检索结果-南通市图书馆

Induction of apoptosis and change of bcl-2 expression in macrophage Ana-1 cells by all-trans retinoic acid

Cell Research 1996年第2期6卷 137-144页

作者： YIN DE LING xiu hai ren SHI ZHONG BU YA LAN WU LI ZHEN JIANG ZHI JIANG WU WEI HU GANG PEI (Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China)(Correspondence: Dr. G. Pei, Shanghai Institute of Cell Biology Chine Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai China

Macrophage cells play an important role in the initiation and regulation of the immune response. All-trans retinoic acid (ATRA) and its natural and synthetic analogs (retinoids) affect a large number of biological *** , retinoids have been shown promise in the therapy and prevention of various cancers. However, many interesting questions related to the activities of retinoids remain to be answered: (Ⅰ) Molecular mechanisms by which retinoids exert their effects; (Ⅱ) why the clinical uses of retinoids give undesirable side effects of varying severity with a higher freqllency of blood system symptoms; (Ⅲ)little is known for its impacts on macrophage cells etc. We set up this experiment, therefore, to examine the apoptosis of ATRA on macrophage Ana-1 cell line. Apoptosis of the cells was quantitated, after staining cells with propidium iodide (PI), by both accounting nuclear condensation and flow cytometry. When the cells were treated with ATRA at or higher than 1 μM for more than 24 h, significant amount of the apoptotic cells was observed. Induction of apoptosis of Ana-1 cells by ATRA was in time- and dose-dependent manners, exhibiting the similar pattern as the apoptosis induced by actinomycin D (ACTD). ATRA treatment of Ana-1 cells also caused the changes of the mRNA levels of apoptosis-associated gene bcl-2, as detected by Northern blot analysis. The temporal changes of bcl-2 expression by ATRA was also parallel to that by ACTD. In conclusion,ATRA can induce apoptosis in macrophage cells, which may be helpful in understanding of immunological functions retinoids.

关键词： All-trans retinoic acid apoptosis Ana-1 cells bcl-2

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Global Probabilistic Voltage Sensitivity Analysis of Active Distribution Networks Based on the Compound Gaussian Mixture Model

引用

Dianwang Jishu/Power System Technology 2025年第1期49卷 295-305页

作者： Zhang, ren Wang, Jian Shang, Jie hai, Chen Liu, Haoming School of Electrical and Power Engineering Hohai University Jiangsu Province Nanjing 211100 China College of Artificial Intelligence and Automation Hohai University Jiangsu Province Nanjing 211100 China

The stochasticity of the high penetration of distributed generations (DGs) exacerbates the voltage fluctuation of the active distribution networks (ADNs) and complicates its voltage safety analysis. Therefore, this paper proposes a global probability voltage sensitivity analysis method based on the compound Gaussian mixture model (GMM). Firstly, a shared node path impedance-based global voltage sensitivity analytical model of ADN is derived to quantify the impact of global power fluctuations on node voltage. Considering that the voltage fluctuation has the non-Gaussian characteristic under the superposition influence of power uncertainty injected by multiple nodes, the GMM is used to characterize the probability characteristics of DG and load forecasting errors. Then, based on the affine transformation of the global sensitivity matrix to the GMM of DG and load forecasting error, the probability analytic expression of the voltage fluctuation is constructed, which is caused by the uncertainty of DG and load. Finally, based on the GMM characteristic function, the compound GMM characteristic function of the combined influence of the uncertainty of DG and load on voltage fluctuation is derived, and the global probabilistic voltage sensitivity analysis model based on the compound GMM is established. The case study results show that the proposed method can reflect the probability characteristics of the impact of all node power fluctuations on node voltage, and can quickly and accurately calculate the probability of over-voltage in ADNs. © 2025 Power System Technology Press. All rights reserved.

关键词： Affine transforms

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

强震区装配式和现浇地铁车站结构地震响应对比研究

引用

工程力学 2025年第1期42卷 164-173页

作者：江志伟杨秀仁李霞城市轨道交通绿色与安全建造技术国家工程研究中心北京100037 北京城建设计发展集团股份有限公司北京100037

以往的地下结构抗震研究大多是针对现浇结构开展的，而装配式结构由独立的预制构件拼装而成，从根本上区别于传统整体现浇结构，已有研究得到的认识对其适用性尚不明确，这极大地限制了装配式地下结构在强震区的推广与应用。该文以实际... 详细信息

以往的地下结构抗震研究大多是针对现浇结构开展的，而装配式结构由独立的预制构件拼装而成，从根本上区别于传统整体现浇结构，已有研究得到的认识对其适用性尚不明确，这极大地限制了装配式地下结构在强震区的推广与应用。该文以实际工程为背景，开展了全装配式和同型现浇车站结构的三维非线性有限元时程分析，对比了结构在八度区设防、罕遇和极罕遇地震下的变形、内力和损伤等响应。结果表明：装配式和现浇车站结构整体的地震变形差异不大，但柔性装配式车站结构榫槽节点可产生张开变形。设防和罕遇地震下，节点张开有利于结构减震，装配式车站结构的损伤小于现浇结构;而在极罕遇地震下，节点张开变大，榫槽、榫头和构件边缘的部分区域损伤集中，装配式和现浇结构地震响应产生了较大差异，但因应变幅值有限且损伤范围较小，此时全装配式与现浇车站结构整体的损伤程度基本相当。

关键词：装配式地铁车站结构地下结构抗震预制装配式地下结构装配式车站结构抗震结构地震损伤

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Effects of invigorating-spleen and anticancer prescription on extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in colon cancer mice model

引用

World Journal of Gastrointestinal Oncology 2024年第11期16卷 4468-4476页

作者： Wei Wang Jing Wang xiu-xiu ren hai-Long Yue Zheng Li Department of Integrated Traditional Chinese and Western Medicine Medical Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042Liaoning ProvinceChina The First Clinical School Liaoning University of Chinese MedicineShenyang 110847Liaoning ProvinceChina

BACKGROUND Colon cancer(CC)is one of the most common malignant tumors in the gastrointestinal ***,CC had the third highest incidence but the second highest mortality rate globally in ***,CC is mainly treated with capecitabine chemotherapy regimen,supplemented by radiotherapy,immunotherapy and targeted therapy,but there are still limitations,so Chinese medicine plays an important *** To investigate the effects of invigorating-spleen and anticancer prescription(ISAP)on body weight,tumor inhibition rate and expression levels of proteins in extracellular-signal-regulated kinase(ERK)/mitogen-activated protein kinase(MAPK)signaling pathway in CC mice *** The CC mice model were established and the mice were randomly divided into 5 groups,including the control group,capecitabine group,the low-dose,mediumdose and high-dose groups of ISAP,with 8 mice in each group,*** 2 weeks of intervention,the body weight and tumor inhibition rate of mice were observed,and the expression of RAS,ERK,phosphorylated ERK(p-ERK),C-MYC and matrix metalloproteinase 2(MMP2)proteins in the tissues of tumors were *** Compared with the control group,the differences of body weight before and after treatment was much smaller in the groups of ISAP,with the smallest difference in the high-dose group of ISAP,while the capecitabine group had the greatest difference,indicating ISAP had a significant inhibiting effect on the growth of transplanted tumor in *** expression of RAS protein was decreased in the low-and medium-dose groups of ISAP,and the change of p-ERK was significant in the medium-and high-dose groups of ***2 protein expression was significantly decreased in both the low-dose and medium-dose groups of *** were no significant changes in ERK in the ISAP group compared to the capecitabine group,while RAS,MMP2,and C-MYC protein expression were reduced in the ISAP *** expression level of C-MYC protein decreased afte

关键词： Colon cancer Invigorating-spleen and anticancer formula Extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway Mice model C-MYC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the consistency of two-phase local/nonlocal piezoelectric integral model

引用

Applied Mathematics and Mechanics(English Edition) 2021年第11期42卷 1581-1598页

作者： Yanming ren hai QING State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In this paper,we propose general strain-and stress-driven two-phase local/nonlocal piezoelectric integral models,which can distinguish the difference of nonlocal effects on the elastic and piezoelectric behaviors of *** nonlocal piezoelectric model is transformed from integral to an equivalent differential form with four constitutive boundary conditions due to the difficulty in solving intergro-differential equations *** nonlocal piezoelectric integral models are used to model the static bending of the Euler-Bernoulli piezoelectric beam on the assumption that the nonlocal elastic and piezoelectric parameters are coincident with each *** governing differential equations as well as constitutive and standard boundary conditions are *** is found that purely strain-and stress-driven nonlocal piezoelectric integral models are ill-posed,because the total number of differential orders for governing equations is less than that of boundary ***,the traditional nonlocal piezoelectric differential model would lead to inconsistent bending response for Euler-Bernoulli piezoelectric beam under different boundary and loading *** nominal variables are introduced to normalize the governing equations and boundary conditions,and the general differential quadrature method(GDQM)is used to obtain the numerical *** results from current models are validated against results in the *** is clearly established that a consistent softening and toughening effects can be obtained for static bending of the Euler-Bernoulli beam based on the general strain-and stress-driven local/nonlocal piezoelectric integral models,respectively.

关键词： nonlocal piezoelectric integral model softening effect toughening effect general differential quadrature method(GDQM)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

杉木目测等级规格材足尺抗弯强度的设计值研究

引用

西部林业科学 2017年第3期46卷 23-27页

作者：龚迎春武国芳王朝辉骆秀琴任海青中国林业科学研究院木材工业研究所北京100091

依据国标GB 50329-2002对杉木规格材进行足尺的抗弯测试,选取正态分布对测试数据进行拟合,利用K-S检验对正态分布进行拟合优度检验,参照极限状态设计法和ASTM D2915-2010标准计算杉木规格材设计值。结果表明,No.1等级规格材的抗弯强度最... 详细信息

依据国标GB 50329-2002对杉木规格材进行足尺的抗弯测试,选取正态分布对测试数据进行拟合,利用K-S检验对正态分布进行拟合优度检验,参照极限状态设计法和ASTM D2915-2010标准计算杉木规格材设计值。结果表明,No.1等级规格材的抗弯强度最小;SS、No.1和No.2等级规格材抗弯强度的测试数据均能与正态分布拟合;SS、No.1和No.2等级抗弯强度设计参考值分别为11.01MPa、9.36MPa和9.03MPa。

关键词：杉木规格材抗弯强度设计值

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bi-Hamiltonian Structure of a Third-Order Nonlinear Evolution Equation on Plane Curve Motions

引用

Communications in Theoretical Physics 2007年第2X期48卷 211-214页

作者： ren Wen-xiu Alatancang Department of Mathematics Inner Mongolia University Hohhot 010021 China Department of Mathematics Inner Mongolia University of Technology Hohhot 010051 China

In the present paper, we identify the integrability of the third-order nonlinear evolution equation ut = （1/2）（（uxz ＋ u）^-2）z in a Hamiltonian viewpoint. We prove that the recursion operator obtained by ***. Sakovich is hereditary, and then deduce a bi-Hamiltonian structure of the equation by using some decomposition of the hereditary operator. A hierarchy associated to the equation is also shown.

关键词： nonlinear evolution equation bi-Hamiltonian structure hereditary operator integrability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polyelectrolyte Complexes and Coacervates Formed by De novo-Designed Peptides and Oligonucleotide

引用

Chinese Journal of Polymer Science 2024年第9期42卷 1333-1340,I0007页

作者： Tian-Hao ren De-hai Liang Beijing National Laboratory for Molecular Sciences Department of Polymer Science and Engineering and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

The liquid-liquid phase separation of biopolymers in living cells contains multiple interactions and occurs in a dynamic *** the regulation mechanism is still a *** this work,we designed a series of peptides(XXLY)_(6)SSSGSS and studied their complexation and coacervation behavior with single-stranded ***“X”and“Y”are varied to combine known amounts of charged and non-charged amino acids,together with the introduction of secondary structures and pH *** show that the electrostatic interaction,which is described as charge density,controls both the strength of complexation and the degree of chain relaxation,and thus determines the growth and size of the *** hydrophobic interaction is prominent when the charges are ***,the secondary structures of peptides exhibit profound effect on the morphology of the phases,such as solid phase to liquid phase *** study gains insight into the phase separation under physiological *** is also helpful to create coacervates with desirable structures and functions.

关键词： Polyelectrolyte complex Coacervate Peptides Secondary structure Electrostatic interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Validation and Application of the Chinese Version of the *** Symptom Inventory in Breast Cancer Patients

引用

Current Medical Science 2022年第2期42卷 426-433页

作者： ren-wang CHEN Qiong WANG Ting HU Yu-xiu XIE hai-yan CHANG Jing CHENG Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective To validate and use the Chinese Version of the *** Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in *** A total of 342 breast cancer patients in China participated in this *** symptoms were investigated with the MDASI-C from November 2020 to February 2021,and the reliability and validity of this tool were evaluated,*** analysis and correlation analysis were also *** The Cronbach’s alpha coefficient values of the symptom and interference items were 0.827 and 0.880,*** validity revealed a four-factor *** Kaiser—Meyer—Olkin value was *** Karnofsky Performance Status,treatment phase,and cancer stage of the patients were grouped,and the differences of scores within the groups were *** addition,the employment status,education level,and age of the patients were significantly correlated with the *** correlation analysis of the education level of the patients showed that most of the symptoms and interference items were reduced as the education level was *** top three symptoms were disturbed sleep(3.10±2.52),difficulty remembering(2.54±2.30),and fatigue(2.24±2.13).The clinical and biochemical indicators such as body mass index and neutral granulocyte lymphocyte ratio had effects on many *** the patients’BMI increased,the patients’pain,disturbed sleep,and difficulty remembering were aggravated,and numbness was *** The MDASI-C is a reliable and effective assessment tool to evaluate patients with breast cancer in *** symptoms are related to many clinical and biochemical indicators.

关键词： M.D.Anderson Symptom Inventory breast cancer validation application quality of life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sampling adaptive block compressed sensing reconstruction algorithm for images based on edge detection

引用

The Journal of China Universities of Posts and Telecommunications 2013年第3期20卷 97-103页

作者： ZHENG hai-bo ZHU xiu-chang School of Telecommunication and Information Engineering Nanjing University of Posts and Telecommunications

In this paper, a sampling adaptive for block compressed sensing with smooth projected Landweber based on edge detection （SA-BCS-SPL-ED） image reconstruction algorithm is presented. This algorithm takes full advantage of the characteristics of the block compressed sensing, which assigns a sampling rate depending on its texture complexity of each block. The block complexity is measured by the variance of its texture gradient, big variance with high sampling rates and small variance with low sampling rates. Meanwhile, in order to avoid over-sampling and sub-sampling, we set up the maximum sampling rate and the minimum sampling rate for each block. Through iterative algorithm, the actual sampling rate of the whole image approximately equals to the set up value. In aspects of the directional transforms, discrete cosine transform （DCT）, dual-tree discrete wavelet transform （DDWT）, discrete wavelet transform （DWT） and Contourlet （CT） are used in experiments. Experimental results show that compared to block compressed sensing with smooth projected Landweber （BCS-SPL）, the proposed algorithm is much better with simple texture images and even complicated texture images at the same sampling rate. Besides, SA-BCS-SPL-ED-DDWT is quite good for the most of images while the SA-BCS-SPL-ED-CT is likely better only for more-complicated texture images.

关键词： block compressed sensing edge detection sampling-adaptive variance directional transforms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：