检索结果-南通市图书馆

Microscopic characterization and formation mechanisms of deep-water sandy-debris-flow and turbidity-current sandstones in a lacustrine basin： a case study in the Yanchang Formation of the Ordos Basin, China

引用

Petroleum Science 2018年第1期15卷 28-40页

作者： Jian-Bo Liao Ai-hua xi Zhi-Yong Li hua-Qing Liu xiang-Bo Li Rong Wanyan School of Geoscience and Technology Southwest Petroleum University Chengdu 610500 Sichuan China Petro China Research Institute of Petroleum Exploration &Development-Northwest Lanzhou 730020 Gansu China Key Laboratory of Reservoir Description CNPCLanzhou 730020 Gansu China

Deep-water deposition is a current issue in sedimentological research. Sandy-debris-flow sandstones and turbidity-current sandstones are the main types of sandstone that are the focus of considerable disputes in this research. Previous studies mainly focused on description of the macroscopic sedimentary structure and theoretical derivation of the formation mechanisms. The microscopic petrological characteristics, reservoir properties, and formation mechanisms of deep-water sandy-debris-flow and turbidity-current sandstones have been studied in the Yanchang Formation of the Ordos Basin,China, by means of field outcrop surveys, thin-section identification, geochemical element analysis, and porosity and permeability measurements under overburden pressure. The content of detrital grains in the sandy-debris-flow sandstones is high, whereas the contents of mica sheets and matrix are low. The fine-grained matrix is distributed unevenly within the pores. A considerable number of residual intergranular pores are preserved in the middle of single sand bodies, resulting in relatively better reservoir properties. The total number of detrital grains in the turbidite sandstone is low, while it contains abundant mica sheets and matrix. The mica sheets and fine-grained matrix are distributed evenly within the pores, resulting in serious damage to pores and poor reservoir properties. The sandy-debris-flow sandstones in the center of the lake basin form a high-quality reservoir; thus, this area is suitable for oil and gas exploration.

关键词： Sandy debris flow Turbidite Ordos Basin Petrology Reservoir properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D-QSAR Models of Anti-tumor Activity for Histone Deacetylase Inhibitors Containing Dihydropyridin-2-one

引用

Chinese Journal of Structural Chemistry 2020年第5期39卷 855-860页

作者： FENG Hui DU xi-hua CHEN Yan FENG Chang-Jun School of Chemistry&Chemical Engineering Xuzhou University of TechnologyXuzhouJiangsu 221018China

A 3D-QSAR study was conducted to analyze the anti-tumor activity(pHs,s=1,6)of dihydropyridin-2-one containing histone deacetylase inhibitor(DHDACi)to histone deacetylase(HDACs,s=1,6)by the comparative molecular field analysis(CoMFA)*** predicting model was established based on the training set of 22 compounds,which was verified by the test set of 6 compounds containing template *** results showed that the contributions of steric and electrostatic fields to pH1 are 37.6%and 62.4%,and those to pH6 are 44.6%and 55.4%,*** coefficients of the cross-validation(Rcv2)and the non cross-validation(R2)are 0.574 and 0.947 for pH1,and 0.488 and 0.884 for pH6,*** models were then used to predict the activities of the compounds for the training and testing *** results indicated that the models had strong stability and good *** on the 3D contour maps,several new potential inhibitors with higher anti-tumor activity were ***,the effectiveness of these potential inhibitors is still needed to be verified by the experimental results.

