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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing

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Food Science and Human Wellness 2024年第1期13卷 75-89页

作者： xiaofei Wang Xiaowen Cheng Huiling Liu Xiaohuan Mu Hao Zheng National Engineering Technology Research Center for Fruit and Vegetable Processing Key Open Laboratory of Fruit and Vegetable ProcessingMinistry of Agriculture and Rural AffairsBeijing Key Laboratory of Food Non-Thermal ProcessingCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Due to the complex natures of dietary food components,it is difficult to elucidate how the compounds affect host *** food often selectively presents its mechanism of action on different cell types,and participates in the modulation of targeted cells and their microenvironments within ***,the limitations of traditional in vitro assays or in vivo animal experiments cannot comprehensively examine cellular heterogeneity and the tissue-biased ***-cell RNA sequencing(sc RNA-seq)has emerged as an indispensable methodology to decompose tissues into different cell types for the demonstration of transcriptional profiles of individual *** RNA-seq applications has been summarized on three typical organs(brain,liver,kidney),and two representative immune-and tumor related health *** everincreasing role of sc RNA-seq in dietary food research with further improvement can provide sub-cellular information and the coupling between other cellular *** this review,we propose utilizing sc RNAseq to more effectively capture the subtle and complex effects of food chemicals,and how they may lead to health problems at single-cell *** novel technique will be valuable to elucidate the underlying mechanism of both the health benefits of food nutrients and the detrimental consequences food toxicants at the cellular level.

关键词： Dietary food Cellular heterogeneity Single-cell RNA sequencing Food nutrients Food toxicants

Creep damage evolution process of asphalt binder based on viscoelastic characteristics

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 497-506页

作者： xiaofei Qi Shuang Tian Liyan Shan Shuang Liu Yajie Wang School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090China College of Water Conservancy&Architectural Engineering Shihezi UniversityShihezi 832003China

The creep damage evolution of asphalt binder plays a significant role in investigating the formation mechanism of *** rutting is the common distress at high temperatures for asphalt ***,the reliability of existing creep damage parameters is under questioned,and these parameters cannot accurately illustrate the change of intrinsic microstructure for asphalt *** this paper,a new test protocol was given access to study the evolution of viscoelastic parameters during creep *** was completed by inserting the frequency sweep during creep *** frequency sweep curve clusters were fitted by the generalized Kelvin-Voigt model for obtaining the change law of model *** on the change law and sensitivity analysis of model parameters,(E_(2)+E_(3))/2 was proposed as the creep damage *** to the curve of(E_(2)+E_(3))/2 versus loading time,two stages during the creep test could be identified:an approximate constant value in phase I and a linear decrease in phase *** differences about creep property of binders could be determined by this new proposed *** results not only ensure better understanding of the creep damage mechanism of binders,but also lay the theoretical foundation on predicting the anti-rutting performance of binders.

关键词： Asphalt binder Multi-stage creep test Damage variable Evolution law

Peak Shaving Strategy of Concentrating Solar Power Generation Based on Multi-Time-Scale and Considering Demand Response

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Energy Engineering 2024年第3期121卷 661-679页

作者： Lei Fang Haiying Dong xiaofei Zhen Shuaibing Li School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhou730070China

According to the multi-time-scale characteristics of power generation and demand-side response(DR)resources,as well as the improvement of prediction accuracy along with the approaching operating point,a rolling peak shaving optimization model consisting of three different time scales has been *** proposed peak shaving optimization model considers not only the generation resources of two different response speeds but also the two different DR resources and determines each unit combination,generation power,and demand response strategy on different time scales so as to participate in the peaking of the power system by taking full advantage of the fast response characteristics of the concentrating solar power(CSP).At the same time,in order to improve the accuracy of the scheduling results,the combination of the day-ahead peak shaving phase with scenario-based stochastic programming can further reduce the influence of wind power prediction errors on scheduling *** testing results have shown that by optimizing the allocation of scheduling resources in each phase,it can effectively reduce the number of starts and stops of thermal power units and improve the economic efficiency of system *** spinning reserve capacity is reduced,and the effectiveness of the peak shaving strategy is verified.

