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Effect of silicone Maintenance Materials on Thermal Aging Resistance of Asphalt Mixture

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武汉理工大学学报 2010年第17期32卷 71-75页

作者： lIN j T wu s p wan l Key laboratory of silicate Materials science and Engineering Wuhan University of TechnologyWuhan 430070China

Early water damage of asphalt pavement is one of the major types of destruction,so taking maintenance on asphalt pavement at the proper time is necessary. Many new maintenance materials and methods are in use nowadays to prevent pavement from water damage and skidding. This paper aims to study the effects of the silicone maintenance materials on thermal aging resistance of asphalt mixture. After thermal aging,the asphalt mixture using silicone materials and the control mixture are evaluated through their engineering properties,including indirect tensile modulus,low-temperature performance and fatigue resistance. The results indicate that the silicone materials used as repairing material can improve low-temperature performance and fatigue resistance of asphalt mixture,and decrease the indirect tensile modulus ratio before and after thermal aging. Consequently,the silicone maintenance material has the ability to protect asphalt mixture from thermal aging.

关键词： asphalt mixture silicone waterproof agent thermal aging properties

Direct mask-free fabrication of patterned hierarchical graphene electrode for on-chip micro-supercapacitors

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journal of Materials science & Technology 2023年第12期143卷 12-19页

作者： Yaopeng wu jinghong Chen Wei Yuan Xiaoqing Zhang shigen Bai Yu Chen Bote Zhao Xuyang wu Chun wang Honglin Huang Yong Tang Zhenping wan shiwei Zhang Yingxi xie school of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510640China Intelligent perception Institute Zhejiang LabHangzhou 311100China school of Environment and Energy South China University of TechnologyGuangzhou 510006China

Graphene-based electrodes with rational structural design have shown extraordinary prospect for en-hanced electrical double-layer capacitance of micro-supercapacitors(MsCs).Herein,a facile fabrication method for flexible planar MsCs based on hierarchical graphene was demonstrated by using a laser-treated membrane for electrode patterning,complemented with hierarchical electrode configuration tak-ing full advantages of size-determined functional *** in-plane interdigital shape of MsCs was defined through vacuum filtration with the assistance of the functionalized polypropylene(pp)*** hierarchical graphene films were built by macroscopic assembly based on size effect of differ-ent lateral sized graphene sheets(rGO-lsl).The sample of MsCs based on rGO-l sl(MsCs-lsl)exhibited excellent volumetric capacitance of 6.7 F cm^(−3) and high energy density of 0.37 mWh cm−*** MsCs-lsl presented superb flexibility and cycling stability with no capacitance deteroriated after 2000 *** newly developed fabrication strategy is of good scalability and designability to manufacture flexible elec-trode for MsCs with customized shapes,while the construction of hierarchical graphene can enlighten the structural design of analogous two-dimensional materials for potential advanced electronics.

关键词： On-chip micro-supercapacitors Mask-free fabrication Macroscopic assembly patterned graphene film Hierarchical structure

Ambient Temperature is A strong selective Factor Influencing Human Development and Immunity

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Genomics, proteomics & Bioinformatics 2020年第5期18卷 489-500页

作者： lindan ji Dongdong wu Haibing xie Binbin Yao Yanming Chen David M.Irwin Dan Huang jin Xu Nelson l.s.Tang Yaping Zhang state Key laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Department of Biochemistry Medical School of Ningbo UniversityNingbo 315211China Department of preventive Medicine Medical School of Ningbo UniversityNingbo 315211China Department of laboratory Medicine and pathobiology University of TorontoTorontoON M5S 1A8Canada Banting and Best Diabetes Centre University of TorontoTorontoON M5S 1A8Canada Department of Chemical pathology and Laboratory for Genetics of Disease SusceptibilityLi Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative RegionChina KIZ/CUHK joint laboratory of Bioresources and Molecular Research in Common Diseases Kunming 650223China laboratory for Conservation and Utilization of Bio-resource Yunnan UniversityKunming 650091China

