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Identification of the Regulator of G-Protein Signaling Protein Responsive to Plant Hormones and Abiotic Stresses in Brassica napus

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Journal of Integrative Agriculture 2014年第12期13卷 2634-2644页

作者： CHEN Yun zhu Xia zhu xiao-bin YU Yi-fan GE Hui-min GAO Yong LIANG Jian-sheng College of Bioscience and Biotechnology Yangzhou University

Regulator of G protein signaling proteins （RGS） accelerate the rate of GTP hydrolysis by Gαproteins, thus acting as negative regulators of G-protein signaling. Studies on Arabidopsis and soybean have proven that RGS proteins are physiologically important in plants and contribute to the signaling pathways regulated by different stimuli. Brassica napus is an important agriculturally relevant plant, the wildly planted oilseed rape in the world, which possesses an identiifed Gα, Gβand Gγsubunits. In the present study, we identiifed and characterized a Brassica napus RGS gene, BnRGS1, which contained an open reading frame of 1 380 bp encoding a putative 52.6 kDa polypeptide of 459 amino acids, within seven putative transmembrane domains in the N-terminal and RGS box in the C-terminal. BnRGS1 is located on the membrane in onion epidermal cells and tobacco leaves, and interacts with BnGA1 in the mating-based split-ubiquitin system. The expression levels of BnRGS1 were quite different in different tissues and developmental stages, and induced by abscisic acid （ABA） and indole-3-acetic acid （IAA）. The effects of gibberellin （GA3） and brassinolide （BR） on the expression of BnRGS1 were irregular under the concentrations tested. Moreover, the transcript level of BnRGS1 was also induced by polyethylene glycol （PEG）, whereas remained little changed by 200 mmol L-1 NaCl. These results suggested that the BnRGS1 may be involved in B. napus response to plant hormone signaling and abiotic stresses.

关键词： BnRGS1 expression plant hormone abiotic stress

Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores

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Neural Regeneration Research 2018年第1期13卷 69-76页

作者： Chan-chan Li xiao-zhu Hao Jia-qi Tian Zhen-wei Yao xiao-yuan Feng Yan-mei Yang Department of Radiology Huashan Hospital Fudan University

Fluid-attenuated inversion recovery （FLAIR） vascular hyperintensity （FVH） is used to assess leptomeningeal collateral circulation, but clinical outcomes of patients with FVH can be very different. The aim of the present study was to assess a FVH score and explore its relationship with clinical outcomes. Patients with acute ischemic stroke due to middle cerebral artery M1 occlusion underwent magnetic resonance imaging and were followed up at 10 days （National Institutes of Health Stroke Scale） and 90 days （modified Rankin Scale） to determine short-term clinical outcomes. Effective collateral circulation indirectly improved recovery of neurological function and short-term clinical outcome by extending the size of the pial penumbra and reducing infarct lesions. FVH score showed no correlation with 90-day functional clinical outcome and was not sufficient as an independent predictor of short-term clinical outcome.

关键词： nerve regeneration National Institutes of Health Stroke Scale middle cerebral artery occlusion collateral circulation modified Rankin Scale score cerebral ischemia acute stroke diffusion-weighted imaging fluid-attenuated inversion recovery neural regeneration

Development of a Compact Photoacoustic Tomography Imaging System with Dual Single-Element Transducers for Image Enhancement

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Current Medical Science 2021年第6期41卷 1151-1157页

作者： Yong-jian ZHAO xiao-long zhu Pei-yu LUO Ang LI Wei xiao xiao xiao Li LIU Max Q.-H.MENG Department of Electronic and Electrical Engineering the Southern University of Science and TechnologyShenzhen 518055China Department of Electronic Engineering The Chinese University of Hong KongHong Kong 999077China Shenzhen Research Institute of The Chinese University of Hong Kong in Shenzhen Shenzhen 518172China

Objective:This paper proposes a new photoacoustic computed tomography(PACT)imaging system employing dual ultrasonic transducers with different *** imaging complex biological tissues,photoacoustic(PA)signals with multiple frequencies are produced simultaneously;however,due to the limited bandwidth of a single-frequency transducer,the received PA signals with specific frequencies may be missing,leading to a low imaging ***:In contrast to our previous work,the proposed system has a compact volume as well as specific selection of the detection center frequency of the transducer,which can provide a comprehensive range for the detection of PA *** this study,a series of numerical simulation and phantom experiments were performed to validate the efficacy of the developed PACT ***:The images generated by our system combined the advantages of both high resolution and ideal brightness/***:The interchangeability of transducers with different frequencies provides potential for clinical deployment under the circumstance where a single frequency transducer cannot perform well.

