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倍骼生修复牙槽突裂的初步临床观察

上海口腔医学 2004年第5期13卷 465-468页

作者：袁奎封来庆国綦成郭秀会石荣纪徐欣魏奉才山东大学第二医院口腔科山东济南250033 山东大学口腔医院山东济南250012 山东大学齐鲁医院山东济南250012

目的:观察人工骨修复材料-倍骼生治疗牙槽突裂的临床效果。方法:牙槽突裂患者39例,年龄6～12岁,随机分成2组,A组25例,用自体髂骨松质骨行牙槽突裂移植修复;B组14例,应用倍骼生修复牙槽突裂。结果:A、B两组牙槽突裂植骨区X线片均示成骨良... 详细信息

目的:观察人工骨修复材料-倍骼生治疗牙槽突裂的临床效果。方法:牙槽突裂患者39例,年龄6～12岁,随机分成2组,A组25例,用自体髂骨松质骨行牙槽突裂移植修复;B组14例,应用倍骼生修复牙槽突裂。结果:A、B两组牙槽突裂植骨区X线片均示成骨良好,尖牙可在植骨区萌出。经统计学分析,A、B两组牙槽突裂植骨术的临床治疗成功率无显著差别,但不同牙槽突裂类型的临床治疗成功率有显著差别,即完全性牙槽突裂的临床治疗成功率显著低于单纯性牙槽突裂组。结论:新型骨修复生物活性材料倍骼生修复牙槽突裂骨性裂隙区可以成骨,尖牙可在移植区萌出。

关键词：牙槽突裂人工合成材料髂骨倍骼生

Hypertonic saline resuscitation reduces apoptosis of intestinal mucosa in a rat model of hemorrhagic shock

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Journal of zhejiang university-Science B(Biomedicine & Biotechnology) 2008年第11期9卷 879-884页

作者： yuan-qiang LU Wei-dong HUANG xiu-jun CAI Lin-hui GU Han-zhou MOU department of Emergency the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China department of General Surgeon Sir Run Rzm Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Cancer Institute Zhejiang Tumor Hospital Hangzhou 310022 China

Objective: To investigate the early effects of hypertonic and isotonic saline solutions on apoptosis of intestinal mucosa in rats with hemorrhagic shock. Methods: A model of rat with severe hemorrhagic shock was established in 21 Sprague-Dawley (SD) rats. The rats were randomly divided into the sham group, normal saline resuscitation (NS) group, and hypertonic saline resuscitation (HTS) group, with 7 in each group. We detected and compared the apoptosis in small intestinal mucosa of rats after hemorrhagic shock and resuscitation by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL), FITC (fluo- rescein-iso-thiocyanate)-Annexin V/PI (propidium iodide) double staining method, and flow cytometry. Results: In the early stage of hemorrhagic shock and resuscitation, marked apoptosis of small intestinal mucosa in the rats of both NS and HTS groups was observed. The numbers of apoptotic cells in these two groups were significantly greater than that in the sham group (P1). In the HTS group, the apoptic cells significantly decreased, compared with the NS group (P1). Conclusion: In this rat model of severe hemorrhagic shock, the HTS resuscitation of small volume is more effective than the NS resuscitation in reducing apoptosis of intestinal mucosa in rats, which may improve the prognosis of trauma.

关键词： Hemorrhagic shock Resuscitation Sodium chloride solution Hypertonic saline Apoptosis Intestinal mucosa Flowcytometry In situ nick-end labelling

Heavy metal availability and impact on activity of soil microorganisms along a Cu/Zn contamination gradient

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Journal of Environmental Sciences 2007年第7期19卷 848-853页

作者： WANG yuan-peng SHI Ji-yan LIN qi CHEN Xin-cai CHEN Ying-xu department of Chemical and Biochemical Engineering College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China. department of Environmental Science and Technology Zhejiang University Hangzhou 310029 China

