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Conceptual design of a 714-MHz RFQ for compact proton injectors and development of a new tuning algorithm on its aluminium prototype

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Nuclear Science and Techniques 2024年第1期35卷 45-58页

作者： yi-xing Lu Wen-Cheng Fang {2.-Sen Guo Zhen-Tang Zhao shanghai Institute of Applied Physics chinese academy of sciences Shanghai 201800China University of chinese academy of sciences Beijing 101408China shanghai Advanced Research Institute chinese academy of sciences Shanghai 201204China shanghai Key Laboratory of Cryogenics&Superconducting RF Technology Shanghai 201800China shanghaiTech University Shanghai 201210China

Radio frequency quadrupoles(RFQs),which are crucial components of proton injectors,significantly affect the performance of proton accelerator *** RFQ with a high frequency of 714 MHz dedicated to compact proton injectors for medi-cal applications is designed in this *** RFQ is designed to accelerate proton beams from 50 keV to 4 MeV within a short length of 2.m and can be matched closely with the downstream drift tube linac to capture more particles through a preliminary *** develop an advanced RFQ,challenging techniques,including fabrication and tuning method,must be evaluated and verified using a *** aluminium prototype is derived from the conceptual design of the RFQ and then redesigned to confirm the radio frequency performance,fabrication procedure,and feasibility of the tuning ***,a new tuning algorithm based on the response matrix and least-squares method is developed,which yields favorable results based on the prototype,i.e.,the errors of the dipole and quadrupole components reduced to a low level after several tuning *** from the conceptual design and techniques obtained from the prototype,the formal mechanical design of the 2.m RFQ is ready for the next manufacturing step.

关键词： Compact proton injector RFQ IH-DTL High gradient Tuning

Amplification effect of intra-seasonal variability of soil moisture on heat extremes over Eurasia

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Advances in Climate Change Research 2024年第1期15卷 1-8页

作者： yi-Nuo WANG Zhi-Yan ZUO Liang QIAO Kai-Wen ZHANG Mei-yu CHANG Dong XIAO Zou-{2. LIN Huan WANG Department of Atmospheric and Oceanic sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Key Laboratory of Cites Mitigation and Adaptation to Climate Change in shanghai China Meteorological AdministrationShanghai 200030China Collaborative Innovation Centeron Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 211800China shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200123China College of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary Shanghai 202183China chinese academy of Meteorological {2. China Meteorological AdministrationBeijing 100081China

Drying soil has been conducive to a high frequency of extreme high-temperature events over many regions worldwide in recent ***,changes in the intraseasonal variability of soil moisture can also influence the likelihood of extremely high *** previous investigators have examined the association between extremely high temperatures and large-scale atmospheric circulation variability,the role of land-atmosphere coupling dominated by soil moisture variability in extremely high temperatures,particularly over the Eurasian continent,is not well *** this study,on the basis of the Land Surface,Snow,and Soil Moisture Model Intercomparison Project,we found that land-atmosphere feedback amplified the variability of soil moisture in most regions of Eurasia during summer from 1980 to *** amplification of soil moisture variability is closely correlated with more intensive intraseasonal variability of surface air temperature and more frequent occurrences of extreme high-temperature events,particularly in Europe,Siberia,Northeast Asia,and the Indochina *** correlation implies that increasing the intraseasonal variability of soil moisture results in a high likelihood of heat extremes during summer in most parts of Eurasia except Asian desert *** the intraseasonal timescale,the land-atmosphere coupling increases the variability of surface sensible heat flux and net long-wave radiation heating the atmosphere by intensifying the soil moisture variability,thus amplifying the variability of surface air temperature and enhancing the extreme high-temperature *** finding demonstrates the importance of changes in intraseasonal soil moisture variability for the increasing likelihood of heat extremes in summer.

关键词： Soil moisture Intraseasonal variability Land-atmosphere coupling Heat extremes

cAMP elevators inhibit LPS-induced IL-12.p40 expression by interfering with phosphorylation of p38 MAPK in Murine Peritoneal Macrophages

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Cell Research 2002年第Z2期 331-337页

作者： WEI Guo FENG, yi BING WANG, JIN SONG ZHANG, xing {2. WANG, CHANG LIN LI, ZONG LIANG CHANGLaboratory of Immune Signaling Transduction, Institute of Biochemistry and Cell Biology, shanghai Institutes for Biological sciences, chinese academy of sciences, shanghai 2.0031, china

cAMP mediated signaling may play a suppressive role in immune response. We previously found that the cAMP-elevators (CTx and 8-Br-cAMP) inhibited IL-12. IL-la, IL-6 gene expression, but increased the transcriptional levels of IL-10 and IL-IRa in LPS-treated murine peritoneal macrophages. The present study examined a possible molecular mechanism involved in cAMP elevators-induced inhibition of IL-12.p40 expression in response to LPS. Our data demonstrated that cAMP elevators downregulated IL-12.p40 mRNA expression and IL-12.p70 production in murine peritoneal macrophages. Subsequent studies revealed that cAMP-elevators blocked phosphorylation of p38 MAPK, but did not affect the activity of NF-kB binding to IL-12.promoter (-136/-112.. This is the first report that cAMP elevators inhibit LPS-induced IL-12.production by a mechanism that is associated, at least in part, with p38-dependent inhibition by cAMP signaling pathways.

关键词： IL-12 cAMP LPS NF-kB P38 MAPK.

