTsinghua University100084 BeijingChina

Elastocapillary phenomena involving elastic deformation of solid structures coupled with capillary effects of liquid droplets/films can be observed in a diversity of fields, e.g., biology and microelectromechanical systems （MEMS）. Understanding the physical mechanisms underlying these phenomena is of great interest for the design of new materials and devices by utilizing the effects of surface tension at micro and nano scales. In this paper, some recent developments in the investigations on elastocapillary phenomena are briefly reviewed. Especially, we consider the deformation, adhesion, self-assembly, buckling and wrinkling of ma- terials and devices induced by surface tensions or capillary forces. The main attention is paid to the experimental results of these phenomena and the theoretical analysis meth- ods based on continuum mechanics. Additionally, the applications of these studies in the fields of MEMS, micro/nanometrology, and biomimetic design of advanced materials and devices are discussed.

关键词： Soft matter. Surface tension Elastocapillarity Self-assembly- Wetting - Adhesion. Instability. Microstructure Biomimetics