HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation
作者机构：Guangdong Provincial Key Laboratory of Biotechnology for Plant DevelopmentSchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Applied BotanyKey Laboratory of South China Agricultural Plant Molecular Analysis and Genetic ImprovementSouth China Botanical GardenCore Botanical GardensChinese Academy of SciencesGuangzhou 510650China College of Life SciencesLeshan Normal UniversityLeshan 614004China College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China School of Advanced Agricultural Sciences and School of Life SciencesPeking University100871 BeijingChina Center of Economic BotanyCore Botanical GardensChinese Academy of SciencesGuangzhou 510650China These authors contributed equally to this article
出 版 物：《Molecular Plant》 (分子植物（英文版）)
年 卷 期：2020年第13卷第3期
页 面：515-531页
核心收录：
学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学]
基 金：supported by grants from the National Natural Science Foundation of China(31900231) National Science Foundation of Guangdong Province(2018A030310505)to C.Y the National Natural Science Foundation of China(31870171 and 31671467),toC.G the Youth Innovation Promotion Association,Chinese Academy of Sciences(2017399) the National Key R&D Program of China(2019YFC1711102) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA13020500)to M.L.,and the National Natural Science Foundation of China(31701246)to W.S
主 题：autophagy histone acetylation HY5 HDA9 light-to-dark shift nitrogen starvation
摘 要：Light is arguably one of the most important environmental factors that determines virtually all aspects of plant growth and development,but the molecular link between light signaling and the autophagy pathway has not been elucidated in *** this study,we demonstrate that autophagy is activated during light-to-dark conversion though transcriptional upregulation of autophagy-related genes(ATGs).We showed that depletion of the ELONGATED HYPOCOTYL 5(HY5),a key component of light signaling,leads to enhanced autophagy activity and resistance to extended darkness and nitrogen starvation treatments,contributing to higher expression ***5 interacts with and recruits HISTONE DEACETYLASE 9(HDA9)to ATG5 and ATG8e loci to repress their expression by deacetylation of the Lys9 and Lys27 of histone ***,we found that both darkness and nitrogen depletion induce the degradation of HY5 via 26S proteasome and the concomitant disassociation of HDA9 from ATG5 and ATG8e loci,leading to their depression and thereby activated *** analysis further confirmed that HY5 and HDA9 act synergistically and function upstream of the autophagy ***,our study unveils a previously unknown transcriptional and epigenetic network that regulates autophagy in response to light-to-dark conversion and nitrogen starvation in plants.
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