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Metachronous contralateral testicular and bilateral adrenal metastasis of chromophobe renal cell carcinoma:a case report and review of the literature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 386-389页

作者： Hai-yang WU li-wei XU You-yun ZHANG Yan-lan YU xin-de li Gong-hui li department of Urology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Chromophobe renal cell carcinoma(ChRCC) metastatic to the testis has not,to the best of our knowledge,been reported in the *** have there been reports of delayed bilateral adrenal metastasis of *** we report a case of metachronous contralateral testicular and bilateral adrenal metastasis of ChRCC in a 70-year-old man who underwent right radical nephrectomy for RCC six years *** was admitted to the hospital because of left intrascrotal enlargement of two-month *** revealed a mass in the upper pole of the left *** tomography(CT) showed irregular masses in the bilateral adrenal *** radical orchiectomy and laparoscopic bilateral adrenalectomy were *** pathologic examination showed metastatic ChRCC in the left testis and bilateral adrenal *** follow-up showed that the patient had survived for at least 56 months without *** case highlights the unique behavior of RCC with an unusual site of metastasis and favorable survival after multiple metastasectomy.

关键词： Renal cell carcinoma(RCC) Testicular metastasis Adrenal metastasis Metastasectomy

determination and pharmacokinetic study of catechin in rat plasma by HPLC

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Journal of Pharmaceutical Analysis 2011年第4期1卷 297-301页

作者： li Xie xin-Nan li de-Xi Jiang Dan Zhang West China School of Pharmacy Siehuan University Chengdu 610041 China

A high performance liquid chromatographic method was developed and validated for the quantitative determination of catechin in rat plasma and its pharmacokinetic study after intragastric administration of Catechu and Xiongdanjiangre Wan into SD rats. Plasma samples were prepared by protein precipitation using methanol-5% aqueous zinc sulfate （70：30, v/v） as precipitant. Chromatographic separation was achieved on Hypersil Cl8 column （250 mm~ 4.6 mm, 10 pm） with acetonitrile-water-triethylamine （6：94：0.3, v/v/v, pH 4.0＋0.1, adjusted with phos- phoric acid） as mobile phase, followed by a UV detection at 207 nm. Good linearity was obtained over the range of 0.143-7.15 mg/L of catechin, with correlation coefficient of 0.9992. The method was simple, sensitive, accurate and reproducible and＇ has been successfully applied to the pharmacokinetic study of catechin in rat plasma.

关键词： HPLC determination Pharmac^kinctic Catechin Rat Plasma

Effects of lianhua Qingwen on Pulmonary Oxidative Lesions Induced by Fine Particulates(PM2.5) in Rats

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Chinese Medical Sciences Journal 2016年第4期31卷 233-238页

作者： Fen Ping Zhen-sheng li Feng-rui Zhang de-xin li Shu-zhi Han department of Respiratory Medicine Hebei General Hospital department of Respiratory Medicine Hebei Chest Hospital

Objective To investigate the antagonistic effects of different doses of lianhua Qingwen on pulmonary injury induced by fine particulates PM2.5 in rats. Methods Fine particulates suspended in the environment were collected. Forty-eight healthy adult wistar rats were randomly divided into 6 groups with 8 rats in each group. Four groups of rats were exposed to PM2.5 by intratracheally dripping suspensions of fine particulates PM2.5(7.5 mg/kg) as dust-exposed model rats. Among them 24 rats in three groups received lianhua Qingwen treatment(crude drug) at a dose of 2 g/kg, 4 g/kg, 8 g/kg per day for 3 days before dust exposure and were defined as low-dose, middle-dose and high-dose lianhua Qingwen treatment groups respectively. The other dust-exposed model rats without treatment were assigned as PM2.5 control group. The un-exposed rats were set as saline control group(1.5 ml/kg saline) and blank control group. All rats were killed after 24 hours of the exposure. Lung tissue, serum and bronchoalveolar lavage fluid(BALF) were collected. The levels of malonaldehyde(MDA), lactate dehydrogenase(LDH), and glutathione peroxidase(GSH-PX) in blood serum and BALF, and superoxide dismutase(SOD) in blood surum were measured using fluorescent quantitation PCR; Expression of NF-E2-related factor 2(NRF-2), heme oxygenase 1(HO-1) and quinone oxidoreductase 1(NQO1) in lung tissues were measured using Western blot. Pathological changes of lung tissues in each group were also examined. Results Pathology revealed thickened alveolar septum, congestion of capillary, interstitial edema and infiltration of lymphocyte and neutrophil surrounding bronchiole in the PM2.5 control group, which weresignificantly relieved in the lianhua Qingwen treatment groups. Compared to the blank and saline control groups, the PM2.5 control group had significantly higher levels of LDH and MDA(p<0.01) and lower level of GSH-PS(p<0.01) in BALF, significantly higher levels of LDH and MDA(p<0.05) and lower level of GSH

