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Elevated peripheral blood lymphocyteto-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma

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癌症 2015年第6期34卷 237-246页

作者： Rou Jiang Xiu-Yu Cai Zhong-Han Yang Yue Yan xiong Zou Ling Guo Rui Sun Dong-Hua Luo Qiu-Yan Chen Pei-Yu Huang Yan-Qun xiang Xing Lu Lin Wang wei-xiong xia Hai-Qiang Mai Ming-Yuan Chen Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine 4. Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center 5. Department of Cancer Prevention 6. Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Biochemistry Zhongshan School of MedicineSun Yat-sen University

Introduction:Patients with metastatic nasopharyngeal carcinoma(NPC)have variable survival *** have previously shown that an elevated peripheral blood lymphocyte-to-monocyte ratio(LMR)is associated with an increased metastatic risk in patients with primary *** present study aimed to investigate the prognostic value of pretreatment LMR in a large cohort of metastatic NPC ***:Clinical data of 672 patients with metastatic NPC diagnosed between January 2003 and December2009 were *** peripheral lymphocyte and monocyte counts were retrieved,and LMR was *** operating characteristic(ROC)curve analysis and univariate and multivariate COX proportional hazards analyses were performed to evaluate the association of LMR with overall survival(OS).Results:Univariate analysis revealed that an elevated absolute lymphocyte count(≥1.390×109/L)and LMR(≥2.475)as well as a decreased monocyte count(<0.665×109/L)were significantly associated with prolonged *** Cox proportional hazard analysis showed that LMR(hazard ratio[HR]=0.50,95%confidence interval[CI]=0.41–0.60,P<0.001),absolute lymphocyte count(HR=0.77,95%CI=0.64–0.93,P=0.007),and monocyte count(HR=1.98,95%CI=1.63–2.41,P<0.001)were independent prognostic *** stratification analyses,only LMR remained a significant predictor of ***:We identified pretreatment LMR as an independent prognostic factor for patients with metastatic *** validation of our findings is needed.

关键词： Metastatic nasopharyngeal carcinoma Lymphocyte count Monocyte count Lymphocyte-to-monocyte ratio Overall survival Prognosis

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Occipital lymph node metastasis from nasopharyngeal carcinoma:a special case report and literature review

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Chinese Journal of Cancer 2016年第4期35卷 196-203页

作者： Jing Yang wei-xiong xia Yan-Qun xiang Xing Lv Liang-Ru Ke Ya-Hui Yu xiang Guo Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center

Cervical lymph node metastasis is common in patients with nasopharyngeal carcinoma(NPC),but occipital lymph node metastasis in NPC patients has not yet been *** this case report,we describe an NPC patient with occipital lymph node *** clinical presentation,diagnostic procedure,treatment,and outcome of this case were presented,with a review of the related literature.

关键词： Nasopharyngeal carcinoma Occipital lymph node Lymphatic metastasis Chemoradiotherapy Intensitymodulated radiation therapy

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Favorable prognosis of female patients with nasopharyngeal carcinoma

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Chinese Journal of Cancer 2013年第5期32卷 283-288页

作者： Xing Lu Fei-Li Wang xiang Guo Lin Wang Hai-Bo Zhang wei-xiong xia Si-wei Li Ning-wei Li Chao-Nan Qian Yan-Qun xiang State Key Laboratory of Oncology in South China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center

The female sex is traditionally considered a favorable prognostic factor for nasopharyngeal carcinoma (NPC). However, no particular study has reported this phenomenon. To explore the prognostic impact of gender on patients with NPC after definitive radiotherapy, we reviewed the clinical data of 2,063 consecutive patients treated between 1st January 2000 and 31st December 2003 in the Sun Yat-sen University Cancer Center. The median follow-up for the whole series was 81 months. The female and male patients with early stage disease comprised 49.4% and 28.1% of the patient population, respectively. Both the 5-year overall survival (OS) and disease-specific survival (DSS) rates of female patients were significantly higher than those of male patients (OS: 79% vs. 69%, P < 0.001; DSS: 81% vs. 70%, P < 0.001). For patients with locoregionally advanced NPC, the 5-year OS and DSS rates of female vs. male patients were 74% vs. 63% (P < 0.001) and 76% vs. 64%, respectively (P < 0.001). A multivariate analysis showed that gender, age, and TNM stage were independent prognostic factors for the 5-year OS and DSS of NPC patients. The favorable prognosis of female patients is not only attributed to the early diagnosis and treatment but might also be attributed to some intrinsic factors of female patients.

