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Chinese Journal of Structural Chemistry 2020年第7期39卷 1271-1276页

作者： xu xue-mei LUO Zai-Gang HAN Xin-Xin LIU Qian-Nan LI Rui College of Chemical Engineering Anhui University of Science and TechnologyHuainan 232001China

The target compounds 3(C14H15NO4)and 4(C20H17NO8)were synthesized and structurally determined by single-crystal X-ray *** crystal of 3 is in the monoclinic system,space group P21/c with a=7.3017(3),b=7.8737(5),c=22.4227(11)?,β=94.837(5)°,C14H15NO4,Mr=261.27,Dc=1.351 g/cm3,V=1284.51(11)?3,Z=4,F(000)=552,μ(MoKa)=0.828 mm–1,T=289.12(10)K,2236 independent reflections with 1827 observed ones(I>2σ(I)),R=0.0515 and w R=0.1394 with GOF=1.044(R=0.0605 and w R=0.1548 for all data).The crystal of compound 4 is in the monoclinic system,space group P21/c with a=7.1269(3),b=12.6518(6),c=20.7540(8)?,β=96.941(4)°,C20H17NO8,Mr=399.35,Dc=1.428 g/cm3,V=1857.61(14)?3,Z=4,F(000)=832.0,μ(MoKa)=0.950 mm–1,T=288.81(10)K,3216 independent reflections with 2253 observed ones(I>2σ(I)),R=0.0612 and wR=0.1548 with GOF=1.055(R=0.0824 and w R=0.1790 for all data).The skeleton of 1,4-dihydroquinoline 3 is noncoplanar,while pyrrolo[1,2-a]-quinoline 4 owns a coplanar frame ***-dimensional interaction model of compound 4 was formed by the one kind ofπ-πinteraction between the two adjacent molecules at upper and lower *** the inhibition to the strand transfer process of HIV-1 integrase of the title compounds was also evaluated.

关键词： 1,4-dihydroquinoline pyrrolo[1,2-a]quinoline synthesis crystal structure HIV-1 integrase

Efficient Visible Electroluminescence from Porous Silicon Diodes Passivated by Carbon Films

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Chinese Physics Letters 2002年第7期19卷 1013-1015页

作者： Li Hong-Jian Peng Jing-Cui Qu Shu Yan Yong-Hong xu xue-mei Zhao Chu-Jun Department of Applied Physics Hu'nan University Changsha 410082 College of Physics Science and Technology Central South University Changsha 410083

By using n-butylamine as a carbon resource, carbon film is deposited on the p-n porous silicon (PS) surface with a radio-frequency glow discharge plasma system. Raman spectra and infrared reflection (IR) spectra of the carbon films indicate that there are amine-group and hydrogen atoms therein. The IR spectra of the passivated PS samples exhibit that the PS surfaces are mainly covered with Si-C, Si-N and Si-O bonds. Electroluminescence (EL) spectra show that the EL intensity of the passivated PS diodes increases greatly and the blueshift of the EL peak occurs compared with the diodes without treatment. Both of these are stable while the passivated diodes are exposed to the air indoors. The I-V characteristics reveal that the passivated diodes have a smaller series resistance and a lower onset voltage. The influence of the carbon film passivation on EL properties of PS has also been discussed. The results have proven that carbon film passivation is a good way to enhance the PS luminescent intensity and stability.

关键词： Passivation

Energy and Charge Transfer from Guest to Host in Doped Organic Electroluminescent Devices

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Chinese Physics Letters 2002年第9期19卷 1356-1358页

作者： Li Hong-Jian Peng Jing-Cui xu xue-mei Qu Shu Luo Xiao-Hua Zhao Chu-Jun Department of Applied Physics Hu'nan University Changsha 410082 College of Physics Science and Technology Central South University Changsha 410083

The luminescence properties of doped organic electroluminescent devices are explained by means of a Hamiltonian model. The results show that there is a corresponding relation between the amount of transferred charge and the change of the energy originating from charge transfer, and the relation can be influenced by dopant concentration. As the amount of transferred charge increases, the total energy decreases and the luminescence intensity increases. Therefore, we deduce that the energy transfer from guest to host may be derived from the charge transfer. For a given organic electroluminescent device, the maximum value of the conductivity can be observed in a specific dopant concentration. The calculated results show that the greater the transferred charges, the higher the conductivities in doped organic electroluminescent devices. The results agree basically with experimental results.

