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RUNX1-205, a novel splice variant of the human RUNX1 gene, has blockage effect on mesoderm-hemogenesis transition and promotion effect during the late stage of hematopoiesis

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Journal of Molecular Cell Biology 2020年第5期12卷 386-396页

作者： Wencui Sun Jiahui Zeng Jing Chang Yuan xue yonggang Zhang Xu Pan Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxing Liu Bo Chen Feng Ma Institute of Blood Transfusion Chinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)Chengdu 610052China State Key Laboratory of Biotherapy Sichuan UniversityChengdu 61006China State Key Laboratory of Experimental Hematology CAMS&PUMCTianjin 300020China

Runt-related transcription factor 1(RUNX1)is required for definitive hematopoiesis;however,the functions of most human RUNX1 isoforms are *** particular,the effects of RUNX1-205(a novel splice variant that lacks exon 6 in comparison with RUNX1b)on human hematopoiesis are not *** this study,a human embryonic stem cell(hESC)line with inducible RUNX1-205 overexpression was *** of these cells revealed that induction of RUNX1-205 overexpression at early stage did not influence the induction of mesoderm but blocked the emergence of CD34+cells,and the production of hematopoietic stem/progenitor cells was significantly *** addition,the expression of hematopoiesis-related factors was ***,these effects were abolished when RUNX1-205 overexpression was induced after Day 6 in co-cultures of hESCs and AGM-S3 cells,indicating that the inhibitory effect occurred prior to generation of hemogenic endothelial cells,while the promotive effect could be observed during the late stage of *** is very similar to that of ***,the mRNA expression profile of RUNX1-205 during hematopoiesis was distinct from that of RUNX1b,and the protein stability of RUNX1-205 was much higher than that of ***,the function of RUNX1-205 in normal and diseased models should be further explored.

关键词： mesoderm-hemogenesis transition hematopoiesis hematopoietic stem/progenitor cells (HSPCs) RUNX1 mesoderm embryonic stem cells (ESCs)

CaCO_(3)@CDs改性聚醚密封胶的制备及其性能研究

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粘接 2024年第10期51卷 1-4页

作者：戴永刚王涵钟巧怡薛俊东徐晓虹唐秀平广东金意陶陶瓷集团有限公司广东佛山528000 珠海科技学院应用化学与材料学院广东珠海519040 武汉理工大学材料科学与工程学院湖北武汉430070

为使聚醚密封胶在保持原有的粘接密封效果的同时,拥有更优异的力学性能。利用无水柠檬酸和甘氨酸为碳源,以微波法制备得到了碳点,并通过静电吸附制备得到CaCO_(3)@CDs复合粒子,并以CaCO_(3)@CDs为填料,制备硅烷改性聚醚密封胶。研究了CD... 详细信息

为使聚醚密封胶在保持原有的粘接密封效果的同时,拥有更优异的力学性能。利用无水柠檬酸和甘氨酸为碳源,以微波法制备得到了碳点,并通过静电吸附制备得到CaCO_(3)@CDs复合粒子,并以CaCO_(3)@CDs为填料,制备硅烷改性聚醚密封胶。研究了CDs的光学性能,以及添加量CaCO_(3)@CDs对密封胶力学性能的影响。研究结果表明,CDs可以被CaCO_(3)进行包覆得到CaCO_(3)@CDs复合粒子,该复合粒子可均匀分布在密封胶基体中。当CaCO_(3)@CDs掺量为100份时,CaCO_(3)@CDs改性聚醚密封胶的力学性能达到最佳。使其在保持原有的粘接密封效果的同时,拥有更优异的力学性能。

关键词：碳点密封胶力学性能

不同饲喂方式对断奶仔猪生长性能和健康状况的影响

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现代畜牧兽医 2024年第7期 24-28页

作者：杨静樊斌嵇宇郗晓龙吴雪儿聂存喜屈勇刚新疆芳草湖天康畜牧科技有限公司新疆昌吉831100 石河子大学动物科技学院新疆石河子832003

试验旨在研究液态和固态两种不同饲喂方式对断奶仔猪生长性能和健康状况的影响。将断奶后健康状况良好且体重较均一的360头“杜×长×大”三元仔猪随机分为对照组和试验组,每组5个重复,每个重复36头仔猪。对照组饲喂固态饲料,试验组饲... 详细信息

