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Drug resistance and new therapies in colorectal cancer

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World Journal of Gastroenterology 2018年第34期24卷 3834-3848页

作者： Kevin Van der Jeught Han-Chen Xu Yu-Jing Li xiong-bin Lu Guang Ji Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese Medicine Department of Medical and Molecular Genetics Indiana University School of Medicine Indiana University Melvin and Bren Simon Cancer Center Indiana University School of Medicine

Colorectal cancer(CRC) is often diagnosed at an advanced stage when tumor cell dissemination has taken place. Chemo-and targeted therapies provide only a limited increase of overall survival for these patients. The major reason for clinical outcome finds its origin in therapy resistance. Escape mechanisms to both chemo-and targeted therapy remain the main culprits. Here, we evaluate major resistant mechanisms and elaborate on potential new therapies. Amongst promising therapies is α-amanitin antibodydrug conjugate targeting hemizygous p53 loss. It becomes clear that a dynamic interaction with the tumor microenvironment exists and that this dictates therapeutic outcome. In addition, CRC displays a limited response to checkpoint inhibitors, as only a minority of patients with microsatellite instable high tumors is susceptible. In this review, we highlight new developments with clinical potentials to augment responses to checkpoint inhibitors.

关键词： Colorectal cancer Therapy resistance Antibody-drug conjugates α-amanitin Tumor microenvironment Immunotherapy Checkpoint inhibitors Microbiome

Laparoscopy-assisted gastrectomy for advanced gastric cancer patients with situs inversus totalis: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2023年第9期15卷 2063-2073页

作者： Hong-Bo Liu Xiao-Peng Cai Zhao Lu bin xiong Chun-Wei Peng Department of Gastrointestinal Surgery Hubei Key Laboratory of Tumor Biological Behaviors&Hubei Cancer Clinical Study CenterWuhan Peritoneal Cancer Clinical Medical CenterZhongnan Hospital of Wuhan UniversityWuhan 430070Hubei ProvinceChina School of Nursing Wuhan UniversityWuhan 430070Hubei ProvinceChina

BACKGROUND Situs inversus totalis(SIT)is a rare condition in which the positions of abdominal and thoracic organs present a“mirror image”of the normal ones in the median sagittal *** minimally invasive surgery has evolved to achieve laparoscopic gastrectomy for gastric cancer(GC)patients with SIT,it is difficult to perform lymphadenectomy(LND)in such a transposed anatomical ***,we report the cases of two patients with SIT who successfully underwent laparoscopy-assisted gastrectomy(LAG)with D2 *** SUMMARY Case 1:A 65-year-old man was admitted for intermittent abdominal pain and distension,occasional belching,and acid reflux for 4 *** was diagnosed with GC(cT3N1-2M0)with *** surgery,he had undergone four cycles of neoadjuvant chemotherapy and ***,the patient was evaluated as having a partial response,and laparoscopy-assisted distal gastrectomy with D2 LND and Billroth II reconstruction were *** operation was performed successfully within 240 min with an estimated blood loss of 50 mL and no severe *** patient was discharged on postoperative day(POD)*** 2:A 55-year-old man was admitted for upper abdominal distension with pain and discomfort after eating for 3 *** was diagnosed with GC(cT3N1M0)with *** had a history of hypertension for more than 10 years;however,his blood pressure was well-controlled via regular *** performed laparoscopy-assisted total gastrectomy with D2 LND and Roux-en-Y *** operation was performed successfully within 168 min with an estimated blood loss of 50 mL and no severe *** patient was discharged on POD *** LAG with D2 LND could be considered an accessible,safe,and curative procedure for advanced GC patients with SIT.

关键词： Situs inversus totalis Laparoscopy-assisted gastrectomy Advanced gastric cancer Surgery modality Lymphadenectomy Case report

Molecular targeted therapy causes hepatic encephalopathy in patients after Transjugular intrahepatic portosystemic shunt(TIPS):A case report and literature review

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Journal of Interventional Medicine 2022年第1期5卷 37-39页

作者： Chen Zhou Yang Chen Jiacheng Liu Qin Shi bin xiong Department of Radiology Union HospitalTongji Medical CollegeWuhan430022HubeiChina Huazhong University of Science and Technology Hubei Province Key Laboratory of Molecular ImagingWuhan430022HubeiChina

We report two cases of hepatic encephalopathy caused by molecular targeted drugs after the Transjugular intrahepatic portosystemic shunt(TIPS)procedure in our *** liver toxicities and anti-angiogenic effects induced by targeted drugs may generate an imbalance in ammonia metabolism,elevating blood ammonia *** diverts partial blood supply from the liver,aggravates liver impairment,and shunts ammonia-rich blood from the intestine into the systemic *** may be the mechanisms leading to hepatic encephalopathy caused by molecular targeted drugs following *** clinicians choose molecular targeted therapy as the second or third targeted therapy for patients who have undergone TIPS,the consequence of drug-induced hepatic encephalopathy should also be considered.