关键词：鼻咽癌患者女性预后中山大学多因素分析 DSS 临床资料

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Effect of induction chemotherapy with cisplatin, fluorouracil, with or without taxane on locoregionally advanced nasopharyngeal carcinoma: a retrospective, propensity score-matched analysis

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Cancer Communications 2018年第1期38卷 237-246页

作者： Guo-Ying Liu Xing Lv Yi-Shan Wu Min-Jie Mao Yan-Fang Ye Ya-Hui Yu Hu Liang Jing Yang Liang-Ru Ke Wen-Ze Qiu Xin-Jun Huang Wang-Zhong Li xiang Guo Yan-Qun xiang wei-xiong xia State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat-Sen University Cancer CenterGuang-zhouGuangdongChina Department of Nasopharyngeal Carcinoma Sun Yat-Sen University Cancer CenterGuangzhouGuangdongChina Department of Clinical Laboratory Sun Yat-Sen University Cancer CenterGuangzhouChina The Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuang-zhouChina Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterShanghaiChina

Background:Available data in the literature comparing different induction chemotherapy(IC)regimens on locoregionally advanced nasopharyngeal carcinoma(NPC)are *** purpose of the present study was to evaluate the outcomes of locoregionally advanced NPC patients who were treated with taxane,cisplatin and 5-fluorouracil(TPF)or cisplatin and 5-fluorouracil(PF)as IC followed by concurrent chemoradiotherapy(CCRT).Methods:In total,1879 patients with locoregionally advanced NPC treated with IC and CCRT from a prospectively maintained database were included in the present observational *** compared overall survival(OS),disease-specific survival(DSS),distant metastasis-free survival(DMFS),and locoregional relapse-free survival,using the pro-pensity score ***:In total,1256 patients received TPF or PF as IC *** TPF group showed significantly better OS(hazard ratio[HR],0.660;95%confidence interval[CI]0.442-0.986;P=0.042),DSS(HR,0.624;95%CI 0.411-0.947;P=0.027)and DMFS(HR,0.589;95%CI 0.406-0.855;P=0.005)compared with the PF group in multivariable *** score matching identified 294 patients in each cohort and confirmed that TPF was associated with significantly improved 5-year OS(88.1%vs.80.7%;P=0.042),DSS(88.5%vs.80.7%;P=0.021)and DMFS(87.9%vs.78.6%;P=0.012)rates compared with the PF *** were no significant differences in locoregional relapse-free survival before or after ***:In our study,IC with the TPF regimen combined with CCRT showed improved long-term survival for the patients with locoregionally advanced NPC compared with the PF ***,a prospective randomized clinical trial to validate these findings is necessary.

关键词： Nasopharyngeal carcinoma Induction chemotherapy Propensity score-matching Taxane

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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： wei xiong Xuan Ye Hongzhang Cheng xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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A model to predict the risk of lethal nasopharyngeal necrosis after re-irradiation with intensity-modulated radiotherapy in nasopharyngeal carcinoma patients

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Chinese Journal of Cancer 2016年第11期35卷 617-624页

作者： Ya-Hui Yu wei-xiong xia Jun-Li Shi Wen-Juan Ma Yong Li Yan-Fang Ye Hu Liang Liang-Ru Ke Xing Lv Jing Yang Yan-Qun xiang xiang Guo State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer Center Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Department of Biodevices and Diagnostics Institute of Bioengineering and NanotechnologySingapore Department of Radiation Therapy 3rd Affiliated Hospital of Guangzhou Medical University Department of Pathology Sun Yat-sen University Cancer Center Department of Biostatistics and Epidemiology School of Public HealthSun Yat-sen University

Background:For patients with nasopharyngeal carcinoma(NPC) who undergo re-irradiation with intensity-modulated radiotherapy(IMRT),lethal nasopharyngeal necrosis(LNN) is a severe late adverse *** purpose of this study was to identify risk factors for LNN and develop a model to predict LNN after radical re-irradiation with IMRT in patients with recurrent ***:Patients who underwent radical re-irradiation with IMRT for locally recurrent NPC between March 2001 and December 2011 and who had no evidence of distant metastasis were included in this *** characteristics,including recurrent carcinoma conditions and dosimetric features,were evaluated as candidate risk factors for *** regression analysis was used to identify independent risk factors and construct the predictive scoring ***:Among 228 patients enrolled in this study,204 were at risk of developing LNN based on risk *** the 204 patients treated,31(15.2%) developed *** regression analysis showed that female sex(P = 0.008),necrosis before re-irradiation(P = 0.008),accumulated total prescription dose to the gross tumor volume(GTV) ≥ 145.5 Gy(P = 0.043),and recurrent tumor volume >25.38 cm3(P = 0.009) were independent risk factors for LNN.A model to predict LNN was then constructed that included these four independent risk ***:A model that includes sex,necrosis before re-irradiation,accumulated total prescription dose to GTV,and recurrent tumor volume can effectively predict the risk of developing LNN in NPC patients who undergo radical re-irradiation with IMRT.

关键词： Nasopharyngeal carcinoma Re-irradiation Intensity-modulated radiotherapy Necrosis

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北碚区气溶胶光学厚度特征及其与颗粒物浓度的相关性

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环境科学 2020年第3期41卷 1067-1077页

作者：曾唯郝庆菊赵仲婧熊维霞陈俊江辛金元江长胜西南大学西南山地生态循环农业国家级培育基地重庆400715 西南大学资源环境学院重庆400715 中国科学院大气物理研究所大气边界层物理和大气化学国家重点实验室北京100029

为了解重庆市北碚区大气质量状况,利用其2014年气溶胶光学厚度和颗粒物质量浓度的同步观测结果进行分析.结果表明,北碚区AOD500 nm的年均值为1.46±0.69,其随月份变化明显,其中11月最高为2.90±1.85, 9月最低为0.54±0.05.北碚区存在颗... 详细信息

为了解重庆市北碚区大气质量状况,利用其2014年气溶胶光学厚度和颗粒物质量浓度的同步观测结果进行分析.结果表明,北碚区AOD500 nm的年均值为1.46±0.69,其随月份变化明显,其中11月最高为2.90±1.85, 9月最低为0.54±0.05.北碚区存在颗粒物污染的现象,PM2.5和PM10的年均值分别为(62±40)μg·m^-3和(94±51)μg·m^-3,均超出GB 3095-2012《环境空气质量标准》二级标准限值,PM2.5与PM10的日均值超标率分别为26%和15%.细粒子PM2.5与可吸入颗粒物PM10浓度之间呈现显著性相关,全年决定系数R^2能够达到0.95(P<0.01),AOD与PM2.5、 PM10之间全年均呈正相关特性,全年决定系数R^2分别为0.48和0.46,且不同季节下的决定系数和相关函数均有差异,其中冬季相关性最好,夏季相关性最差.全年AOD与AQI呈正相关特性,决定系数R2为0.15(P<0.05).AOD值受天气要素综合作用的影响,观测期间也应将温度、湿度、水汽等要素数据进行同步采集.

关键词：北碚区气溶胶光学厚度(AOD) 颗粒物浓度空气质量指数(AQI) 气象要素

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铁碳微电解及沸石组合人工湿地的废水处理效果

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环境科学 2021年第6期42卷 2875-2884页

作者：赵仲婧郝庆菊张尧钰熊维霞曾唯陈俊江江长胜西南大学资源环境学院西南山地生态循环农业国家级培育基地重庆400716 三峡库区生态环境教育部重点实验室重庆400715

铁碳微电解填料和沸石由于对废水中污染物具有良好的处理效果,因而被作为基质逐渐运用于人工湿地中.本研究构建了铁碳微电解填料+砾石(湿地A)、铁碳微电解填料+沸石(湿地B)、沸石(湿地C)以及砾石(湿地D)为基质的4组人工湿地,并利用间歇... 详细信息

铁碳微电解填料和沸石由于对废水中污染物具有良好的处理效果,因而被作为基质逐渐运用于人工湿地中.本研究构建了铁碳微电解填料+砾石(湿地A)、铁碳微电解填料+沸石(湿地B)、沸石(湿地C)以及砾石(湿地D)为基质的4组人工湿地,并利用间歇曝气对湿地系统进行增氧,探究不同填料对人工湿地废水处理效果的影响.结果表明,与湿地D相比,铁碳微电解填料显著提高了湿地出水的溶解氧含量(DO)(P0.05);对TN而言,湿地A、B和C的平均去除率分别比湿地D提高了7.94%(P<0.05)、9.29%(P<0.05)和3.63%(P<0.05),铁碳微电解填料和沸石对提升人工湿地TN去除效果的贡献率分别为73.55%和26.45%;各组湿地对NH_(4)^(+)的平均去除率为67.93%~76.90%,与湿地D相比,其它3组湿地均明显改善了NH_(4)^(+)的去除效果(P<0.05);铁碳微电解填料对湿地NO_(3)^(-)的去除效果极佳,去除率高达99%以上,显著高于不添加铁碳微电解的人工湿地系统(P<0.05).综合对碳氮污染物的处理效果来看,湿地B在间歇曝气的条件下对人工湿地中污染物去除效率最高.

