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Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2038-2059页

作者： xiang-Hui Wan Guo-Bing Jin Qun yang Ji-Long Hu Zhi-Liang Liu Jun Rao Can Wen Peng-Ling Li xi-mei yang Bo Huang xiao-Zhong Wang Jiangxi Medical College Nanchang UniversityNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Jiangxi Key Laboratory of Translational Research for Cancer Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Abdominal Surgery Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Pathology Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Science and Education Section Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Children’s HospitalNanchang 330006Jiangxi ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Province Key Laboratory of Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Heterogeneous ribonucleoprotein A1(hnRNPA1)has been reported to enhance the Warburg effect and promote colon cancer(CC)cell proliferation,but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been *** To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT *** Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of *** relationship between the expression values and the clinicopathological features of the patients was *** in mRNA expression were analyzed using quantitative real-time polymerase chain reaction,while differences in protein expression were analyzed using western *** proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays,and cell cycle and apoptosis were detected using flow cytometric *** targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter *** Warburg effect was evaluated by glucose uptake and lactic acid production *** The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls(P<0.05).Immunohistochemical results demonstrated significant variations in the expression of the hnRNPA1-b antigen in different stages of CC,including stage I,II-III,and ***,the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T ***1-b was found to enhance the Warburg effect through the PI3K/AKT pathway,thereby promoting proliferation of HCT116 and SW620 ***,the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNPA1-b,effectively blocking the Warburg ***

关键词： Heterogeneous ribonucleoprotein A1-b MiR-490-3p Colon cancer Alternative splicing Warburg effect

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin Jun Xu Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity

城市公共交通站点间实时动态行程时间预测的模型

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吉林大学学报（工学版） 2002年第1期32卷 47-51页

作者：孙喜梅杨兆升吉林大学数学学院吉林长春130025 吉林大学交通学院吉林长春130025

利用随机服务系统理论 ,给出了进入路段 (含信号交叉口 )

关键词：智能运输系统 ITS 公共交通实时动态行程时间平均行驶速度排队等待时间

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使用二维码进行固定资产盘点的研究

现代工业经济和信息化 2017年第1期7卷 17-18页

作者：张娜陈宁陈习杨眉吕志鹏付越海南电网有限责任公司信息通信分公司海南海口570203

探讨了固定资产盘点工作现状,分析了二维码的优势及劣势,研究了二维码标签的制作及使用。

关键词：二维码固定资产盘点电网公司

纳米尺度下水液滴撞击固体表面润湿性行为的分子动力学模拟

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原子与分子物理学报 2025年第2期42卷 91-97页

作者：王美婷祁影霞陶杰陈曦杨宇水张蕾刘妮杨果成上海理工大学能源与动力工程学院上海200093 上海海立集团股份有限公司上海201206

本文采用分子动力学方法研究纳米尺度下水液滴碰撞铜壁面的润湿过程,水滴温度和固液作用强度对润湿性行为的影响以及直径为4.67 nm球形液滴在273 K-353 K温区、固液作用强度在1-3范围内,水滴的润湿行为和平衡接触角与温度、固液作用强... 详细信息

本文采用分子动力学方法研究纳米尺度下水液滴碰撞铜壁面的润湿过程,水滴温度和固液作用强度对润湿性行为的影响以及直径为4.67 nm球形液滴在273 K-353 K温区、固液作用强度在1-3范围内,水滴的润湿行为和平衡接触角与温度、固液作用强度之间的变化关系.研究结果显示:液滴在不同润湿性壁面上会产生明显不同的润湿演化特性.模拟结果表明对于亲水材料,由于壁面附近水分子所受的势能束缚随温度升高而增强,平衡接触角则相应减小;对于疏水材料,由于随温度的升高分子之间增加的势能大于固液之间增加的势能而表现出平衡接触角随着温度升高而增大的趋势.因此,针对其材料亲水性能,可以通过改变温度影响其润湿行为,从而提高传热、传质和自清洁性能.

