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A Case Study of the Impacts of Dust Aerosols on Surface Atmospheric Variables and Energy Budgets in a Semi-Arid Region of China

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Atmospheric and Oceanic Science Letters 2010年第3期3卷 145-150页

作者： ling xiao-lu Guo Wei-Dong Zhang Lei Zhang Ren-Jian Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric Sciences Lanzhou University Lanzhou 730000 China Key Laboratory of Regional Climate-Environment for East Asia Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Insititute for Climate and Global Change Research University School of Atmospheric Sciences Nanjing University Nanjing 210093 China

The authors present a case study investigating the impacts of dust aerosols on surface atmospheric variables and energy budgets in a semi-arid region of China. Enhanced observational meteorological data, radiative fluxes, near-surface heat fluxes, and concentrations of dust aerosols were collected from Tongyu station, one of the reference sites of the International Coordinated Energy and Water Cycle Observations Project (CEOP), during a typical dust storm event in June 2006. A comprehensive analysis of these data show that in this semi-arid area, higher wind velocities and a continuously reduced air pressure were identified during the dust storm period. Dust storm events are usually associated with low relative humidity weather conditions, which result in low latent heat flux values. Dust aerosols suspended in the air decrease the net radiation, mainly by reducing the direct solar radiation reaching the land surface. This reduction in net radiation results in a decrease in soil temperatures at a depth of 2 cm. The combination of increased air temperature and decreased soil temperature strengthens the energy exchange of the atmosphere-earth system, increasing the surface sensible heat flux. After the dust storm event, the atmosphere was dominated by higher pressures and was relatively wet and cold. Net radiation and latent heat flux show an evident increase, while the surface sensible heat flux shows a clear decrease.

关键词： case study dust aerosol energy budget semiarid region

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A Case Study of a Typical Dust Storm Event over the Loess Plateau of Northwest China

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Atmospheric and Oceanic Science Letters 2011年第6期4卷 344-348页

作者： ling xiao-lu GUO Wei-Dong ZHAO Qian-Fei ZHANG Bei-Dou Institute for Climate and Global Change Research School of Atmospheric Sciences Nanjing University Nanjing 210093 China Key Laboratory of Regional Climate-Environment for East Asia Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric Seiences Lanzhou University Lanzhou 730000. China

Enhanced observational meteorological elements,energy fluxes,and the concentration of dust aerosols collected from the Semi-Arid Climate Observatory and Laboratory(SACOL) during a typical dust storm period in March 2010 at Lanzhou were used in this paper to investigate the impact of dust aerosols on near surface atmospheric variables and energy *** results show that the entire dust storm event was associated with high wind velocities and decreasing air pressure,and the air changed from cold and wet to warm and dry and then recovered to its initial *** response of energy fluxes occurred behind meteorological *** high dust concentration periods,the net radiation was significantly less in the daytime and higher at night,while the heat fluxes displayed the same trend,indicating the weakening of the land-atmosphere energy *** results can be used to provide verification for numerical model results in semi-arid areas.

关键词： case study dust storm energy budget Loess Plateau

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Cloning of fatty acid elongase1 gene and molecular identification of A and C genome in Brassica species

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Science China(Life Sciences) 2007年第3期50卷 343-349页

作者： WU YuHua, xiao ling, WU Gang & lu ChangMing Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China 1. Oil Crops Research Institute Chinese Academy of Agricultural Sciences Wuhan 430062 China

The fatty acid elongase 1 (FAE1) genes of Brassic napus were cloned from two cultivars, i.e. Zhong- shuan No. 9 with low erucic acid content, and Zhongyou 821 with high erucic acid content, using the degenerate PCR primers. The sequence analysis showed that there was no intron within the FAE1 genes. The FAE1 genes from Zhongyou 821 contained a coding sequence of 1521 nucleotides, and those cloned from Zhongshuan No. 9 contained a 1517 bp coding sequence. Alignment of the FAE1 sequences from Brassica rapa, B. oleracea and B. napus detected 31 single nucleotide polymorphic sites (2.03%), which resulted in 7 amino-acid substitutions. Further analysis indicated that 19 SNPs were genome-specific, of which, 95% were synonymous mutations. The nucleotide substitution at po- sition 1217 in the FAE1 genes led to a specific site of restricted cleavage. An AvrII cleavage site was present only in the C genome genes and absent in the A genome FAE1 genes. Digestion profile of the FAE1 sequences from B. rapa, B. oleracea and B. napus produced with AvrII confirmed that the FAE1 genes of B. oleracea origin was recognized and digested, while that of B. rapa origin could not. The results indicated that by AvrII cleavage it was possible to distinguish B. rapa from B. oleracea and be- tween the A and C genome of B. napus. In addition, the FAE1 genes could be used as marker genes to detect the pollen flow of B. napus, thus providing an alternative method for risk assessment of gene flow.