关键词：铁碳微电解沸石潜流人工湿地间歇曝气废水处理

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Adaptive-basis decomposition-based low-rank network for efficient non-uniform motion deblurring

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Optoelectronics Letters 2025年第1期21卷 43-50页

作者： CHEN Lei xiong Qingbo ZHANG wei LI Runde School of Software Henan University School of Applied Technology China University of Labor Relations

In this study, we present a unified sparsity-driven framework that significantly enhances motion deblurring performance by integrating two key components: a custom-designed dataset and a low-rank module(LRM). This framework leverages the inherent sparsity of per-pixel blur kernels to bolster both deblurring accuracy and model interpretability. Firstly, we propose an adaptive-basis decomposition-based deblurring(ADD) approach, which constructs a tailored training dataset to enhance the generalization capacity of the deblurring network. The ADD framework adaptively decomposes motion blur into sparse basis elements, effectively addressing the intricacies associated with non-uniform blurs. Secondly, an LRM is proposed to improve the interpretability of deblurring models as a plug-and-play module, primarily designed to identify and harness the intrinsic sparse features in sharp images. A series of ablation studies have been conducted to substantiate the synergistic advantages of combining the proposed ADD with the LRM for overall improvement in deblurring efficacy. Subsequently, we empirically demonstrate through rigorous experimentation that incorporating the LRM into an existing Uformer network leads to substantial enhancement in reconstruction performance. This integration yields a sparsity-guided low-rank network(SGLRN). Operating under the overarching principle of sparsity, SGLRN consistently outperforms state-of-the-art methods across multiple standard deblurring benchmarks. Comprehensive experimental results, assessed through quantitative metrics and qualitative visual evaluations, provide compelling evidence of its effectiveness. The overall deblurring results are available at Google Drive.

关键词： Image enhancement

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Oral JS-38,a metabolite from Xenorhabdus sp.,has both anti-tumor activity and the ability to elevate peripheral neutrophils

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Chinese Journal of Natural Medicines 2014年第10期12卷 768-776页

作者： LIU Min-Yu xiaO Lin CHEN Geng-Hui WANG Yong-xiang xiong wei-xia LI Fei LIU Ying HUANG xiao-Ling DENG Yi-Fang ZHANG Zhen SUN Hai-Yan LIU Quan-Hai YIN Ming School of Pharmacy Shanghai Jiao Tong University Department of Pharmacology Shanghai Institute of Pharmaceutical Industry Beijing Wenfeng Tianji Pharmaceuticals Ltd.

AIM: JS-38(mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell(WBC) elevating activities. METHOD: These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY human hepatoma in nude mice. The anti-tumor interactions of JS-38 and cyclophosphamide(CTX) or 5-fluorouracil(5-Fu) were studied in a S180 sarcoma model in ICR mice. Specific stimulatory effects were determined on peripheral neutrophils in normal and CTX- and 5-Fu-induced neutropenic mice. RESULTS: The IC50 values ranged from 0.1 to 2.0 μmol·L-1. JS-38(1 μmol·L-1) caused an increase in A549 tumor cell apoptosis. Multi-daily gavage of JS-38(15, 30, and 60 mg?kg-1?d-1) inhibited in vivo tumor progression without a significant effect on body weight. JS-38 additively enhanced the in vivo anti-tumor effects of CTX or 5-Fu. JS-38 increased peripheral neutrophil counts and neutrophil rates in normal BALB/c mice almost as effectively as granulocyte colony-stimulating factor(G-CSF). In mice with neutropenia induced by CTX or 5-Fu, JS-38 rapidly restored neutrophil counts. CONCLUSION: These results suggest that JS-38 has anti-tumor activity, and also has the ability to increase peripheral blood neutrophils.

关键词： JS-38 (mitothiolore) Xenorhabdus sp. Anti-tumor activity Neutrophils Apoptosis

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