关键词： Transjugular intrahepatic portosystemic shunt(TIPS) Hepatic encephalopathy Molecular targeted therapy Case report

A Study of Agricultural Tridimension Pollution and Discussion on Its Control

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Agricultural Sciences in China 2005年第3期4卷 214-223页

作者： ZHANGLi-jian CAIDian-xiong WANGXiao-bin ZHANGJian-jun JINKe ChineseAcademyofAgriculturalSciences Beijing100081P.R.China

The paper outlines the background of the research on control of agriculture tridimensional pollution and its *** new concept of agricultural tridimension pollution (ATriP) with its control theory is initially proposed as a result ofcontinuously increased agricultural pollution within the systems of hydrosphere, pedosphere, biosphere and atmospheredue to improper use of agricultural management measures. Furthermore, the high priority of the next 5-10 years nationalresearch domains and areas, and techniques for strengthening of ATriP prevention and control is discussed.

关键词： Agricultural tridimension pollution (ATriP) Pollution-filtering technology Pollution governance Synthetic study

Effect of Strain Rate on Compression Behavior of Vinyl Ester Resin Casting

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材料工程 2006年第5期34卷 63-67,72页

作者： xiong Tao YANG bin xiong Jie XU Xian-jian ZHOU Kai MAO Ming-zhong Key Laboratory of Advanced Textile Materialsand Manufacturing Technology Ministry of EducationZhejiang Sci-Tech University Hangzhou 310018 China

Quasi-static and high strain rate compressive experiments on vinyl ester casting were carried out by means of MTS (Material Test System) and Hopkinson bar. The behaviors of the compressed unstable and fracture of the resin casting at different strain rates were *** results indicate that the response behavior of the resin casting is controlled by different mechanisms at different strain rate, and some mechanical properties of vinyl ester casting are rate-dependent: the casting are destroyed in toughness model under strain rate 3.3×10 -4～6.6×10 -3/s, while the casting are destroyed in brittleness model under strain rate 950～5800/s. The yield stress, yield strain energy density are all increased with the increasing strain rates at quasi-static as well as at high strain rates. What is interesting is that the yield strain decreased with the strain rates increasing at quasi-static while increased at high strain rates. It is considered that the casting occurred forcing high elastic deformation at high strain rates. The damage of the specimens is mainly controlled by axial stress before unstable deformation, while mainly controlled by shear stress after unstable deformation, and then developed to fracture finally. This progress is rate-dependent: the development of the cracks inside the castings increased with the strain rate increasing.

关键词： vinyl ester resin quasi-static high strain rate strain rate response and crack development

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基于基流退水过程的非一致性枯水频率分析

水利学报 2016年第7期47卷 873-883页

作者：熊斌熊立华武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072

枯水流量频率研究在水资源管理中具有重要作用。在气候变化和人类活动的影响下,水文极值序列的频率分布随时间变化。近年来,非一致性水文系列频率分析作为一项新课题逐渐被水文学者重视和研究。非一致性序列的频率计算方法主要集中于洪... 详细信息

枯水流量频率研究在水资源管理中具有重要作用。在气候变化和人类活动的影响下,水文极值序列的频率分布随时间变化。近年来,非一致性水文系列频率分析作为一项新课题逐渐被水文学者重视和研究。非一致性序列的频率计算方法主要集中于洪水和年径流,而对枯水频率研究不足。本文探讨了流域基流退水和降雨特征对河道枯水流量的重要影响,并通过结合基流退水分析和广义回归模型,研究了基于基流退水过程的非一致性枯水频率分析方法。以渭河为实例,结果表明:以流域退水参数和降雨参数为协变量的非一致性模型更好地描述了渭河华县站枯水流量分布特征的变化;渭河华县站枯水流量总体呈减少趋势,主要原因是基流退水速率加快、日平均降雨深减少以及降雨事件平均时间间隔增加。研究成果对变化环境下水资源供水设计管理、河流生态系统保护以及旱灾风险管理等问题具有实践意义。

关键词：枯水频率分析非一致性退水分析渭河流域

Tissue array for Tp53,C-myc,CCND1 gene over-expression in different tumors

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World Journal of Gastroenterology 2008年第47期14卷 7199-7207页