关键词： Peak shaving strategy concentrating solar power multi-time-scale demand-side response rolling optimization

A Novel Multi-Attribute Decision-Making Method Based on Probabilistic Hesitant Fuzzy Soft Set and Its Application

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Journal of Systems Science and Information 2024年第2期12卷 294-308页

作者： Zhenchun zang Jielu LI Meng WEI College of Computer and Information Engineering Henan University of Economics and LawZhengzhou 450046China

The probabilistic hesitant fuzzy multi-attribute group decision-making method introduces probability and hesitation into decision-making problems at the same time,which can improve the reliability and accuracy of decision-making results,and has become a research hotspots in recent ***,there are still many problems,such as overly complex calculations and difficulty in obtaining probability *** on these,the paper proposes a multi-attribute group decision-making model based on probability hesitant fuzzy soft ***,the definition of probabilistic hesitant fuzzy soft set is ***,based on soft set theory and probabilistic hesitant fuzzy set,the similarity measure of probabilistic hesitant fuzzy soft set is proposed,and the two measures are further ***,it is applied to the construction of multi-attribute group decision-making model,and the effectiveness and rationality of the model are verified by an *** example shows that the new similarity calculation formula and algorithm model in this paper have higher accuracy,and the calculation process is more simple,it provides a feasible method for multi-attribute group decision making problems.

关键词： probabilistic hesitant fuzzy soft sets similarity multi-attribute group decision-making model

Conditional Generative Adversarial Network Enabled Localized Stress Recovery of Periodic Composites

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 957-974页

作者： Chengkan Xu xiaofei Wang Yixuan Li Guannan Wang He Zhang Transportation and Municipal Engineering Institute Powerchina Huadong Engineering CorporationHangzhou310014China College of Civil Engineering and Architecture Zhejiang UniversityHangzhou310058China Anhui Transport Consulting&Design Institute Co. Ltd.Hefei230088China Center for Balance Architecture Zhejiang UniversityHangzhou310058China

Structural damage in heterogeneousmaterials typically originates frommicrostructures where stress concentration ***,evaluating the magnitude and location of localized stress distributions within microstructures under external loading is *** unit cells(RUCs)are commonly used to represent microstructural details and homogenize the effective response of *** work develops a machine learning-based micromechanics tool to accurately predict the stress distributions of extracted *** locally exact homogenization theory efficiently generates the microstructural stresses of RUCs with a wide range of parameters,including volume fraction,fiber/matrix property ratio,fiber shapes,and loading ***,the conditional generative adversarial network(cGAN)is employed and constructed as a surrogate model to establish the statistical correlation between these parameters and the corresponding localized *** stresses predicted by cGAN are validated against the remaining true data not used for training,showing good *** work demonstrates that the cGAN-based micromechanics tool effectively captures the local responses of composite *** can be used for predicting potential crack initiations starting from microstructures and evaluating the effective behavior of periodic composites.

关键词： Periodic composites localized stress recovery conditional generative adversarial network

SEI/dead Li-turning capacity loss for high-performance anode-free solid-state lithium batteries

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Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin Tianyu Li Hongzhang Zhang Guiming Zhong xiaofei Yang Xianfeng Li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and Lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead Li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead Li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical LiPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead Li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active Li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of Li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead Li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in Li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead Li

Pindel-TD:A Tandem Duplication Detector Based on A Pattern Growth Approach

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 99-104页

作者： xiaofei Yang Gaoyang Zheng Peng Jia Songbo Wang Kai Ye School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Center for Mathematical Medical the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Genome Institute the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China MOE Key Lab for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Automation Science and Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Life Science and Technology Xi’an Jiaotong UniversityXi’an 710049China Faculty of Science Leiden UniversityLeiden 2311 EZNetherland

Tandem duplication(TD)is a major type of structural variations(SVs)that plays an important role in novel gene formation and human ***,TDs are often missed or incorrectly classified as insertions by most modern SV detection methods due to the lack of specialized operation on TD-related mutational ***,we developed a TD detection module for the Pindel tool,referred to as Pindel-TD,based on a TD-specific pattern growth ***-TD is capable of detecting TDs with a wide size range at single nucleotide *** simulated and real read data from HG002,we demonstrated that Pindel-TD outperforms other leading methods in terms of precision,recall,F1-score,and ***,by applying Pindel-TD to data generated from the K562 cancer cell line,we identified a TD located at the seventh exon of SAGE1,providing an explanation for its high ***-TD is available for non-commercial use at https://***/xjtu-omics/pindel.

