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Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics

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Bioactive Materials 2023年第11期29卷 50-71页

作者： xueli xu Shanbin xu Jipeng Wan Diqing Wang Xinlong Pang Yuan Gao Nengyi Ni Dawei Chen Xiao Sun School of Science Shandong Jianzhu UniversityJinan250101China Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117China Department of Gynecology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250021China School of Chemistry and Pharmaceutical Engineering Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan250000China Department of Chemical and Biomolecular Engineering National University of Singapore117585Singapore

Cytoskeleton plays a significant role in the shape change,migration,movement,adhesion,cytokinesis,and phagocytosis of tumor *** clinical practice,some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different cytoskeletal protein ***,in the absence of cell-specific targeting,unnecessary cytoskeletal recombination in organisms would be disastrous,which would also bring about severe side effects during anticancer *** have been proven to be superior to some small molecule drugs in cancer treatment due to better stability and targeting,and lower side ***,this review summarized the recent developments of various nanomaterials disturbing cytoskeleton for enhanced cancer therapeutics,including carbon,noble metals,metal oxides,black phosphorus,calcium,silicon,polymers,peptides,and metal-organic frameworks,etc.A comprehensive analysis of the characteristics of cytoskeleton therapy as well as the future prospects and challenges towards clinical application were also *** aim to drive on this emerging topic through refreshing perspectives based on our own work and what we have also learnt from *** review will help researchers quickly understand relevant cytoskeletal therapeutic information to further advance the development of cancer nanomedicine.

关键词： Nanomedicine Disturbing cytoskeleton Migration inhibition Tumor therapy

Application of Sturm Theorem in the Global Controllability of a Class of High Dimensional Polynomial Systems

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Journal of Systems Engineering and Electronics 2015年第5期26卷 1049-1057页

作者： xu xueli LI Qianqian SUN Yimin Guangdong Province Key Laboratory of Computational Science School of Mathematics and Computational Science Sun Yat-Sen University

In this paper, the global controllability for a class of high dimensional polynomial systems has been investigated and a constructive algebraic criterion algorithm for their global controllability has been obtained. By the criterion algorithm, the global controllability can be determined in finite steps of arithmetic operations. The algorithm is imposed on the coefficients of the polynomials only and the analysis technique is based on Sturm Theorem in real algebraic geometry and its modern progress. Finally, the authors will give some examples to show the application of our results.

关键词： Global controllability high dimensional systems number of sign variations polynomial,Sturm theorem.

Microstructure and Mechanical Properties of Graphene Reinforced K418 Superalloy by Selective Laser Melting

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1477-1493页

作者： Yongxin Lu Fan Luo Zhen Chen Jian Cao Kai Song Lei Zhao xueli xu Hongduo Wang Wenya Li School of Material Science and Engineering Xi’an Shiyou UniversityXi’an710065China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an710049China School of Materials Science and Engineering Tianjin UniversityTianjin300350China Xi’an Key Laboratory of High Performance Oil and Gas Field Materials Xi’an Shiyou UniversityXi’an710065China

In order to obtain the superalloy with excellent properties, graphene reinforced K418 nickel base superalloy(GNPs/K418 composite) was prepared by selective laser melting technique in this study. Through systematically comparing and analyzing the microstructure and mechanical property of K418 superalloy and GNPs/K418 composite, it is found that the percentage of small-diameter grain(≤ 15 μm) increased from 84% to 90%, and the max strength of grain orientation() reduce from 5.76 to 4.17 due to the addition of GNPs. And GNPs can also improve the height and the full width at the half peak of the strong diffraction peak of GNPs/K418 composite. Besides, GNPs/K418 composite is a kind of sandwiched structure, which is consist of GNPs, carbides, and K418 matrix. Therefore, the hardness of the GNPs/K418 composite is 4.1% and 6.9% higher than that of the K418 matrix in the transverse and vertical direction, respectively. The room temperature tensile strength of the GNPs/K418 composite is 9% higher than that of the K418 matrix. And the 600℃ and 900℃ tensile strengths of the GNPs/K418 composite are 7.6% and 10.4% higher than that of the K418 matrix, respectively. It is inferred that the effect of graphene on K418 matrix strengthening is mainly fine grain strengthening and Orowan strengthening. However, the elongation rate of the composite material is reduced, which is attributed to crack sprouting at the interface between the matrix and GNPs under high stress.