solar energy,which is essential for the origin and evolution of all life forms on Earth,can be objectively recorded through attributes such as climatic ambient temperature(CAT),ultraviolet radiation(UVR),and sunlight duration(sD).These attributes have specific geographical variations and may cause different adaptation ***,the adaptation profile of each attribute and the selective role of solar energy as a whole during human evolution remain ***,we performed a genome-wide adaptation study with respect to CAT,UVR,and sD using the Human Genome Diversity project-Centre Etude polymorphism Humain(HGDp-CEpH)panel *** singled out CAT as the most important driving force with the highest number of adaptive loci(6 sNps at the genome-wide 1×10^(-7)level;401 at the suggestive 1×10^(-5)level).Five of the six genomewide significant adaptation sNps were successfully replicated in an independent Chinese population(N=1395).The corresponding 316 CAT adaptation genes were mostly involved in development and *** addition,265(84%)genes were related to at least one genome-wide association study(GWAs)-mapped human trait,being significantly enriched in anthropometric loci such as those associated with body mass index(χ^(2);plic syndrome,and cancer(χ^(2);pse adaptive sNps,balancing selection was evident in Euro-Asians,whereas obvious positive and/or purifying selection was observed in *** together,our study indicates that CAT is the most important attribute of solar energy that has driven genetic adaptation in development and immunity among global human *** also supports the non-neutral hypothesis for the origin of disease-predisposition alleles in common diseases.

关键词： solar radiation Ambient temperature Natural selection Development Immunity

Effect of electroacupuncture on chemotherapy-induced peripheral neuropathy in patients with malignant tumor：a single-blinded,randomized controlled trial

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journal of Traditional Chinese Medicine 2017年第2期37卷 179-184页

作者： Zhang shiqiang wu Tingting Zhang Haisheng Yang Yun jiang Haiyan Cao shengcheng xie Fang Xia Xiaoting lü junqiang Zhong Yi Department Shanghai Traditional Chinese Medicine-integratedHospital Shanghai University of Traditional Chinese Medicine Shanghai 200082 China Oncology Department Fangta Traditional Chinese Medicine Hospital of Songjiang District Shanghai 201600 China Oncology Department Jing'an District CentreHospital of Shanghai Shanghai 200040 China

OBjECTIVE:To evaluate the effect of electroacupuncture on chemotherapy-induced peripheral neuropathy(CIpN), quality of life and immune status of patients with malignant ***:From jan, 2013 to May, 2014, 37 patients with malignant tumors were included in this prospective single-blinded study, and randomized to receive either electroacupuncture or acupuncture treatment on basis of *** chemotherapy was continued for 2 courses as previous before the treatments, with 21 days as a course of *** received acupuncture and electroacupuncture once per day starting at the day before chemotherapy for consecutive 7 days followed by 14 days off, with 21 days as a course of treatment, and continued for two courses of *** CIpN, traditional Chinese clinical symptoms,quality of life and immune status were all evaluated for each patient prior treatment and after two courses of ***:The gender, age, cancer species as well as incidence(83.3% vs 84.2%) and grades of CIpN before treatments were all similar in patients receiving acupuncture or electroacupuncture(all p >0.05).After treatments, most patients with peripheral neuropathy were cured by two courses of electroacupuncture(84.2% vs 21.1%), whereas the other group of patients had similar incidences of peripheral neuropathy compared with prior-acupuncture(83.3% vs 72.2%).Besides, patients receiving electroacupuncture had lower incidence of peripheral neuropathy than those receiving acupuncture treatment(χ~2= 9.745, p = 0.002).The grades of peripheral neuropathy were significantly different in the two groups post-treatment(χ~2= 13.983, p =0.007).The total effective rates for traditional Chinese clinical symptoms were 16.7% and 84.2% in acupuncture and electroacupuncture groups, respectively(Z =-4.239, p lectroacupuncture treatment provided a more satisfactory life for patients compared with acupuncture(Z =-4.76, p lectroacupuncture and acupuncture

关键词： Electroacupuncture Quality of life Chemotherapy-induced peripheral neuropathy Randomized controlled trial

stability evaluation of reference genes for real-time quantitative pCR normalization in spodoptera frugiperda(lepidoptera:Noctuidae)

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journal of Integrative Agriculture 2021年第9期20卷 2471-2482页

作者： sHU Ben-shui YU Hai-kuo DAI jing-hua xie Zi-ge QIAN wan-qiang lIN jin-tian Guangzhou City Key laboratory of subtropical Fruit Trees Outbreak Control Zhongkai University of Agriculture and EngineeringGuangzhou 510225P.R.China Agricultural Genomics Institute at shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120P.R.China