关键词： dihydropyridin-2-one histone deacetylase inhibitor anti-tumor activity 3D-QSAR comparative molecular field analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Constraint-induced movement therapy in treatment of acute and sub-acute stroke: a meta-analysis of 16 randomized controlled trials

引用

Neural Regeneration Research 2017年第9期12卷 1443-1450页

作者： xi-hua Liu Juan huai Jie Gao Yang Zhang Shou-wei Yue Department of Physical Medicine & Rehabilitation Qilu Hospital Shandong University Department of Physical Medicine & Rehabilitation The Affiliated Hospital of Shandong Traditional Chinese Medicine University Shandong Institute of Prevention and Control for Endemic Disease

OBJECTIVE： The aim of this meta-analysis was to evaluate the clinical efficacy of constraint-induced movement therapy in acute and sub-acute stroke. DATA SOURCES： The key words were stroke, cerebrovascular accident, constraint-induced therapy, forced use, and randomized controlled trial. The databases, including China National Knowledge Infrastructure, WanFang, Weipu Information Resources System, Chinese Biomedical Literature Database, PubMed, Med- line, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews, were searched for studies on randomized controlled trials for treating acute or sub-acute stroke published before March 2016. DATA SELECTION： We retrieved relevant randomized controlled trials that compared constraint-induced movement therapy in treatment of acute or sub-acute stroke with traditional rehabilitation therapy （tradi- tional occupational therapy）. Patients were older than 18 years, had disease courses less than 6 months, and were evaluated with at least one upper extremity function scale. Study quality was evaluated, and data that met the criteria were extracted. Stata 11.0 software was used for the meta-analysis. OUTCOME MEASURES： Fugl-Meyer motor assessment of the arm, the action research-arm test, a motor activity log for amount of use and quality of movement, the Wolf motor function test, and a modified Bar- thel index. RESULTS： A total of 16 prospective randomized controlled trials （379 patients in the constraint-induced movement-therapy group and 359 in the control group） met inclusion criteria. Analysis showed significant mean differences in favor of constraint-induced movement therapy for the Fugl-Meyer motor assessment of the arm （weighted mean difference （WMD） = 10.822; 95% confidence intervals （95% CI）： 7.419-14.226）, the action research-arm test （WMD = 10.718; 95% CI： 5.704-15.733）, the motor activity log for amount of use and quality of movement （WMD = 0.812; 95% CI： 0.331-1.293） and

关键词： nerve regeneration stroke constraint-induced movement therapy meta-analysis upper extremity function rehabilitation intensity neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis

引用

World Journal of Gastroenterology 2021年第17期27卷 1973-1992页

作者： xi-hua Dong Di Dai Zhi-Dong Yang xiao-Ou Yu hua Li Hui Kang Department of Laboratory Medicine The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Primary biliary cholangitis(PBC)is a chronic and slowly progressing cholestatic disease,which causes damage to the small intrahepatic bile duct by immunoregulation,and may lead to cholestasis,liver fibrosis,cirrhosis and,eventually,liver *** To explore the potential diagnosis and staging value of plasma S100 calcium binding protein A6(S100A6)messenger ribonucleic acid(mRNA),LINC00312,LINC00472,and LINC01257 in primary biliary *** A total of 145 PBC patients and 110 healthy controls(HCs)were *** them,80 PBC patients and 60 HCs were used as the training set,and 65 PBC patients and 50 HCs were used as the validation *** relative expression levels of plasma S100A6 mRNA,long noncoding ribonucleic acids LINC00312,LINC00472 and LINC01257 were analyzed using quantitative reverse transcription-polymerase chain *** bile duct ligation(BDL)mouse model was used to simulate *** double immunofluorescence was conducted to verify the overexpression of S100A6 protein in intrahepatic bile duct cells of BDL *** intrahepatic biliary epithelial cells were treated with glycochenodeoxycholate to simulate the cholestatic environment of intrahepatic biliary epithelial cells in *** The expression of S100A6 protein in intrahepatic bile duct cells was up-regulated in the BDL mouse model compared with sham *** relative expression levels of plasma S100A6 mRNA,log10 LINC00472 and LINC01257 were upregulated while LINC00312 was down-regulated in plasma of PBC patients compared with HCs(3.01±1.04 vs 2.09±0.87,P<0.0001;2.46±1.03 vs 1.77±0.84,P<0.0001;3.49±1.64 vs 2.37±0.96,P<0.0001;1.70±0.33 vs 2.07±0.53,P<0.0001,respectively).The relative expression levels of S100A6 mRNA,LINC00472 and LINC01257 were up-regulated and LINC00312 was down-regulated in human intrahepatic biliary epithelial cells treated with glycochenodeoxycholate compared with control(2.97±0.43 vs 1.09±0.08,P=0.0018;2.70±0.26 vs 1.10±0.10,P=0.0006;2.23±0.