关键词： Graphene K418 nickel base superalloy Selective laser melting Tensile properties

Optical spectroscopy study of Ca_3(Ru_(0.91)Mn_(0.09))_2O_7 single crystal in high magnetic fields

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Science Bulletin 2019年第1期64卷 20-25页

作者： xueli xu Jin Peng Junpei Zhang Zongwei Ma Cheng Chen Junbo Han Bingjie Liu Lingfang Lin Xiaoshan Wu Zhiqiang Mao Zhe Qu Zhigao Sheng Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory Chinese Academy of Sciences University of Science and Technology of China Collaborative Innovation Center of Advanced Microstructures Nanjing University School of Physics Southeast University Wuhan National High Magnetic Field Center Huazhong University of Science and Technology School of Physics Nanjing University Department of Physics and Engineering Physics Tulane University

The magneto-optical spectrum, with magnetic fields up to 42 T, of double layered ruthenates Ca_3(Ru_(0.91)Mn_(0.09))_2O_7(CRMO) single crystal is studied. Both the temperature and magnetic field induced insulator-to-metal transitions(IMTs) are observed via magneto-optical properties of the crystal. The critical magnetic field(H//c) of IMT for CRMO is found to be as large as 35 T at 5 K. The fine structure of optical spectra identified the antiferromagnetic/ferro-orbital-ordering configurations of Ru 4d orbitals at low temperatures. Meanwhile, the configuration of orbital polarization of such double-layer CRMO single crystal is discussed. These results suggest that the orbital degree of freedom plays an important role in the field induced IMT of multi-orbital system.

关键词： Ruthenates High magnetic field Optical spectroscopy Insulator to metal transition

Transient Photoconductivity in LaRhO3 Thin Film

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Chinese Physics Letters 2019年第11期36卷 70-73页

作者： Zhi Meng Lei Shen Zongwei Ma Muhammad Adnan Aslam Liqiang xu xueli xu Wang Zhu Long Cheng Yuecheng Bian Li Pi Chun Zhou Zhigao Sheng Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChinese Academy of SciencesHefei 230031 University of Science and Technology of China Hefei 230026

High-quality epitaxial LaRhO3(LRO) thin films on SrTiO3(110) single-crystalline substrates are fabricated by pulsed laser deposition and their photoconductivity properties are studied. The transient photoconductivity(TPC) effect is found in this semiconductor LRO film at room temperature. The magnitude of TPC increases almost linearly with the laser power intensities and the photon energies in visible light range. Moreover, the difference in the TPC results under two airflow conditions confirms that both intrinsic photoinduced carrier accumulation and extrinsic photoinduced heating effects contribute to the magnitude of TPC effect.

关键词： temperature. conductivity transient

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稀疏谱聚类算法在高维数据上的应用

中国科学技术大学学报 2017年第4期47卷 311-319页

作者：徐雪丽赵学靖兰州大学数学与统计学院甘肃兰州730000

提出一种新的稀疏谱聚类算法——基于PAM算法的HSSPAM聚类(high-dimensional sparse spectral clustering based on partitioning around medoids).该算法先用高相关系数过滤及主成分分析降维方法以有效减小甚至消除维度灾难对高维数据... 详细信息

提出一种新的稀疏谱聚类算法——基于PAM算法的HSSPAM聚类(high-dimensional sparse spectral clustering based on partitioning around medoids).该算法先用高相关系数过滤及主成分分析降维方法以有效减小甚至消除维度灾难对高维数据处理的影响,再采用Minkowski距离指数变换函数及稀疏化算法来构建分块对角矩阵以重新解释样本之间的相似度;然后构造新颖的拉普拉斯矩阵以实现进一步压缩数据矩阵,进而结合partitioning around medoids(PAM)算法取代传统谱聚类中的K-means算法对特征向量聚类以提高算法的聚类稳定性;最后引入高维基因数据设计了实验,并以不同的聚类评价指标来衡量该研究算法的聚类质量,实验结果表明,新算法能够更精确、更稳定地对基因数据聚类.

