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The coordinated evolution of ecological environment,public service,and tourism economy along the Silk Road Economic Belt,using the Dual-Carbon Targets

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 34-47页

作者： Shuo Yang Wei Guo tianjun xu Tongtong Liu School of Economic and Management Yanshan UniversityQinhuangdao 066004China Regional Economic Development Center Yanshan UniversityQinhuangdao 066004China

Carbon peak and carbon neutrality(dual-carbon)are important targets for the international response to climate *** Silk Road Economic Belt is a strategic resource region and is important for future ecological environment and tourism *** on the“dual-carbon”targets,the Single index quantification,Multiple index synthesis,and Poly-criteria integration evaluation model were used in this study to measure the coordinated development index of the ecological environment,public service,and tourism economy along the Silk Road Economic Belt and to analyze its spatial and temporal ***,it explores the dynamic evolution and development trend of the three systems using the Kernel Density and Grey Markov Prediction *** results show that the coordinated development index along this region needs to be improved during the study ***,the coordinated development index of the Southwest region is relatively higher than that of the Northwest *** the development trend of the three systems,all of them develop in a stable manner;however,the tourism economy system is easily affected by external *** coordinated development index of the three systems changes dynamically and tends to be in a good state of *** is a certain spatial and temporal *** gravity center of the coordinated development index has been in the Southwest *** the forecast period,the coordinated development index along this region will improve significantly,while insufficient and unbalanced development will continue.

关键词： Dual-carbon Ecological environment Public services Tourist economy Silk Road Economic Belt

Coupling and coordination relationship of tourism inclusive green growth system:Evidence from Shandong Province

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Chinese Journal of Population,Resources and Environment 2024年第3期22卷 334-342页

作者： tianjun xu Gangmin Weng Wei Guo School of Economics and Management Yanshan UniversityQinhuangdao 066004China Regional Economic Development Center Yanshan UniversityQinhuangdao 066004China

Sustainable growth is a prerequisite for high-quality development,and inclusive green growth is regarded as an important way to realize sustainable *** paper constructs a tourism inclusive green growth index(IGGI)system based on the 2018 Asian Development Bank *** Shandong Province from 2017 to 2019,the entropy weight method is utilized to explore the degree of coupling and coordination among the subsystems of tourism inclusive green *** study shows that:(1)the tourism IGGI continues to grow;(2)in the tourism inclusive green growth system,the social equity subsystem shows a trend of steady improvement;and(3)in the system,there is a slight discordance between the economic growth subsystem and the environmental sustainability *** study aims to provide the scientific basis for the high-quality development of tourism and theoretical support for the field of tourism and environmental sustainability.

关键词： Tourism inclusive green growth system Coupled coordination Entropy law Tourism quality development

MicroRNA negatively regulates NF-κB-mediated immune responses by targeting NOD1 in the teleost fish Miichthys miiuy

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Science China(Life Sciences) 2021年第5期64卷 803-815页

作者： Qing Chu Dekun Bi Weiwei Zheng tianjun xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai 201306China Laboratory of Marine Biology and Biotechnology Qingdao Pilot National Laboratory for Marine Science and TechnologyQingdao 266071China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai 201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai 201306China

Inflammation is a self-protection mechanism that can be triggered when innate immune cells detect *** of pathogen infection requires appropriate immune and inflammatory responses,but excessive inflammatory responses can cause uncontrolled inflammation,autoimmune diseases,or pathogen *** evidence has shown that microRNAs(miRNAs)in mammals act as important and versatile regulators of innate immunity and ***,miRNAmediated regulation networks are largely unknown in inflammatory responses in lower ***,miR-144 and miR-217 are identified as negative regulators in teleost inflammatory *** find that Vibrio harveyi and lipopolysaccharide(LPS)treatment significantly upregulate the expression of fish miR-144 and *** miR-144 and miR-217 suppress LPS-induced inflammatory cytokine expression by targeting nucleotide-binding oligomerization domain-containing protein 1(NOD1),thereby avoiding excessive inflammatory *** addition,miR-144 and miR-217 regulate inflammatory responses through NOD1-induced nuclear factor kappa(NF-κB)signaling *** findings demonstrate that miR-144 and miR-217 play regulatory roles in inflammatory responses by modulating the NOD1-induced NF-κB signaling pathway.