关键词：润湿性接触角分子动力学模拟纳米液滴

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8-ranks of Class Groups of Some Imaginary Quadratic Number Fields

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Acta Mathematica Sinica,English Series 2007年第11期23卷 2061-2068页

作者： xi mei WU Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016 P. R. China State Key Laboratory of Information Security Graduate School of Chinese Academy of Sciences Beijing 100039 P. R. China

Let F = Q（√-p1p2） be an imaginary quadratic field with distinct primes p1 = p2 = 1 mod 8 and the Legendre symbol （p1/p2） = 1. Then the 8-rank of the class group of F is equal to 2 if and only Pl if the following conditions hold：（1） The quartic residue symbols （p1/p2）4 = （p2/p1）4 = 1; （2） Either both p1 and p2 are represented by the form a^2 ＋ 32b^2 over Z and p^h2＋（2p1）/4=x^2-2p1y^2,x,y∈Z,or both p1 and p2 are not represented by the form a^2 ＋ 32b^2 over Z and p^h2＋（2p1）/4=ε（2x^2-p1y^2）,x,y∈Z,ε∈{±1},where h＋（2p1） is the narrow class number of Q（√2p1）,Moreover, we also generalize these results.

关键词： class group Rédei matrix reciprocity law

A Unified Measurement Solution of Software Trustworthiness Based on Social-to-Software Framework

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Journal of Computer Science & Technology 2018年第3期33卷 603-620页

作者： xi yang Gul Jabeen Ping Luo xiao-Ling Zhu mei-Hua Liu Key Laboratory for Information System Security School of Software Tsinghua University Beijing 100084 China School of Computer and Information Hefei University of Technology Hefei 230009 China Department of Foreign Languages and Literatures Tsinghua University Beijing 100084 China

As trust becomes increasingly important in software domain, software trustworthiness--as a complex high- composite concept, has developed into a big challenge people have to face, especially in the current open, dynamic and ever-changing Internet environment. Furthermore, how to recognize and define trust problem from its nature and how to measure software trustworthiness correctly and effectively play a key role in improving users＇ trust in choosing software. Based on trust theory in the field of humanities and sociology, this paper proposes a measurable S2S （Social-to-Software） software trustworthiness framework, introduces a generalized indicator loss to unify three parts of trustworthiness result, and presents a whole metric solution for software trustworthiness, including the advanced J-M model based on power function and time-loss rate for ability trustworthiness measurement, the fuzzy comprehensive evaluation advanced-model considering effect of multiple short boards for basic standard trustworthiness, and the identity trustworthiness measurement method based on the code homology detecting tools. Finally, it provides a case study to verify that the solution is applicable and effective.

关键词： software trustworthiness measurement solution loss social-to-software(S2S)framework generalized indicator

Dynamics of coherence-induced state ordering under Markovian channels

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Frontiers of physics 2018年第5期13卷 319-325页

作者： Long-mei yang Bin Chen Shao-Ming Fei Zhi-xi Wang School of Mathematical Sciences Capital Normal University Beijing 100048 China School of Mathematical Sciences Tianjin Normal University Tianjin 300387 China

We study the dynamics of coherence-induced state ordering under incoherent channels, particularly four specific Markovian channels： amplitude damping channel, phase damping channel, depolarizing channel and bit flit channel for single-qnbit states. We show that the amplitude damping channel, phase damping channel, and depolarizing channel do not change the coherence-induced state ordering by l1 norm of coherence, relative entropy of coherence, geometric measure of coherence, and Tsallis relative α-entropies, while the bit flit channel does change for some special cases.

关键词： l1-norm of coherence relative entropy of coherence geometric measure of coherence Tsallis relative a-entropies of coherence ordering state

Spheroidizing Behavior and Spheroidizing Kinetics of W-phase During Solid-Solution Treatment in Mg–Zn–Y–Mn–(B)Alloys

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Acta Metallurgica Sinica(English Letters) 2017年第5期30卷 464-469页

作者： Kai yang Jin-Shan Zhang xi-mei Zong Wei Liu Chun-xiang Xu College of Materials Science and Engineering TaiyuanUniversity of Technology Taiyuan 030024 China Shanxi Key Laboratory of Advanced Magnesium-based Materials Taiyuan 030024China

The spheroidizing mechanism of W-phase in the Mg–Zn–Y–Mn–（B） alloys during solid-solution treatment was investigated by using kinetic methodologies. The microstructure and mechanical properties of heat-treated Mg_（94）Zn_（2.5）-Y_（2.5）Mn_1 alloy containing 0.003 wt% B were compared with heat-treated Mg_（94）Zn_（2.5）-Y_（2.5）Mn_1 alloy. The heat-treated Mg_（94）Zn_（2.5）-Y_（2.5）Mn_1 alloy with 0.003 wt% B contained fine and uniform W-phase particles, which exhibited optimal mechanical performance. The ultimate tensile strength, yield strength and elongation were 287.7, 125.5 MPa and 21.1%,respectively.

关键词： Magnesium alloys W-phase Spheroidizing Kinetics Microstructure Mechanical properties