关键词：高维数据聚类稀疏谱聚类算法降维方法分块对角矩阵聚类评价指标

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负载型杂多酸催化合成烷基二苯胺

石油化工 2006年第2期35卷 141-145页

作者：张龙宋伟姜丹蕾徐雪丽长春工业大学化学工程学院吉林长春130012 中国石油吉化集团公司精细化工技术中心吉林吉林132021

研究了以α-C14烯烃(C1=4)、二苯胺为原料,S iO2负载磷钨酸为催化剂,经烷基化反应合成抗氧剂烷基二苯胺的新工艺。探讨了磷钨酸负载量、催化剂用量、反应物配比、反应温度、反应时间等对烷基化反应的影响,获得了适宜的工艺条件:磷钨酸... 详细信息

研究了以α-C14烯烃(C1=4)、二苯胺为原料,S iO2负载磷钨酸为催化剂,经烷基化反应合成抗氧剂烷基二苯胺的新工艺。探讨了磷钨酸负载量、催化剂用量、反应物配比、反应温度、反应时间等对烷基化反应的影响,获得了适宜的工艺条件:磷钨酸负载量(质量分数)40%,催化剂用量(占总反应物的质量分数)1.0%,反应温度200℃,n(二苯胺)∶n(C14=)=1∶1.1,反应时间7h。在此条件下,二苯胺的转化率为98.2%。所得产物经检测为目的产品烷基二苯胺,产品质量已达到国外同类产品的标准。催化剂经35次重复使用的实验结果表明,催化剂的稳定性良好。催化剂活性降低的主要原因是反应物和生成物覆盖了催化剂的表面。同时提出了溶剂萃取再生催化剂的方法。

关键词：二苯胺负载磷钨酸烷基二苯胺抗氧剂 α-烯烃烷基化催化剂

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低重金属城市污泥钢渣陶粒的制备

新型建筑材料 2016年第9期43卷 105-110页

作者：徐雪丽宋伟南阳理工学院生物与化学工程学院河南南阳473004

在对城市污泥和炼钢废渣进行元素分析的基础上,进一步利用处理后的城市污泥和炼钢废渣制备出轻骨料陶粒,获得了适宜的工艺条件:炼钢废渣加入量为城市污泥质量的35%,预热温度为400℃,预热时间为20~25 min,焙烧温度为1100℃,焙烧时间为15~... 详细信息

在对城市污泥和炼钢废渣进行元素分析的基础上,进一步利用处理后的城市污泥和炼钢废渣制备出轻骨料陶粒,获得了适宜的工艺条件:炼钢废渣加入量为城市污泥质量的35%,预热温度为400℃,预热时间为20~25 min,焙烧温度为1100℃,焙烧时间为15~20 min。在此条件下,制备的陶粒堆积密度为546~523 kg/m^3,吸水率为7.6%~7.8%,抗压强度为5.7~6.1 MPa,符合GB/T17431—2010中600密度等级高强轻集料的性能要求。

关键词：城市污泥炼钢废渣陶粒动电技术

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膜全热交换器内热湿交换过程的熵分析

化工学报 2005年第11期56卷 2069-2072页

作者：张明瑞张立志徐学利华南理工大学化工与能源学院传热强化与过程节能教育部重点实验室广东广州510640

A membrane-based heat and mass exchanger (MHME) using hydrophilic membranes to recover the heat and mass of the exhaust air was *** the second law of thermodynamics, the process of the heat and mass transfer between the fresh and the exhaust in the MHME was *** the typical summer operating condition, thermal entropy increase, mechanical entropy increase, latent entropy and total entropy increase were analysed. The entropy generation per quantity of heat exchanged (EGPH), which. reflects the process’s thermodynamic irreversibility was analysed. It showed that the spacing between the membranes influenced the mechanical entropy increase most. The results also indicated that the mass velocity of the gas, the spacing between two membranes and the length of the membranes would influence the EGPH. There existed an optimal spacing where the EGPH was the least.

关键词：膜全热交换熵增