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Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location

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World Journal of Gastroenterology 2024年第33期30卷 3823-3836页

作者： Qian-Yu Wang Wen-Tao Zhong Yi Xiao Guo-le Lin Jun-Yang Lu Lai xu Guan-Nan Zhang Jun-Feng Du Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Medical Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers(LCC)and right-sided colon cancers(RCC).Pan-immune-inflammation value(PIV)is a systemic immune response marker that can predict the prognosis of patients with colon ***,the specific distinction between PIV of LCC and RCC remains *** To investigate the prognostic and clinical significance of PIV in LCC and RCC *** This multicenter retrospective cohort study included 1510 patients with colon cancer,comprising 801 with LCC and 709 with *** used generalized lifting regression analysis to evaluate the relative impact of PIV on disease-free survival(DFS)in these ***-Meier analysis,as well as univariate and multivariate analyses,were used to examine the risk factors for *** correlation between PIV and the clinical characteristics was statistically analyzed in these *** A total of 1510 patients{872 female patients(58%);median age 63 years[interquartile ranges(IQR):54-71];patients with LCC 801(53%);median follow-up 44.17 months(IQR 29.67-62.32)}were *** was significantly higher in patients with RCC[median(IQR):214.34(121.78-386.72)vs 175.87(111.92-286.84),P227.84)was associated with worse DFS in LCC[PIV-high:Adjusted hazard ratio(aHR)=2.39;95%confidence interval:1.70-3.38;P<0.001]but not in RCC(PIV-high:aHR=0.72;95%confidence interval:0.48-1.08;P=0.114).CONCLUSION These findings suggest that PIV may predict recurrence in patients with LCC but not RCC,underscoring the importance of tumor location when using PIV as a colon cancer biomarker.

关键词： Colon cancer left-sided colon cancer Right-sided colon cancer Pan-immune-inflammation value Systemic inflammatory biomarkers Prognosis

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A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts

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Science China(Life Sciences) 2024年第6期67卷 1242-1254页

作者： Xianliang Huang Qing Li Yanan xu Ang Li Shanzheng Wang Yusheng Chen Chunrui Zhang Xia Zhang Hailin Wang Cong Lv Baofa Sun Shaoqin Li le Kang Bing Chen School of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230601China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain ***,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta *** results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or *** individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary ***,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of *** summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria

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Rare earth element-modified MOF materials:synthesis and photocatalytic applications in environmental remediation

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Rare Metals 2024年第4期43卷 1390-1406页

作者： Shu-Kun le Qi-Jie Jin Jia-Ao Han Hua-Cong Zhou Quan-Sheng Liu Fu Yang Jie Miao Pei-Pei Liu Cheng-Zhang Zhu Hai-Tao xu Inner Mongolia Key Laboratory of High-Value Functional Utilization of Low Rank Carbon Resources Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot010050China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing210009China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications MontrealQCJ3X 1P7Canada

Metal-organic framework-like materials(MOFs)have been developed in the fields of photocatalysis for their excellent optical properties and physicochemical properties,including environmental remediation,CO_(2)photoreduction,water splitting,and so *** their important roles in various fields,rare earth elements have received growing interests from *** MOFs with rare earth elements for modification allows broadening the absorption spectrum,while the active electrons on their empty 4f orbitals can act as traps to capture photoexcited carriers to inhibit the recombination of electron-hole pairs,thus promoting photocatalytic ***,rare earth elements modified MOFs provide an attractive way to achieve their high value *** this mini-review,the synthesis of rare earth element-modified MOFs photocatalysts and corresponding applications in the removal of antibiotics,CO_(2)reduction,and hydrogen production are constructively summarized and ***,the latest advancements and current difficulties of these materials as well as the application prospects are also provided.

关键词： Rare earth metals MOFs Photocatalytic CO_(2) reduction Environmental remediation Water splitting

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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying Li Tian-tian xu Ya-lin Yang Hui-yong Yang Heng-bing Li le-jin Zhou Yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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X射线荧光光谱法对橡胶鞋底的分类

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化学研究与应用 2020年第5期32卷 832-834页

作者：姜红徐乐乐付钧泽中国人民公安大学刑事科学技术学院北京100038

为建立案件现场常见橡胶鞋底物证的分类方法,利用X射线荧光光谱,对40个不同品牌、不同系列的橡胶鞋底样品中的无机元素进行了检验。并结合多元统计学,分别选用主成分分析法、k均值聚类法及判别分析法等对实验结果进行分析。结果表明,该... 详细信息

为建立案件现场常见橡胶鞋底物证的分类方法,利用X射线荧光光谱,对40个不同品牌、不同系列的橡胶鞋底样品中的无机元素进行了检验。并结合多元统计学,分别选用主成分分析法、k均值聚类法及判别分析法等对实验结果进行分析。结果表明,该方法简便快速、结果准确可靠且无损检材,对样品的分类效果较好。利用该方法可以对橡胶鞋底物证进行分类。

关键词： X射线荧光光谱法橡胶鞋底主成分分析法 K均值聚类法判别分析

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The"4+4"Medical Doctor(MD)Pilot Program at PUMC:Implementation,Performance,and Prospects

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Chinese Medical Sciences Journal 2024年第2期39卷 144-148页

作者： Jing-Jing Yi Wei-Wei xu Chao Ma He Di Jing Jin le Zeng Wen-Ji Tu Wen-Wen Sun Qin Zhang Office of Educational Affairs Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100730China