试验旨在研究液态和固态两种不同饲喂方式对断奶仔猪生长性能和健康状况的影响。将断奶后健康状况良好且体重较均一的360头“杜×长×大”三元仔猪随机分为对照组和试验组,每组5个重复,每个重复36头仔猪。对照组饲喂固态饲料,试验组饲喂水料比2.5∶1的液态料。试验期40 d。结果显示:试验组断奶仔猪的平均日增重较对照组提高了17.82%(P0.05);成活率较对照组提高了1.41%,腹泻率降低了30.51%。试验第7 d时,试验组断奶仔猪腹泻率比对照组降低了16.64%;随着饲养日龄逐渐增加,两组的腹泻率均呈不同趋势逐步降低;试验第40 d时,试验组和对照组断奶仔猪的腹泻率分别为0.46%、1.16%。不同饲喂方式对断奶仔猪的毛况和肤色影响不显著(P>0.05),但具有一定的改善趋势。研究表明,液态饲喂对断奶仔猪的生长性能和健康状况均具有一定的改善作用。

关键词：饲喂方式断奶仔猪生长性能健康状况

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汉中粮菜轮作发展模式现状及对策

长江蔬菜 2024年第6期 75-78页

作者：薛莲刘勇何忠军荆丹吴建静陈永刚牛娜魏芳勤顾朝军汉中市农业技术推广与培训中心陕西汉中723000

粮菜轮作模式既稳定粮食安全生产,又保障“菜篮子”供给,有着较高的经济效益和社会效益。近年来,汉中市粮菜轮作规模逐年扩增,轮作模式日益丰富。现有轮作模式以水稻—大蒜、水稻—松花菜、玉米—花椰菜等一年两茬模式为主。通过实地调... 详细信息

粮菜轮作模式既稳定粮食安全生产,又保障“菜篮子”供给,有着较高的经济效益和社会效益。近年来,汉中市粮菜轮作规模逐年扩增,轮作模式日益丰富。现有轮作模式以水稻—大蒜、水稻—松花菜、玉米—花椰菜等一年两茬模式为主。通过实地调查、填写问卷及座谈交流等方式,对汉中市粮菜轮作模式进行了深入调查,探索粮菜轮作发展现状及存在的问题,并提出可行的建议,旨在为汉中市粮菜轮作模式大面积示范推广提供参考。

关键词：粮菜轮作品种模式水稻玉米菜花

Robust Student’s t-based Rauch-Tung-Striebel Smoother for Non-stationary Heavy-tailed Measurement Noises

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Robust Student’s t-based Rauch-Tung-Striebel Smoother for N...

第40届中国控制会议

作者： Fengchi Zhu Chao xue Yulong Huang yonggang Zhang College of Intelligent Systems Science and Engineering Harbin Engineering University

To address the fixed-interval smoothing problem for a linear state-space model with non-stationary heavy-tailed measurement noises,a robust Student’s t-based Rauch-Tung-Striebel smoother is proposed in this *** measurement noise is modelled as a non-stationary Student’s t-distribution,which is written as a Gaussian hierarchical form by introducing Gaussian and Gamma random *** time-varying state trajectory,Student’s t-distribution parameters and auxiliary random variables are jointly estimated by using the variational Bayesian *** study shows that the proposed smoother outperforms the existing up-to-date smoothers in the face of non-stationary heavy-tailed measurement noises.

关键词： State estimation Rauch-Tung-Striebel smoother non-stationary heavy-tailed measurement noises variational Bayesian Student’s t-distribution

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喷嘴直径对等离子射流扩展特性的影响

弹道学报 2023年第4期35卷 27-34页

作者：薛皓琦余永刚南京理工大学能源与动力工程学院江苏南京210094

基于脉冲等离子体的电热化学发射是一种新概念超高速发射技术,脉冲等离子射流的喷嘴直径对其扩展特性影响较大。为研究喷嘴直径的变化所带来的影响,建立了等离子射流在大气中扩展的非稳态二维轴对称模型,根据等离子射流在大气中扩展的... 详细信息

基于脉冲等离子体的电热化学发射是一种新概念超高速发射技术,脉冲等离子射流的喷嘴直径对其扩展特性影响较大。为研究喷嘴直径的变化所带来的影响,建立了等离子射流在大气中扩展的非稳态二维轴对称模型,根据等离子射流在大气中扩展的特点设计了计算区域,并对计算域进行了网格无关性验证。选用Fluent软件对等离子射流自由喷射进行了数值模拟,设计了等离子发生器并开展了实验研究,验证了模型的合理性。针对5 mm、6 mm、7 mm三种喷嘴直径,数值分析了等离子射流扩展特性及特征参数变化规律。结果表明:等离子射流在大气中扩展时,喷嘴附近流场参数变化比较剧烈,后期随着喷射时间的推移逐渐衰减;喷嘴直径越大,Taylor空腔的扩展能力越强,初期主要表现在径向扩展,而后期主要表现在轴向扩展;同时扩展过程中压力呈现高低压相间分布的规律,等离子射流与空气的掺混现象也在增强,等离子体射流的Taylor空腔破碎加剧,说明等离子射流扩展稳定性随着喷嘴直径的增大受到了影响。

