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Mitigation of polycyclic aromatic hydrocarbons(PAHs)in roasted beef patties by cold plasma treatment and products quality evaluation

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Food Science and Human Wellness 2024年第5期13卷 2993-3005页

作者： Yuke Hou Yangjian Hu Min Li Jiahui Nong Fengyuan Xie Yuhan Fan Jianhao Zhang Xianming Zeng minyi Han Xinglian xu Xia Wang Key Laboratory of Animal Products Processing Ministry of AgricultureKey Laboratory of Meat Processing and Quality ControlMinistry of EducationJiangsu Synergetic Innovation Center of Meat Production and ProcessingCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 2100095China Center for Food and Drug Safety Inspection of Maanshan Maanshan Administration for Market RegulationMaanshan 243000China Henan Key Laboratory of Cold Chain Food Quality and Safety Control Zhengzhou University of Light IndustryZhengzhou 450001China Collaborative Innovation Center for Modern Grain Circulation and Safety Key Laboratory of Grains and Oils Quality Control and ProcessingCollege of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023China

The cold plasma(CP)technique was applied to alleviate the contamination of polycyclic aromatic hydrocarbon(PAH)in this *** different CP treatments methods were implemented in the production of beef patties,to investigate their inhibition and degradation capacity on *** 5 different cooking oils and fats addition,the inhibition mechanism of in-package cold plasma(ICP)pretreatment was explored from the aspect of raw patties fatty acids composition *** results of principal component analysis showed that the first two principal components accounted for more than 80%of the total variation in the original data,indicating that the content of saturated fatty acids was significantly positively correlated with the formation of *** pretreatment inhibited the formation of PAHs by changing the composition of fatty acids,which showed that the total amount of polyunsaturated fatty acids decreased and the total amount of monounsaturated fatty acids *** discrimination tests demonstrated there were discernable differences between 2 CP treated samples and the controls,utilization of the ICP pretreatment in meat products processing was expected to achieve satisfying eating *** conclusion,CP treatment degraded PAHs through stepwise ring-opening oxidation in 2 reported pathways,the toxicity of PAHs contaminated products was alleviated after CP treatment.

关键词： Roasted beef Polycyclic aromatic hydrocarbons Cold plasma Mitigation mechanism Product quality evaluation

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临床试验随机分配的两步法及其参数配置

东南国防医药 2023年第2期25卷 113-116页

作者：熊殷刘雅琦刘曼陈文松许敏怡巩浩雯李维勤刘玉秀南京医科大学金陵临床医学院南京210002 南京医科大学公共卫生学院生物统计学系南京211166 南方医科大学公共卫生学院生物统计学系广州510515 东部战区总医院重症医学科南京210002

目的提出用两步法再造随机分配流程,并探讨其科学性和可行性,以改进随机分配的整体随机性能,减小试验的潜在偏倚。方法文章提出的两步法包括两个步骤:随机分层和随机分组。其关键是在传统随机分配方法的分组之前增加一个随机分层过程。... 详细信息

目的提出用两步法再造随机分配流程,并探讨其科学性和可行性,以改进随机分配的整体随机性能,减小试验的潜在偏倚。方法文章提出的两步法包括两个步骤:随机分层和随机分组。其关键是在传统随机分配方法的分组之前增加一个随机分层过程。该法可通过分析组间均衡性对把握度(power)及总样本量的影响进行参数大小配置。结果该随机分配及参数配置方法简单易行,增强了整体的随机性能,且只要参数配置不超过4×4,组间例数不均衡性对总例数和把握度的影响微乎其微。结论建立了一种简单易行的随机分配两步法,尤其适用于非盲的随机对照试验。

关键词：随机对照试验随机分配随机性能均衡性参数配置

Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1856-1870页

作者： xuejing Shao Yingqian Chen Wei Wang Wenxin Du Xingya Zhang minyi Cai Shaowei Bing Ji Cao Xiaojun xu Bo Yang Qiaojun He Meidan Ying Institute of Pharmacology and Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Cancer Center Zhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 310058China