关键词： FAE acid Cloning of fatty acid elongase1 gene and molecular identification of A and C genome in Brassica species gene

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Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4444-4447页

作者： xiao-mei Yang Xuan-dong Lin Wei Shi Shen-xia Xie Xia-ning Huang Shi-hua Yin xiao-bing Jiang Bruce D.Hammock Zhi Ping Xu xiao-ling lu Guangxi Key Laboratory of Nanobody Research Guangxi Nanobody Engineering Research CenterCollege of StomatologyHospital of StomatologyLaboratory Animal CenterSchool of Basic Medical SciencePharmaceutical CollegeGuangxi Medical UniversityNanning CityGuangxi 530021P.R.China Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan CityHubei 430022P.R.China Department of Entomology and Nematology UCD Comprehensive Cancer CenterUniversity of CaliforniaDavisCA 95616USA Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia Institute of Biomedical Health Technology and Engineering and Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518107P.R.China

A novel bispecific T-cell engager(BiTE)has been developed as an efficient immunotherapeutic molecule specifically bringing the T-cell and the tumor target together for enhanced *** general BiTE construct consists of two single-chain variable antibody fragments(scFvs)targeting a tumor-associated antigen(TAA)and a T-cell marker in *** binding of BiTEs to tumor antigens induces immediate T-cells’cytotoxicity against tumor cells without involving any typical costimulatory signals,specific TCR and MHC recognition.

关键词： immunotherapy tumor cytotoxicity

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia Zeng Donglin Gan Kun ling Mingfang He Jianshu Li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Targeting of AUF1 to vascular endothelial cells as a novel anti-aging therapy

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Journal of Geriatric Cardiology 2017年第8期14卷 515-523页

作者： Jian HE Ya-Feng JIANG Liu LIANG Du-jin WANG Wen-Xin WEI Pan-Pan JI Yao-Chan HUANG Hui SONG xiao-ling lu Yong-Xiang ZHAO National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis andTherapy Research 'Collaborative lnnovatton Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanningGuangxiChina

Background Inhibition of aging of vascular endothelial cells （VECs） may delay aging and prolong life. The goal of this study was to prepare anti-CD31 monoclonal antibody conjugated PEG-modified liposomes containing the AU-rich region connecting factor 1 （AUF1） gene （CD31-PILs-AUF1） and to explore the effects of targeting CD31-PILs-AUF1 to aging VECs. Methods The mean particle sizes of various PEGylated immunoliposomes （PILs） were measured using a Zetasizer Nano ZS. Gel retardation assay was used to confirm whether PILs had encapsulated the AUF1 plasmid successfully. Fluorescence microscopy and flow cytometry were used to quantify binding of CD31-PILs-AUF1 to target cells. Flow cytometry was also used to analyze the cell cycles of aging bEnd3 cells treated with CD31-PILs-AUF1. We also developed an aging mouse model by treating mice with D-galactose. Enzyme-linked immunosorbent assay （ELISA） was used to evaluate the levels of interleuldn-6 （IL-6） and tumor necrosis factor-or （TNF-ct）. The malondialdehyde （MDA） and the superoxide dismutase （SOD） levels were detected by commercial kits. Hematoxylin-eosin （HE） staining was used to determine whether treatment with CD31-PILs-AUF 1 was toxic to the mice. Results CD31-PILs-AUF 1 specifically could targeted bEnd3 VECs and increased the percentage of cells in the S and G2/M phases of aging bEnd3 cells. ELISA showed that content of the IL-6 and TNF-ct decreased in CD31-PILs-AUF1 group. The level of SOD increased, whereas MDA decreased in the CD31-PILs-AUF1 group. Additionally, CD31-PILs-AUF 1 was not toxic to the mice. Conclusion CD31-PILs-AUF 1 targets VECs and may delay their senescence.

关键词： Aging AU-rich region connecting factor 1 PEGylated immunoliposomes Vascular endothelial ceils

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Bone morphogenetic proteins and inner ear development

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第2期20卷 131-145页

作者： Jiao-yao MA Dan YOU Wen-yan LI xiao-ling lu Shan SUN Hua-wei LI Ear Nose&Throat Institute and Otorhinolaryngology Department of Affiliated Eye and ENT HospitalNHC Key Laboratory of Hearing MedicineShanghai Engineering Research Centre of Cochlear ImplantState Key Laboratory of Medical NeurobiologyFudan University Institutes of Biomedical Sciences and the Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan University

Bone morphogenetic proteins(BMPs)are the largest subfamily of the transforming growth factor-βsuperfamily,and they play important roles in the development of numerous organs,including the inner *** inner ear is a relatively small organ but has a highly complex structure and is involved in both hearing and ***,we discuss BMPs and BMP signaling pathways and then focus on the role of BMP signal pathway regulation in the development of the inner ear and the implications this has for the treatment of human hearing loss and balance dysfunction.