强化表达SAM合成酶促进SAM在毕赤酵母中累积

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生物化学与生物物理学报 2003年第2期35卷 127-132页

作者：余志良吴星佳李东阳杨晟周政蔡谨袁中一浙江大学材料与化工学院中国科学院上海生命科学研究院生物化学和细胞生物学研究所中国科学院上海生命科学研究院植物生理和生态研究所中国科学院上海生命科学研究院生物化学和细胞生物学研究所杭州31002. 上海2.0031 上海2.0032

S 腺苷甲硫氨酸 (S adenosyl L methionine ,SAM)是生物体硫代谢的重要中间代谢物质 ,在体内起着转甲基、转硫基、转氨丙基的作用 ,具有重要的药用和保健价值。将酿酒酵母来源的SAM合成酶 2.因置于GAP启动子调控下 ,构建胞内组成型表... 详细信息

S 腺苷甲硫氨酸 (S adenosyl L methionine ,SAM)是生物体硫代谢的重要中间代谢物质 ,在体内起着转甲基、转硫基、转氨丙基的作用 ,具有重要的药用和保健价值。将酿酒酵母来源的SAM合成酶 2.因置于GAP启动子调控下 ,构建胞内组成型表达质粒 ,并电转化至毕赤酵母菌株GS115。经Zeocin抗性和培养筛选到一株高产SAM的重组菌。对重组菌表达工艺的研究表明 ,碳源、氮源、pH和溶解氧对SAM的累积有较大影响。在优化条件下 ,重组细胞培养 3天 ,SAM累积量可达 2..49g/L。

关键词： S-腺苷甲硫氨酸 S-腺苷甲硫氨酸合成酶2 巴斯德毕赤酵母代谢工程表达优化

A Search for High-velocity Gas Associated H_2. Masers and Ultracompact HII Regions

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chinese Journal of Astronomy and Astrophysics 2001年第1期1卷 60-65页

作者： YeXu Dong－RongJiang 等 shanghaiastronomicalObservatory ChineseAcademyofSciencesShanghai200030 NationalastronomicalObservato

With the objective of studying the relationships between high-velocity gas and water maser emissions the results of a search from 95 IRAS sources for high-velocity gas associated with star forming molecular clouds are... 详细信息

关键词： HII regions - ISM: jets and outflows - stars: formation - masers

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo yi Su yu-Ya-Nan Zhang Hao yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li yun-Dan Liao Zhe-Wei Kang Li-Fang Wang yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv yin Yao yun-Long Tan Gerome Breen Ian Everall Hong-xing Wang Zhuo Huang Dai Zhang Wei-Hua yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2.18RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the chinese academy of sciences and yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2.07)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=2.5)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2. for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2.SBNO1,KCNG2.SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

NνDEx-100 conceptual design report

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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-yuan Huang Ze-yu Huang Lei Lang yu-Lan Li Zhi-Jie Li Tian-yu Liang Jun Liu Chen-Gui Lu Fa-Tai Mai yuan Mei Hao Qiu Xiang-Ming Sun Xiao-xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-yun Xiao Jian-yu Xin Nu Xu Peng Yang yi-Chen Yang Zhen Yang Zong-Yang yu Dong-Liang Zhang Jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central china Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North china University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82.SeF_(6) gas and Topmetal silicon sensors for readout in the china Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82.e,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82.e and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82.SeF_(6) china Jinping Underground Laboratory

基于运算放大器的超导纳米线单光子探测器低温直流耦合读出电路

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物理学报 2024年第13期73卷 367-377页

作者：陈志刚张伟君张兴雨王钰泽熊佳敏洪逸裕原蒲升吴玲王镇尤立星中国科学院上海微系统与信息技术研究所上海市超导集成电路技术重点实验室上海200050 中国科学院大学材料科学与光电子工程中心北京100049

超导纳米线单光子探测器(SNSPD)具有高计数率、高探测效率和低暗计数等优点,在光量子通信、光量子计算、激光测距与成像等领域发挥着重要作用.SNSPD的最大计数率(探测速度)会受前级读出电路的影响,为了提升最大计数率,通常需要使用一个... 详细信息

超导纳米线单光子探测器(SNSPD)具有高计数率、高探测效率和低暗计数等优点,在光量子通信、光量子计算、激光测距与成像等领域发挥着重要作用.SNSPD的最大计数率(探测速度)会受前级读出电路的影响,为了提升最大计数率,通常需要使用一个宽带宽的低温直流耦合读出电路.本文报道了基于商用高速运算放大芯片OPA855搭建的SNSPD低温直流耦合放大读出电路,系统表征了该电路从室温300 K到低温4.2.K下的性能参数.通过提升OPA855的工作电压,解决了电路在低温下带宽损失的问题.进一步,将OPA855放大电路安装在40 K温区,使用其实现了SNSPD探测性能的实验评估.相对于常规室温交流耦合电路,SNSPD的最大计数率约提升了1.3倍.本研究可为OPA855芯片在高速SNSPD等低温领域提供相关参考信息.

关键词：运算放大器低温读出电路直流耦合超导纳米线单光子探测器

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Reduced clinical severity during 2.2. shanghai Spring epidemic of SARS-CoV-2.omicron BA.2.variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu {2.lin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu {2.chen Jia Mian Shao Guorong Gu Xiangwei Wang Ye Yao {2.ng Wang Shaodie Chen Zhigao yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long Jian Sun Lingyu xing Jiayuan Shen {2. Han yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong Zeng Jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2.variant of concern omicron BA.2.led to high infection incidence rates as well as reduced severity of COVID-19 during the shanghai Spring epidemic of 2.2. [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 2.8 confirmed COVID-19cases identified between April and June of 2.2., from four COVID-19 designated hospitals located in two areas of shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： REPLICATION