关键词： Charge transfer

Synthesis, Crystal Structure and Thermal Property of Dimethyl Phenanthrene-9,10-dicarboxylate

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Chinese Journal of Structural Chemistry 2020年第5期39卷 908-912页

作者： LUO Zai-Gang LIU Qian-Nan LI Rui xu xue-mei College of Chemical Engineering Anhui University of Science and TechnologyHuainan 232001China

The target compound(C18H14O4)was synthesized and structurally determined by single-crystal X-ray *** crystal is of monoclinic system,space group P21/n with a=7.9383(6),b=19.5083(13),c=9.4189(7)?,β=98.981(2)°,C18H14O4,Mr=294.29,Dc=1.357 g/cm^3,V=1440.75(18)?3,Z=4,F(000)=616,μ(MoKa)=0.096 mm-1,T=293(2)K,3320 independent reflections with 1845 observed ones(I>2σ(I)),R=0.0529 and wR=0.1082 with GOF=1.015(R=0.1202 and wR=0.1278 for all data).The phenanthrene skeleton is *** overall crystal packing revealed that it has reverse staggered parallel and stratified *** a one-dimensional interaction model was formed by two kinds ofπ-πinteractions between the two adjacent molecules at upper and lower *** decomposition mechanism of compound 3 is complex.

关键词： phenanthrene synthesis crystal structure thermal property

Synthesis and Crystal Structure of 6-Cyclohexyl-8-methylphenanthridine

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Chinese Journal of Structural Chemistry 2021年第10期40卷 1284-1290页

作者： LUO Zai-Gang WEI Dan-Dan PENG Cheng-Tong LIU Chen-Fu CHEN Qi-Hua ZHANG Rong-Hao xu xue-mei State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines College of Chemical EngineeringAnhui University of Science and TechnologyHuainan 232001China School of Pharmaceutical Science Gcwnan Medical UniversityGanzhou 341000China

The target compound Ⅳ (C_(20)H_(21)N) was synthesized through four-step reactions and structurally determined by single-crystal X-ray *** crystal of compound Ⅳ is in the orthorhombic system,space group Fdd2 with a=41.178(19),b=30.389(8),c=4.8182(17)Å,β=90°,C_(20)H_(21)N,M_(r)=275.38,D_(c)=1.213g/cm^(3),V=6029(4)Å^(3),Z=16,F(000)=2368,μ(Mo Ka)=0.527 mm^(-1),T=240(2) K,2200 independent reflections with 1233 observed ones (I>2σ(I)),R=0.1285 and w R=0.2589 with GOF=1.050 (R=0.2058 and w R=0.3055for all data).A one-dimensional interaction model of the title compound was formed by one kind of π-π interactions between the two phenyl rings of the adjacent molecules at upper and lower *** inhibition to the strand transfer process of HIV-1 integrase of the target compound was also evaluated.

关键词： phenanthridine synthesis crystal structure HIV-1 integrase

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人乳头瘤病毒及宫颈癌疫苗的研究--解读2008年诺贝尔生理学或医学奖

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生物化学与生物物理进展 2008年第10期35卷 1095-1103页

作者：许雪梅中国医学科学院基础医学研究所、北京协和医院基础学院北京100005

德国科学家Harald zur Hausen因发现人乳头瘤病毒(HPV)导致子宫颈癌,与另外两位科学家共享了2008年的诺贝尔生理学或医学奖.HPV是一组小DNA病毒,目前已鉴定有118型.HPV感染人的上皮组织,诱发产生包括妇女宫颈癌和尖锐湿疣在内的多种良... 详细信息

德国科学家Harald zur Hausen因发现人乳头瘤病毒(HPV)导致子宫颈癌,与另外两位科学家共享了2008年的诺贝尔生理学或医学奖.HPV是一组小DNA病毒,目前已鉴定有118型.HPV感染人的上皮组织,诱发产生包括妇女宫颈癌和尖锐湿疣在内的多种良恶性增生性疾病,目前已有两种人乳头瘤病毒预防性疫苗上市.对病毒的生物学特性、致癌机制及相关的疫苗的研究进行综述.

关键词：人乳头瘤病毒宫颈癌疫苗

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基于DoDAF的靶场体系结构设计

系统工程理论与实践 2013年第1期33卷 249-254页

作者：王雪峥许雪梅 92493部队98分队

信息化武器装备的发展,对靶场试验能力的要求不断提升.靶场体系结构的建立迫在眉睫.统一规范的体系结构为新系统的开发提供标准框架,防止各自为战的"烟囱式"建设,促进体系内各系统之间的互连、互通和互操作,最大限度的发挥系统效能.避... 详细信息

信息化武器装备的发展,对靶场试验能力的要求不断提升.靶场体系结构的建立迫在眉睫.统一规范的体系结构为新系统的开发提供标准框架,防止各自为战的"烟囱式"建设,促进体系内各系统之间的互连、互通和互操作,最大限度的发挥系统效能.避免浪费.通过对美国国防部体系结构框架(DoDAF)的研究,综合分析靶场具体领域的实际需求.根据DoDAF体系结构设计方法,研究提出了靶场体系结构的设计思路.对靶场以及其它相关领域的体系结构设计都具有一定的参考价值.