Peking Union Medical College(PUMC)launched the"4+4"Medical Doctor(MD)pilot program in 2018,admitting students with non-medical backgrounds from top universities,aligning with national medical talent training policies to foster diverse and eager learners in *** the occasion of the graduation of the first class of the"4+4"MD pilot class at PUMC in 2023,we reviewed the teaching reform in the pilot program and carried out a systematic survey and interviews with students,faculties,and management staff of the pilot *** article reports on the measures taken by the pilot class at PUMC in enrollment and curriculum setting,and demonstrates the achievements of the pilot class in terms of student academic background structure,knowledge acquisition and skill learning,scientific research ability,and course *** results indicated that the pilot class had met the national demand for the"Medicine+X"talent training *** specifically,with a diverse academic backgrounds,the pilot class graduates had academic levels comparable to the eight-year medical education graduates,and their scientific research abilities were *** pilot program at PUMC will optimize the curriculum setting,strengthen the construction of faculty,learning resources,and teaching facilities,and reform the academic evaluation methods,thus deepening the reform of medical education and improving the"4+4"MD program as a novel medical education model.

关键词： "4+4"MD pilot program teaching reform medical education

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Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

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Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su le Chang Guanzhong Jiao Yang Ou Mei Yang Chao xu Pengtao Liu Zejia Wang Zewen Qi Wenwen Liu Linhua Sun Guangming He Xing Wang Deng Hang He School of Advanced Agriculture Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain *** reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related *** interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in *** compartment domain(CD)boundaries,the distal interactions were more in hybrids than their *** the hybrids of CURLY leAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower ***-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance *** addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop *** findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

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Improved decoy-state quantum key distribution with uncharacterized heralded single-photon sources

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Chinese Physics B 2024年第2期33卷 204-208页

作者：徐乐辰张春辉周星宇王琴 Institute of Quantum Information and Technology Nanjing 210003China Broadband Wireless Communication and Sensor Network Technology Key Laboratory of Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China Telecommunication and Networks National Engineering Research Center Nanjing University of Posts and TelecommunicationsNanjing 210003China

Encoding system plays a significant role in quantum key distribution(QKD).However,the security and performance of QKD systems can be compromised by encoding misalignment due to the inevitable defects in realistic *** alleviate the influence of misalignments,a method exploiting statistics from mismatched basis is proposed to enable uncharacterized sources to generate secure keys in *** this work,we propose a scheme on four-intensity decoy-state quantum key distribution with uncharacterized heralded single-photon *** only requires the source states are prepared in a two-dimensional Hilbert space,and can thus reduce the complexity of practical ***,we carry out corresponding numerical simulations and demonstrate that our present four-intensity decoy-state scheme can achieve a much higher key rate compared than a three-intensity decoy-state method,and meantime it can obtain a longer transmission distance compared than the one using weak coherent sources.

关键词： quantum key distribution heralded single-photon source decoy-state method

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基于薄壁磁通管的ABS电磁阀行程力特性仿真与实验研究

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液压与气动 2015年第7期39卷 24-27页

作者：刘伟胥乐乐李其朋浙江万向精工有限公司浙江杭州310012 浙江科技学院机械与汽车工程学院浙江杭州310023 浙江大学流体动力与机电系统国家重点实验室浙江杭州310027

梯形沟槽的薄壁磁通管能够改进ABS电磁阀的加工工艺,但同时造成了电磁力特性对薄壁位置参数的高依赖性。基于有限元模型仿真探讨了梯形沟槽的上下倾角、薄壁长度、薄壁厚度、薄壁初始高度等结构参数对电磁力的作用规律,并进行了实验对... 详细信息

梯形沟槽的薄壁磁通管能够改进ABS电磁阀的加工工艺,但同时造成了电磁力特性对薄壁位置参数的高依赖性。基于有限元模型仿真探讨了梯形沟槽的上下倾角、薄壁长度、薄壁厚度、薄壁初始高度等结构参数对电磁力的作用规律,并进行了实验对比研究。仿真数据与实验数据基本吻合,验证了分析模型的正确性。研究结果表明,较小的梯形沟槽角度以及适当的薄壁长度、薄壁厚度和薄壁初始位置可获得良好的行程力特性。

关键词： ABS电磁阀薄壁磁通管行程力特性仿真与实验

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乡村少年的文化认同危机及教育策略——基于文化人类学视角

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广西师范大学学报（哲学社会科学版） 2018年第6期54卷 87-93页

作者：徐乐乐广西师范大学教育学部广西桂林541004

随着现代化水平不断提高,乡村少年大量涌入城市。然而,许多从小浸淫于乡村文化的乡村少年遭遇迥异的城市文化时,既放弃了对乡村文化的认同,又不能被城市文化认同和承认,产生了文化认同危机,成了游离于城乡文化之间的文化流浪者。乡村少... 详细信息

随着现代化水平不断提高,乡村少年大量涌入城市。然而,许多从小浸淫于乡村文化的乡村少年遭遇迥异的城市文化时,既放弃了对乡村文化的认同,又不能被城市文化认同和承认,产生了文化认同危机,成了游离于城乡文化之间的文化流浪者。乡村少年的文化认同危机包括价值认同危机、身份认同危机和自我认同危机。从教育学的视角来看,教育作为社会中最重要的文化传承与传播系统,应该摆正乡村教育的位序;乡村教师需要引导乡村少年进行文化反思;重视地方与校本课程的开发实施,以建构乡村少年的文化认同。

关键词：文化人类学文化认同危机乡村少年乡村教育

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