Real-time quantitative pCR(qpCR)is a reliable and widely used technique for analyzing the expression profiles of target genes in different species,and reference genes with stable expressions have been introduced for the normalization of the ***,stability evaluation should be considered as the initial step for qpCR *** fall armyworm spodoptera frugiperda(***)(lepidoptera:Noctuidae)is a polyphagous pest that consumes many plant species and seriously threatens corn production around the ***,no studies thus far have examined the stability of reference genes in this *** this study,the expression profiles of the eight candidate reference genes of Actin,elongation factor 1 alpha(EF1α),elongation factor 2(EF2),glyceraldehyde-3-phosphate dehydrogenase(GApDH),ribosomal protein l3(Rpl3),ribosomal protein l13(Rpl13),alpha-tubulin(α-TUB),and beta-1-tubulin(β-1-TUB)were obtained from *** in different samples and the stability was evaluated byΔCt,BestKeeper,geNorm,NormFinder,and RefFinder *** results of pairwise variation(V)calculated by GeNorm indicated two reference genes could be selected for ***,the combinations of the most stable reference genes for different experimental conditions of *** were shown as follows:EF2 and Rpl13 for developmental stages,Rpl3 andβ-1-TUB for larval tissue samples,EF2 and EF1αfor the larval samples treated with different temperatures,Rpl3 and EF1αfor the larval samples under starvation stress,and Rpl13 and EF1αfor all the *** results lay the foundation for the normalization of qpCR analyses in *** and could help guarantee the accuracy of subsequent research.

关键词： spodoptera frugiperda reference genes qpCR stability evaluation different experimental conditions

synthesis,Crystal structure and photoluminescence of a Dinulear Copper Complex

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Chinese journal of structural Chemistry 2018年第10期37卷 1645-1650页

作者： lI Xiao-Ning wu Xiao-Yuan ZHAO wan-wan YANG Ming-Xue YU Rong-Min lU Can-Zhong CAs Key laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of Sciences College of Chemistry and Materials science Fujian Normal University

A binuclear cuprous complex [Cu（μ-I）（Npph）]2（1,Npph = 1-（2-（diphenylphosphanyl）phenyl）-3-phenyl-4,5-dihydro-1 H-pyrazole） was synthesized and characterized by elemental analysis,NMR and X-ray single-crystal structure *** crystallizes in triclinic space group p2_1/n with a = 10.7520（3）,b = 18.1860（5）,c = 11.8487（3）？,β = 91.864（2）,V = 2315.61（11）？~3,Z = 4,Mr = 594.87,Dc = 1.706 g/cm^3,F（000） = 1176.0,μ = 12.582 mm（-1）,GOOF = 1.048,the final R = 0.0289 and wR = 0.0670 for 3787 observed reflections with I 〉 2σ（I）.The Cu atoms in the complex are four-coordinated and adopt distorted tetrahedral coordination *** the solid state,the complex exhibits greenish yellow photoluminescence with a peak maximum of 533 nm,a decay time of 34 μs,and a photoluminescence quantum yield of 63.6% at room temperature,respectively.

关键词： cuprous complex crystal structure emissive property

spatiotemporal expression of inducible nitric oxide synthase and cyclooxygenase 2 in the spinal cord during early stage sciatic nerve crush injury

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Neural Regeneration Research 2010年第10期5卷 747-751页

作者： Qiben wang linfeng Zheng Yinggui xie Qinghong Huang He Huang Zhicheng Zeng song wu Department of Human Anatomy XiangNan University Chenzhou 423000 Hunan Province China Department of Radiology Shanghai First People's Hospital Medical College Shanghai Jiaotong University Shanghai 200080 China Department of Orthopaedics Third Xiangya Hospital Central South University Changsha 410013 Hunan Province China Department of Human Anatomy and Neurobiology Xiangya School of Medicine Central South University Changsha 410013 Hunan Province China

BACKGROUND： previous studies have shown that inducible nitric oxide synthase （iNOs） and cyclooxygenase 2 （COX-2） participate in inflammatory immune responses and neuropathic pain following peripheral nerve injury. However, few reports have addressed time-dependent expression of iNOs and COX-2 following peripheral nerve injury. OBjECTIVE： To investigate spatiotemporal expression of iNOs and COX-2 during early stage sciatic nerve crush ***, TIME AND sETTING： The randomized, controlled, animal experiment was performed at the laboratory of Applied Anatomy, Department of Human Anatomy and Neurobiology, Central south University, China from september 2006 to september ***： Mouse anti-rat iNOs monoclonal antibody and goat anti-rat COX-2 monoclonal antibody （Transduction laboratory, UsA）, as well as biotinylated rabbit anti-mouse lgG and biotinylated rabbit anti-goat IgG （santa Cruz Biotechnology, UsA） were used in the present ***： A total of 48 healthy, adult, sprague Dawley rats were randomly assigned to three groups. In the model group （n = 32）, crush injury to the right sciatic nerve was established using an artery clamp. The model group was further assigned to four subgroups according to survival time （6,12, 24, and 72 hours）, respectively （n = 8）. sham surgery （n = 8） and normal control （n = 8） groups were also *** OUTCOME MEAsUREs： iNOs and COX-2 expression was detected in the l4-6 spinal cord with immunohistochemistry. Gray values of iNOs- and COX-2-postive cells in the anterior horn and posterior horn of spinal cord, as well as quantification of iNOs- and COX-2-positive cells in the anterior horn of spinal cord, were ***： iNOs and COX-2 expression gradually increased in the anterior horn and posterior horn of the spinal cord on the damaged side over time from 6 hours following sciatic nerve injury （p〈0.05） and peaked at 72 hours. simultaneously, the number of iNOs- and COX-2-positive cells similarly increased

