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An experimental study of using Chai Lai Prescription to treat in vitro rabbit models of reflux esophagitis

Chinese Medical Journal 2013年第23期126卷 4557-4561页

作者： WANG xiao-hua wen Hao YOU Si-hong XU xiao-fei wen Wei Digestive Medical Center Second Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210011 China

Background Chai Lai Prescription is a Chinese herbal compound which is used to sooth the liver,strengthen the spleen and harmonize the stomach for descending adverse *** initiated the study to investigate its mechanism of treating in vitro rabbit reflux esophagitis *** Adult male Japanese white rabbits,weighing 1.8-2.2 kg,were divided into five groups of three each,which were：normal control group （Krebs buffer,pH7.4）,esophagitis model group （Krebs buffer,pH5.8）,esophagitis model proup＋low-dose Chinese herbal medicine protection group （0.6 mg·ml1·kg1）,esophagitis model group＋moderate-dose Chinese herbal medicine protection group （6 mg·ml1·kg1）,esophagitis model group＋high-dose Chinese herbal medicine protection group （60 mg·ml1·kg1）.The RT-PCR method was used to test the influence of Chai Lai Prescription on IL-1 and IL-6 in in vitro rabbit models of *** treated the in vitro models with different doses of Chinese herbal *** Esophageal mucosa were filled with various ***-6 and IL-1β mRNA expression was increased in rabbit esophageal mucosa stimulated with *** herbal medicine significantly reduced the levels of IL-6 and IL-1β mRNA expression in the in vitro cultured rabbit esophageal *** Chinese herbal medicine to treat in vitro models of RE,we found that the IL-6 and IL-1β mRNA expression levels went down,near to or lower than the normal control levels,compared with the group treated with acidified buffer *** Chai Lai Prescription lowered the IL-1β and IL-6 cytokine mRNA levels and protected the esophageal mucosa in the in vitro models of reflux esophagitis,suggesting that the traditional Chinese herbal compound may be able to treat reflux esophagitis by inhibiting the its inflammatory mediators.

关键词： chai lai prescription reflux esophagitis model

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Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations

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Chinese Medical Journal 2012年第5期125卷 874-881页

作者： HAN Jing ZHANG Tian-ou xiao wen-hua CHANG Cui-qing AI hua Department of Nutrition and Biochemistry Institute of SportsMedicine Peking University Third HospitalBeijing 100191 China Department ofEndocrinology Peking University Third HospitalBeijing 100191 China

Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation.

关键词： thyroid dysfunction adipocytokines thyroid hormone 3T3-L1 cells

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Reversal of multidrug resistance in renal cell carcinoma by short hairpin RNA targeting MDR1 gene

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Chinese Medical Journal 2012年第15期125卷 2741-2745页

作者： HAO Yi-xin HE Zheng-wen ZHU Jian-hua SHEN Qian SUN Jun-zhong DU Nan xiao wen-hua Department of Oncology First Affiliated Hospital of the People'sLiberation Army General Hospital Beijing 100048 China Department of Laboratory Diagnosis Claanghai Hospital SecondMilitary Medical University Shanghai 200433 China

Background Over-expression of P-glycoprotein （P-gp）, encoded by the MDR1 gene, confers multidrug resistance （MDR） in renal cell carcinoma （RCC） and is a major reason for unsuccessful chemotherapy. This study aimed to determine the effct of RNA interference （RNAi） on the reversal of MDR in human RCC. Methods We designed and selected one short hairpin RNA （shRNA） targeting MDR1 gene, which is stably expressed from integrated plasmid and transfected by lentivirus fluid in human RCC A498 cell. Results The MDRl-targeted RNAi resulted in decreased MDR1 gene mRNA level （P 〈0.001）, almost abolished P-gp expression and reversed MDR to different chemotherapy drugs in the RCC A498 cell line. Conclusion MDR could be reversed by RNAi in human RCC A498 cell line, which may be used for clinical application

关键词： multidrug resistance, P-glycoprotein short hairpin RNA renal cell carcinoma

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Reinvestigation on the Reaction of Salicylic Chloride with Salicylic Amide and X-ray Crystal Structure of a New Macrocyclic Polyester

