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Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-Hua Zhang zhi-Hua xu Shuang-Shuang Ni Hong-Xia luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

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Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang Pan-Quan luo zhi-Jian Wei A-Man xu Tao Guo Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laboratory of Digestive Disease Hefei 230031Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230000Anhui ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor,long non-coding RNA and microRNA(miRNA)are important regulators that affect tumor proliferation,metastasis and chemotherapy resistance,and thus participate in tumor ***19 is a new bio-marker which can promote tumor invasion and ***,the mechanism by which CASC19 affects the progression of GC through miRNA is not *** To explore the role of the CASC19/miR-491-5p/HMGA2 regulatory axis in *** To explore the expression and prognosis of CASC19 in GC through clinical samples,and investigate the effects of inhibiting CASC19 on the proliferation,migration,invasion and other functions of GC cells through cell counting Kit-8(CCK-8),ethynyldeoxyuridine,Wound healing assay,Transwell,Western blot and flow cytometry *** effect of miR-491-5p and HMGA2 in GC were also *** regulatory relationship between CASC19 and miR-491-5p,miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transcription *** CCK-8,Transwell,Wound healing assay,flow cytometry and animal experiments verify the role of CASC19/miR-491-5p/HMGA2 regulatory *** The expression level of CASC19 is related to the T stage,N stage,and tumor size of *** of the expression of CASC19 can inhibit the ability of proliferation,migration,invasion and EMT conversion of GC cells,and knocking down the expression of CASC19 can promote the apoptosis of GC *** the expression of miR-491-5p can inhibit the proliferation of GC cells,miR-491-5p mimics can inhibit EMT conversion,and promote the apoptosis of GC cells,while decreasing the expression of miR-491-5p can promote the proliferation and EMT conversion and inhibit the apoptosis of GC *** expression of HMGA2 in GC tissues is higher than that in adjacent *** the same time,the expression level of HMGA2 is related to the N and T stages of the *** the level of HMGA2 can pr

关键词： Gastric cancer Long non-coding RNA CASC19 miR-491-5p HMGA2 Prognosis

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A risk assessment method considering risk attributes and work safety informational needs and its application

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Chinese Journal of Chemical Engineering 2024年第4期68卷 253-262页

作者： Cong luo Yunsheng Zhao Ke xu School of Political Science and Public Administration Shandong UniversityQingdao 266200China Faculty of Engineering China University of GeosciencesWuhan 430074China Department of Emergency Management of Hubei Province Wuhan 430064China

The technological revolution has spawned a new generation of industrial systems,but it has also put forward higher requirements for safety management accuracy,timeliness,and *** assessment needs to evolve to address the existing and future challenges by considering the new demands and advancements in safety *** study aims to propose a systematic and comprehensive risk assessment method to meet the needs of process system safety *** methodology first incorporates possibility,severity,and dynamicity(PSD)to structure the“51X”evaluation indicator system,including the inherent,management,and disturbance risk ***,the four-tier(risk point-unit-enterprise-region)risk assessment(RA)mathematical model has been established to consider supervision *** in conclusion,the application of the PSD-RA method in ammonia refrigeration workshop cases and safety risk monitoring systems is presented to illustrate the feasibility and effectiveness of the proposed PSD-RA method in safety *** findings show that the PSD-RA method can be well integrated with the needs of safety work informatization,which is also helpful for implementing the enterprise's safety work responsibility and the government's safety supervision responsibility.

关键词： Risk assessment Safey “51X”evaluation indicator system Four-tier risk assessment model Risk attributes Process system

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Low friction under ultrahigh contact pressure enabled by self-assembled fluorinated azobenzene layers

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Friction 2024年第7期12卷 1434-1448页

作者： Dandan xuE zhi xu Linyuan GUO Wendi luo Liran MA Yu TIAN Ming MA Qingdao ZENG Ke DENG Wenjing ZHANG Yichun XIA Shizhu WEN Jianbin luo State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China National Center for Nanoscience and Technology Beijing 100190China

