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基于大数据应用的高职院校高水平专业群建设管理研究

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武汉职业技术学院学报 2024年第2期23卷 49-55页

作者：廖海生徐晓丽广东科学技术职业学院计算机学院广东珠海519090 广东科学技术职业学院旅游学院广东珠海519090

高水平专业群建设是一项复杂的系统性工程,是专业群内部与外部结构要素的深度融合。涉及专业领域众多、数据和资源繁杂,必须采用数字化管理,运用大数据思维构建专业群建设管理体系,以教师发展、学生成长为目标开展专业群的诊改,动态调... 详细信息

高水平专业群建设是一项复杂的系统性工程,是专业群内部与外部结构要素的深度融合。涉及专业领域众多、数据和资源繁杂,必须采用数字化管理,运用大数据思维构建专业群建设管理体系,以教师发展、学生成长为目标开展专业群的诊改,动态调整专业群组建和优化专业群资源配置,提升专业群建设管理水平和建设质量。

关键词：双高计划高水平专业群专业群管理专业群诊改

Unified Variable Selection for Varying Coefficient Models with Longitudinal Data

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Journal of Systems Science & Complexity 2023年第2期36卷 822-842页

作者： xu xiaoli ZHOU Yan ZHANG Kongsheng ZHAO Mingtao School of Management Science and Engineering Anhui University of Finance and Economics College of Mathematics and Statistics Institute of Statistical SciencesShenzhen Key Laboratory of Advanced Machine Learning and ApplicationsShenzhen University Institute of Statistics and Applied Mathematics Anhui University of Finance and Economics

Variable selection for varying coefficient models includes the separation of varying and constant effects,and the selection of variables with nonzero varying effects and those with nonzero constant *** paper proposes a unified variable selection approach called the double-penalized quadratic inference functions method for varying coefficient models of longitudinal *** proposed method can not only separate varying coefficients and constant coefficients,but also estimate and select the nonzero varying coefficients and nonzero constant *** is suitable for variable selection of linear models,varying coefficient models,and partial linear varying coefficient *** regularity conditions,the proposed method is consistent in both separation and selection of varying coefficients and constant *** obtained estimators of varying coefficients possess the optimal convergence rate of non-parametric function estimation,and the estimators of nonzero constant coefficients are consistent and asymptotically ***,the authors investigate the finite sample performance of the proposed method through simulation studies and a real data *** results show that the proposed method performs better than the existing competitor.

关键词： Double-penalized quadratic inference functions longitudinal data variable selection varying coefficient models

数智化时代高校思政课教师教学思维创新的意蕴与图景

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锦州医科大学学报（社会科学版） 2024年第3期22卷 1-5页

作者：匡宁徐晓莉安徽师范大学马克思主义学院安徽芜湖241000

党的二十大开启了以中国式现代化全面推进中华民族伟大复兴的新征程。要走好新时代新征程,全面建成社会主义现代化强国,需要强化现代化建设的人才支撑。高校思政课教师作为落实立德树人根本任务关键课程的重要责任人,必须立足于数智化... 详细信息

党的二十大开启了以中国式现代化全面推进中华民族伟大复兴的新征程。要走好新时代新征程,全面建成社会主义现代化强国,需要强化现代化建设的人才支撑。高校思政课教师作为落实立德树人根本任务关键课程的重要责任人,必须立足于数智化时代的特殊境遇,以培养担当中国式现代化建设时代重任、助力中华民族伟大复兴的时代新人为目标引领,创新教学思维,做到由“讲”到“问”、由“独”到“众”、由“予”到“取”。惟有以创新的教学思维为引领,才能顺应时势发展、契合学生需求,及时更新教学理念、革新教学内容、创新教学方法,继而提升教学实效,实现立德树人根本任务,完成为党育人、为国育才的重要使命。

关键词：数智化时代高校思政课教师教学思维创新

Fault diagnosis model based on multi-manifold learning and PSO-SVM for machinery

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仪器仪表学报 2014年第S2期35卷 210-214页

作者： Wang Hongjun xu xiaoli Rosen B G Key Laboratory of Modern Measurement & Control Technology Beijing Information Science & Technology University School of Mechanic and Electric Engineering Beijing Information Science&Technology University Halmstad University

Fault diagnosis technology plays an important role in the industries due to the emergency fault of a machine could bring the heavy lost for the people and the company. A fault diagnosis model based on multi-manifold learning and particle swarm optimization support vector machine(PSO-SVM) is studied. This fault diagnosis model is used for a rolling bearing experimental of three kinds faults. The results are verified that this model based on multi-manifold learning and PSO-SVM is good at the fault sensitive features acquisition with effective accuracy.