关键词： S100 calcium binding protein A6 Long noncoding ribonucleic acids Primary biliary cholangitis Biomarker Diagnosis Staging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

血清β-arrestin 2、HIF-1a及CA125联合预测慢性乙型肝炎肝纤维化的价值

引用

肝脏 2024年第5期29卷 521-525页

作者：汪蕾陈晨华喜梅胡丰芬宿迁市第一人民医院医学检验科江苏223800 宿迁市第一人民医院普外肝胆江苏223800 宿迁市沭阳县疾控中心检验科 223600 宿迁市沭阳县中医院医学检验科 223800

目的探讨血清β-抑制蛋白2(β-arrestin2)、缺氧诱导因子1a(hypoxia inducible factor1α,HIF-1a)及糖类抗原125(carbohydrate antigen 125,CA125)联合预测慢性乙型肝炎(chronic Hepatitis B,CHB)肝纤维化的价值。方法选择宿迁市第一人民医院于2019年5月—2022年5月收治的110例CHB患者为研究对象,设为观察组,另选同期于我院体检中心体检的110名健康者为对照组。比较两组血清β-arrestin2、HIF-1a、CA125水平、观察肝纤维化不同病理分期患者以上指标水平,另通过ROC明确以上指标联合预测CHB处于S4的价值,采用多因素logistic回归分析CHB处于S4的危险因素,采用Pearson相关性分析以上指标与肝硬化病理分期的相关性。结果与对照组相比,观察组血清β-arrestin2、HIF-1a、CA125水平均有显著升高(t=21.376、21.548、71.752,P<0.05);肝纤维化S1、S2、S3、S4患者的血清β-arrestin2、HIF-1a、CA125水平逐渐升高(F=140.309、63.837、82.963,P<0.05);经ROC分析证实血清β-arrestin2、HIF-1a、CA125水平均可用于CHB处于S4的预测中,曲线下面积分别为0.984、0.926、0.956,且联合诊断能够获得更高的曲线下面积0.999,均有P<0.05;多因素logistic回归分析显示,β-arrestin2≥96.37 pg/mL(OR=2.011,95%CI:1.211~3.339)、HIF-1a≥74.345μg/L(OR=1.696,95%CI:1.026~2.804)、CA125≥173.27 U/mL(OR=2.117,95%CI:1.974~3.987)是CHB处于S4的危险因素;血清β-arrestin2、HIF-1a、CA125水平与CHB肝纤维化分期呈正相关(r=0.458、0.651、0.531,均有P<0.05)。结论血清β-arrestin2、HIF-1a、CA125水平均能用于预测CHB肝纤维化,当以上指标水平越高肝纤维化程度越重,且联合应用时的敏感度更高,多个参数联合诊断可进一步提高诊断结果的客观性以及准确率,减少漏诊、误诊情况的发生,值得临床推广。

关键词：血清β-抑制蛋白2 缺氧诱导因子1a 糖类抗原125 慢性乙型肝炎肝纤维化

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Early constraint-induced movement therapy affects behavior and neuronal plasticity in ischemia-injured rat brains

引用

Neural Regeneration Research 2019年第5期14卷 775-782页

作者： xi-hua Liu Hong-Yan Bi Jie Cao Shuo Ren Shou-Wei Yue Department of Physical Medicine & Rehabilitation Affiliated Hospital of Shandong Traditional Chinese Medicine University Maternal and Child Health Development Research Center Shandong Maternal and Child Health Hospital Department of Physical Medicine & Rehabilitation Qilu Hospital Shandong University