关键词： fine particulates (PM2.5) pulmonary lesion oxidative stress lianhua Qingwen rats

Using 16S rDNA Sequencing Technology to Preliminarily Analyze Intestinal Flora in Children with Mycoplasma pneumoniae Pneumonia

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Biomedical and Environmental Sciences 2022年第6期35卷 528-537页

作者： SHI Da Wei WANG Dong Mei NING li Hua li Jing DONG Yan ZHANG Zhi Kun DOU Hai Wei WAN Rui Jie JIA Chun Mei xin de li department of Pediatrics Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China department of Pediatrics Baotou Fourth Hospital(Baotou Children’s Hospital)Baotou 014030Inner Mongolia Autonomous RegionChina department of Pediatrics Beijing Chang Ping Hospital of Integrated Chinese and Western MedicineBeijing 100096China Tropical Medicine Research Institute Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Objective We investigated changes in the intestinal flora of children with Mycoplasma pneumoniae pneumonia(MPP).Methods Between September 2019 and November 2019,stool samples from 14 children with MPP from The Fourth Hospital of Baotou city,Inner Mongolia Autonomous Region,were collected and divided into general treatment(AF)and probiotic(AFY)groups,according to the treatment of“combined Bifidobacterium,Lactobacillus,Enterococcus,and Bacillus cereus tablets live”.Highthroughput 16S rDNA sequencing was used to identify intestinal *** Intestinal flora abundance and diversity in children with MPP were *** Shannon and Simpson indices were lower in the AF group when compared with healthy controls(Pli-Shigella in the AFY group after treatment was decreased(Pdecreased abundance and diversity,and decreased *** probiotic mixture partly improved intestinal flora disorders.

关键词： Intestinal flora Mycoplasma pneumoniae pneumonia Probiotics Respiratory tract infection

Establishment of a Predictive Diagnostic Model for Acute Mycoplasma Pneumoniae Infection in Elderly Patients with Community-acquired Pneumonia

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Biomedical and Environmental Sciences 2017年第7期30卷 540-544页

作者： XiAO Hong li xin de li WANG Yan CUI li Jian liU Xiao Ya liU Song SONG li Hong liU Chun ling YIN Cheng Hong department of Emergency Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Beijing Institute of Clinical Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China department of Infectious Disease and Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China department of Internal Medicine Beijing Obstetrics and Gynaecology Hospital Capital Medical University Beijing 100026 China Respiratory department Beijing Friendship Hospital Capital Medical University Beijing 100050 China department of Emergency Medicine Beijing Guang Wai Hospital Beijing 100080 China department of Infectious Disease Air Force General Hospital PLA Beijing 100142 China

We established a diagnostic model to predict acute Mycoplasma pneumoniae （M. pneumonia） infection in elderly Community-acquired pneumonia （CAP） patients. We divided 456 patients into acute and non-acute M. pneumoniae infection groups. Binary logistic regression and receiver operating characteristic （ROC） curves were used to establish a predictive model. The following independent factors were identified： age 〉 70 years; serum cTNT level 〉 0.0S ng/mL; lobar consolidation; mediastinal lymphadenopathy; and antibody titer in the acute phase 〉 1：40. The area under the ROC curve of the model was 0.923 and a score of 2 7 score predicted acute M. pneumoniae infection in elderly patients with CAP. The predictive model developed in this study has high diagnostic accuracy for the identification of elderly acute M. pneumoniae infection.

关键词： in as of were Establishment of a Predictive Diagnostic Model for Acute Mycoplasma Pneumoniae Infection in Elderly Patients with Community-acquired Pneumonia for with

Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?