关键词： fault diagnosis multi-manifold learning particle swarm optimization support vector machine

上海市闵行区青少年青春期新媒体健康干预效果评估

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职业与健康 2024年第3期40卷 393-397,403页

作者：徐晓莉丁克颖上海市闵行区疾病预防控制中心综合防制办公室上海201101

目的针对上海市闵行区高年级小学生的青春期健康知识态度行为以及青春期健康信息获取情况开展调查,分析评价新媒体应用于青少年青春期健康干预的效果与满意度,完善干预策略。方法采取随机整群对照试验,于2021年9—12月采用新媒体对抽取... 详细信息

目的针对上海市闵行区高年级小学生的青春期健康知识态度行为以及青春期健康信息获取情况开展调查,分析评价新媒体应用于青少年青春期健康干预的效果与满意度,完善干预策略。方法采取随机整群对照试验,于2021年9—12月采用新媒体对抽取班级内的所有学生进行健康调查与干预。抽取闵行区4所小学的1354名小学高年级学生进行调查干预。结果本次研究共调查1354名闵行区青少年,收回有效问卷1314份,问卷有效率达到97.05%。通过新媒体进行青春期健康干预后,干预组健康知识总得分中位数(9分)明显高于对照组健康知识总得分(7分)(满分10分),差异有统计学意义(Z=-18.148,P<0.01),干预组的健康知识合格率(97.89%)显著高于对照组(74.00%)(χ^(2)=156.406,P<0.01);干预组各项正确态度和正确行为的比例均显著高于对照组(均P<0.01);获取途径排序前3位的依次为:网络媒体(64.00%)、亲子交流(59.89%)、医生专家(58.98%);2组调查对象在网络资源获取途径方面差异有统计学意义(χ^(2)=12.715,P<0.01);有86.60%的调查对象对于此次新媒体青春期健康干预表示满意,男女差异有统计学意义(χ^(2)=4.525,P<0.05)。结论新媒体应用于闵行区青少年青春期健康干预可行且有效,女性较男性青少年对此次新媒体青春期健康干预满意度更高。建议相关部门充分利用亲子交流和网络媒体相结合的方式,并从多方面为身处信息时代的青少年提供既科学实用又优质专业的健康传播知识,稳步提升青少年的健康水平。

关键词：新媒体青少年青春期健康干预

昆虫抗白僵菌免疫应答及其在害虫防治中的应用潜力

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浙江农业学报 2024年第4期36卷 825-836页

作者：杨蕾汪小福魏巍陈笑芸彭城徐晓丽徐俊锋浙江省农业科学院浙江省农产品质量安全危害因子与风险防控国家重点实验室农业农村部农业转基因生物溯源重点实验室浙江杭州310021

昆虫病原真菌白僵菌能成功侵染多种昆虫寄主并致其死亡,是农业生产中有效的生物杀虫剂。相应地,昆虫依赖多种策略抵御真菌感染,其中先天免疫防御是对抗真菌感染的重要手段。昆虫表皮是抵御真菌入侵的第一道屏障,表皮和外分泌腺可分泌多... 详细信息

昆虫病原真菌白僵菌能成功侵染多种昆虫寄主并致其死亡,是农业生产中有效的生物杀虫剂。相应地,昆虫依赖多种策略抵御真菌感染,其中先天免疫防御是对抗真菌感染的重要手段。昆虫表皮是抵御真菌入侵的第一道屏障,表皮和外分泌腺可分泌多种抑菌化合物降低真菌毒力,当真菌孢子进入血淋巴后,细胞免疫和体液免疫共同作用产生系统性免疫应答,表达的多种防御效应因子在细胞包囊、细胞凋亡、黑化反应中发挥功能。然而昆虫强烈的免疫反应影响田间施用白僵菌的效果,导致该真菌制剂应用的局限性。文章详细阐述昆虫感染白僵菌后的免疫应答机制,参与抗真菌免疫的基因与作用手段。该研究为了解昆虫抗真菌免疫机制提供了详实的基础,为合理改造白僵菌、有效提高白僵菌毒力水平提供坚实基础,为农业虫害治理提供新的策略。

关键词：虫生真菌表皮免疫免疫通路抗真菌免疫应答害虫防治

维普期刊数据库博看期刊

Subacute toxicity of exogenous manganese on rat hippocampal neurons Examination by MRI and optical microscopy

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Neural Regeneration Research 2008年第5期3卷 550-553页

作者： xiaoli xu Yun Xiang Min Yang School of Medicine ＆ Life Science Jianghan University Wuhan 430056 Hubei Province China