关键词： Tandem duplication Pattern growth Short-read sequencing Structural variation SAGE1

A survey on dynamic graph processing on GPUs: concepts, terminologies and systems

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Frontiers of Computer Science 2024年第4期18卷 1-23页

作者： Hongru GAO xiaofei LIAO Zhiyuan SHAO Kexin LI Jiajie CHEN Hai JIN National Engineering Research Center for Big Data Technology and System/Services Computing Technology and System Lab/Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Zhejiang Lab Hangzhou 311121China

Graphs that are used to model real-world entities with vertices and relationships among entities with edges,have proven to be a powerful tool for describing real-world problems in *** most real-world scenarios,entities and their relationships are subject to constant *** that record such changes are called dynamic *** recent years,the widespread application scenarios of dynamic graphs have stimulated extensive research on dynamic graph processing systems that continuously ingest graph updates and produce up-to-date graph analytics *** the scale of dynamic graphs becomes larger,higher performance requirements are demanded to dynamic graph processing *** the massive parallel processing power and high memory bandwidth,GPUs become mainstream vehicles to accelerate dynamic graph processing ***-based dynamic graph processing systems mainly address two challenges:maintaining the graph data when updates occur(i.e.,graph updating)and producing analytics results in time(i.e.,graph computing).In this paper,we survey GPU-based dynamic graph processing systems and review their methods on addressing both graph updating and graph *** comprehensively discuss existing dynamic graph processing systems on GPUs,we first introduce the terminologies of dynamic graph processing and then develop a taxonomy to describe the methods employed for graph updating and graph *** addition,we discuss the challenges and future research directions of dynamic graph processing on GPUs.

关键词： dynamic graphs graph processing graph algorithms GPUs

Large-scale manufacturing of functional single-atom ink for convenient glucose sensing

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Nano Research 2024年第8期17卷 7256-7263页

作者： Muyu Yan xiaofei Zhu Can Xiong Xiao Han Zhenggang Xue Yuen Wu Department of Endocrinology Institute of Endocrine and Metabolic DiseasesThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Deep Space Exploration Laboratory University of Science and Technology of ChinaHefei 230026China NEST Laboratory Department of PhysicsDepartment of ChemistryCollege of ScienceShanghai UniversityShanghai 200444China Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China

Printing techniques hold great potential in the manufacture of electronics such as sensors,micro-supercapacitors,and flexible ***,developing large-scale functional conductive inks with appropriate rheological properties and active components still remains a ***,through optimizing the formulations of ink,iron single sites supported N-doped carbon black(Fe_(1)-NC)inks can serve as both conductive electrodes and high-reactive catalysts to realize convenient glucose detection,which pronouncedly reduces the dosage of enzyme and simplifies the sensors *** detail,utilizing in-situ pyrolysis method,Fe_(1)-NC single-atom catalysts(SACs)are prepared in bulk(dekagram-level).The batched Fe_(1)-NC SACs materials can be uniformly mixed with modulated ink to realize the screen printing with high resolution and ***,the whole scalable preparation and ink-functional process can be extended to various metals(including Co,Ni,Cu,and Mn).The introduction of highly active Fe_(1)-NC sites reduces the amount of enzyme used in glucose detection by at least 50%,contributing to the cost reduction of *** strategy in harnessing the SACs onto the carbon inks thus provides a broad prospect for the low-cost and large-scale printing of sensitive sensing devices.

关键词： large-scale manufacturing single-atom inks screen printing glucose sensing low enzyme dosage