关键词： photoacoustic tomography dual transducers image enhancement signal responding range

Ferruginol alleviates inflammation in dextran sulfate sodium-induced colitis in mice through inhibiting COX-2, MMP-9 and NF-κB signaling

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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 308-315页

作者： xiao-Yan zhu Chun-Ling Zhang Yukiat Lin Min-Yan Dang Department of Gastroenterology Jinan Central Hospital Affiliated to Shandong UniversityJinan250013Shandong ProvinceChina Department of Emergency Taian City Central HospitalTaian271000Shandong ProvinceChina Innoscience Research Sdn Bhd Subang Jaya47650SelangorMalaysia

Objective:To assess the anti-inflammatory efficacy of ferruginol on dextran sulfate sodium(DSS)stimulated ulcerative colitis ***:Ulcerative colitis was induced in C57 BL/6 J mice by administering 2%of DSS through drinking water for 7 *** mice in the treatment group were treated with DAA+50 mg/kg/day ferruginol *** the positive control group,sulfasalazine(50 mg/kg/day)was used alongside with *** induction,the bodyweight,character of stool and feces occult blood were recorded daily,the disease activity index was calculated,and the colon length,colon weight,and spleen weight were *** myeloperoxidase activity was assayed by ***(IL)-6,IL-1β,and tumor necrosis factor-αwere determined by ELISA method,and nuclear factor-κB,cyclooxygenase-2,matrix metalloproteinases-9,and inducible nitric oxide synthase by Western blotting ***:Ferruginol significantly increased the bodyweight,colon weight,colon length,and decreased disease activity index and spleen *** exhibited anti-inflammatory activity against DSS induced ulcerative colitis in mice by reducing the activities of myeloperoxidase,tumor necrosis factor-α,nuclear factor-κB,IL-1β,cyclooxygenase-2,matrix metalloproteinases-9,IL-6,and inducible nitric oxide ***:Ferruginol could be used to treat ulcerative colitis by attenuating the inflammation in colon cells and maintaining colonic mucosal barrier integrity.

关键词： Ferruginol Dextran sulfate sodium Inflammation Sulfasalazine Ucerative colitis

AtHAP5A regulates iron translocation in iron-deficient Arabidopsis thaliana

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Journal of Integrative Plant Biology 2020年第12期62卷 1910-1924页

作者： xiao Fang zhu Qi Wu Yu Ting Meng Ye Tao Ren Fang Shen State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing210008China University of Chinese Academy of Sciences Beijing100049China

Iron(Fe)deficient plants employ multiple strategies to increase root uptake and root-to-shoot translocation of *** identification of genes that are responsible for these processes,and a comprehensive understanding of the regulatory effects of transcriptional networks on their expression,including transcription factors(TFs),is underway in Arabidopsis ***,we show that a Histone-or heme-associated proteins(HAP)transcription factor(TF),HAP5A,is necessary for the response to Fe deficiency in *** ex-pression was induced under Fe deficiency,and the lack of HAP5A significantly decreased Fe translocation from the root to the shoot,resulting in substantial chlorosis of the newly expanded leaves,compared with the wild-type(WT,Col-0).Further analysis found that the expression of a gene encoding nicotianamine(NA)synthase(NAS1)was dramatically decreased in the hap5a mutant,regardless of the Fe ***-one-hybrid and ChIP analyses suggested that HAP5A directly binds to the promoter region of ***,overexpression of NAS1 could rescue the chlorosis phenotype of hap5a in Fe deficient *** summary,a novel pathway was elucidated,showing that NAS1-dependent translocation of Fe from the root to the shoot is controlled by HAP5A in Fe-deficient Arabidopsis thaliana.

关键词： Arabidopsis translocation expanded

Synthesis and Fluorescent and Magnetic Properties of a New Europium Complex Eu(C_(20)H_(14)O_(3)N)_(3)(2,2’-bipy)(H_(2)O)·H_(2)O

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Chinese Journal of Structural Chemistry 2021年第4期40卷 507-511,408页

作者： YANG Ying-Qun KUANG Yun-Fei zhu xiao-Ming Key Laboratory of Functional Metal-organic Compounds of Hunan Province&Key Laboratory of Functional Organometallic Materials of Hunan Province College Hengyang 421008China Department of Chemistry and Materials Science Hengyang Normal UniversityHengyang 421008China

A new europium(Ⅲ)complex Eu(C_(20)H_(14)O_(3)N)_(3)(2,2'-bipy)(H2O)·H2O has been synthesized with2-diphenylanine carbonyl benzoic acid and 2,2'-bipyridine as *** data for the complex are as follows:triclinic,space group Pi,a=11.3334(5),b=16.0883(7),c=17.0116(8)A,α=70.411(4)o,β=82.435(4)o,γ=85.095(4)o,V=2894.0(2)A^(3),Dc=1.484 g/cm^(3),Z=2,μ=1.15 mm^(-1),F(000)=1320 and the final R=0.0447 and w R=*** Eu(Ⅲ)ion is coordinated by nine atoms to give a monocapped square antiprism coordination *** complex shows two intense fluorescence emission bands arising from the transitions of Eu^(3+):^(5)D0→^(7)F_(1)(592 nm)and ^(5)D_(0)→^(7)F_(2)(616 nm),*** reported is the magnetic property of the *** complex exhibits antiferromagnetism in the temperature range of 300~2 K.

