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超声心动图评估肝硬化患者心脏病变的研究进展

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赣南医学院学报 2024年第7期44卷 691-697页

作者：许玉洁夏怡浓陈卫华赣南医科大学第一临床医学院赣南医科大学第一附属医院超声医学科江西赣州341000

肝硬化性心肌病(Cirrhotic cardiomyopathy,CCM)是指终末期肝病患者在排除其他既往心脏病的基础上,因系统血流动力学改变引起的慢性心功能不全。既往研究表明,超负荷容量及超动力循环可导致肝硬化患者心脏结构及功能改变。因此,应用超... 详细信息

肝硬化性心肌病(Cirrhotic cardiomyopathy,CCM)是指终末期肝病患者在排除其他既往心脏病的基础上,因系统血流动力学改变引起的慢性心功能不全。既往研究表明,超负荷容量及超动力循环可导致肝硬化患者心脏结构及功能改变。因此,应用超声心动图早期评估其心脏病变,以适时干预病变发生发展,是改善预后的核心环节。本文就近年来各种超声心动图技术评估肝硬化患者的心脏结构、功能及血流动力学等研究进展进行综述,并提出联合多种超声心动图新技术能相互取长补短,提供更全面的定量分析。

关键词：肝硬化肝硬化性心肌病组织多普勒成像斑点追踪成像技术实时三维超声心动图无创心肌做功

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基于视觉人体姿态识别的人机交互机器人课程教学研究

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湖北第二师范学院学报 2024年第2期41卷 77-83页

作者：李宪华徐玉杰胡坤朱延松安徽理工大学人工智能学院安徽淮南232001 安徽理工大学机械工程学院安徽淮南232001

为了解决机器人学教材和课程内容更新滞后、人工智能等前沿领域知识匮乏、缺乏学科交叉知识等问题,本文提出了一种基于视觉人体姿态识别的人机交互教学方法,旨在帮助学生深入接触机器人学领域的前沿知识,拓宽跨学科背景,深刻理解运动控... 详细信息

为了解决机器人学教材和课程内容更新滞后、人工智能等前沿领域知识匮乏、缺乏学科交叉知识等问题,本文提出了一种基于视觉人体姿态识别的人机交互教学方法,旨在帮助学生深入接触机器人学领域的前沿知识,拓宽跨学科背景,深刻理解运动控制原理。在激发学生学习兴趣的同时,协助学生更加有效地掌握机器人学领域的知识。

关键词：机器人学人机交互教学实践

New Vacuum Solar Telescope Achieves Narrowband Infrared Solar Imaging Observation at He I 10830 A

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Research in Astronomy and Astrophysics 2024年第5期24卷 76-84页

作者： Wei-jie Meng Fang-yu xu Zhen-yu Jin yunnan Observatories Chinese Academy of SciencesKunming 650011China yunnan Key Laboratory of Solar Physics and Space Science Kunming 650216China University of Chinese Academy of Sciences Beijing 100049China

The near-infrared imaging channel constitutes a crucial component of the multichannel high-resolution imaging system of the New Vacuum Solar Telescope(NVST). We have successfully achieved high-resolution, narrowband imaging of the chromosphere using He I 10830 A triplet within this channel, which significantly enhances the imaging observation capabilities of NVST. This paper provides a concise overview of the optical system associated with the near-infrared imaging channel, detailing data processing procedures and presenting several observed images. Leveraging a high-resolution image reconstruction algorithm, we were able to generate a narrowband image near the diffraction limit at 10830 A with a temporal resolution of less than 10 s.

关键词： instrumentation detectors-instrumentation high angular resolution-Sun chromosphere-Sun infrared

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智能叠衣机设计

蚌埠学院学报 2024年第2期13卷 42-46页

作者：王鹏许羽颉汪嘉明纪嘉懿淮南师范学院机械与电气工程学院安徽淮南232038

为满足家居智能化需求,拟推出的智能叠衣机可以解决衣物折叠工作量增加且过程繁杂的问题,首先根据设计要求确定装置的整体结构;采用模块化设计思想进行传衣机构、取衣机构、叠衣机构、分类存放机构和消毒机构的结构设计,环形导轨式传衣... 详细信息