All the regulations that define a maximum concentration of metals in the receiving soil are based on total soil metal concentration. However, the potential toxicity of a heavy metal in the soil depends on its speciation and availability. We studied the effects of heavy metal speciation and availability on soil microorganism activities along a Cu/Zn contamination gradient. Microbial biomass and enzyme activity of soil contaminated with both Cu and Zn were investigated. The results showed that microbial biomass was negatively affected by the elevated metal levels. The microbial biomass-C （Cmic）/organic C （Corg） ratio was closely correlated to heavy metal stress. There were negative correlations between soil microbial biomass, phosphatase activity and NH4NO3 extractable heavy metals. The soil microorganism activity could be predicted using empirical models with the availability of Cu and Zn. We observed that 72% of the variation in phosphatase activity could be explained by the NH4NO3-extractable and total heavy metal concentration. By considering different monitoring approaches and different viewpoints, this set of methods applied in this study seemed sensitive to site differences and contributed to a better understanding of the effects of heavy metals on the size and activity of microorganisms in soils. The data presented demonstrate the relationship between heavy metals availability and heavy metal toxicity to soil microorganism along a contamination gradient.

关键词： heavy metals availability speciation activity soil microorganism

Delicate synthesis of quasi-inverse opal structural Na_(3)V_(2)(PO_(4))_(3)/N-C and Na4MnV(PO_(4))_(3)/N-C as cathode for high-rate sodium-ion batteries

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Rare Metals 2022年第5期41卷 1637-1646页

作者： Xin-Ran qi yuan Liu Lin-Lin Ma Bao-xiu Hou Hong-Wei Zhang Xiao-Hui Li Ya-Shi Wang Yi-qing Hui Ruo-Xun Wang Chong-Yang Bai Hao Liu Jian-Jun Song Xiao-Xian Zhao department of Chemistry College of ScienceHebei Agricultural UniversityBaoding 071001China College of Physics Qingdao UniversityQingdao 266071China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneySydney NSW 2007Australia

Poor conductivity and sluggish Na^(+) diffusion kinetic are two major drawbacks for practical application of sodium super-ionic conductor(NASICON) in sodium-ion batteries. In this work, we report a simple approach to synthesize quasi-inverse opal structural NASICON/N-doped carbon for the first time by a delicate one-pot solution-freeze drying-calcination process, aiming at fostering the overall electrochemical performance. Especially, the quasi-inverse opal structural Na_(3)V_(2)(PO_(4))_(3)/N-C(Q-NVP/N-C) displayed continuous pores, which provides interconnected channels for electrolyte permeation and abundant contacting interfaces between electrolyte and materials, resulting in faster kinetics of redox reaction and higher proportion of capacitive *** a cathode material for sodium-ion batteries, the Q-NVP/N-C exhibits high specific capacity of 115 mAh·g^(-1) at 1C, still 61 mAh·g^(-1) at ultra-high current density of 100C,and a specific capacity of 89.7mAh·g^(-1) after 2000 cycles at *** work displays the general validity of preparation method for not only Q-NVP/N-C,but also Na_(3)V_(2)(PO_(4))_(3),which provides a prospect for delicate synthesis of NASICON materials with excellent electrochemical performance.

关键词： Sodium battery Structural regulation Inverse opal structure Sodium super-ionic conductor(NASICON) Na_(3)V_(2)(PO_(4))_(3)

Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3920-3922页

作者： yushang Yang Yanguo Li Haopeng yu Zhenyu Ding Longqi Chen Xiaoxi Zeng Shunmin He qi Liao Yi Zhao Yong yuan department of Thoracic Surgery West China HospitalSichuan UniversityChengduSichuanChina zhejiang Key Laboratory of Pathophysiology Health Science CenterNingbo UniversityNingboZhejiangChina West china Biomedical Big Data Center West China HospitalSichuan UniversityChengduSichuanChina

Dear Editor,Preoperative neoadjuvant therapy combined with surgical resection is the standard treatment for locally advanced esopha-geal squamous cell carcinoma(ESCC).However,more than half of patients having a partial response to neoadjuvant therapy,which is considered as a therapy-resistant phenotype and the mechan-ism is still *** heterogeneity of the ESCC with surgery alone therapy were characterized by single-cell RNA sequencing(scRNA-seq)previously,but few report was about ESCC patients with neoadjuvant therapy.1 It is emergent to illustrate the comprehensive hallmarks of neoadjuvant therapy-resistance in ESCC at single cell level.

