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Hydrothermal Synthesis and Characterization of a Novel Supramolecular Network Compound [Co(IN)_2(H_2O)_4](IN=Isonicotinate)

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Chemical Research in Chinese Universities 2002年第4期18卷 385-388页

作者： jia Hong-bin YU Jie-hui DING Hong xu Ji-qing YE Ling JING Wei-jieWANG Tie-gang xu jia-ning QU xue-jian LI Zeng-chun College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130023P.R.China Key Laboratory of Supramolecular Structure and Materials of Ministry of Education Jilin UniversityChangchun 130023P.R.China Department of Chemistry Inner Mongolia University for NationalitiesTongliao 028000P.R.China

A novel supramolecular compound, [Co(IN)_2(H_2O)_4](1), was synthesized by means of the hydrothermal method and its structure was characterized with elemental analysis, FT-IR spectrum, TGA and X-ray diffraction. Though the unit cell structure of the title compound is only monomeric, all these units as building blocks are assembled into a novel three-dimensional supramolecular network via the widely hydrogen-bonding and π-π stacking interactions.

关键词： Hydrothermal synthesis Cobalt(Ⅱ) complex X-Ray diffraction Isonicotinate Supramolecule

Tetramethylguanidium Lactate Ionic Liquid: Catalyst-free Medium for Michael Addition Reaction

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Chemical Research in Chinese Universities 2008年第1期24卷 36-41页

作者： LIANG Da-peng XIN Xin DUAN Hai-feng YIN Yan-zhen GAO Han LIN Ying-jie xu jia-ning Department of Organic Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

A catalyst-free, facile and efficient Michael addition reaction of active methylene compounds as well as nitromethane with chalcones catalyzed by guanidinium lactate ionic liquid was done. A series of chalcones, nitromethane, and active methylene compounds were converted smoothly to the corresponding products in high yields. The simple procedure, very mild conditions, high yields, and reuse of the IL without any loss of catalytic activity make this protocol considerably attractive for academic researches and practical applications.

关键词： Guanidinium lactate ionic liquid Michael addition reaction Chalcone Active methylene compound

Recycle Adsorption of Cu2＋ on Amine-functionalized Mesoporous Silica Monolithic

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Chemical Research in Chinese Universities 2013年第4期29卷 793-797页

作者： ZHAO Da-zhou JING Shu-bo xu jia-ning YANG Hong ZHENG Wei SONG Tian-you ZHANG Ping State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

3-Aminopropyltriethoxysilane functionalized worm-like mesoporous silica monolithic（WMSM-NH2） was prepared and used as a new regenerable adsorbent for the removal of Cu2＋ ions. The analysis results show that the WMSM-NH2 monolithic had a high efficiency value of 99.3% for Cu2＋ remediation when the Cu2＋ solution was at an initial concentration of 10.32 mg/L. The regeneration study of the WMSM-NH2 monolithic presented that the adsorp- tion efficiency of 89.0% was remained and a mass of 92.0% was left after seven adsorption-desorption cycles were executed. The monolithic material with high resistance to the acid and good mechanical stability can facilitate the operations of adsorption and regeneration of the adsorbent.

关键词： Amine-functionalized mesoporous silica monolithic(WMSM-NH2) Cu2+ removal Multiple cycle Adsorp- tion Easy operation

Synthesis and Crystal Structure of 1,7,7-Trimethyl-4-(4-methoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under Microwave Irradiation

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Chinese Journal of Structural Chemistry 2006年第5期25卷 599-603页

作者： HUA Guo-Ping ZHU Xiao-Tong ZHANG Jin-Peng xu jia-ning WANG Qian JI Shun-Jun ZHANG Yong TU Shu-jiang xuzhou Institute of Architectural Technology Xuzhou Jiangsu 221008 China Department of Chemistry Xuzhou Normal University Key Laboratory of Biotechnology on Medical Plant Xuzhou Jiangsu 221116 China College of Chemistry and Chemical Engineering Key Laboratory of Organic Synthesis of Jiangsu Province Suzhou University Suzhou Jiangsu 215006 China

The title compound （C19H23NO3） was synthesized by the one-pot reaction ofp-methoxybenzaldehyde, Meldrum＇s acid, dimedone and CH3NH3Cl （NaOAc） in ethanol under microwave irradiation without catalyst and its crystal structure was determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 8.7462（10）, b = 17.7367（19）, c = 11.5959（14） A, β = 110.981（3）°, V= 1679.6（3） A^3, Z = 4, Dc = 1.239 g/cm^3,μ（MoKa） = 0.083 mm^-1, F（000） = 672 and Mr = 313.38. The structure was refined to R = 0.0530 and wR = 0.1216. X-ray analysis reveals that the dihedral angle between plane 1 （N（1）, C（1）, C（2）, C（3）） and plane 2 （C（1）, C（2）, C（6）, C（7）, C（9）） is 3.64°, andt hat between plane 2 and plane 3 （C（11）～C（16）） is 85.33°.