关键词： microRNA negative regulation NF-κB NOD1 Miichthys miiuy

Long noncoding RNA AANCR modulates innate antiviral responses by blocking miR-210-dependent MITA downregulation in teleost fish,Miichthys miiuy

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Science China(Life Sciences) 2021年第7期64卷 1131-1148页

作者： Qing Chu tianjun xu Weiwei Zheng Renjie Chang Lei Zhang Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai 201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratoiy for Marine Science and TechnologyQingdao 266237China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministiy of EducationShanghai Ocean UniversityShanghai 201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai 201306China

Viral infection induces the initiation of antiviral effectors and cytokines which are critical mediators of innate antiviral *** critical molecular determinants are responsible for triggering an appropriate immune *** noncoding RNAs(lncRNAs)have emerged as new gene modulators involved in various biological processes,while how lncRNAs operate in lower vertebrates are still ***,we discover a long noncoding RNA,termed antiviral-associated long noncoding RNA(AANCR),as a novel regulator for innate antiviral responses in teleost *** results indicate that fish MITA plays an essential role in host antiviral responses and inhibition of Siniperca chuatsi rhabdovirus(SCRV)***-210 reduces MITA expression and suppress MITA-mediated antiviral responses,which may help viruses evade host antiviral ***,AANCR functions as a competing endogenous RNA(ceRNA)for miR-210 to control protein abundance of MITA,thereby inhibiting SCRV replication and promoting antiviral *** data not only shed new light on understanding the function role of lncRNA in biological processes in teleost fish,but confirmed the hypothesis that ceRNA networks exist widely in vertebrates.

关键词： long noncoding RNAs microRNA ceRNA MITA antiviral responses teleost fish

Long noncoding RNA TARL promotes antibacterial activity and prevents bacterial escape in Miichthys miiuy through suppression of TAK1 downregulation

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Science China(Life Sciences) 2023年第6期66卷 1340-1357页

作者： Weiwei Zheng Xing Lv Shiying Xin Yuena Sun tianjun xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266237China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Shanghai Ocean UniversityMinistry of EducationShanghai201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China

Noncoding RNA(ncRNA)is an important regulatory factor that plays a major role in innate ***,most studies on ncRNA have focused on mammals,resulting in a knowledge gap on nc RNA in lower vertebrates such as teleost *** this study,we identified a new long noncoding RNA(lncRNA),termed TAK1-related lnc RNA(TARL),which can play a positive role in the antibacterial immunity of Miichthys miiuy to Vibrio anguillarum and *** also found a novel micro RNA miR-2188-3p that could target TAK1 and inhibit the host antibacterial response and promote bacterial *** further found that the antibacterial effect inhibited by miR-2188-3p could be reversed with ***,*** and *** are the two most susceptible Gram-negative pathogens of aquaculture fish,and the economic losses caused by these two bacteria are immeasurable every *** study is the first to report on the ability of lnc RNA to prevent the escape of *** and *** in fish through the competing endogenous RNA(ceRNA)*** results not only elucidate the ce RNA mechanism of the lncRNA in antibacterial immune responses but also provide new insights into the impact of lnc RNA on host immunity and bacterial escape.

关键词： lncRNA microRNA ceRNA innate immunity antibacterial

A chromosome-level genome assembly of the blackspotted croaker(Protonibea diacanthus)

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Aquaculture and Fisheries 2022年第6期7卷 616-622页

The blackspotted croaker(Protonibea diacanthus)is an endangered coastal marine *** is also a valuable species that is cultured on the southeast coast of *** some genetic studies have been conducted to protect this species,genomic resources are ***,we report a chromosome-scale assembly of *** genome by high-depth genome sequencing,assembly,and *** genome scale was 635.69 Mb with contig and scaffold N50 length of 3.33 Mb and 25.60 Mb,***-C scaffolding of the genome resulted in 24 chromosomes of 94.15%total *** predicted 23,971 protein-coding *** addition,we constructed a phylogenetic tree using 2755 single-copy gene families and identified 462 unique gene families in *** genome compared to three other ***’s more,from the analysis of gene families,we found that several gene families related to innate immunity were significantly expanded in the blackspotted croaker genome compared to other teleost *** high-quality genome can improve our understanding of the molecular mechanisms behind economically valuable traits and provide insights into characteristics of the immune system.