Constraint-induced movement therapy is an effective rehabilitative training technique used to improve the restoration of impaired upper extremity movement after stroke. However, whether constraint-induced movement therapy is more effective than conventional rehabilitation in acute or sub-acute stroke remains controversial. The aim of the present study was to identify the optimal time to start constraint-induced movement therapy after ischemic stroke and to explore the mechanisms by which constraint-induced movement therapy leads to post-stroke recovery. Sixty-four adult male Sprague-Dawley rats were randomly divided into four groups: sham-surgery group, cerebral ischemia/reperfusion group, early constraint-induced movement therapy group, and late constraint-induced movement therapy group. Rat models of left middle cerebral artery occlusion were established according to the Zea Longa line embolism method. Constraint-induced movement therapy was conducted starting on day 1 or day 14 in the early constraint-induced movement therapy and late constraint-induced movement therapy groups, respectively. To explore the effect of each intervention time on neuromotor function, behavioral function was assessed using a balance beam walking test before surgery and at 8 and 21 days after surgery. The expression levels of brain-derived neurotrophic factor, nerve growth factor and Nogo receptor were evaluated using real time-polymerase chain reaction and western blot assay to assess the effect of each intervention time. The results showed that the behavioral score was significantly lower in the early constraint-induced movement therapy group than in the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. At 21 days, the scores had significantly decreased in the early constraint-induced movement therapy and late constraint-induced movement therapy groups. At 8 days, only mild pyknosis appeared in neurons of the ischemic penumbra in the early co

关键词： nerve regeneration ischemic stroke rehabilitation constraint-induced movement therapy nerve growth factors functional recovery neuronal plasticity real time-polymerase chain reaction western blot assay rats neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

腹腔镜阑尾切除术后切口感染发生情况及高危因素分析

引用

中国实用医药 2024年第17期19卷 63-66页

作者：曹成斌翁细华姚学勤余干县人民医院 335100

目的探讨急性阑尾炎(AA)患者行腹腔镜阑尾切除术(LA)治疗后切口感染发生情况及其影响因素。方法回顾性分析542例AA患者的临床资料,均行LA进行治疗,依据术后是否发生切口感染分为非感染组(n=462)与感染组(n=80)。采用调查问卷调查两组一... 详细信息

目的探讨急性阑尾炎(AA)患者行腹腔镜阑尾切除术(LA)治疗后切口感染发生情况及其影响因素。方法回顾性分析542例AA患者的临床资料,均行LA进行治疗,依据术后是否发生切口感染分为非感染组(n=462)与感染组(n=80)。采用调查问卷调查两组一般资料,并采取单因素分析、多因素Logistic回归分析法,分析LA术后发生切口感染的高危因素。结果542例患者中,共发生切口感染80例,切口感染发生率为14.76%(80/542)。单因素分析显示,感染组年龄>50岁、病程>24 h、病理类型为化脓性或坏疽穿孔性阑尾炎、合并基础疾病、手术时间>1.5 h及有吸烟史占比分别为67.5%(54/80)、66.3%(53/80)、72.5%(58/80)、62.5%(50/80)、68.8%(55/80)、36.3%(29/80),均高于非感染组的44.8%(207/462)、31.0%(143/462)、24.9%(115/462)、27.1%(125/462)、35.1%(162/462)、21.9%(101/462)(P50岁、病程>24 h、病理类型为化脓性或坏疽穿孔性阑尾炎、合并基础疾病、手术时间>1.5 h及有吸烟史均是导致AA患者行LA术后发生切口感染的高危因素(P<0.05)。结论年龄、病程、病理类型、合并基础疾病、手术时间及吸烟史均是导致AA患者术后切口感染发生的影响因素,临床护理过程中应加以重视,并开展相应的干预措施。

