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Human-micromanipulator cooperation using a variable admittance controller

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Science China(Information Sciences) 2019年第5期62卷 14-16页

作者： Hsieh-Yu LI Theshani NURADHA Sebaratnam Alex xavier U-Xuan TAN Pillar of Engineering Product Development Singapore University of Technology and Design Department of Electronic and Telecommunication Faculty of Engineering University of Moratuwa

Dear editor,Micro-scale operations, such as microsurgery [1]and micro-devices assembly [2], have been gaining importance among different industries. However,it is challenging to execute these operations owing to the accuracy requirements of the operation which are close to the limit of the human hand accuracy. For example, microsurgery is a diffi-

关键词： Human-micromanipulator cooperation using a variable admittance controller

Health care-associated hepatitis C virus infection

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World Journal of Gastroenterology 2014年第46期20卷 17265-17278页

作者： Bruno Pozzetto Meriam Memmi Olivier Garraud xavier Roblin Philippe Berthelot Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP EA3064) Faculty of Medecine of Saint-EtienneUniversity of Lyon42023 Saint-EtienneFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-Etienne42055 Saint-EtienneFrance Institut National de la Transfusion Sanguine 75015 ParisFrance Department of Gastroenterology and Hepatology University-Hospital of Saint-Etienne42055 Saint-EtienneFrance Department of Infectious Diseases and Hygiene University-Hospital of Saint-Etienne42055 Saint-EtienneFrance

Hepatitis C virus(HCV)is a blood-borne pathogen that has a worldwide distribution and infects millions of ***-associated HCV infections represented a huge part of hepatitis C burden in the past via contaminated blood and unsafe injections and continue to be a serious problem of public *** present review proposes a panorama of health care-associated HCV infections via the three mode of contamination that have been identified:(1)infected patient to non-infected patient;(2)infected patient to non-infected health careworker(HCW);and(3)infected HCW to non infected *** each condition,the circumstances of contamination are described together with the means to prevent *** a whole,the more important risk is represented by unsafe practices regarding injections,notably with the improper use of multidose vials used for multiple *** questions of occupational exposures and infected HCWs are also *** terms of prevention and surveillance,the main arm for combating care-associated HCV infections is the implementation of standard precautions in all the fields of cares,with training programs and audits to verify their good *** must be sensitized to the risk of blood-borne pathogens,notably by the use of safety devices for injections and good hygiene practices in the operating theatre and in all the invasive *** providers performing exposed-prone procedures must monitor their HCV serology regularly in order to detect early any primary infection and to treat it without *** the need to stay vigilant because HCV infection is often a hidden risk,it can be hoped that the number of people infected by HCV via health care will decrease very significantly in the next years.

关键词： Hepatitis C virus Health care-associated infection Health care worker Standard precautions Hemodialysis Unsafe injections Occupational exposure Antiviral drugs

Assessing the extent of community spread caused by mink-derived SARS-CoV-2 variants

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The Innovation 2021年第3期2卷 70-78页

作者： Liang Wang xavier Didelot Yuhai Bi George F.Gao CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China School of Life Sciences and Department of Statistics University of WarwickCoventry CV47ALUK University of Chinese Academy of Sciences Beijing 101408China

SARS-CoV-2 has recently been found to have spread from humans to minks and then to have transmitted back to ***,it is unknown to what extent the human-to-human transmission caused by the variant has ***,we used publicly available SARS-CoV-2 genomic sequences from both humans and minks collected in Denmark and the Netherlands,and combined phylogenetic analysis with Bayesian inference under an epidemiological model,to trace the possibility of person-to-person *** results showed that at least 12.5%of all people being infected with dominated minkderived SARS-CoV-2 variants in Denmark and the Netherlands were caused by human-to-human transmission,indicating that this“backto-human”SARS-CoV-2 variant has already caused human-to-human *** study also indicated the need for monitoring this mink-derived and other animal source“back-to-human”SARS-CoV-2 in future and that prevention and control measures should be tailored to avoid large-scale community transmission caused by the virus jumping between animals and humans.

关键词： SARS-CoV-2 mink human-to-human transmission

Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study

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World Journal of Gastroenterology 2007年第16期13卷 2328-2332页

作者： Laurent Peyrin-Biroulet Cécile Laclotte xavier Roblin Marc-André Bigard Department of Hepato-Gastroenterology University Hospital of Nancy Vandoeuvre-les-Nancy France Department of Hepato-Gastroenterology University Hospital of Grenoble La Tronche France

AIM: To evaluate the efficacy of adalimumab induction therapy in patients with ulcerative colitis who previously responded to infliximab and then lost response or became intolerant. METHODS: Ten patients with ulcerative colitis were enrolled in a 4-wk open-label trial. The patients received a loading dose of 160 mg adalimumab at wk 0 followed by 80 mg at wk 2. The primary efficacy measure was clinical improvement at wk 4, as defined by a decrease in clinical activity index (CAI) of more than 4. RESULTS: Four of 10 patients (40%) benefited from subsequent adalimumab therapy; one patient achieved remission (CAI 12) at baseline, none achieved remission and only one patient had clinical improvement at wk 4. CONCLUSION: The small advantage of adalimumab in patients with mild to moderate ulcerative colitis and lost response or intolerance to infliximab needs to be confirmed in randomised, double-blind, placebo- controlled trials.