关键词： Blackspotted croaker Chromosomal assembly Genome annotation Genome evolution Phylogenetic

A chromosome-level genome assembly of the red drum, Sciaenops ocellatus

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Aquaculture and Fisheries 2021年第2期6卷 178-185页

作者： tianjun xu Ye Li Qing Chu Weiwei Zheng Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266200China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of Education201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University201306China

Sciaenops ocellatus,also known as red drum,is a valuable commercial fish that is widely cultured in *** recent years,while the genetic research and molecular breeding on *** has been widely performed,whole-genome resources are *** our study,we assembled the *** genome by high-quality genome sequencing,followed by complete *** size of final genome was 686.62 Mb and N50 length of contig and scaffold is 99.71 Kb and 25.62 Mb,*** the Hi-C technology,we obtained 24 pseudochromosomes containing 87.82%of the total *** annotated 20,053 protein-coding genes in *** genome,of which 99.93%were homologous to proteins in different ***,we detected 133.54 Mb repeat sequences,which accounts for 19.45%of the *** to the phylogenetic analysis,*** is most closed to *** with a divergence time about 30 million years *** assembled a high-quality genome that will be a valuable resource to further study the biology of *** and will inform how to breed the red drum to enhance its economic traits.

关键词： Red drum Whole-genome Chromosomal assembly Phylogenetic Genome evolution

Cloning,characterization of two female-specific AFLP markers and development of PCR-based sex identification method for the half-smooth tongue sole Cynoglossus semilaevis

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Current Zoology 2009年第4期55卷 309-314页

作者： Hongyu MA Songlin CHEN Jing LI Jin-Zhen BI tianjun xu Key Lab for Sustainable Utilization of Marine Fisheries Resources Ministry of Agriculture Yellow Sea Fisheries Researchinstitute Chinese Academy of Fishery Sciences Qingdao 266071 China College of Marine Life Sciences Ocean University of China Qingdao 266003 China

Two female-specific AFLP(amplified fragment length polymorphism)markers(named CseF464 and CseF136)were isolated by using one selective primer combination(E-AGC/M-CTG)from the genomic DNA of 20 females and 20 males of the half-smooth tongue sole Cynoglossus *** the markers were re-amplified,recovered from the agarose gels,cloned and *** analysis indicated that the length of the two markers were 468 bp and 134 bp,respectively,and the sequences showed no similarity to each other,as well as to the known sequences deposited in the GenBank database using *** pairs of SCAR(sequence characterized amplified regions)primers were designed based on the sequences of the two female-specific ***,PCR-based genetic sex identification method was developed in Cynoglossus semilaevis.A specific fragment was amplified in all females but not in any males by using these SCAR primers on the initial 20 female and 20 male individuals of Cynoglossus *** feasibility of the two SCAR primer pairs was confirmed in additional 100 individuals(50 females and 50 males).This allowed for reliable,rapid molecular identification of genetic sex of the species,genetic mapping on the sex chromosomes and better understanding of the sex determination and sex differentiation in the half-smooth tongue sole.

关键词： AFLP Cynoglossus semilaevis Female-specific marker SCAR Molecular sexing

LncRNA MIR144HG-derived miR-144 suppresses antibacterial signaling and facilitates bacteria escape in fish

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Water Biology and Security 2023年第1期2卷 72-85页

作者： Weiwei Zheng Junxia Cui Xing Lv Shiying Xin tianjun xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai201306China Laboratory of Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266200China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources(Shanghai Ocean University) Ministry of EducationShanghai201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China

Growing number studies show that lncRNA is an important regulatory factor and plays an irreplaceable role in innate ***,most studies on lncRNA have focused on mammals and it is unknown in lower *** this study,we identify a new lncRNA,named MIR144HG,which can have a negative role in antibacterial immunity of Miichthys miiuy caused by Vibrio anguillarum and ***88,TAK1 and p65 are very important pathway genes in antibacterial innate immune responses,whether in mammals or lower ***,we found that miR-144–3p could target MyD88,TAK1 and p65,inhibit host antibacterial response and promote bacterial *** studies found that miR-144–3p can be derived by MIR144HG,and finally enhance the inhibitory effect of miR-144–3p on host antibacterial ***,*** and *** are the two most susceptible Gram-negative pathogens in aquaculture,and the economic losses caused by these two bacteria are immeasurable every *** results not only elucidate the mechanism of the lncRNAmiRNA-mRNA axis in antibacterial immune responses,but also provide new insights for understanding the impact of lncRNA on host immunity and bacteria escape.

关键词： Antibacterial Fish Innate immunity lncRNA microRNA Precursor