Synthesis, Crystal Structure and Biological Activity of Dimethyl 1-Methyl-1,4-dihydroquinoline-3,4-dicarboxylate and Tetramethyl Pyrrolo-[1,2-a]quinoline-2,3,4,5-tetracarboxylate

作     者：XU Xue-Mei LUO Zai-Gang HAN Xin-Xin LIU Qian-Nan LI Rui XU Xue-Mei;LUO Zai-Gang;HAN Xin-Xin;LIU Qian-Nan;LI Rui

作者机构：College of Chemical EngineeringAnhui University of Science and TechnologyHuainan 232001China 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2020年第39卷第7期

页      面：1271-1276页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the Natural Science Research Projects in Colleges and Universities of Anhui Province(No.KJ2019A0116) Natural Science Foundation of Anhui Province(No.1608085MB38) 

主　　题：1,4-dihydroquinoline pyrrolo[1,2-a]quinoline synthesis crystal structure HIV-1 integrase 

摘      要：The target compounds 3(C14H15NO4)and 4(C20H17NO8)were synthesized and structurally determined by single-crystal X-ray *** crystal of 3 is in the monoclinic system,space group P21/c with a=7.3017(3),b=7.8737(5),c=22.4227(11)?,β=94.837(5)°,C14H15NO4,Mr=261.27,Dc=1.351 g/cm3,V=1284.51(11)?3,Z=4,F(000)=552,μ(MoKa)=0.828 mm–1,T=289.12(10)K,2236 independent reflections with 1827 observed ones(I2σ(I)),R=0.0515 and w R=0.1394 with GOF=1.044(R=0.0605 and w R=0.1548 for all data).The crystal of compound 4 is in the monoclinic system,space group P21/c with a=7.1269(3),b=12.6518(6),c=20.7540(8)?,β=96.941(4)°,C20H17NO8,Mr=399.35,Dc=1.428 g/cm3,V=1857.61(14)?3,Z=4,F(000)=832.0,μ(MoKa)=0.950 mm–1,T=288.81(10)K,3216 independent reflections with 2253 observed ones(I2σ(I)),R=0.0612 and wR=0.1548 with GOF=1.055(R=0.0824 and w R=0.1790 for all data).The skeleton of 1,4-dihydroquinoline 3 is noncoplanar,while pyrrolo[1,2-a]-quinoline 4 owns a coplanar frame ***-dimensional interaction model of compound 4 was formed by the one kind ofπ-πinteraction between the two adjacent molecules at upper and lower *** the inhibition to the strand transfer process of HIV-1 integrase of the title compounds was also evaluated.