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Chinese Journal of Structural Chemistry 2003年第5期22卷 512-516页

作者： DU Da-Ming② CHEN xiao hua wen-Ting JIN Xiang-Lin (Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China) College of Chemistry and Molecular Engineering Peking University Key Laboratory of Bioorganic Chemistry and Molecular Engineering Ministry of Education 北京 100871

The reaction of salicylic chloride and salicylic amide at 170 ℃ gave benzoxazine and a new macrocyclic polyester 3, whose crystal structure has been determined by single-crystal X-ray diffraction analysis. Compound 3: C28H16O8, Mr = 480.41, monoclinic, space group P21/n, a = 15.353(3), b = 14.196(3), c = 21.147(4) ? b = 103.32(3), V = 4485(2) ?, Z = 8, F(000) = 1984, Dc = 1.423 g/cm3 and m = 0.106 mm-1. The final R = 0.0535 and wR = 0.1275 for 7903 observed reflections (I ≥ 2(I)). In the asymmetric unit of the compound there exist two independent molecules which are connected by weak aromatic CH…O hydrogen bonding between C(47)?H(47) and atom O(7) of the carbonyl group.

关键词： salicylic chloride salicylic amide polyester macrocycle crystal structure

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Synthesis and Structure of a Mixed Phosphine- Thiolato Polymer with a Linear Chain Network [Ag_2(μ_2-dppe)_3 (S-mbo)_2]_n·2nDMF [dppe = 1,2-Bis (diphenylphosphino) ethane, Hmbo = 2-Mercaptobenzoxazole]

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Chemical Research in Chinese Universities 2000年第4期16卷 375-377页

作者： DENG Liang-rong, WANG Xiu-jian, xiao wen, ZHANG hua-xin, SU Cheng-yong and KANG Bei-sheng (School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275, P. R. China) 中山大学广东广州中山大学广东广州 510275

Diphosphino organochalcogenide metal complexes have been investigated presently for their possible use as anti-cancer agents. This article discusses the X-ray crystal structure of a self-assembled coordination polymer [Ag2 (μ2-dppe)3(S-mbo)2]n·2nDMF (dppe=1,2-bis(diphenylphosphino)ethane, Hmbo-2-mercaptobenzoxazole, DMF=dimethyl formamide).

关键词： Self-assembly Silver complex Mixed phosphine-thiolato complex Coordination polymer

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悬浮体进样-基体改进效应石墨炉原子吸收光谱法直接测定土壤中的铅和镉

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光谱学与光谱分析 2006年第5期26卷 950-954页

作者：孙汉文温晓华梁淑轩河北大学化学与环境科学学院

建立了以悬浮体进样-基体改进效应石墨炉原子吸收法测定污灌区土壤中痕量铅和镉的新方法.以琼脂为悬浮剂、NH4H2PO4作基体改进剂,研究了土壤悬浮液的稳定性和基体改进效应及干扰效应.基于原子化峰值时间的对数值与原子化温度之间的线性... 详细信息

建立了以悬浮体进样-基体改进效应石墨炉原子吸收法测定污灌区土壤中痕量铅和镉的新方法.以琼脂为悬浮剂、NH4H2PO4作基体改进剂,研究了土壤悬浮液的稳定性和基体改进效应及干扰效应.基于原子化峰值时间的对数值与原子化温度之间的线性关系测得Cd和Pb的表观活化能,探讨了基体改进效应机理.应用标准曲线进行校准,Pb和Cd的检出限分别为9.05×10^-10g·mL^-1和1.76×10g·mL^-1-11g·mL^-1,Pb和Cd的回收率分别为91%～97%和93%～109%,相对标准偏差为4.2%～7.8%.以土壤标准品作参照,测得值与标准值相符.