Extensive efforts have been made to pursue a low-friction state with promising applications in many fields,such as mechanical and biomedical *** which,the load capacity of the low-friction state has been considered to be crucial for industrial ***,we report a low friction under ultrahigh contact pressure by building a novel self-assembled fluorinated azobenzene layer on an atomically smooth highly-oriented pyrolytic graphite(HOPG)*** friction coefficients could be as low as 0.0005 or even lower under a contact pressure of up to 4 *** demonstrates that the low friction under ultrahigh contact pressure is attributed to molecular *** fluorination leads to effective and robust lubrication between the tip and the self-assembled layer and enhances tighter rigidity which can reduce the stress concentration in the substrate,which was verified by density functional theory(DFT)and molecular dynamics(MD)*** work provides a new approach to avoid the failure of ultralow friction coefficient under relatively high contact pressure,which has promising potential application value in the future.

关键词： ultrahigh contact pressure self-assembled layer fluorination robust lubrication

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Chemoselective Catalytic Hydrogenation of α,β-Unsaturated Ketones and α,β-Unsaturated Carboxylic Esters

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Chemical Research in Chinese Universities 1998年第2期14卷 17-22页

作者： ZHANG Jing-wen ZHAO Jian-zhang ZHANG Xiao-long JIANG Yu-lin MA Xiu-li SUN Yun-xiu JIANG Wen-pu LI Yao-xian xu zhi-luo Department of Chemistry Jilin UniversityChangchun130023

The effect of catalysts P-2 00-Ni(Nickel boride) and P-2 00-Ni-M(M: Co, Fe, Cu, Sn), prepared by adopting a modified recipe, on the chemoselective hydrogenation of carbon carbon double bonds in α,β- unsaturated ketones, and the activity of catalysts P-1.80-Ni, P-2 00-Ni or P-1.80(2 00) -Ni-M(M: Pd, Co, Cu) in the selective hydrogenation of carbon carbon double bonds in α,β-unsaturated carboxylic esters, were investigated systematically. According to the experimental results, the selectivities of these catalysts toward the hydrogenation of the carbon carbon double bonds of α,β-unsaturated keones or α,β-unsaturated carboxylic esters are 96%—100% or 100%, respectively.

关键词： α β-Unsaturated ketone Nickel boride α β-Unsaturated carboxylic ester

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Elucidating the anti-obesity phytochemicals in Chenpi and their molecular mechanisms

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Food Science and Human Wellness 2024年

作者： Jinhai luo Weiqi Yan zhi Chen Baojun xu Guangdong Provincial Key Laboratory IRADS and Department of Life Sciences， BNU-HKBU United International College Centre for Cancer and Inflammation Research， School of Chinese Medicine， Hong Kong Baptist University Faculty of Biochemistry and Molecular Medicine， University of Oulu

Obesity has become a significant global public health issue. Previous studies have found that the Chenpi has the anti-obesity activity. However， the anti-obesity phytochemicals and their mechanisms are still unclear. This study investigated the anti-obesity phytochemicals and molecular mechanisms involved in treating obesity by Chenpi through network pharmacology and molecular docking. Seventeen bioactive phytochemicals from Chenpi and its 475 related anti-obesity targets have been identified. The KEGG pathway analysis showed that the PI3K/Akt signaling pathway， MAPK signaling pathway， AMPK signaling pathway， and NF-kappa B signaling pathway are the main signaling pathways involved in the anti-obesity effect of Chenpi. According to molecular docking analysis， the phytochemicals of Chenpi can bind to central anti-obesity targets. Based on the ADMET analysis and network pharmacology results， tangeretin exhibited the lowest predicted toxicity and the highest potential for anti-obesity effects. In the in vitro lipid accumulation model， tangeretin effectively suppressed the FFA-induced lipid in HepG2 cells by upregulating the PI3K/Akt/GSK3β signaling pathway based on the result of q-PCR and Western Blotting. The outcomes of this research give insights for future research on the anti-obesity phytochemicals and molecular mechanisms derived from Chenpi， also providing the theoretical basis for developing anti-obesity functional foods based on Chenpi.