BACKGROUND： Manganism may cause learning and memory impairment by influencing the normal function of the hippocampus, however, this effect requires further examination. OBJECTIVE： To investigate the effects of manganism on the rat hippocampus using immunohistochemistry and MRI examination. DESIGN, TIME AND SETTING： A randomized controlled study, performed in the School of Medicine and Life Science, Jianghan University and the State Key Laboratory of Atomic ＆ Molecular Physics and Spectroscopy, Chinese Academy of Science, from July to September 2005. MATERIALS： Fourteen healthy SD rats aged two months were selected for this study. MnCl2 4H2O （BHD, UK）（batch number： 9791325）; glial fibrillary acidic protein （GFAP） staining kit （Beijing Zhongshan Biotechnology）; Biospec 4.7T/30 animal MRI formatter （Bruker, Germany）. METHODS： Fourteen rats were randomly divided into a control group （n =7） and a manganism group （n = 7）. Rats in the manganism group received intraperitoneal injection of MnCl2 · 4H2O （50 mg/kg）, once a day, for four successive days. Rats in the control group were injected according to the manganism regimen, but using saline instead of manganese solution. MAIN OUTCOME MEASURES： Twenty-four hours after the last injection, rats were examined using MRI. Immunohistochemically stained GFAP and hematoxylin-eosin stained hippocampal sections were observed under optical microscopy. RESULTS： Fourteen rats were included in the final analysis. After manganese treatment, T1 weighted image and inversion recovery MR1 demonstrated that the signal intensity was significantly enhanced in hippocampus, compared to controls. Neuronal necrosis was not observed in the hippocampus after HE staining. As compared to the control group, GFAP expression was markedly enhanced in the hippocampus of the manganism group. CONCLUSION： Within the rat brain, manganese preferentially localizes to the hippocampus and can induce astroctye activation.

关键词： manganism hippocampus rats MRI glial fibrillary acidic protein

Modulation of protein fate decision by small molecules:targeting molecular chaperone machinery

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1904-1925页

作者： Lei Wang xiaoli xu Zhengyu Jiang Qidong You State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization China Pharmaceutical UniversityNanjing 210009China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Modulation of protein fate decision and protein homeostasis plays a significant role in altering the protein level,which acts as an orientation to develop drugs with new *** molecular chaperones exert significant biological functions on modulation of protein fate decision and protein homeostasis under constantly changing environmental conditions through extensive protein-protein interactions(PPIs)with their client *** the help of molecular chaperone machinery the processes of protein folding,trafficking,quality control and degradation of client proteins could be arranged *** core members of molecular chaperones,including heat shock proteins(HSPs)family and their co-chaperones,are emerging as potential drug targets since they are involved in numerous disease *** of small molecule modulators targeting not only chaperones themselves but also the PPIs among chaperones,co-chaperones and clients is attracting more and more *** modulators are widely used as chemical tools to study chaperone networks as well as potential drug candidates for a broader set of ***,we reviewed the key checkpoints of molecular chaperone machinery HSPs as well as their co-chaperones to discuss the small molecules targeting on them for modulation of protein fate decision.

关键词： Molecular chaperone Heat shock protein family Small molecule inhibitors Protein fate Protein-protein interaction

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中国新质生产力指标构建与时空演进

工业技术经济 2024年第3期43卷 44-53页

作者：朱富显李瑞雪徐晓莉孙家昌新疆大学经济与管理学院乌鲁木齐830046 新疆大学计算机科学与技术学院乌鲁木齐830046

加快构建以新质生产力为核心的创新体系,是中国加快实现高水平科技自立自强和高质量发展的重要基础。本文从新质劳动者、新质劳动资料和新质劳动对象3个维度构建了新质生产力水平指标测度体系,采用投影寻踪模型测度了2011~2022年中国地... 详细信息

加快构建以新质生产力为核心的创新体系,是中国加快实现高水平科技自立自强和高质量发展的重要基础。本文从新质劳动者、新质劳动资料和新质劳动对象3个维度构建了新质生产力水平指标测度体系,采用投影寻踪模型测度了2011~2022年中国地级市层面新质生产力发展水平,并运用Dagum基尼系数法、Kernel密度估计法以及Moran's I全面探究并验证了新质生产力对不同时间维度、空间维度的动态演变特征。研究发现:新质生产力发展水平呈现稳步增长态势,相比于新质劳动者、新质劳动对象,新质劳动资料占新质生产力比重更大。各地区新质生产力发展水平存在较大差异,其中,东部地区是新质生产力发展的高地,西部地区和东北地区是新质生产力发展的洼地,并且地区内新质生产力水平也存在较大差异。同时,新质生产力的涌现与生产关系具有一定的协调性,且新质生产力能够正向促进地区的全要素生产率水平的提升。本文为如何捕捉新质生产力的动态演化特征以及生产关系如何更好的引导新质生产力能效发挥提供了参考。

关键词：新质生产力投影寻踪模型生产关系高质量发展地区异质性动态演化特征