为满足家居智能化需求,拟推出的智能叠衣机可以解决衣物折叠工作量增加且过程繁杂的问题,首先根据设计要求确定装置的整体结构;采用模块化设计思想进行传衣机构、取衣机构、叠衣机构、分类存放机构和消毒机构的结构设计,环形导轨式传衣机构在节约空间的同时可提高效率,机械爪式取衣机构最大程度提高抓取的灵活性,采用可翻转的叠衣板模拟人工叠衣过程,实现简单、高效的叠衣。最后在SolidWorks环境中完成虚拟样机设计,验证了设计结构的可行性。最后编写了控制软件,进行在线联机系统程序功能测试,结果能够满足叠衣机功能需求,为后期实物设计、制作提供参考。

关键词：智能叠衣机传衣叠衣结构设计控制软件

Electromagnetic fields in ultra-peripheral relativistic heavy-ion collisions

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Nuclear Science and Techniques 2024年第2期35卷 103-109页

作者： jie Zhao Jin-Hui Chen xu-Guang Huang yu-Gang Ma Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200438China

Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic *** these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon *** exchange of photons can induce photonuclear and two-photon interactions and excite *** excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other ***,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ***,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted *** a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.

关键词： Electromagnetic fields Neutrons Ultra-peripheral relativistic heavy-ion collisions(UPC)

Resolving the geometric structure of trastuzumab by mobility capillary electrophoresis and native mass spectrometry

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Chinese Chemical Letters 2024年第3期35卷 221-225页

作者： Wenjing Zhang jie Hong Lei Yang Zuqiang xu yu Xiang Wei xu School of Life Science Beijing Institute of TechnologyBeijing 100081China

Available online Immunoglobulins G(IgGs)are Y-shaped globular proteins,however,their high flexibility and heterogeneity pose great challenges to their structure and conformation *** structure of IgG closely correlates to its biofunctions,such as the antibody escape of human immunodeficiency virus(HIV)could attribute to the distance mismatch between the ends of two Fab arms(antigen-binding sites)and envelope glycoprotein spikes on virion ***,we report the first use of mobility capillary electrophoresis(MCE)and native mass spectrometry(nMS)to resolve the internal geometric structure and conformation of an IgG(trastuzumab)in solution *** proteolysis,the ellipsoid dimensions of IgG and its subunits were measured by MCE-nMS *** was then reconstructed,in which the sizes and relative positions of these three subunits in three-dimensional space were *** was found that the two Fab arms have an angle of~102.1°and a distance of~11.0 nm between the two antigen-binding sites under native condition,and the Fc arm was tilted~16.0°towards one of the Fab *** was not on the plane of Fab-Fab,but has an angle of no larger than 103.1°.Under acidic environment(pH 3.0),each subunit of the IgG would unfold into larger dimensions,and the angles between these subunits also *** great potential for tumor imaging and therapy,the structure of F(ab')_(2)fragments was also measured and validated by molecular dynamic *** was found that the electrostatic force among these three subunits and steric hindrance stemming from Fc help maintaining the angle between two Fab arms.

关键词： Native mass spectrometry Mobility capillary electrophoresis Trastuzumab Protein structure Geometric structure

Span-based joint entity and relation extraction augmented with sequence tagging mechanism

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Science China(Information Sciences) 2024年第5期67卷 84-98页

作者： Bin JI Shasha LI Hao xu jie yu Jun MA Huijun LIU Jing YANG College of Computer National University of Defense Technology

Span-based joint extraction simultaneously conducts named entity recognition(NER) and relation extraction(RE) in a text span form. However, since previous span-based models rely on span-level classifications, they cannot benefit from token-level label information, which has been proven advantageous for the task. In this paper, we propose a sequence tagging augmented span-based network(STSN), a spanbased joint model that can make use of token-level label information. In STSN, we construct a core neural architecture by deep stacking multiple attention layers, each of which consists of three basic attention *** the one hand, the core architecture enables our model to learn token-level label information via the sequence tagging mechanism and then uses the information in the span-based joint extraction; on the other hand, it establishes a bi-directional information interaction between NER and RE. Experimental results on three benchmark datasets show that STSN consistently outperforms the strongest baselines in terms of F1,creating new state-of-the-art results.

