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Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling

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Science China(Life Sciences) 2016年第12期59卷 1290-1296页

作者： di xie Shasha Zhu Li Bai CAS Key Laboratory of lnnate lmmunity and Chronic disease CAS Center for Excellence in Molecular Cell Science School of Life Sciences and Medical Center University of Science and Technology of China Hefei 230027 China Innovation Center for Cell signaling Network Hefei National Laboratory for Physical Sciences at Microscale Hefei 230027 China

Cellular metabolism has been shown to regulate differentiation and function of immune cells. Tumor associated immune cells undergo phenotypic and functional alterations due to the change of cellular metabolism in tumor microenvironments. NKT cells are good candidates for immunotherapies against tumors and have been used in several clinical trials. However, the influences of tumor microenvironments on NKT cell functions remain unclear. In our studies, lactic acid in tumor microenvironments inhibited IFN？ and IL4 productions from NKT cells, and more profound influence on IFN？ was observed. By adjusting the pH of culture medium we fiu-ther showed that, dysfunction of NKT cells could simply be induced by low extracellular pH. Moreover, low extracellular pH inhibited NKT cell functions by inhibiting mammalian target of rapamycin （roTOR） signaling and nuclear translocation of promyelocytic leukemia zinc-finger （PLZF）. Together, our results suggest that tumor acidic microenvironments could interfere with NKT cell functions through metabolic controls.

关键词： lactic acid NKT cell IFNT mTOR PLZF

User-friendly prognostic model for rectal neuroendocrine tumours: In the era of precision management

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World Journal of Gastroenterology 2024年第45期30卷 4850-4854页

作者： si-Hai Chen Chuan xie Department of Gastroenterology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

In this letter,we explore into the potential role of the recent study by Zeng et *** neuroendocrine tumours(rNETs)are rare,originate from peptidergic neurons and neuroendocrine cells,and express corresponding *** most rNETs patients have a favourable prognosis,the median survival period significantly decreases when high-risk factors,such as larger tumours,poorer differentiation,and lymph node metastasis exist,are *** prediction models play a vital role in guiding diagnosis and prognosis in health care,but their complex calculation formulae limit clinical ***,the prognostic models that have been developed for rNETs to date still have several limitations,such as insufficient sample sizes and the lack of external validation.A high-quality prognostic model for rNETs would guide treatment and follow-up,enabling the precise formulation of individual patient treatment and follow-up *** future development of models for rNETs should involve closer collab-oration with statistical experts,which would allow the construction of clinical prediction models to be standardized and robust,accurate,and highly general-izable prediction models to be created,ultimately achieving the goal of precision medicine.

关键词： Rectal neuroendocrine tumours High-risk factors Prognosis Clinical prediction models Precision medicine Statistical collaboration

Local structure engineering for active sites in fuel cell electrocatalysts

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Science China Chemistry 2020年第11期63卷 1543-1556页

作者： Han Cheng Renjie Gui si Liu Yi xie Changzheng Wu Hefei National Laboratory for Physical Science at the Microscale CAS Centre for Excellence in NanoscienceCollaborative Innovation Centre of Chemistry for Energy Materials(iChEM)CAS Key Laboratory of Mechanical Behavior and Design of MaterialsUniversity of Science and Technology of ChinaHefei 230026China Institute of Energy Hefei Comprehensive National Science CenterHefei 230026China

In this review,we surveyed the significance of local structure engineering on electrocatalysts and electrodes for the performance of oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs).Both on precious metal catalysts(PMC)and non-precious metal catalysts(NPMC),the main methods to modulate local structure of active sites have been *** change of atomic coordination,modulation of bonding distortion and synergy effect from hierarchical structure,local structure engineering has influence on the intrinsic activity and stability of ***,we emphasized the intimate correlation between lyophobicity of electrocatalysts and membrane electrodes by local structure *** review aimed to inspire the exploration of advanced electrocatalysts and mechanism study for PEMFCs based on local structure engineering.