关键词：喷嘴直径等离子射流电热化学发射数值模拟扩展特性

Characteristics of the lunar samples returned by the Chang'E-5 mission

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National Science Review 2022年第2期9卷 21-33页

作者： Chunlai Li Hao Hu Meng-Fei Yang Zhao-Yu Pei Qin Zhou Xin Ren Bin Liu Dawei Liu Xingguo Zeng Guangliang Zhang Hongbo Zhang Jianjun Liu Qiong Wang Xiangjin Deng Caijin Xiao yonggang Yao Dingshuai xue Wei Zuo Yan Su Weibin Wen Ziyuan Ouyang Key Laboratory of Lunar and Deep Space Exploration National Astronomical Observatories Chinese Academy of Sciences Lunar Exploration and Space Engineering Center Beijing Institute of Spacecraft System Engineering Department of Nuclear Physics China Institute of Atomic Energy State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Institute of Geochemistry Chinese Academy of Sciences

Forty-five years after the Apollo and Luna missions returned lunar samples,China’s Chang’E-5(CE-5)mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the *** study shows that 95% of CE-5 lunar soil sizes are found to be within the range of 1.40-9.35 μm,while 95% of the soils by mass are within the size range of 4.84-432.27 μ*** bulk density,true density and specific surface area of CE-5 soils are 1.2387 g/cm~3,3.1952 g/cm~3 and 0.56 m~2/g,*** from the CE-5 regolith are classified into igneous clasts(mostly basalt),agglutinate and glass.A few breccias were also *** minerals and compositions of CE-5 soils are consistent with mare basalts and can be classified as low-Ti/low-Al/low-K type with lower rare-earth-element contents than materials rich in potassium,rare earth element and ***-5 soils have high FeO and low Mg index,which could represent a new class of basalt.

关键词： Chang’E-5 lunar soils physical properties petrography mineralogy chemistry

Robust Elliptically Contoured Distribution Based Kalman Filter for INS/DVL Integrated Navigation

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Robust Elliptically Contoured Distribution Based Kalman Filt...

控轧控冷技术对汽车钢10B33免退火性能的改善

第40届中国控制会议

作者： Chao xue Yulong Huang Xiaofeng Li xuejun Huang yonggang Zhang College of Intelligent Systems Science and Engineering Harbin Engineering University

In complex underwater environment, the outputs of Doppler velocity log（DVL） often contain outliers induced by external disturbance or soft failure, which will degrade the performance of the traditional Kalman filter based INS/DVL integrated navigation system. To address this problem, a novel robust Kalman filter with outlier-contaminated measurement noise modelled as elliptically contoured distributed is proposed. Firstly, an analytical update form of the joint posterior probability density function is derived via introducing an unknown parameter. Then the fixed-point iteration method is exploited to achieve an approximate estimate of the unknown parameter, based on which the required joint posterior probability density function is analytically updated. Finally, simulation results of INS/DVL integrated navigation are used to verify the validity and advantages of the proposed method.

关键词： Integrated navigation robust Kalman filter outliers elliptically contoured distribution fixed-point iteration method

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特钢技术 2024年第3期30卷 36-38页

作者：邱雪李文武江苏永钢集团有限公司江苏张家港215628

对汽车用冷镦钢10B33采取在线低温大变形轧制,并通过控制冷却技术进行在线保温,使钢中片状珠光体转变为大量铁素体+小尺寸粒状珠光体,珠光体团小而分散,其硬度较常规线材显著降低,断面收缩率提高,冷加工性显著提高,实现冷镦钢线材在线... 详细信息

对汽车用冷镦钢10B33采取在线低温大变形轧制,并通过控制冷却技术进行在线保温,使钢中片状珠光体转变为大量铁素体+小尺寸粒状珠光体,珠光体团小而分散,其硬度较常规线材显著降低,断面收缩率提高,冷加工性显著提高,实现冷镦钢线材在线软化退火,从而实现下游客户直接拉拔使用,有效降低工序成本。

关键词： 10B33 免退火控轧控冷