关键词： joint extraction named entity recognition relation extraction span sequence tagging mechanism

Multimodal Machine Learning Guides Low Carbon Aeration Strategies in Urban Wastewater Treatment

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Engineering 2024年第5期36卷 51-62页

作者： Hong-Cheng Wang yu-Qi Wang xu Wang Wan-Xin Yin Ting-Chao yu Chen-Hao xue Ai-jie Wang State Key Laboratory of Urban Water Resource and Environment School of Civil and Environmental EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Key Laboratory of Drinking Water Safety and Distribution Technology of Zhejiang Province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou 310058China

The potential for reducing greenhouse gas(GHG)emissions and energy consumption in wastewater treatment can be realized through intelligent control,with machine learning(ML)and multimodality emerging as a promising ***,we introduce an ML technique based on multimodal strategies,focusing specifically on intelligent aeration control in wastewater treatment plants(WWTPs).The generalization of the multimodal strategy is demonstrated on eight ML *** results demonstrate that this multimodal strategy significantly enhances model indicators for ML in environmental science and the efficiency of aeration control,exhibiting exceptional performance and *** random forest with visual models achieves the highest accuracy in forecasting aeration quantity in multimodal models,with a mean absolute percentage error of 4.4%and a coefficient of determination of *** testing in a full-scale plant reveals that the multimodal model can reduce operation costs by 19.8%compared to traditional fuzzy control *** potential application of these strategies in critical water science domains is *** foster accessibility and promote widespread adoption,the multimodal ML models are freely available on GitHub,thereby eliminating technical barriers and encouraging the application of artificial intelligence in urban wastewater treatment.

关键词： Wastewater treatment Multimodal machine learning Deep learning Aeration control Interpretable machine learning

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孕早期蔬菜和水果摄入与肠道菌群的关系

现代预防医学 2024年第7期51卷 1222-1228页

作者：张可馨王一迪刘雪婷徐裕杰张琴田野何春雷毛泳雯成果四川大学华西公共卫生学院/华西第四医院四川大学华西第二医院西部妇幼医学研究院妇儿营养中心四川大学华西护理学院

目的探讨成都市孕早期妇女蔬菜和水果摄入与肠道菌群组成及多样性之间的关系。方法本研究纳入104例成都市孕早期妇女，使用膳食频率问卷收集其蔬菜和水果摄入情况，并分别依据蔬菜、水果摄入量中位数将孕早期妇女分为摄入量高组和摄... 详细信息

目的探讨成都市孕早期妇女蔬菜和水果摄入与肠道菌群组成及多样性之间的关系。方法本研究纳入104例成都市孕早期妇女，使用膳食频率问卷收集其蔬菜和水果摄入情况，并分别依据蔬菜、水果摄入量中位数将孕早期妇女分为摄入量高组和摄入量低组。使用16S r RNA高通量测序检测孕早期妇女粪便样本肠道菌群，比较组间肠道菌群差异。采用多重线性回归探讨蔬菜、水果摄入和孕早期妇女肠道菌群的关系。结果孕早期妇女蔬菜和水果摄入量中位数分别是90.0 g/d和200.0 g/d。孕早期蔬菜、水果摄入高低组孕早期妇女肠道菌群α多样性和β多样性无统计学差异。LEfSe分析显示，孕早期妇女多个肠道菌群的相对丰度在蔬菜、水果摄入量高低组间存在显著差异（P<0.01）。多重线性回归分析显示，在调整了年龄、孕前体质指数和能量摄入后，孕早期妇女蔬菜摄入量与Eubacterium siraeum group相对丰度呈正比（β=0.007, P=0.012），与Bacteroides相对丰度呈反比（β=-0.167, P=0.023）；水果摄入量与Ruminococcus gnavus group相对丰度呈正比（β=0.004, P=0.034），与Agathobacter相对丰度呈反比（β=0.004, P=0.044）。结论孕早期蔬菜、水果摄入引起肠道菌群相对丰度的变化，本研究为孕期膳食调控肠道菌群提供新的科学依据。

关键词：肠道菌群孕早期蔬菜水果 16S rRNA