Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations

作     者：HAN Jing ZHANG Tian-ou XIAO Wen-hua CHANG Cui-qing AI Hua 

作者机构：Department of Nutrition and Biochemistry Institute of SportsMedicine Peking University Third HospitalBeijing 100191 China Department ofEndocrinology Peking University Third HospitalBeijing 100191 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第5期

页      面：874-881页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 071010[理学-生物化学与分子生物学] 100705[医学-微生物与生化药学] 1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 10[医学] 

基　　金：This study was partially supported by grants from the National Natural Science Foundation of China (No. 30270636 and 30671015) 

主　　题：thyroid dysfunction adipocytokines thyroid hormone 3T3-L1 cells 

摘      要：Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation.