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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong Dong Ziwei fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

基于建构主义的“信息素养与检索实践”课程思政元素挖掘与实践

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大学图书情报学刊 2025年第1期43卷 79-85页

作者：袁帆李佳上海第二工业大学图书馆 201209 华东师范大学课程与教学研究所上海200062

文章基于建构主义理论探讨在“信息素养与检索实践”课程中如何融入思政元素,以期提升新时代高校学生信息素养及思想政治素养。通过案例教学与项目教学法挖掘课程思政元素,以能力和知识目标为抓手,构建思政元素融入信息素养教育的研究... 详细信息

文章基于建构主义理论探讨在“信息素养与检索实践”课程中如何融入思政元素,以期提升新时代高校学生信息素养及思想政治素养。通过案例教学与项目教学法挖掘课程思政元素,以能力和知识目标为抓手,构建思政元素融入信息素养教育的研究体系。研究表明,政治认同、家国情怀、科学精神及信息道德是培育课程思政的关键要素,是促进高校信息素养教学质量发展的核心指标。建立以创设问题情境、引导自主探究为主的课程思政实践机制,有助于增强独立思考与批判分析能力,提升学生的信息处理能力。研究为高校图书馆信息素养教育实现立德树人目标提供了教学策略和研究启示。

关键词：信息素养文献检索课程思政建构主义

Multifunctional core/satellite polydopamine@Nd^3＋- sensitized upconversion nanocomposite： A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

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Nano Research 2017年第10期10卷 3434-3446页

作者： xing Ding Jianhua liu Dapeng liu Junqi li fan Wang Leijiao li Yinghui Wang Shuyan Song Hongjie Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry (CIAC) Chinese Academy of Sciences (CAS) Changchun 130022 China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 China Department of Radiology the Second Hospital of Jilin University Changchun 130041 China

Significant attenuation and overheating, caused by the absorption of the excitation band （980 nm） in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles （UCNPs）. Therefore, appropriately- structured Nd3^＋-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core-shell-shell structured Nd3^＋-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine （PDA） to construct a novel multifunctional core/satellite nanotheranostic （PDA@UCNPs） for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core-shell-shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bio- application-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.

关键词： Nd^3+-sensitized upconversion nanopartides dual-modality imaging photothermal therapy multifunctional theranostic platform biocompatibility

Experimental study on rehydration conditions of freeze-dried platelets

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第5期10卷 697-703页

作者： Ju-li fan Xian-guo XU Shao-zhi ZHANG Fa-ming ZHU Guang-ming CHEN li-xing YAN Institute of Refrigeration and Cryogenics Zhejiang Universit Hangzhou 310027 China Key Laboratory of Blood Safety Research Ministry of Health Blood Center of Zhejiang Province Hangzhou 310006 China

A rehydration process for freeze-dried human platelets was studied on 1 ml of samples. The effects of prehydration duration, prehydration temperature, an rehydration solution on the recovery rate, mean platelet volume （MPV）, and platelet distribution width （PDW） were investigated. The mass changes during the prehydration process were also studied. Three prehydration durations： 0, 1.5, and 3.5 h, and two rehydration solutions： platelet-poor plasma and phosphate-buffered saline （PBS）, were tested. It was found that：（1） the prehydration was of significance; （2） 1.5 h of prehydration had better effects than 3.5 h of prehydration; （3） as a rehydration solution, the platelet-poor plasma behaved better than the PBS. The impacts of prehydration duration and temperature on the results were studied. There was almost no difference between 35 and 37 ℃. Among all the prehydration durations tested, 15, 30, 60, 90, and 120 min, the best result was achieved with the time duration of 15 min. The weights of prehydrated platelets at the end of each test were measured and the water contents were calculated. After 15 min ofprehydration, the water contents in the samples were about （4.8±0.01）% and （5.27±0.29）% （w/w） corresponding to the conditions of 35 and 37 ℃, respectively. These results will be helpful for further studies on the freeze-drying of mammalian cells.

关键词： Freeze-drying Platelets Rehydration Prehydration Rehydration solution

Bed type and flow mechanism of deep water sub-lacustrine fan fringe facies:an example from the Middle Permian Lucaogou Formation in Southern Junggar Basin of NW China

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Petroleum Science 2021年第2期18卷 339-361页

作者： Xin Shan xing-He Yu lina Jin Ya-Long li Cheng-Peng Tan Shun-li li Jun-Hui Wang Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao266061ShandongChina Department of Energy Resources China University of Geosciences(Beijing)Beijing100083China Laboratory for Marine Geology Pilot Qingdao National Laboratory for Marine Science and TechnologyQingdao266061China School of Earth Sciences China University of Petroleum(Beijing)Beijing102200China

Submarine or sub-lacustrine lobe deposits are important reservoirs,but the fan fringe deposits form heterogeneities within deep water fan *** fringe facies records the complex sediment gravity flow *** understanding of the bed types and flow mechanisms,we can identify the fan fringe deposit,which aids in the reconstruction of deep water fan and reservoir *** Jiucaiyuanzi and Dalongkou sections in the West Bogda Mountains preserve well-exposed 536-m and 171-m thick successions,respectively,of a deep water lacustrine depositional system from the Middle Permian Lucaogou *** types of the Lucaogou Formation include high-density turbidite,low-density turbidite,incomplete Bouma-type turbidite,hybrid event beds,and slump *** Lucaogou Formation is interpreted here as a fan fringe facies due to the thin bed thickness that characterize turbidites and hybrid event beds,as well as the predominance of the isolated sheet *** studies suggest that these deposits were considered as deposited in a deep water setting due to the absence of wave-related *** presence of abundant mud clasts in massive medium-coarse grained sandstone beds reflects the significant erosional capability and interactions between high-density turbidity currents and lake *** fan fringe facies here contains amalgamated and thick-bedded homolithic facies(~30%)and thin-bedded heterolithic facies(~70%).The examination of the bed type is of wider significance for facies prediction and reservoir heterogeneity in the sub-lacustrine fan fringe facies.