关键词： inducible nitric oxide synthase cyclooxygenase 2 sciatic nerve spinal cord peripheral nerve injury neural regeneration

Design, synthesis and Biological Activities of Novel Anthranilic Diamides Containing Dihydroisoxazoline and Isoxazole

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Chemical Research in Chinese Universities 2016年第1期32卷 41-48页

作者： lIU jingbo lI Yuxin CHEN Youwei wu Changchun wan Yingying WEI Wei XIONG lixia ZHANG Xiao YU shujing lI Zhengming state Key laboratory of Elemento-organie Chemistry Institute of Elemento-organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Nankai University Tianjin 300071 P. R. China

Anthranilic diamides are one of the most important classes of modern agrochemical insecticides. To discover new structures with higher activity, lower toxicity and lower residue, a series of novel anthranilic diamides containing dihydroisoxazoline and isoxazole was designed and synthesized. Their structures were characterized by means of melting points, proton nuclear magnetic resonance（IH NMR）, 13C NMR and high resolution mass spectrometry（HRMs）. According to the bioassay data, it was found that some of the title compounds exhibit moderate insecticidal activity and good antifungal activity. In particularly, compound 15b with a concentration of 50 mg/l shows a lethality rate of 60.0% against Mythimna separata Walker and a lethality rate of 50.0% against Culex pipiens pallens with a concentration of 1 mg/l. Moreover, compound 15b showed good antifungal activities（58.8%, 77.1%, 70.7%, 55.3%, 60.7%, 65.4%） when against all the tested fungi（Cercospora araehidicola tIori, physalospora piricola, Rhizoctonia cerealis, Bipolaris maydis, Watermelon anthracnose, Fusarium moniliforme）. The effects of compounds 14h, 14j and 15b on the concentration of intracellular calcium ion（[Ca2＋]i） in the central neurons of Mythimna separate Walker were well investigated via calcium imaging technique. The results demonstrate that the novel compounds can elevate the calcium concentration in the neurons, denoting that some new structures are potential modulators of the insect ryanodine receptor（RyR）.

关键词： Anthranilic diamide Dihydroisoxazoline Isoxazole Biological activity Calcium channel

Hypoxia signaling in human health and diseases:implications and prospects for therapeutics

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signal Transduction and Targeted Therapy 2022年第8期7卷 2787-2816页

作者： Zhen luo Mingfu Tian Ge Yang Qiaoru Tan Yubing Chen Geng li Qiwei Zhang Yongkui li pin wan jianguo wu Guangdong provincial Key laboratory of Virology Institute of Medical MicrobiologyJinan UniversityGuangzhou 510632China Foshan Institute of Medical Microbiology Foshan 528315China The First Affiliated Hospital of jinan University Guangzhou 510632China The Affiliated shunde Hospital of jinan University Foshan 528303China

Molecular oxygen(O2)is essential for most biological reactions in mammalian *** the intracellular oxygen content decreases,it is called *** process of hypoxia is linked to several biological processes,including pathogenic microbe infection,metabolic adaptation,cancer,acute and chronic diseases,and other stress *** mechanism underlying cells respond to oxygen changes to mediate subsequent signal response is the central question during ***-inducible factors(HIFs)sense hypoxia to regulate the expressions of a series of downstream genes expression,which participate in multiple processes including cell metabolism,cell growth/death,cell proliferation,glycolysis,immune response,microbe infection,tumorigenesis,and ***,hypoxia signaling also interacts with other cellular pathways,such as phosphoinositide 3-kinase(pI3K)-mammalian target of rapamycin(mTOR)signaling,nuclear factor kappa-B(NF-κB)pathway,extracellular signal-regulated kinases(ERK)signaling,and endoplasmic reticulum(ER)*** paper systematically reviews the mechanisms of hypoxia signaling activation,the control of HIF signaling,and the function of HIF signaling in human health and *** addition,the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted,which would provide novel strategies for the design and development of therapeutic drugs.

关键词： diseases metabolism drugs