In most acute promyelocytic leukemia(APL)cells,promyelocytic leukemia(PML)fuses to retinoic acid receptor α (RARα)due to chromosomal translocation,thus generating PML/RARαoncoprotein,which is a relatively stable oncoprotein for degradation in *** the mechanism regulating the stability of PML/RARαmay help to degrade PML/RARαand eradicate APL ***,we describe a deubiquitinase(DUB)-involved regulatory mechanism for the maintenance of PML/RARαstability and develop a novel pharmacological approach to degrading PML/RARαby inhibiting *** utilized a DUB siRNA library to identify the ovarian tumor protease(OTU)family member deubiquitinase YOD1 as a critical DUB of PML/RARα.Suppression of YOD1 promoted the degradation of PML/RARα,thus inhibiting APL cells and prolonging the survival time of APL cell-bearing *** phenotypic screening of small molecules allowed us to identify ubiquitin isopeptidase inhibitor I(G5)as the first YOD1 pharmacological *** expected,G5 notably degraded PML/RARαprotein and eradicated APL,particularly drug-resistant APL ***,G5 also showed a strong killing effect on primary patient-derived APL ***,our study not only reveals the DUB-involved regulatory mechanism on PML/RARαstability and validates YOD1 as a potential therapeutic target for APL,but also identifies G5 as a YOD1 inhibitor and a promising candidate for APL,particularly drug-resistant APL treatment.

关键词： Acute promyelocytic leukemia PML/RARa Deubiquitinase YOD1 Degradation Drug resistance Inhibitor Therapy

HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation

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Molecular Plant 2020年第3期13卷 515-531页

作者： Chao Yang Wenjin Shen Lianming Yang Yun Sun Xibao Li minyi Lai Juan Wei Chaojun Wang Yingchao xu Faqiang Li Shan Liang Chengwei Yang Shangwei Zhong Ming Luo Caiji Gao Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic ImprovementSouth China Botanical GardenCore Botanical GardensChinese Academy of SciencesGuangzhou 510650China College of Life Sciences Leshan Normal UniversityLeshan 614004China College of Life Sciences South China Agricultural UniversityGuangzhou 510642China School of Advanced Agricultural Sciences and School of Life Sciences Peking University100871 BeijingChina Center of Economic Botany Core Botanical GardensChinese Academy of SciencesGuangzhou 510650China These authors contributed equally to this article

Light is arguably one of the most important environmental factors that determines virtually all aspects of plant growth and development,but the molecular link between light signaling and the autophagy pathway has not been elucidated in *** this study,we demonstrate that autophagy is activated during light-to-dark conversion though transcriptional upregulation of autophagy-related genes(ATGs).We showed that depletion of the ELONGATED HYPOCOTYL 5(HY5),a key component of light signaling,leads to enhanced autophagy activity and resistance to extended darkness and nitrogen starvation treatments,contributing to higher expression ***5 interacts with and recruits HISTONE DEACETYLASE 9(HDA9)to ATG5 and ATG8e loci to repress their expression by deacetylation of the Lys9 and Lys27 of histone ***,we found that both darkness and nitrogen depletion induce the degradation of HY5 via 26S proteasome and the concomitant disassociation of HDA9 from ATG5 and ATG8e loci,leading to their depression and thereby activated *** analysis further confirmed that HY5 and HDA9 act synergistically and function upstream of the autophagy ***,our study unveils a previously unknown transcriptional and epigenetic network that regulates autophagy in response to light-to-dark conversion and nitrogen starvation in plants.

关键词： autophagy histone acetylation HY5 HDA9 light-to-dark shift nitrogen starvation

Power synchronization:taming massive diversified serverless functions under power constraints

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Science China(Information Sciences) 2024年

作者： Du LIU Lu ZHANG Yechen xu Xinkai WANG Lingyu SUN Yifei PU Xiaofeng HOU Chao LI minyi GUO Department of Computer Science and Engineering Shanghai Jiao Tong University AI Chip Center for Emerging Smart Systems The Hong Kong University of Science and Technology

Carbon neutrality has become an important design objective ***,the on-going shift to cloud-naive era does not necessarily mean energy *** the perspective of power management,co-hosted serverless functions are difficult to *** are lightweight,short-lived applications sensitive to power capping *** addition,they exhibit great individual and temporal variability,presenting idiosyncratic performance/power scaling goals that are often at odds with one *** date,very few proposals exist in terms of tailored power management for serverless *** this work,we introduce power synchronization,a novel yet generic mechanism for managing serverless functions in a power-efficient *** insight with power synchronization is that uniform application power behavior enables consistent and uncompromised function operation on shared host *** also propose PowerSync,a synchronization-based power management framework that ensures optimal efficiency based on a clear understanding of *** evaluation shows that PowerSync can improve the energy efficiency of functions by up to 16%without performance loss compared to conventional power management strategies.

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The influence of atrazine on intestinal histology, microbial community and short chain fatty acids in Pelophylax nigromaculatus tadpoles

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The influence of atrazine on intestinal histology, microbial...

HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation

中国毒理学会环境与生态毒理学专业委员会第七届学术研讨会

作者： Zhao Qiang Liu Yang WanYuyue Cao Xiaohong xu Xiang Huang minyi College of Agriculture and Biotechnology Hunan University of HumanitiesScience and Technology

The intestine is the main organ for amphibians to absorb nutrients. It is sensitive to atrazine, which is a herbicide widely used in agricultural areas. At present,there is a lack of systematic research on the effect of atrazine on amphibian *** this study, we evaluated the effects of atrazine exposure for 20 days on intestinal histology, microbiota, and short chain fatty acids in Pelophylax nigromaculatus tadpoles. Our research showed that 500 μg/L atrazine exposures caused the loss of intestinal villi and the disorder of epithelial cells, and altered the composition and diversity of intestinal microbiota in P. nigromaculatus tadpoles as compared to the control. At the phylum level, the abundance of Fusobacteria and Bacteroidetes increased significantly, while that of Verrucomicrobia and Firmicutes decreased significantly in atrazine exposure group. At the genus level, Akkermansia and Lactococcus had significantly lower abundance in the atrazine exposure group, while Cetobacterium was only detected in the atrazine-treated group. Also, function prediction of intestinal microbiota showed that atrazine treatment significantly changed the metabolism pathways of P. nigromaculatus tadpoles. In addition, atrazine exposure changed the content of short chain fatty acids by significantly increasing the content of total SFCAs, butyric acid, and valeric acid, and decreasing the content of isovaleric acid in the intestine. Taken together, atrazine exposure could affect the intestinal histology and induce intestinal microbiota imbalance and metabolic disorder in amphibian tadpoles.

关键词： atrazine intestinal microbiota fatty acids

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Molecular Plant 2022年第10期15卷 1632-1634页

作者： Chao Yang Wenjin Shen Lianming Yang Yun Sun Xibao Li minyi Lai Juan Wei Chaojun Wang Yingchao xu Faqiang Li Shan Liang Chengwei Yang Shangwei Zhong Ming Luo Caiji Gao 不详

(Molecular Plant 13,515-531;March 2020)After publication of our original manuscript,we became aware of errors in Figure *** the preparation of Figure 4C in this article as originally published,we inadvertently duplicated the image of hda9-1(MS-N)as that of the hda9-1-C(MS+N).Also,in Figure 4H,the image of pUBQ10:GFP-ATG8a/hda9-1(MS+L)was mistakenly a duplicate of pUBQ10:GFP-ATG8a/WT(MS+L)shown in Figure S7C.A corrected version of Figure 4 is shown *** scientific conclusions of this article have not been affected by this *** authors apologize for not detecting this error prior to publication and for any inconvenience that may have been caused.

关键词： Figure Plant Conversion

水合肼液相还原法制备银包覆超细铜粉反应机理研究

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稀有金属材料与工程 2008年第5期37卷 905-908页

作者：徐锐周康根胡敏艺中南大学

反应体系中引入强还原剂水合肼,通过反应条件抑制置换反应,使银氨溶液优先发生液相还原反应,制备了与原铜粉粒径和形貌大致相同的铜-银双金属粉。敏化、活化处理过程中采用新的活化剂AgNO3取代传统的PdCl2,经济可行又避免引入新的杂质... 详细信息

反应体系中引入强还原剂水合肼,通过反应条件抑制置换反应,使银氨溶液优先发生液相还原反应,制备了与原铜粉粒径和形貌大致相同的铜-银双金属粉。敏化、活化处理过程中采用新的活化剂AgNO3取代传统的PdCl2,经济可行又避免引入新的杂质。采用XRD,SEM,EDX等检测方法对预处理后铜粉和包覆双金属粉的晶相组成及含量、铜-银双金属粉形貌、表面包覆层相组成及含量以及整个包覆过程的机理加以研究。研究表明:水合肼还原法经过3次包覆后,铜粉表面形成连续的银膜,克服了置换反应消耗过多的铜粉、制备的铜-银双金属粉呈胶状不易洗涤、干燥后易于结块等不足。

关键词：水合肼超细铜粉双金属粉机理

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

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Protein & Cell 2020年第10期11卷 723-739页

作者： Rui Xiong Leike Zhang Shiliang Li Yuan Sun minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke xu State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus ***,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against ***,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted *** results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out *** work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not.

关键词： de novo pyrimidine biosynthesis DHODH inhibitors SARS-CoV-2 influenza viruses virus replication immuno-regulation