关键词： europium(Ⅲ)complex crystal structure fluorescent and magnetic properties

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Parallel optimization of underwater acoustic models:A survey

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Chinese Physics B 2022年第10期31卷 189-207页

作者： Zi-jie zhu Shu-qing Ma xiao-Qian zhu Qiang Lan Sheng-Chun Piao Yu-Sheng Cheng College of Computer Science and Technology National University of Defense TechnologyChangsha 410073China College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Acoustic Science and Technology Laboratory Harbin Engineering UniversityHarbin 150001China Underwater Acoustics Center Navy Submarine AcademyQingdao 266000China

Underwater acoustic models are effective tools for simulating underwater sound *** than 50 years of research have been conducted on the theory and computational models of sound propagation in the ***,underwater sound propagation models were unable to solve practical large-scale three-dimensional problems for many years due to limited computing power and hardware *** the mid-1980s,research on high performance computing for acoustic propagation models in the field of underwater acoustics has flourished with the emergence of high-performance computing platforms,enabling underwater acoustic propagation models to solve many practical application problems that could not be solved *** this paper,the contributions of research on high-performance computing for underwater acoustic propagation models since the 1980s are thoroughly reviewed and the possible development directions for the future are outlined.

关键词： underwater acoustic models underwater sound propagation high-performance computing modeling three-dimensional problems

Electric-field-controlled magnetism due to field-induced transition of Pna2_(1)/R3c in Bi_(1-x)Gd_(x)FeO_(3) ceramics

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Journal of Materiomics 2021年第5期7卷 967-975页

作者： Jing Chen Nan Su xiao Li zhu xiao Qiang Liu Jin-Xing Zhang Xiang Ming Chen Laboratory of Dielectric Materials School of Materials Science and EngineeringZhejiang UniversityNo.38 Zheda RoadHangzhou310027China Department of Physics Beijing Normal UniversityNo.19 Xinjiekouwai StBeijing100875China

BiFeO_(3) has been recognized as one of the most important room-temperature single-phase multiferroic materials,but it still suffers from several drawbacks especially the weak magnetoelectric *** the present work,the electric-field-controlled magnetism is achieved in Bi_(1-x)Gd_(x)FeO_(3) system,which involves a field-induced transition of Pna2_(1)/R3c at the morphotropic phase boundary region,and the magnetic state is switched between cycloidal state and canted antiferromagnetic *** electric-field-controlled magnetism becomes reversible with the help of annealing,which is confirmed by magnetic hysteresis loops and the quantitative ratio of the involved phases for the as-sintered,as-poled and as-annealed *** with the systems of Bi_(1-x)Nd_(x)FeO_(3) and Bi_(1-x)Sm_(x)FeO_(3),it is easier to tune the symmetry from R3c to Pna21 with lower rare earth-content,and the field-induced transition is more apparent and subsequently leads to more significant electric-field-controlled magnetism in a wider composition range.

关键词： Bi_(1-x)Gd_(x)FeO_(3) Morphotropic phase boundary Magnetic properties Electric-field-controlled magnetism

Shenkang Ⅶ Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway

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Current Medical Science 2020年第5期40卷 917-930页

作者： Shan-shan ZHOU Zhong-zhu AI Wei-nan LI Liang LI xiao-yun zhu Yuan-ming BA Hubei University of Chinese Medicine Wuhan 430065China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061China Hubei Provincial Academy of Traditional Chinese Medicine Wuhan 430061China

This study aimed to explore the protective effects of the traditional Chinese Medicine formula Shenkang Ⅶ recipe(SK-7)on renal fibrosis and the *** fibrosis was induced by unilateral ureteral obstruction(UUO)in *** rats were then divided into 5 groups:control group(Sham operation),UUO model group,UUO model plus low to high doses of SK-7(0.5,1.0,or 2.0 g/kg/day,for 14 days)*** animals were sacrificed on the 7th or 14th day.K idney tissues were collected for histopathological exarminations(hematoxylin and cosin and Masson's trichrome staining).Immunohistochemistry was used to detect the expression of collagen type II(Col II),fibronectin(FN),α-smooth muscle actin(a-SMA),TIMP metallopeptidase inhibitor 2(TIMP2),matrix metallopeptidase 2(MMP2),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and monocyte chemotactic protein-1(MCP-1).The TGF-β1/Smad,NF-κB and Sonic hedgehog signaling proteins were detected by Western *** results showed that SK-7 prevented UUO-induced renal injury and accumulation of collagen *** fbrosis biomarkers Col Ⅲ,FN,α-SMA and TMP2 were increased in the rats after UUO and decreased by SK-7,while MMP2 was upregulated after ***-7 also suppressed the levels of TNF-α,IL-1βand MCP-1 in UUO *** addition,SK-7 inhibited activation of the TGF-B/Smad,NF-κB and sonic hedgehog signaling(SHH)*** together,these findings suggest that SK-7 may regulate the synthesis and degradation of extracellular matrix,reduce inflammation and suppress the proliferation of fibroblasts,by blocking the TGF-β1/Smad,NF-κB and SHH signaling pathways to exert its anti-renal fbrosis effect in UUO rats.

关键词： ShenkangⅦrecipe(SK-7) chronic kidney disease renal fibrosis signaling pathway