关键词：石墨炉原子吸收悬浮进样基体改进表观活化能土壤铅镉

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Evaluation of Family Sex Education on Middle School Students in Shanghai

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Journal of Reproduction and Contraception 2006年第4期17卷 260-269页

作者： Xia-yun ZUO xiao-wen TU Chao-hua LOU Er-sheng GAO Shanghai Institute of Planned Parenthood Research Shanghai 200032 China

Objective To evaluate the impact of family-school combined sex education among middle school students. Methods This is a school-based intervention study. Four junior middle schools and two senior middle schools in Xuhui District, Shanghai, were selected as study sites involving parents, two junior middle schools and one senior middle school as the intervention group and others as control group. The intervention group was provided with both school and family education which contained giving lectures, distributing leaflets, organizing group discussions and parent-adolescent communicating activities to parents. Data were collected through anonymous and self-administered questionnaires before and after one-year intervention to evaluate the effect of the intervention. Results The average score of parents in the intervention group was higher than that in the control group after intervention. Particularly, the mean score of AIDS knowledge in the intervention group was increased by 10.5, which was more than that of control group （5.3）. The intervention increased the parents＇ intention to family sex education. The percentage of parents in the intervention group approving ＂sex education should be provided by parents＂ had increased, much higher than that in the control group. Intervention also promoted parent-adolescent communication about sex. The percentage of parents reporting ＂they actively talked with their children about sex or their teens asked them questions related to sex＂ had increased, much higher than that in the control group. Conclusion Family-school combined sex education significantly increased sexual knowledge and sex education intention of parents, promoted the parent-adolescent communication about sex as well.

关键词： family sex education middle school students parent intervention

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Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： ZHENG Weilin WANG Qijiao xiao huahua CHEN xiaoxiao XIE Fan ZENG wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

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基于DoDAF的装备体系任务建模与仿真

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系统工程与电子技术 2012年第9期34卷 1846-1851页

作者：潘星尹宝石温晓华北京航空航天大学可靠性与系统工程学院北京100191

装备体系任务建模与仿真是对装备体系进行模型验证和分析的基础。以四元组(目标,装备,活动,关系)为基础,建立了装备体系任务的描述模型,并基于美国国防部体系结构框架(Department of Defense Archi-tecture Framework,DoDAF),提出了基... 详细信息

装备体系任务建模与仿真是对装备体系进行模型验证和分析的基础。以四元组(目标,装备,活动,关系)为基础,建立了装备体系任务的描述模型,并基于美国国防部体系结构框架(Department of Defense Archi-tecture Framework,DoDAF),提出了基于活动建模的装备体系任务静态模型建模方法和采用IDEF3语言来建立装备体系任务仿真模型的方法以及其具体建模步骤。最后以航母体系的典型任务为例,对上述建模与仿真方法进行应用,证明了所提方法的有效性。

关键词：装备体系任务模型建模与仿真

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5-脱氧杂氮胞苷诱导肝癌细胞株p16基因高表达

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第三军医大学学报 2000年第11期22卷 1033-1035页

作者：刘丽华肖文华刘为纹第三军医大学附属西南医院肿瘤科重庆400038 第三军医大学附属西南医院消化内科重庆400038

目的　研究 5 脱氧杂氮胞苷对肝癌细胞株p16基因表达的影响及其机制。方法　肝癌细胞株SMMC 72 2 1、HePG2 用 5 脱氧杂氮胞苷处理 ,处理前后采用RT PCR和免疫组织化学染色法观察和分析其mRNA和蛋白表达变化。结果　经 5 脱氧杂氮胞... 详细信息

目的　研究 5 脱氧杂氮胞苷对肝癌细胞株p16基因表达的影响及其机制。方法　肝癌细胞株SMMC 72 2 1、HePG2 用 5 脱氧杂氮胞苷处理 ,处理前后采用RT PCR和免疫组织化学染色法观察和分析其mRNA和蛋白表达变化。结果　经 5 脱氧杂氮胞苷处理的肝癌细胞株mRNA和蛋白表达均明显增强。结论　 5 脱氧杂氮胞苷可使p16基因在转录水平和翻译水平表达增高。

关键词：肝癌细胞株 p16基因甲基化 5-脱氧杂氮胞苷

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