关键词：急性阑尾炎腹腔镜阑尾切除术切口感染高危因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

短凯伦藻高效溶藻菌Pseudoalteromonas shioyasakiensis SE3的分离、鉴定及溶藻作用研究

引用

海洋与湖沼 2024年第4期55卷 896-904页

作者：姚玉芳吴在兴袁涌铨贺立燕曹西华宋秀贤俞志明中国科学院海洋研究所、海洋生态与环境科学重点实验室山东青岛266071 青岛海洋科技中心、海洋生态与环境科学功能实验室山东青岛266237 中国科学院大学北京100049

微生物防控法以其生态调控功能和环境友好特征成为赤潮治理领域备受关注的一种方法。从短凯伦藻(Karenia brevis)藻际微生物中筛选出一株高效溶藻菌,研究了其对短凯伦藻的溶藻特性、溶藻作用方式及机制。经16S rDNA鉴定,该溶藻菌属于假... 详细信息

微生物防控法以其生态调控功能和环境友好特征成为赤潮治理领域备受关注的一种方法。从短凯伦藻(Karenia brevis)藻际微生物中筛选出一株高效溶藻菌,研究了其对短凯伦藻的溶藻特性、溶藻作用方式及机制。经16S rDNA鉴定,该溶藻菌属于假交替单胞菌属细菌Pseudoalteromonas shioyasakiensis SE3。结果表明,菌株SE3的溶藻效果不受细菌生长阶段的影响,主要受细菌数量的影响,当细菌密度为1.2×107 cells/mL时,在6 h即能达到100%的溶藻率。基于扫描与透射电镜等研究发现,菌株SE3主要以与藻细胞直接接触的作用方式溶藻,菌株SE3首先破坏短凯伦藻膜结构,侵入藻细胞内部,导致藻细胞的死亡。上述研究结果为利用藻际细菌防控赤潮提供了重要参考。

关键词：赤潮治理微生物方法溶藻细菌假交替单胞菌溶藻机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of cerebrovascular changes in Alzheimer's disease mice by photoacoustic imaging

引用

Journal of Innovative Optical Health Sciences 2024年第6期17卷 29-40页

作者： xi Li Zhongyang Zhang hua Shi Feifan Zhou Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical Engineering Hainan University Sanya 572025P.R.China

The cerebral vasculature plays a significant role in the development of Alzheimer's disease(AD),however,the specific association between them remains *** this paper,based on the benefits of photoacoustic imaging(PAI),including label-free,high-resolution,in vivo imaging of vessels,we investigated the structural changes of cerebral vascular in wild-type(WT)mice and AD mice at different ages,analyzed the characteristics of the vascular in different brain regions,and correlated vascular characteristics with cognitive *** results showed that vascular density and vascular branching index in the cortical and frontal regions of both WT and AD mice decreased with ***,vascular lacunarity increased with age,and the changes in vascular structure were more pronounced in AD *** trend of vascular dysfunction aligns with the worsening cognitive dysfunction as the disease ***,we utilized in vivo PAI to analyze the changes in vascular structure during the progression of AD,elucidating the spatial and temporal correlation with cognitive impairment,which will provide more intuitive data for the study of the correlation between cerebrovascular and the development of AD.

关键词： Photoacoustic imaging Alzheimer's disease cerebrovascular vascular network cognitive impairment.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Systematic Synthesis on Pathological Models of CCCII and Modified CCCII

引用

Journal of Electronic Science and Technology 2018年第2期16卷 163-168页

作者： Yong-An Li Yan-hua xi Zhan-Ting Fan Yu-Ye Zhang Ji-xia Wu School of Physics and Electronic Engineering Xianyang Normal UniversityXianyang 712000

According to the equivalent view for the terminal current-voltage constraint relationship between pathological elements and the various second-generation current-controlled convegors （CCCIIs）, four patholo- gical models for the CCCII are first derived by means of the nodal admittance matrix expansion in this paper. Moreover, 48 new pathological models for the modified CCCII are also synthesized. The derived pathological models for the various CCCIIs are expected to be useful in circuit analysis and synthesis.

关键词： Modified second-generation currentcontrolled conveyor pathological elements secondgeneration current-controlled conveyor systematic synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：