关键词： 4,6,7,8-tetrahydroquinoline-2,5-diones synthesis microwave irradiation crystal structure

Studies on BN rats model to determine the potential allergenicity of proteins from genetically modified foods

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World Journal of Gastroenterology 2005年第34期11卷 5381-5384页

作者： xu-Dong jia ning Li Yong-ning Wu Xiao-Guang Yang National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050China

AIM： To develop a Brown Norway （BN） rat model to determine the potential allergenicity of novel proteins in genetically modified food. METHODS： The allergenicity of different proteins were compared, including ovalbumin （OVA）, a potent respiratory and food allergen, bovine serum albumin （BSA）, a protein that is considered to have a lesser allergenic potential, and potato acid phosphatase （PAP）, a non-allergenic protein when administered to BN rats via different routes of exposure （intraperitoneally or by gavage）. IgG and IgE antibody responses were determined by ELISA and PEA, respectively. An immunoassay kit was used to determine the plasma histamine level. In addition, possible systemic effect of allergens was investigated by monitoring blood pressure. RESULTS： OVA provoked very vigorous protein-specific IgG and IgE responses, low grade protein-specific IgG and IgE responses were elicited by BSA, while by neither route did PAP elicit anything. In either routes of exposure, plasma histamine level in BN rats sensitized with OVA was higher than that of BSA or PAP. In addition, an oral challenge with BSA and PAP did not induce any effect on blood pressure, while a temporary drop in systolic blood pressure in few animals of each routes of exposure was found by an oral challenge with OVA. CONCLUSION： BN rat model might be a useful and predictive animal model to study the potential allergenicity of novel food proteins.

关键词： Animal model Food protein Allergenicity

Studies of Mixed-valence Compounds(Ⅰ)──In-Situ FTIR and UV-Visible-Near-IR Spectroelectrochemical Studies of Mixed-valence Isopolyanion Mo_6O_(19)^(3-) in Aprotic Media

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Chemical Research in Chinese Universities 1996年第1期12卷 6-9页

作者： SUN Hao-ran YANG Guo-yu xu jia-ning and xu Ji-qing (Department of Chemistry, Jilin University, Changchun, 130023)

The mixed-valence isopolyanion Mo6O193- was investigated by means of cyclic voltammographic, in-situ FTIR and UV-Visible-Near-IR spectro-electrochemicalmethods in aprotic media. The experimental results indicate that the Mo6O193-was formed whereafter Mo6O193- was reduced, (E0' = - 0. 690 V, n = 1 ). The characteristic absorptions of Mo6O193- are 500 nm, 900 nm and 1100 nm in UV-VisibleNear-IR spectrum and 940 cm-1 in IR spectrum.

关键词： Mixed-valence compound Electrochemistry In-situ spectro-electrochemistry

Assessment on Dietary Melamine Exposure from Tainted Infant Formula

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Biomedical and Environmental Sciences 2009年第2期22卷 100-103页

作者： xu-DONG jia ning LI ZHU-TIAN WANG YUN-FENG ZHAO YONG-ning WU AND WEI-XING YAN Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To estimate the dietary melamine exposure in Chinese infants and young children from the consumption of melamine adulterated Sanlu infant formula. Methods Four age groups of infants and young children （3, 6, 12, and 24 months） were chosen as the assessed subjects and the maximum amount of infant formula consumption was estimated based on the recommended usage level in the package insert of Sanlu infant formula and other brands. Melamine was analyzed in 111 Sanlu infant fbrmula samples collected from the markets in Beijing and Gansu province using the LC-MS-MS with a limit of quantification of 0.05 mg/kg. Four levels of melamine concentration were chosen to estimate the dietary intakes, including the mean, median, 90th percentile, and maximum. Results The infants of 3 months had the highest intake of melamine, and with the increase of the age （inonth）, the intake decreased. Based on the median melamine concentration （1 000 mg/kg） as an example, the melamine intakes fur the infants of 3, 6, 12, and 24 months were 23.4, 21.4, 15.0, and 8.6 mg/kg bw/d, respectively. Conclusion Dietary melamine intakes from tainted Sanln infant formula significantly exceeded the TDI level （0.2 mg/kg bw/d） recommended by the WHO Expert Meeting in 2008. However, the present assessment has some limitations including the poor representative samples, the varied melamine concentrations in the adulterated Sanlu infant formula, and other brand infant formula possibly consumed by these infants.

关键词： Dietary exposure assessment Melamine Infant formula

基于Web2.0的非正式科学交流过程及其特点

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情报科学 2008年第1期26卷 53-59页

作者：徐佳宁徐州师范大学图书馆信息咨询部江苏徐州221116

基于Web2.0的非正式科学交流是基于用户创造内容、互动、分享理念的新的科学交流方式,借助于Web2.0的应用元素blog、Wiki、RSS、Tag、Bookmark进行非正式科学交流具有在线动态、多向交互、成本低、效率高和自组织管理特性。本文分析了基... 详细信息

基于Web2.0的非正式科学交流是基于用户创造内容、互动、分享理念的新的科学交流方式,借助于Web2.0的应用元素blog、Wiki、RSS、Tag、Bookmark进行非正式科学交流具有在线动态、多向交互、成本低、效率高和自组织管理特性。本文分析了基于Web2.0的非正式科学信息发布主体及其发布行为特征、发布内容及其正确性、信息的接收和互动方式,研究了基于Web2.0的非正式科学交流过程及其特点。

关键词：非正式科学交流信息交流过程科学交流特点信息聚合互动 Web2.0

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing ning Shi Lv Qian Wang Yuzhen xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury