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传统聚落中的资源共享、治理模式及现代重构——以芋头侗寨为例

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城市规划 2024年第8期48卷 125-134页

作者：何婧周恺涂婳汤爽爽湖南大学建筑与规划学院中南林业科技大学湖南大学建筑与规划学院城乡规划系江西农业大学南京师范大学地理科学学院

为了追溯人类聚落中“共享”活动的源流,以湘西芋头侗寨为典型案例,对传统聚落中资源共享的治理模式进行解析。首先,从“经济互惠”“社群合作”和“空间营建”角度,相关文献指出共享活动是传统文化基因的重要组成部分;其次,芋头侗寨的... 详细信息

为了追溯人类聚落中“共享”活动的源流,以湘西芋头侗寨为典型案例,对传统聚落中资源共享的治理模式进行解析。首先,从“经济互惠”“社群合作”和“空间营建”角度,相关文献指出共享活动是传统文化基因的重要组成部分;其次,芋头侗寨的案例揭示了传统聚落中共享行为的动因机制、资源类型及相关制度的建立与维护;再次,传统社群中的共享必须依托有效的“共享制度”设计和供给,形成明确的“正负向激励机制”,才能成功构建并维系社群的“共享文化”。最后,原生共享文化可以通过嵌入式、搭接式和传承式现代重构,发掘传统聚落的地方治理和传承智慧,构建“共建共治共享”的现代乡村治理格局。

关键词：共享发展理念共享资源乡村治理社群文化侗寨

Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

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Genes & Diseases 2024年第3期11卷 368-384页

作者： Yulu Shi Quan Kang Hong zhou Xiaohan Yue Yang Bi Qing Luo Stem Cell Biology and Therapy Laboratory The Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Pediatric Surgery The Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Osteosarcoma is a differentiation-deficient disease,and despite the unique advan-tages and great potential of differentiation therapy,there are only a few known differentia-tion inducers,and little research has been done on their *** differentiation is associated with an increase in mitochondrial content and *** metabolism of some tu-mor cells is characterized by impaired oxidative phosphorylation,as well as up-regulation of aerobic glycolysis and pentose phosphate ***-containing zipper and EF-hand transmembrane protein 1(LETM1)is involved in the maintenance of mitochondrial morphology and is closely associated with tumorigenesis and progression,as well as cancer cell *** found that MG63 and 143B osteosarcoma cells overexpress LETM1 and exhibit abnormalities in mitochondrial structure and *** of LETM1 partially restored the mitochon-drial structure and function,inhibited the pentose phosphate pathway,promoted oxidative phosphorylation,and led to osteogenic *** also inhibited spheroid cell forma-tion,proliferation,migration,and invasion in an in vitro *** LETM1 was knocked down in vivo,there was reduced tumor formation and lung *** data suggest that mitochondria are aberrant in LETM1-overexpressing osteosarcoma cells,and knockdown of LETM1 partially restores the mitochondrial structure and function,inhibits the pentose phosphate pathway,promotes oxidative phosphorylation,and increases osteogenic differentiation,thereby reducing malignant biological behavior of the cells.

关键词： Cancer metabolism Differentiation LETM1 Osteosarcoma Stemness

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大别山板栗片热泵干燥特性及动力学模型分析

保鲜与加工 2024年第7期24卷 35-43页

作者：刘涛周舟王清涂剑秋孙闪闪信阳农林学院食品科学与工程学院河南信阳464000

为了研究大别山板栗片热泵干燥过程和特性,建立其干燥动力学模型,并优化干燥工艺以提高干燥后的品质,以大别山板栗为研究对象进行热泵干燥动力学研究,通过对7种常用干燥模型线性化处理,筛选适合用来描述板栗片热泵干燥特性的数学模型,... 详细信息

为了研究大别山板栗片热泵干燥过程和特性,建立其干燥动力学模型,并优化干燥工艺以提高干燥后的品质,以大别山板栗为研究对象进行热泵干燥动力学研究,通过对7种常用干燥模型线性化处理,筛选适合用来描述板栗片热泵干燥特性的数学模型,并利用试验数据与模型进行回归拟合,确定并建立最适合的数学模型。结果表明:Page模型的预测值曲线和实测值曲线高度吻合,Page模型可用来描述板栗片热泵干燥过程中水分的变化规律。研究结果可为板栗片实际生产中的热泵干燥加工提供一定参考。

关键词：板栗片热泵干燥干燥特性动力学模型有效水分扩散系数

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC(CTONG1804):a multicenter open-label phase II study

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Signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-Yang Liu Song Dong Xue-Ning Yang Ri-Qiang Liao Ben-Yuan Jiang Qun Wang Xiao-Song Ben Gui-Bin Qiao Jun-Tao Lin Hong-Hong Yan Li-Xu Yan Qiang Nie Hai-Yan tu Bin-Chao Wang Jin-Ji Yang Qing zhou Hong-Rui Li Ke Liu Wendy Wu Si-Yang Maggie Liu Wen-Zhao Zhong Yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTONG) GuangzhouChina Department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(N)and nivolumab–chemotherapy(N/C)combinations based on PD-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)NSCLC without EGFR/ALK *** received either mono-nivolumab(N)or nivolumab+nabpaclitaxel+carboplatin(N/C)for three cycles based on PD-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFS).Baseline PD-L1 expression and perioperative circulating tumor DNA(ctDNA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with PD-L1≥50%in N and N/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctDNA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFS rate was 64.8%(95%CI 51.9–81.0%).For patients with ctDNA–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression≥50%.ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(NCT04015778).

关键词： chemotherapy NSCLC treatment

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

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Protein & Cell 2024年第6期15卷 419-440页

作者： Wei Ma Lu Zhang Weilong Chen Zhaoxia Chang Juchuanli tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun Ding Siqin Li Fengkai Li Qiaodan Deng Yifei Yang Tingting Feng Fanrong Zhang Xiying Shao Xueyan He Lixing Zhang Guohong Hu Quentin Liu Yi-zhou Jiang Shu Zhu Zhi Xiao Dan Su Tong Liu Suling Liu Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesDepartment of OncologyKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Intelligent Pathology Institute and Department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230071China Department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’an 710032China Institute of Immunology CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Pathology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Surgery The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Medical Oncology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Shanghai Institute of Nutrition and Health University of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Department of Breast Surgery Xiangya HospitalChangsha 410008China Department of Breast Surgery Tumor Hospital of Harbin Medic

tumor-resident microbiota in breast cancer promotes cancer initiation and malignant ***,targeting microbiota to improve the effects of breast cancer therapy has not been investigated in ***,we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis(ETBF)was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant ***,albeit at low biomass,secreted the toxic protein BFT-1 to promote breast cancer cell stemness and *** studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 ***1 was highly expressed on ALDH+breast cancer stem cells(BCSCs)and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation,thereby activating the NOTCH1-HEY1 signaling pathway to increase ***1 inhibition and ETBF clearance increase the chemosensitivity of breast cancer by impairing BCSCs.

关键词： NOD1 breast chemotherapy

基于改进Yolov5模型的纱筒余纱量检测方法

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纺织学报 2024年第7期45卷 196-203页

作者：史伟民李洲陆伟健屠佳佳徐寅哲浙江理工大学浙江省现代纺织装备技术重点实验室浙江杭州310018 浙江机电职业技术学院自动化学院浙江杭州310053

为实现针织圆纬机纱架上纱筒余纱量的实时检测,提出一种深度学习与传统图像处理相结合的检测方法。通过优化Yolov5的主干网络并加入Shuffle-Attention注意力机制,利用改进后模型在图像中检测并框出纱筒位置;然后利用透视变换、均值偏移... 详细信息

为实现针织圆纬机纱架上纱筒余纱量的实时检测,提出一种深度学习与传统图像处理相结合的检测方法。通过优化Yolov5的主干网络并加入Shuffle-Attention注意力机制,利用改进后模型在图像中检测并框出纱筒位置;然后利用透视变换、均值偏移、canny轮廓检测、闭操作等处理获取纱筒内外圆轮廓,设计基于梯度下降的圆拟合算法,拟合纱筒内外圆的轮廓,得到纱筒的内外圆半径;最后结合小孔成像的原理完成纱筒余纱量的测量。结果表明:改进后的Yolov5模型在纱筒检测精度上达到99.5%,检测速度可达20帧/s,同时模型参数减少至3.255×106可检测的最小纱筒余纱量为3 mm,当纱筒余纱量小于3 mm后,将其视为空筒,进行延时更换。本文算法拟合圆所花费时间是传统霍夫圆检测算法的1/4左右,因此可满足针织车间的实际应用需求。

关键词：改进Yolov5模型透视变换均值偏移梯度下降法纱筒余纱量针织圆纬机

不同闷黄时间对平阳黄汤滋味成分和品质的影响

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中国食品学报 2024年第6期24卷 297-307页

作者：楼桢优周拥军钟维标项圣翔屠幼英何普明浙江大学农业与生物技术学院茶学系杭州310058 浙江子久文化股份有限公司浙江温州325400

为了解不同闷黄时间的平阳黄汤(一种黄茶)滋味成分和品质差异,通过感官评定、生化成分测定、化学计量学分析等研究闷黄时间对黄汤滋味品质及其主要成分的影响。结果表明:在一定闷黄时间范围内,平阳黄汤表现出不同的滋味特征,样品中的水... 详细信息

为了解不同闷黄时间的平阳黄汤(一种黄茶)滋味成分和品质差异,通过感官评定、生化成分测定、化学计量学分析等研究闷黄时间对黄汤滋味品质及其主要成分的影响。结果表明:在一定闷黄时间范围内,平阳黄汤表现出不同的滋味特征,样品中的水浸出物含量和游离氨基酸总量先增加后减少,水浸出物质量比例在闷黄24 h时最高,达到54.88%,其茶汤更为鲜爽、甘醇。总儿茶素、酯型儿茶素和咖啡碱的含量随着闷黄时间增加均呈下降的趋势,而非酯型儿茶素和没食子酸有所增加。同时,基于主成分分析显示,各生化成分之间具有一定相关性,其中表没食子儿茶素没食子酸酯、表没食子儿茶素等、没食子儿茶素等,咖啡碱和茶氨酸等对黄茶滋味具有较大贡献作用,表明闷黄过程中滋味品质的变化是各种相关的化学组分共同表达的结果。根据最小偏二乘法分析模型获得标志性差异化合物没食子儿茶素、咖啡碱、没食子酸、表儿茶素和天冬酰胺等,可作为一定闷黄时间下定向加工优质平阳黄汤的指标物质。

关键词：平阳黄汤闷黄时间滋味品质主成分分析

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正丙醇装置弛放气回收方法及工业应用

中国氯碱 2024年第4期 50-56页

作者：周强涂齐辉宁波巨化化工科技有限公司浙江宁波

介绍了几种正丙醇装置弛放气回收的方法及其特点。通过对这些方法的工艺技术条件、运行经济性及投资的比较,推荐了一种高效回收乙烯和乙烷的方法。

关键词：正丙醇装置弛放气深冷塔膜分离变压吸附尾气反应器

Granulomatosis with polyangiitis presented as multiple cutaneous abscesses after hysterectomy

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Chinese Medical Journal 2024年第6期137卷 755-756页

作者： Xiaoting Song Mengrui Li Yinggai Song Ping tu Hang Li Yang Wang Rong Xu Min Chen Xiaojuan Yu Suxia Wang Fude zhou Minghui Zhao Ruoyu Li Xiaoyu Jia Xiaowen Wang Department of Dermatology and Venereology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing 100034China National Clinical Research Center for Skin and Immune Diseases Beijing 100034China Renal Division Department of MedicinePeking University First HospitalBeijing 100034China Institute of Nephrology Peking UniversityBeijing 100034China Key Laboratory of Renal Disease Ministry of Health of ChinaBeijing 100034China Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China

To the Editor:A 62-year-old woman presented to the dermatology department with a 5-month history of multiple painless cutaneous abscesses and ulcers[Figure 1A],occurring 1 month after a transvaginal hysterectomy due to uterine *** general condition was good before and after the surgery,with no abnormal physical signs apart from *** reported no fever,night sweat,cough,or abdominal pain,but 10 kg *** has no history of diabetes,autoimmune diseases,or chronic infectious *** was no similar illness in her family.

关键词： hysterectomy pain surgery