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Immune states:integrated views of immunity by combining traditional Chinese medicine and modern medicine

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Science China(Life Sciences) 2024年第10期67卷 2271-2273页

作者： Anlong xu Yuxing zhi School of Life Sciences and Qi-Huang School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China

Human immune system is an extraordinarily complex physiological system composed of multiple anatomical systems,diverse tissues and molecules from macroscopic to microscopic *** cells and molecules collectively partici... 详细信息

关键词： immunity homeostasis Immune

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Effectively improved piezoelectricityyinhigh-temperature Arrhenius CBT ceramics by modifying potential energy profile and spontaneous polarization

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Journal of Advanced Ceramics 2024年第8期13卷 1143-1152页

作者： Jingwen Xi Linlin Liu Hongwei Qiao Jiacheng luo Xin Su Xin Zhao Yugen xu Hao Chen zhi Tan Jianguo Zhu Nuclear Power Institution of China Chengdu 610213China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China

Enhancing the piezoelectricity of CaBi_(4)Ti_(4)O_(15)(CBT)ceramics is crucial for improving their application potential in high-temperature piezoelectric ***,we propose a strategy involving the introduction of larger Na/Bi ions at the A-site,effectively inhibiting the tilt of oxygen octahedra and flattening the potential energy *** flattening enhances the variation in polarization under external ***,substituting Nb/Mn at the B-site increases the deviation between positive and negative ionic centers,leading to stronger spontaneous polarization,while the induced defect dipoles restrict oxygen vacancy migration and increase the direct current resistivity(ρ_(dc)).The flattened potential energy profile and increased spontaneous polarization significantly enhance the overall performance of cBT ceramics,with the piezoelectric constant(d_(33))reaching 25 pC/N when the Curie temperature(Tc)=752℃.Piezoresponse force microscopy(PFM)and transmission electron microscopy(TEM)revealed submicron-long rectangular domains and nanoscale domains in the modified composition,indicating a high density of domain *** study presents an effective approach for enhancing the piezoelectric properties of bismuth layered-structured ferroelectrics(BLSFs),thereby improving the application potential of BLSFsathightemperatures.

关键词： piezoelectricity bismuth layered-structured ferroelectrics(BLSFs) potential energy profile spontaneous polarization high temperatures

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Multi-UAV cooperative maneuver decision-making for pursuitevasion using improved MADRL

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Defence Technology（防务技术） 2024年第5期35卷 187-197页

作者： Delin luo Zihao Fan Ziyi Yang Yang xu School of Aerospace Engineering Xiamen UniversityXiamen 361102China School of Civil Aviation Northwestern Polytechnical UniversityXi'an 710072China

Aiming at the problem of multi-UAV pursuit-evasion confrontation, a UAV cooperative maneuver method based on an improved multi-agent deep reinforcement learning(MADRL) is proposed. In this method, an improved Comm Net network based on a communication mechanism is introduced into a deep reinforcement learning algorithm to solve the multi-agent problem. A layer of gated recurrent unit(GRU) is added to the actor-network structure to remember historical environmental states. Subsequently,another GRU is designed as a communication channel in the Comm Net core network layer to refine communication information between UAVs. Finally, the simulation results of the algorithm in two sets of scenarios are given, and the results show that the method has good effectiveness and applicability.

关键词： Reinforcement learning UAV Maneuver decision GRU Cooperative control

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Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis

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Military Medical Research 2024年第2期11卷 287-307页

作者： Pan luo Fu-Qiang Gao Wei Sun Jun-You Li Cheng Wang Qing-Yu Zhang zhi-Zhuo Li Peng xu Department of Joint Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an 710054China Department of Orthopedics China-Japan Friendship HospitalBeijing 100029China Department of Orthopaedic Surgery of the Perelman School of Medicine University of PennsylvaniaPhiladelphiaPA 19104USA School of Mechanical Engineering Sungkyunkwan UniversitySuwon 16419South Korea Department of Orthopaedic Surgery Peking University Third HospitalPeking UniversityBeijing 100191China Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability,thus adversely affecting locomotion ability and life ***,good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of *** fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo ***,we review the fluorescent probes developed for the detection and imaging of RA biomarkers,namely reactive oxygen/nitrogen species(hypochlorous acid,peroxynitrite,hydroxyl radical,nitroxyl),pH,and cysteine,and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.

关键词： Rheumatoid arthritis Fluorescent probe Imaging Diagnosis Biomarker

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