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Biomedical and Environmental Sciences 2020年第12期33卷 916-924页

作者： DOU Hai Wei TIAN Xiu Jun xin de li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao Ping GE li Xia SHI Da Wei Beijing Tropical Medicine Research Institute Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Disease Capital Medical UniversityBeijing 100050China Qingdao Women and Children`s Hospital Qingdao 266000ShandongChina department of Pediatrics Peking University Third HospitalBeijing 100191China department of Pediatrics Civil Aviation General HospitalBeijing 100123China department of Pediatrics Beijing Chao-yang HospitalCapital Medical UniversityBeijing 100043China department of Pediatrics Emergency General Hospital(China Meitan General Hospital)Beijing 100028China department of Respiratory Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China department of Pediatrics Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric *** Real-time quantitative polymerase chain reaction(PCR)was used to identify ***,and MLVA was *** domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point *** also investigated the activities of antibiotics against *** isolates in *** The PCR detection rate of *** in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type *** other types were *** strains were resistant to levofloxacin or *** In 2016,a specific decrease in the macrolide resistance rate occurred in *** detection rate and macrolide resistance rate of outpatients are lower than those of *** A2063 G mutants *** have high levels of resistance to erythromycin and *** primary MLVA type is 4-5-7-2,followed by *** other MLVA types were *** strains resistant to tetracycline or levofloxacin were found in vitro.

关键词： Culture Macrolide resistance MLVA type Mycoplasma pneumoniae

Efficacy of Mild Hypothermia for the Treatment of Patients with Cardiac Arrest

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Chinese Medical Journal 2015年第11期128卷 1536-1542页

作者： Yu Gao Kang-li Hui Yu-Jie Wang lin Wu Man-lin Duan Jian-Guo Xu de-xin li Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu 210000 China department of Anesthesiology Jinling Hospital School of Medicine Nanjing University Nanjing Jiangsu 210000 China

Background： Therapeutic hypothermia has been recommended for the treatment of cardiac arrest patients who remain comatose after the return of spontaneous circulation. The aim of this study was to evaluate the effectiveness and safety of mild hypothermia on patients with cardiac arrest by conducting a meta-analysis. Methods： The relevant trials were searched in Cochrane library, PubMed, Web of Science, Embase, CNKI and Wan Fang Data from the date of their establishment to October 2014. Thereafter, the studies retrieved were screened based on predeflned inclusion and exclusion criteria. Data were extracted, and the quality of the included studies was evaluated. A meta-analysis was conducted using the Cochrane Collaboration Review Manager 5.2 sottware. Results： Six randomized controlled trials involving 531 cases were included, among which 273 cases were assigned to the treatment group and the other 258 cases to the control group. The meta-analysis indicated that mild hypothermia therapy alter cardiac arrest produced significant differences ill survival rate （relative risk [RR] =1.23, 95% confidence interval [C/]： 1.02-1.48, P = 0.03） and neurological function （RR - 1.33, 95% （.7： 1.08-1.65, P - 0.007） alter 6 months compared with normothermia therapy. However, no significant differences were observed in the survival to the hospital discharge （RR = 1.35, 95% CI： 0.87-2.10, P - 0.1 8）, favorable neurological outcome at hospital discharge （RR = 1.53, 95% CI： 0.95 2.45, P = 0.08） and adverse events. Conclusions： The meta-analysis demonstrated that mild hypothermia can improve the survival rate and neurological function of patients with cardiac arrest after 6 months. On the other hand, regarding the survival to hospital discharge, favorable neurological outcome at hospital discharge, and adverse events, our meta-analysis produced nonsignificant results.

关键词： Cardiac Arrest Cardiopulmonary Resuscitation Mild Hypothermia Neurological Function Survival Rate

P1 gene of Mycoplasmapneumoniae in clinical isolates collected in Beijing in 2010 and relationship between genotyping and macrolide resistance

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Chinese Medical Journal 2013年第20期126卷 3944-3948页

作者： Tian Xiu-jun Dong Yan-qing Dong Xiao-pei li Jing-yi li Dan Jiang Yue xin de-li Capital Med Univ Beijing Trop Med Res Inst Beijing Friendship Hosp Beijing 100050 Peoples R China

Background Mycoplasma pneumoniae is a common pathogen that caused community-acquired pneumonia （CAP）. P1 protein served as major adhesion and immunodominant protein in Mycoplasma pneumoniae, but little about P1 gene... 详细信息

关键词： Mycoplasma pneumoniae genotype, P1 gene macrolide resistance,A GT tri-nucleotide

Syntheses,Crystal Structure and Thermal Analyses of the Complex of Copper(Ⅱ) with N,N'-Bis-Sal icy1idene-Ethyl enediamine(H_2Salen)

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Chemical Research in Chinese Universities 1992年第2期8卷 173-176页

作者： liU de-xin, li Xiao-yan, SUN Hong-jian, CUI Xue-gui and KANG Yong-jun (department of Applied Chemistry, Shandong University, Jinan, 250100)

Introduction In recent years, the syntheses, properties and applications of the complexes of transition-metal ions with Schiff bases have been a very interesting subject in coordination chemistry. It has been clearly ... 详细信息

关键词： Schiff base Copper complex Crystal structure Thermal analyses