关键词： local structure engineering proton exchange membrane fuel cells oxygen reduction reaction active sites

Synthesis, characterization, theoretical investigation, and properties of monoclinic-phase InWO4 hollow nanospheres

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Nano Research 2018年第9期11卷 4664-4672页

作者： Yuping Wang di Wang Ying xie Guofeng Wang Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education School of Chemistry and Materials ScienceHeilongjiang University Harbin 150080 China

As a newly discovered member of the ttmgstate famil3~ InWO4 hollow nanospheres with a monoclinic wolframite structure were synthesized successfully. The crystal phase of InWO4 was investigated via a combination of CASTEP geometric optimization and experimental simulation. InWO, has a space group of P2/c with two InWO, formula units per unit cell. The optimized cell dimensions are a = 5.16 A, b = 5.97 A, and c = 5.23 A, with a = 90°, β= 92.11°, 7 = 90°, giving a unit cell volume of 161.10 A^3, which is consistent with the experimental measurements. More importantly, InWO4 was a promising host material for different Ln^3＋（Ln = Eu and Yb/Er） ions. For InWO4：Yb^3＋/Er^3＋ excited at 980 nm, transitions from the ^4G11/2 （384 nm）, ^2H9/2 （411 nm）, and ^4F7/2 （487 nm） levels to the ground state （^4I15/2） of Er^3＋ were observed. In addition to the aforementioned properties, the InWO4 hollow nanospheres can be used to improve the performance of dye-sensitized solar cells, which is chiefly attributed to their light scattering.

关键词： InWO4 rare earth hollow nanospheres luminescence

Three-dimensional constitutive model for magneto-mechanical deformation of NiMnGa ferromagnetic shape memory alloy single crystals

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Acta Mechanica sinica 2019年第3期35卷 563-588页

作者： Chao Yu Guozheng Kang di Song Xi xie State Key Laboratory of Traction Power Southwest Jiaotong UniversityChengdu 610031China Applied Mechanics and Structure Safety Key Laboratory of sichuan Province School of Mechanics and EngineeringSouthwest Jiaotong UniversityChengdu 610031China School of Mechatronics Engineering University of Electronic Science and Technology of ChinaChengdu 610031China

Existing experimental results have shown that four types of physical mechanisms, namely, martensite transformation, martensite reorientation, magnetic domain wall motion and magnetization vector rotation, can be activated during the magneto-mechanical deformation of NiMnGa ferromagnetic shape memory alloy (FSMA) single crystals. In this work, based on irreversible thermodynamics, a three-dimensional (3D) single crystal constitutive model is constructed by considering the aforementioned four mechanisms simultaneously. Three types of internal variables, i.e., the volume fraction of each martensite variant, the volume fraction of magnetic domain in each variant and the deviation angle between the magnetization vector, and easy axis are introduced to characterize the magneto-mechanical state of the single crystals. The thermodynamic driving force of each mechanism and the thermodynamic constraints on the constitutive model are obtained from Clausius's dissipative inequality and constructed Gibbs free energy. Then, thermodynamically consistent kinetic equations for the four mechanisms are proposed, respectively. Finally, the ability of the proposed model to describe the magneto-mechanical deformation of NiMnGa FSMA single crystals is verified by comparing the predictions with corresponding experimental results. It is shown that the proposed model can quantitatively capture the main experimental phenomena. Further, the proposed model is used to predict the deformations of the single crystals under the non-proportional mechanical loading conditions.

关键词： Ferromagnetic shape memory alloys single crystals Magneto-mechanical deformation Martensite transformation Martensite reorientation Constitutive model

The factorization-assisted topological-amplitude approach and its applications

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Frontiers of physics 2023年第6期18卷 1-14页

作者： Qin Qin Chao Wang di Wang si-Hong Zhou School of Physics Huazhong University of Science and TechnologyWuhan 430074China Faculty of Mathematics and Physics Huaiyin Institute of TechnologyHuaian 223001China Department of Physics Hunan Normal UniversityChangsha 410081China School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China

Heavy meson decays provide an important platform for studies of both QCD and electroweak dynamics,which may contain some portals to understanding of nonperturbative QCD and physics beyond the Standard *** factorization-assisted topological-amplitude approach was proposed to study two-body non-leptonic D meson decays,where a promising QCD inspired approach from first principles is still *** was also applied to B meson decays whose subleading power contributions are difficult to *** factorizing topological amplitudes into short distance Wilson coefficients and long distance hadronic matrix elements either to be calculated or to be parameterized,it provides an effective framework to extract information of nonperturbative dynamics *** important flavor SU(3)breaking effects taken into account,the data of the decay branching ratios(and also CP asymmetries in B decays)can be fitted *** extracted amplitudes were further applied to make predictions for other observables,such as CP asymmetries in D decays,mixing parameters in the *** this review,we will describe the formulation of the factorization-assisted topological-amplitude approach and summarize its applications in D and B meson decays and highlight some of its achievements.

