Effectiveness of adjunctive corticosteroid therapy in patients with severe COVID-19:A retrospective cohort study

作     者：Bin Xiong Li-Min He Yuan-Yuan Qin Hu Du Zhu Zhan Yi-Hong Zhou Yao-Kai Chen An Zhang 

作者机构：Department of Critical Care MedicineThe Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of CardiologyThe First Branch of The First Affiliated HospitalChongqing Medical UniversityChongqing 400015China Division of Infectious DiseasesChongqing Public Health Medical CenterChongqing 400036China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第15期

页      面：3546-3558页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Chongqing Health Commission  (2020NCPZX04) 

主　　题：COVID-19 Corticosteroid SARS-CoV-2 Outcomes 

摘      要：BACKGROUND The effectiveness of adjunctive corticosteroid use in patients with coronavirus disease 2019(COVID-19)remains *** To investigate the effectiveness of adjunctive corticosteroid therapy in patients with severe *** We conducted a retrospective analysis of the difference in several outcomes between patients with severe COVID-19 who received corticosteroid therapy(the corticosteroid group)and patients with severe COVID-19 who did not receive corticosteroid therapy(the non-corticosteroid group).RESULTS Seventy-five patients were included in this *** these,47 patients were in the corticosteroid group and 28 patients were in the non-corticosteroid *** were no differences between the two groups in the total length of hospital stay,the length of intensive care unit stay,high-flow oxygen days,non-invasive ventilator days,invasive ventilation days,and mortality *** lesion volume ratio,consolidation volume ratio and ground-glass opacity volume ratio in the corticosteroid group decreased significantly on day 14,while those in the noncorticosteroid group did not show a significant *** Our results show that adjunctive corticosteroid use did not significantly improveclinical outcomes in severe COVID-19 patients,but might promote the absorptionof pulmonary *** multicenter randomized controlled studies may beneeded to confirm this.