作者： Guo-Yan Liu Qi Luo bin xiong Chao Pan Ping Yin Hong-Feng Liao Wei-Chun Zhuang Hong-Zhi Gao Zhongnan Hospital Wuhan UniversityWuhan 430071 China The General Surgery of the AffiliatedZhongshan Hospital of Xiamen University The Digest DiseaseResearch Institution of Xiamen University Xiamen 361004Fujian Province China Department of GeneralHong-Feng Liao Wei-ChunSurgery Affiliated ZhongshanHospital of Xiamen University Digest Disease ResearchInstitute of Xiamen University Xiamen 361004 FujianProvince. China Zhongnan Hospital Wuhan University Wuhan430071 Hubei Proyince China The Second Affiliated Hospital of FujianMedical University Fujian Province China

AIM:To rapidly detect molecular alterations in different malignancies and investigate the possible role of Tp53,C-myc,and CCND1 genes in development of tumors in human organs and their adjacent normal tissues,as well as the possible relation between well-and poorly-differentiated ***:A tissue array consisting of seven different tumors was *** tissue array included 120 points of esophagus,120 points of stomach,80 points of rectum,60 points of thyroid gland,100 points of mammary gland,80 points of liver,and 80 points of *** of Tp53,C-myc,and CCND1 were determined by RNA in situ hybridization.3' terminal digoxin-labeled anti-sense single stranded oligonucleotide and locked nucleic acid modifying probe were ***:The expression level of Tp53 gene was higher in six different carcinoma tissue samples than in paracancerous tissue samples with the exception in colon carcinoma tissue samples(P < 0.05).The expression level of CCND1 gene was significantly different in different carcinoma tissue samples with the exception in esophagus and colon carcinoma tissue *** expression level of C-myc gene was different in esophagus carcinoma tissue samples(c2 = 18.495,P = 0.000),stomach carcinoma tissue samples(c2 = 23.750,P = 0.000),and thyroid gland tissue samples(c2 = 10.999,P = 0.004).The intensity of signals was also different in different carcinoma tissue samples and paracancerous tissue ***:Over-expression of the Tp53,CCND1,and C-myc genes appears to play a role in development of human cancer by regulating the expression of ***53,CCND1 and C-myc genes are significantly correlated with the development of different carcinomas.

关键词： Tp53 C-myc CCND1 Tissue microarray RNA in situ hybridization

Effect of South Korean Pop Culture on the Potential Tourists from Chinese Mainland

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Chinese Business Review 2007年第2期6卷 20-25,32页

作者： xiong Yuan-bin LI Sheng School of Economics and Management Wuhan University Wuhan 430072 China

Following along with South Korean Pop culture sweeping across Chinese Mainland, Chinese market of South Korea tour is developing rapidly. An analysis demonstrates that the movie and television industry of South Korea is one of the most essential factors to attract the potential tourist from China. South Korean Pop culture is directly affecting rather the image of South Korean as a tourist destination than tourists＇ purchasing. And the paper suggests a set of ＂4S＂ strategy for South Korean to combine the elements of South Korean movies with those of tourism, so as to create an industrial development pattern characterized as ＂movies ＋ tourism＂.

关键词： South Korean Pop culture tourism effect

Effectiveness of adjunctive corticosteroid therapy in patients with severe COVID-19:A retrospective cohort study

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World Journal of Clinical Cases 2021年第15期9卷 3546-3558页

作者： bin xiong Li-Min He Yuan-Yuan Qin Hu Du Zhu Zhan Yi-Hong Zhou Yao-Kai Chen An Zhang Department of Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Cardiology The First Branch of The First Affiliated HospitalChongqing Medical UniversityChongqing 400015China Division of Infectious Diseases Chongqing Public Health Medical CenterChongqing 400036China

BACKGROUND The effectiveness of adjunctive corticosteroid use in patients with coronavirus disease 2019(COVID-19)remains *** To investigate the effectiveness of adjunctive corticosteroid therapy in patients with severe *** We conducted a retrospective analysis of the difference in several outcomes between patients with severe COVID-19 who received corticosteroid therapy(the corticosteroid group)and patients with severe COVID-19 who did not receive corticosteroid therapy(the non-corticosteroid group).RESULTS Seventy-five patients were included in this *** these,47 patients were in the corticosteroid group and 28 patients were in the non-corticosteroid *** were no differences between the two groups in the total length of hospital stay,the length of intensive care unit stay,high-flow oxygen days,non-invasive ventilator days,invasive ventilation days,and mortality *** lesion volume ratio,consolidation volume ratio and ground-glass opacity volume ratio in the corticosteroid group decreased significantly on day 14,while those in the noncorticosteroid group did not show a significant *** Our results show that adjunctive corticosteroid use did not significantly improveclinical outcomes in severe COVID-19 patients,but might promote the absorptionof pulmonary *** multicenter randomized controlled studies may beneeded to confirm this.

关键词： COVID-19 Corticosteroid SARS-CoV-2 Outcomes