关键词： heavy meson decay factorization-assisted topologicalamplitudeapproach SU(3)breaking

Boundary Control for a Class of Reaction-diffusion Systems

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International Journal of Automation and computing 2018年第1期15卷 94-102页

作者： Yuan-Chao si Cheng-Kang xie Na Zhao School of Mathematics and System Science Southwest University School of Mathematics and System Science Guizhou University

Boundary control for a class of partial integro-differential systems with space and time dependent coefficients is consid- ered. A control law is derived via the partial differential equation （PDE） backstepping. The existence of kernel equations is proved. Exponential stability of the closed-loop system is achieved. simulation results are presented through figures.

关键词： Stability reaction-diffusion system boundary control backstepping partial differential equation.

Semi-analytical Formula for Pricing Bilateral Counterparty Risk of CDS with Correlated Credit Risks

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Acta Mathematicae Applicatae sinica 2018年第2期34卷 209-236页

作者： Feng LIN si-yuan xie Jing-ping YANG LMEQF Department of Financial Mathematics Peking University

Based on the framework of [7], we discuss pricing bilateral counterparty risk of CDS, where each individual default intensity is modeled by a shifted CIR process with jump （3CIR＋＋）, and the correlation between the default times is modeled by a copula function. We present a semi-analytical formula for pricing bilateral counterparty risk of CDS, which is more convenient to compute through calculating multiple numerical integration or using Monte-Carlo simulation without simulating default times. Moreover, we obtain simpler formulae under FGM copulas, Bernstein copulas and CA＇B copulas, which can be applied for speeding up the computation and reducing the pricing error. Numerical results under FGM copulas and CA＇B copulas show that our method performs better both in computation speed and accuracy.

关键词： bilateral counterparty risk CDS JCIR++ copula function semi-analytical formula

Metabolic landscape in cardiac aging:insights into molecular biology and therapeutic implications

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signal Transduction and Targeted Therapy 2023年第4期8卷 1610-1629页

作者： Saiyang xie si-Chi Xu Wei Deng Qizhu Tang Department of Cardiology Renmin Hospital of Wuhan UniversityHubei Key Laboratory of Metabolic and Chronic DiseasesCardiovascular Research Institute of Wuhan UniversityWuhanPR China State Key Laboratory of Complex Severe and Rare diseases Department of CardiologyPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingPR China Department of Cardiology Renmin Hospital of Wuhan UniversityDepartment of CardiologyThe Fifth Affiliated Hospital of Xinjiang Medical UniversityÜrümqiPR China

Cardiac aging is evident by a reduction in function which subsequently contributes to heart *** metabolic microenvironment has been identified as a hallmark of malignancy,but recent studies have shed light on its role in cardiovascular diseases(CVDs).Various metabolic pathways in cardiomyocytes and noncardiomyocytes determine cellular senescence in the aging *** alteration is a common process throughout cardiac ***,the involvement of cellular senescence in cardiac injuries,including heart failure and myocardial ischemia and infarction,has been ***,metabolic complexity among human aging hearts hinders the development of strategies that targets metabolic *** over the past decade have linked cellular senescence and function with their metabolic reprogramming pathway in cardiac aging,including autophagy,oxidative stress,epigenetic modifications,chronic inflammation,and myocyte systolic phenotype *** addition,metabolic status is involved in crucial aspects of myocardial biology,from fibrosis to hypertrophy and chronic ***,further elucidation of the metabolism involvement in cardiac degeneration is still ***,deciphering the mechanisms underlying how metabolic reprogramming impacts cardiac aging is thought to contribute to the novel interventions to protect or even restore cardiac function in aging ***,we summarize emerging concepts about metabolic landscapes of cardiac aging,with specific focuses on why metabolic profile alters during cardiac degeneration and how we could utilize the current knowledge to improve the management of cardiac aging.

关键词： cardiac degeneration involvement