关键词： Anti-TNF Intolerance Loss of response Adalimumab Ulcerative colitis

A Review of Transparent and Artificial Boundary Conditions Techniques for Linear and Nonlinear Schrodinger Equations

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Communications in Computational Physics 2008年第9期4卷 729-796页

作者： xavier Antoine Anton Arnold Christophe Besse Matthias Ehrhardt Achim Schadle Institut Elie Cartan Nancy(IECN) Universite Henri Poincare Nancy 1UMR 7502INRIA CoridaNancy-UniversiteFrance. Institut fur Analysis und Scientific Computing Technische Universitat WienWiedner Hauptstr.81040 WienAustria. Project-Team SIMPAF INRIA Lille Nord Europe Research Centre Laboratoire Paul Painleve U.M.R CNRS 8524 Universite des Sciences et Technologies de LilleFrance. Weierstrass Institute for Applied Analysis and Stochastics Mohrenstr.3910117 BerlinGermany. Zuse-Institut Berlin Takustrasse 714195 BerlinGermany.

In this review article we discuss different techniques to solve numerically the time-dependent Schrodinger equation on unbounded *** present in detail the most recent approaches and describe briefly alternative ideas pointing out the relations between these *** conclude with several numerical examples from different application areas to compare the presented *** mainly focus on the one-dimensional problem but also touch upon the situation in two space dimensions and the cubic nonlinear case.

关键词： Schrodinger equation transparent boundary conditions discrete convolution unbounded domain finite difference schemes finite elements

Associations between testicular development and fetal size in the pig

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1340-1350页

作者： Claire Stenhouse Yennifer Cortes-Araya F.xavier Donadeu Cheryl J.Ashworth Functional Genetics and Development Division The Roslin Institute and Royal(Dick)School of Veterinary StudiesUniversity of EdinburghMidlothianUK Department of Animal Science Texas A&M University440 Kleberg CenterCollege StationTX 77843-2471USA

Background:Impaired reproductive performance is the largest contributing factor for the removal of boars from commercial *** growth restricted piglets represent 25%of the total number of piglets born and have impaired reproductive *** study aimed to improve the understanding of temporal changes in testicular gene expression during testes development in fetuses of different *** lightest and closest to mean litter weight(CTMLW)male Large White×Landrace littermates were collected at gestational days(GD)45,60 and 90(n=5-6 litters/GD).Results:Testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at GD60 or *** plasma testosterone was not associated with fetal size at *** was no association between fetal size and seminiferous tubule area and number,number of germ or Sertoli cells per *** lightest fetuses tended to have wider seminiferous tubules compared to the CTMLW fetuses at GD90(P=0.077).The testicular expression of KI67(P≤0.01)and BAX:BCL2 ratio(P=0.058)mRNAs decreased as gestation *** SPP1 mRNA expression was observed at GD60 when compared with GD45 and 90(P≤0.05).Lower expression of DMRT1 and SPP1(P<0.01)mRNAs was observed in testes associated with the lightest fetuses compared to the CTMLW fetuses at ***:These findings provide novel insights into the expression profiles of genes associated with testicular development and ***,these data suggest that programming of reproductive potential in IUGR boars occurs late in gestation,providing a platform for further mechanistic investigation.

关键词： Fetal growth Intrauterine growth restriction(IUGR) Porcine Pregnancy Testes

Spatiotemporal patterns of burned areas,fire drivers,and fire probability across the equatorial Andes

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Journal of Mountain Science 2021年第4期18卷 952-972页

作者： xavier ZAPATA-RiOS Carmen LOPEZ-FABARA Abigail NAVARRETE Sandra TORRES-PAGUAY Miguel FLORES Department of Civil and Environmental Engineering Escuela Politecnica NacionalLadron de Guevara E11-253P.O.Box 17-01-2759QuitoEcuador Center for Research and Water Resources Studies(CIERHI) Escuela Politecnica NacionalLadron de Guevara E11-253P.O.Box 17-01-2759QuitoEcuador Faculty of Agricultural Sciences Universidad Central del EcuadorAv.UniversitariaP.O.Box 17-03-100QuitoEcuador Modeling Optimization and Inferential Statistics Group(MODES)Department of MathematicsEscuela Politecnica NacionalLadron de Guevara Ell-253P.O.Box 17-01-2759QuitoEcuador