关键词： Bone morphogenetic protein(BMP) signaling Development Inner ear Hearing Balance

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Induction of the Epstein-Barr Virus Latent Membrane Protein 2 Antigen-specific Cytotoxic T Lymphocytes Using Human Leukocyte Antigen Tetramer-based Artificial Antigen-presenting Cells

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Acta Biochimica et Biophysica Sinica 2006年第3期38卷 157-163页

作者： xiao-ling lu~# Zhi-Hui LIANG~# Cai-E ZHANG Sheng-Jun lu Xiu-Fang WENG Xiong-Wen WU~* Department of Immunology,Tongji Medieal College,Huazhong University of Science and Technology,Wuhan 430030,China DepartmentofImmunology TongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030China

Cytotoxic T lymphocytes (CTLs) specific for the Epstein-Barr virus (EBV) latent membraneprotein 2 (LMP2) antigen are important reagents for the treatment of some EBV-associated malignancies,such as EBV-positive Hodgkin’s disease and nasopharyngeal ***,the therapeutic amount ofCTLs is often hampered by the limited supply of antigen-presenting *** address this issue,an artificialantigen-presenting cell (aAPC) was made by coating a human leukocyte antigen (HLA)-pLMP2 tetramericcomplex,anti-CD28 antibody and CD54 molecule to a cell-sized latex bead,which provided the dual signalsrequired for T cell *** co-culture of the HLA-A2-LMP2 bearing aAPC and peripheral bloodmononuclear cells from HLA-A2 positive healthy donors,LMP2 antigen-specific CTLs were induced andexpanded in *** specificity of the aAPC-induced CTLs was demonstrated by both HLA-A2-LMP2tetramer staining and cytotoxicity against HLA-A2-LMP2 bearing T2 cell,the cytotoxicity was inhibited bythe anti-HLA class Ⅰ antibody (W6/32).These results showed that LMP2 antigen-specific CTLs could beinduced and expanded in vitro by the HLA-A2-LMP2-bearing ***,aAPCs coated with an HLA-pLMP2 complex,anti-CD28 and CD54 might be promising tools for the enrichment of LMP2-specificCTLs for adoptive immunotherapy.

关键词： immunotherapy cytotoxic T lymphocyte artificial antigen-presenting cell Epstein-Barr virus

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UTRA TDD模式与时间切换波束形成相结合的WCDMA系统容量

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铁道学报 2003年第3期25卷 59-64页

作者：肖扬鲁凌云北方交通大学信息科学研究所北京100044

主要证明将UTRATDD(通用陆基无线时分双工)模式与时间切换阵列天线技术相结合,可进一步增大WCDMA系统容量。WCDMA系统进行空间编码将会引起频繁的空间切换问题。本文所提技术可避免这一问题。对阵列模式进行分析,证明分扇区UTRATDD模式... 详细信息

主要证明将UTRATDD(通用陆基无线时分双工)模式与时间切换阵列天线技术相结合,可进一步增大WCDMA系统容量。WCDMA系统进行空间编码将会引起频繁的空间切换问题。本文所提技术可避免这一问题。对阵列模式进行分析,证明分扇区UTRATDD模式的WCDMA系统能有效抑制多址干扰。同时提出系统容量计算方法。仿真结果表明当系统信道被大量用户占用时,分扇区WCDMA系统仍能够获得较好的信干比(SINR)和误比特率(BER)。

关键词：通信容量多用户检测 WCDMA系统时间切换阵列天线

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Strategies on Sample Size Determination and Qualitative and Quantitative Traits Integration to Construct Core Collection of Rice (Oryza sativa)

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Rice science 2011年第1期18卷 46-55页

作者： LI xiao-ling lu Yong-gen LI Jin-quan XU Hai-ming Muhammad Qasim SHAHID Guangdong Provincial Key Laboratory of Plant Molecular Breeding South China Agricultural University Guangzhou 510642 China Department of Agronomy College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China Now work at Hubei Provincial Key Laboratory of Natural Products Research and Development China Three Gorges University Yicang 443002 China

The development of a core collection could enhance the utilization of germplasm collections in crop improvement programs and simplify their management. Selection of an appropriate sampling strategy is an important prerequisite to construct a core collection with appropriate size in order to adequately represent the genetic spectrum and maximally capture the genetic diversity in available crop collections. The present study was initiated to construct nested core collections to determine the appropriate sample size to represent the genetic diversity of rice landrace collection based on 15 quantitative traits and 34 qualitative traits of 2 262 rice accessions. The results showed that 50-225 nested core collections, whose sampling rate was 2.2%-9.9%, were sufficient to maintain the maximum genetic diversity of the initial collections. Of these, 150 accessions （6.6%） could capture the maximal genetic diversity of the initial collection. Three data types, i.e. qualitative traits （QT1）, quantitative traits （QT2） and integrated qualitative and quantitative traits （QTT）, were compared for their efficiency in constructing core collections based on the weighted pair-group average method combined with stepwise clustering and preferred sampling on adjusted Euclidean distances. Every combining scheme constructed eight rice core collections （225, 200, 175, 150, 125, 100, 75 and 50）. The results showed that the QTT data was the best in constructing a core collection as indicated by the genetic diversity of core collections. A core collection constructed only on the information of QT1 could not represent the initial collection effectively. QTT should be used together to construct a productive core collection.

关键词： nested core collection sample size quantitative traits qualitative traits integrated qualitative and quantitative traits rice

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