关键词： DoDAF 体系结构靶场

Encapsidating artificial human papillomavirus-16 mE7 protein in human papillomavirus-6b L1/L2 virus like particles

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Chinese Medical Journal 2007年第6期120卷 503-508页

作者： xu Yu-fei WANG Qing-yong ZHANG Hong-tao HAN Ye-hua SONG Guo-xing xu xue-mei Department of Biophysics and Structural Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China Laboratory of Molecular Modelling and Drug Design Lindsley E Kimball Research Institute New York Blood Centre 310 E 67th Street New York NY 10021 USA

Background Human papillomaviruses （HPVs） can infect squamous or mucosal epithelia and cause cervical cancer or genital warts. Coinfection with multiple HPV types is a common finding of many epidemiological studies. Therefore, it is necessary to develop a vaccine, which can eradicate established HPV infections and prevent other HPV infections. In this study, we generated chimeric virus like particles （cVLPs） composed of HPV-6b L1, HPV-6b L2 and one artificial HPV-16 mE7 proteins. Methods The artificial HPV-16 mE7 gene was designed by codon modification, point mutation and gene shuffling then chemically synthesized and subcloned behind HPV-6b L2. HPV-6b L1 and L2-mE7 were expressed in insect cells by using Bac-to-Bac system. The generated cVLPs were purified by CsCI gradient ultracentrifuge and analyzed by immunoblot, electron microscope and haemagglutination assay. Results The HPV-6b L1 and L2-mE7 proteins were well expressed in insect cells and could selfassemble into cVLPs, whose diameter was about 55 nm and similar to that of HPV-6b L1/L2 VLPs. Intact cVLPs could be recognized by H6.M48 neutralizing monoclonal antibody and HPV-6b L2 polyclonal antibody, while the denatured cVLPs, but not the intact cVLPs, were reactive to HPV-16 E7 polyclonal antibody. HPV-6b LI/L2-mE7 cVLPs haemaggiutinated mouse erythrocytes as efficiently as HPV-6b L1/L2 VLPs did. Conclusions The insertion of the 158 amino acid HPV-16 mE7 protein behind L2 did not disrupt the correct assembling of cVLPs. The morphological characteristics and haemagglutinating activity of cVLPs were similar to those of HPV-6b LI/L2 VLPs. The cVLPs retained conformational B cell epitopes of HPV-6 VLPs and HPV-16 mE7 protein had an internal location in the cVLPs. Therefore, large modified E7 protein with higher immunogenicity could be incorporated into cVLPs by fusing to the C-terminus of L2, which would help to improve the therapeutic effects of LI/L2-E7 cVLPs.

关键词： human papillomavirus chimeric virus like particles cervical cancer vaccine

Vehicle detection algorithm based on codebook and local binary patterns algorithms

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Journal of Central South University 2015年第2期22卷 593-600页

作者：许雪梅周立超墨芹郭巧云 School of Physics and Electronics Central South University

Detecting the moving vehicles in jittering traffic scenes is a very difficult problem because of the complex *** by the color features of the pixel or only by the texture features of image cannot establish a suitable background model for the moving vehicles. In order to solve this problem, the Gaussian pyramid layered algorithm is proposed, combining with the advantages of the Codebook algorithm and the Local binary patterns(LBP) algorithm. Firstly, the image pyramid is established to eliminate the noises generated by the camera shake. Then, codebook model and LBP model are constructed on the low-resolution level and the high-resolution level of Gaussian pyramid, respectively. At last, the final test results are obtained through a set of operations according to the spatial relations of pixels. The experimental results show that this algorithm can not only eliminate the noises effectively, but also save the calculating time with high detection sensitivity and high detection accuracy.

关键词： background modeling Gaussian pyramid Codebook Local binary patterns(LBP) moving vehicle detection

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环境脆弱区水资源有偿使用制度研究

财经问题研究 2005年第12期 30-34页

作者：徐雪梅东北财经大学公共管理学院辽宁大连116025

随着可持续发展理念的不断深入,经济学的方法被更多地应用在自然资源的使用上,以转变经济发展的道路。引入经济手段,体现生态资产的价值,并从制度上规范资源的管理,将是今后环境脆弱地区走上可持续发展道路的一个重要选择。本文基于对... 详细信息

随着可持续发展理念的不断深入,经济学的方法被更多地应用在自然资源的使用上,以转变经济发展的道路。引入经济手段,体现生态资产的价值,并从制度上规范资源的管理,将是今后环境脆弱地区走上可持续发展道路的一个重要选择。本文基于对我国环境脆弱区基本特征及水资源有偿使用的前提与基础的分析,提出了我国环境脆弱区水资源有偿使用的制度与措施。

关键词：水资源环境脆弱区资源有偿使用