关键词： fan fringe High-density turbidite Low-density turbidite Hybrid event bed Lucaogou Formation Junggar basin

Preparation of Polyporus Albicans Teng Sulfate andIts Anti-coagulation Activity

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Chemical Research in Chinese Universities 2010年第6期26卷 948-954页

作者： YANG Xi-ming fan Cong GUO Nan YAO xing-wei ZHANG li-ping School of life Sciences Northeast Normal University Changchun 130024 P. R. China Laboratory of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing 100700 P. R. China

More studies have indicated that polysaccharide sulfate has anti-coagulant ***,heparin is the most popular anticoagulant used in clinic,however,its side effects have also caused highly *** is still under intensive investigations to synthesize effective safe polysaccharide sulfate as heparin *** extracted water-soluble polysaccharide from fermented mycelium of edible polyporus albicans（Imaz.） teng,and got the water-soluble polyporus albicans teng sulfate（PATS） by modifying the water-solubility polyose with the method of chlorosulfonic *** anti-coagulant assay of PATS in vitro towards normal human plasma indicates its remarkable anticoagulant activity,while the dose could be as low as 5 mg/L for *** anti-coagulant effect was equivalent to that of heparin about 150 U when the concentration of PATS was 10 mg/*** study on anti-coagulation mechanism suggests that PATS got involved in the intrinsic *** anti-coagulation activity of PATS was due to the inhibition of the coagulation factors IIa and Xa activities mediated by antithrombin Ⅲ（ATIII）.The anti-coagulation mechanism of PATS is absolutely identical to that of *** conclusion,we suggest that PATS has the similar anti-coagulation characteristic to heparin,but with a better anti-coagulation ***,derived from edible fungus-polysaccharide,PATS has more bio-safety ***,PATS has promising future to be developed and used as an ideal substitute for heparin in clinic.

关键词： Polyporus albicans(Imaz.) teng sulfate(PATS) Anti-coagulation activity Polysaccharide sulfate

Biomimetic porous silicon oxycarbide ceramics with improved specific strength and efficient thermal insulation

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Journal of Materials Science & Technology 2024年第1期168卷 185-193页

作者： Zhuoqing Zhang Jinghan li Lei Cao Yu Shi Huajie Yang Rui Yang fan Xie xing Zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Shenyang Aircraft Design and Research Institute Shenyang 110035China

Considering the challenge of aerodynamic heating,the development of high-performance insulating ce-ramic materials with lightweight and low thermal conductivity is crucially important for aerospace vehi-cles to achieve flight at high speed for a long *** this work,macro-porous silicon oxycarbide(SiOC)ceramics with directional pores(DP-SiOC)(mean pore size of 88.1μm)were prepared using polysiloxane precursors via freeze casting and photocrosslinking,followed by *** DP-SiOC samples were lightweight(density∼0.135 g cm^(-3))with a porosity of 90.4%,which showed good shapability through the molding of polysiloxane *** DP-SiOC samples also exhibited an ultra-low thermal con-ductivity of 0.048 W(m K)^(-1)at room temperature,which can also withstand heat treatment at 1200°C for 1 *** addition,scaffolds with triply periodic minimal surfaces(TPMS)were fabricated using digital light processing(DLP)printing,which was further filled with polysiloxane precursors for increasing the strength of *** TPMS scaffolds filled with macro-porous SiOC ceramics(TPMS-DP-SiOC)showed good integration between TPMS and macro-pore structures,which had a porosity∼75%and high specific strength of 9.73×10^(3)N m kg^(-1).The thermal conductivity of TPMS-DP-SiOC samples was 0.255 W(m K)^(-1)at room *** biomimetic TPMS-DP-SiOC ceramics developed in this study are likely used for thermal protection systems.

关键词： Thermal insulation light weight Macro-porous ceramics SiOC

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang Juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

CHD3 chromatin-remodeling factor PICKLE regulates floral transition partially via modulating LEAFY expression at the chromatin level in Arabidopsis

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Science China(life Sciences) 2016年第5期59卷 516-528页

作者： xing Fu Chaonan li Qing liang Yangyang Zhou Hang He liu-Min fan State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University Beijing 100871 China

PICKLE(PKL), a putative CHD3 chromatin remodeling factor, has been suggested to be involved in multiple processes in Arabidopsis. Here, we confirmed the late-flowering phenotype caused by pkl mutation with pkl mutants in two different ecotypes, and investigated the possible mechanisms that account for PKL regulation of flowering time. Quantitative RT-PCR and RNA-seq assays showed that expression of the LEAFY gene(LFY) and a number of LFY-regulated floral homeotic genes were down-regulated in seedlings of the pkl mutants. As predicted, overexpression of LFY restored normal flowering time of pkl mutants. Our results suggest that PKL may be involved in regulating flowering time via LFY expression. To uncover the underlying mechanism, Ch IP-PCR using anti-PKL was performed on materials from three developmental stages of seedlings. Our results showed that PKL associated with the genomic sequences of LFY, particularly at 10-day and 25-day after germination. We also showed that loss of PKL affected H3K27me3 level at the promoter of LFY. Taken together, our data suggest that transcriptional regulation of LFY at the chromatin level by PKL may at least partially account for the late-flowering phenotype of pkl mutants.

关键词： chromatin-remodeling factor PICKLE floral transition LEAFY Arabidopsis