关键词： neoadjuvant squamous esophageal

Oxyresveratrol suppresses proliferation and metastasis of hepatocellular carcinoma by inhibiting autophagy in vitro and in vivo

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中国药理学与毒理学杂志 2019年第9期33卷 695-696页

作者： SONG Ying-qi WU Xi-cheng LI Rong JI Zhen-ni MA xiu-ying XIONG Wen-bi ZHANG yuan-yuan ZHOU Li-ming department of Pharmacology West China School of Basic Medical Sciences and Forensic MedicineSichuan UniversityChengdu 610041China Basic Medicine 2015 Undergraduate Students West China School of Basic Medical Sciences and Forensic MedicineSichuan UniversityChengdu 610041China State Key Lab of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China

OBJECTIVE Oxyresveratrol(OXY)has many biological activities including anti-inflammation,anti-oxida⁃tive stress,anti-cancer and ***,the mechanisms underlying its effects against hepatocellular carcinoma(HCC)remain poorly *** Two HCC cell lines,HepG2 and SMMC-7721 cells,were *** proliferation was determined by CCK8 *** migration and invasion of cells were examined by wound healing and transwell *** of HCC was detected by in vivo ***,transcriptome analysis was applied to explore the mechanisms of *** results of transcriptome analysis were validated by in vitro ***⁃more,western blot was used to measure the expression of LC3 and p62 *** OXY significantly inhibited the proliferation,migration and invasion of HCC cells in *** suppressed the metastasis of HCC in Balb/c mice with attenuated side effects compared to *** profiling analysis revealed that OXY may affect autophagy related signaling pathway of HepG2 *** blotting showed that OXY significantly inhibite autophagy by downregulating LC3 and upregulating p62 genes *** Our study demonstrated that OXY inhibits the metastasis of HCC by inhibiting autophagy,which suggested OXY to be a candidate for HCC metastasis.

关键词： oxyresveratrol autophagy metastasis

Laparoscopic surgery for early gallbladder carcinoma:A systematic review and meta-analysis

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World Journal of Clinical Cases 2020年第6期8卷 1074-1086页

作者： Xu Feng Jia-Sheng Cao Ming-yu Chen Bin Zhang Sarun Juengpanich Jia-Hao Hu Win Topatana Shi-Jie Li Ji-Liang Shen Guang-yuan Xiao xiu-Jun Cai Hong yu department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina department of General Surgery Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314000Zhejiang ProvinceChina

BACKGROUND There is a controversy as to whether laparoscopic surgery leads to a poor prognosis compared to the open approach for early gallbladder carcinoma (GBC)We hypothesized that the laparoscopic approach is an alternative for early *** To identify and evaluate the safety and feasibility of laparoscopic surgery in the treatment of early *** A comprehensive search of online databases,including MEDLINE (PubMed),Cochrane libraries,and Web of Science,was performed to identify noncomparative studies reporting the outcomes of laparoscopic surgery and comparative studies involving laparoscopic surgery and open surgery in early GBC from January 2009 to October 2019.A fixed-effects meta-analysis was performed for 1-and 5-year overall survival and postoperative complications,while 3-year overall survival,operation time,blood loss,the number of lymph node dissected,and postoperative hospital stay were analyzed by random-effects *** The review identified 7 comparative studies and 8 non-comparative studies.1068 patients (laparoscopic surgery:613;open surgery:455) were included in the meta-analysis of 1-,3-,and 5-year overall survival with no significant differences observed [(HR=0.54;95%CI:0.29-1.00;12=0.0%;P=0.051),(HR=0.75;95%CI:0.34-1.65;I^2=60.7%;P=0.474),(HR=0.71;95%CI:0.47-1.08;I^2=49.6%;P=0.107),respectively].There were no significant differences in operation time[weighted mean difference (WMD)=18.69;95%CI:-19.98-57.36;I^2=81.4%;P=0.343],intraoperative blood loss (WMD=-169.14;95%CI:-377.86-39.57;I2=89.5%;P=0.112),the number of lymph nodes resected (WMD=0.12;95%CI:-2.95-3.18;I^2=73.4%;P=0.940),and the complication rate (OR=0.69;95%CI:0.30-1.58;I2=0.0%;P=0.377) between the two groups,while patients who underwent laparoscopic surgery had a reduced length of hospital stay (WMD=-5.09;95%CI:-8.74--1.45;I2=91.0%;P=0.006).CONCLUSION This systematic review and meta-analysis confirms that laparoscopic surgery is a safe and feasible alternative to open sur