Field-based fire studies in the equatorial Andes indicate that fires are strongly associated with biophysical and anthropogenic ***,fire controls and fire regimes at the regional scale remain ***,this paper describes spatial and temporal burned-area patterns,identifies biophysical and anthropogenic fire drivers,and quantifies fire probability across 6°of latitude and 3°of longitude in the equatorial *** spatial and temporal burned-area analysis was carried out based on 18 years(2001-2018)of the MCD64 A1 MODIS burned-area ***,topography,vegetation,and anthropogenic variables were integrated in a logistic regression model to identify the significance of explanatory variables and determine fire occurrence probability.A total of 5779 fire events were registered during the 18 years of this study,located primarily along the western cordillera of the Andes and spreading from North to ***-eight percent of these fires took place within two fire hotspots located in the northwestern and southwestern corners of the study ***-nine percent occurred during the second part of the year,between June and *** largest density of fires was primarily located on herbaceous vegetation and *** show that mean monthly temperature,precipitation and NDVI during the prefire season,the location of land cover classes such as forest and agriculture,distance to roads and urban areas,slope,and aspect were the most important determinants of spatial and temporal fire *** logistic regression model achieved a good accuracy in predicting fire probability(80%).Probability was higher in the southwestern and northern corners of the study area,and lower towards the north in the western and eastern piedmonts of the *** analysis contributes to the understanding of fires in mountains within the *** results here presented have the potential to contribute to fire management and control in the regi

关键词： MODIS MCD64A1 Spectral vegetation indices Pre-fire season NDVI and precipitation Remote sensing

Tunnel junctions in a III-V nanowire by surface engineering

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Nano Research 2015年第3期8卷 980-989页

作者： Salman Nadar Chloe Rolland Jean-Frangois Lampin xavier Wallart Philippe Caroff Renaud Leturcq Institute of Electronics Microelectronics and Nanotechnology CNRS-UMR 8520 ISEN Department Avenue Poincare CS 60069 59652 Villeneuve d'Ascq Cedex France Department of Electronic Materials Engineering Research School of Physics and Engineering The Australian National University Canberra ACT0200 Australia Departement Science et Analyse des Mat~riaux Centre de Recherche Public-Gabriel Lippmann 41 rue du Brill L-4422 Belvaux Luxembourg

We demonstrate a simple way of fabricating high performance tunnel devices from p-doped InAs nanowires by tailoring the n-doped surface accumulation layer inherent to InAs surfaces. By using appropriate ammonium sulfide based surface passivation before metallization without any further thermal treatment, we demonstrate characteristics of tunnel p-n junctions, namely Esaki and backward diodes, with figures of merit better than previously published for InAs homojunctions. The further optimization of both the surface doping, in a quantitative way, and the device geometry allows us to demonstrate that these nanowire-based technologically-simple diodes have promising direct current characteristics for integrated high frequency detection or generation.

关键词： semiconductor nanowire tunnel junction indium arsenidecompounds doping Ⅲ-Ⅴ semiconductors

XDEM multi-physics and multi-scale simulation technology: Review of DEM-CFD coupling, methodology and engineering applications

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Particuology 2019年第3期17卷 176-193页

作者： Bernhard Peters Maryam Baniasadi Mehdi Baniasadi xavier Besseron Alvaro Estupinan Donoso Mohammad Mohseni Gabriele Pozzetti Universite du Luxembourg 6. rue Coudenhove-Kalergi L-1359 Luxembourg

The extended discrete element method (XDEM) multi-physics and multi-scale simulation platform is being developed at the Institute of Computational Engineering, the University of Luxembourg. The platform is an advanced multi-physics simulation technology that combines flexibility and versatility to establish the next generation of multi-physics and multi-scale simulation tools. For this purpose, the simulation framework relies on coupling various predictive tools based on an Eulerian and Lagrangian approach. The Euleria n approach represents the wide field of con tinuum models;the Lagra ngian approach is perfect for characterising discrete phases. Continuum models thus include classical simulation tools, such as computational fluid dynamics simulation and finite element analysis, while an extended configuration of the classical discrete element method addresses the discrete (e.g., particulate) phase. Apart from predicting the trajectories of in dividual particles, XDEM-suite extends the application of the XDEM to estimating the thermodynamic state of each particle using advanced and optimised algorithms. The thermodynamic state may include temperature and species distributions due to chemical reaction and external heat sources. Hence, coupling these extended features with either computational fluid dynamics simulation or finite element analysis opens a wide range of applications as diverse as pharmaceuticals, agriculture, food processing, mining, construction and agricultural machinery, metals manufacturing, energy production and systems biology.

关键词： Multi-phase modelling Coupled computational fluid dynamics-discrete element method