关键词： Laparoscopic surgery Open surgery Early gallbladder carcinoma Survival Meta-analysis

汽油激光诱导火花点火与电火花点火燃烧过程对比研究（英文）

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Journal of zhejiang university-Science A(Applied Physics & Engineering) 2015年第10期16卷 830-838页

作者： Cang-su XU Dong-hua FANG qi-yuan LUO Jian MA Yang xie Xu ZHENG College of Energy Engineering Zhejiang University

目的:激光诱导火花点火(简称激光点火)是取代传统的靠近缸壁的单点电火花点火以实现稀薄燃烧、提高热效率和改善排放的新型点火方式之一。本文通过对比分析两种点火方式在定容弹中的点火及燃烧过程的压力上升率、最大爆发压力及放热率... 详细信息

目的:激光诱导火花点火(简称激光点火)是取代传统的靠近缸壁的单点电火花点火以实现稀薄燃烧、提高热效率和改善排放的新型点火方式之一。本文通过对比分析两种点火方式在定容弹中的点火及燃烧过程的压力上升率、最大爆发压力及放热率为激光点火技术在内燃机中的应用提供设计过程的参考依据。创新点:1.同时进行两种点火方式的试验,保证对比研究的准确性;2.激光点火采用532 nm和1064 nm波长的两种激光进行对比;3.直接采用汽油进行研究。方法:通过记录不同当量比的汽油空气混合气在定容燃烧弹内激光点火(532 nm和1064 nm波长)及电火花点火的燃烧过程压力变化:1.对比分析三种点火情况的压力上升率和最大爆发压力;2.通过公式计算,对比分析三种点火情况的放热率。结论:1.532 nm与1064 nm波长激光点火的压力上升率和最大爆发压力都在当量比为1.8时出现最大值,其中532 nm波长激光为39.4 MPa/μs和0.68 MPa,1064 nm波长激光为38.8 MPa/μs和0.67 MPa;而电火花点火的压力上升率和最大爆发压力则在当量比为1.6时出现最大值,分别为38.1 MPa/μs和0.67 MPa;2.激光点火的稀燃极限相对电火花点火对应的当量比更小;3.三种点火类型的放热率规律与压力上升率变化规律一致。

关键词：激光点火电火花点火压力上升率最大爆发压力放热率

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室内环境下多孔有机织物水汽输运问题的研究

大学物理 2024年第5期43卷 60-67,85页

作者：周瑞吴思远马启博陈锦渝方爱平田蓬勃冯俊蒋臣威刘丽娜张修兴王小力西安交通大学物理学院陕西西安710049 吕梁学院物理系山西吕梁033001 渭南师范学院物理与电气工程学院陕西渭南714099

为提高本科生借助仿真软件解决实际问题的能力,本文从一个简单的衣物晾晒的问题出发,采用假设-建模-仿真-分析的顺序介绍了针对室内环境下多孔有机织物水汽输运问题的研究模式,可以视为解决输运问题的典型案例.本文以图像的形式给出室... 详细信息

为提高本科生借助仿真软件解决实际问题的能力,本文从一个简单的衣物晾晒的问题出发,采用假设-建模-仿真-分析的顺序介绍了针对室内环境下多孔有机织物水汽输运问题的研究模式,可以视为解决输运问题的典型案例.本文以图像的形式给出室内环境下多孔有机织物温度、相对湿度以及含水量随时间的变化关系,并通过改变初始条件(如通风面积、平均风速和环境温度)进一步探究环境参量对织物水汽输运的影响,对于学习输运过程理论以及提高实际运用能力都有一定的参考价值.

关键词：多孔介质有机织物输运过程仿真模拟