检索结果-南通市图书馆

chinese Journal of Structural Chemistry 2021年第1期40卷 109-113,4页

作者： SUN Su-Su LI Qing GAO Wei LI xiao-Tian CHEN Lai zhang {2.-Lin College of Plant Protection Hebei Agricultural UniversityBaoding 071001China

The target compound(Z)-4.[3-(4.methyl-1,2.3-thiadiazol-5-yl)-3-(4.trifluoromethylphenyl)acryloyl]morpholine was synthesized by the nucleophilic substitution,Horner-Emmons reaction,ester hydrolysis,and *** structure was characterized by NMR,H RMS and single-crystal X-ray *** crystal of the target compound belongs to monoclinic system,space group P2.(1) with a=11.5058(15),b=6.662.(10),c=2..184.3)Å,V=1777.3(4.Å^(3),Z=8,D_(c)=1.4.6 Mg/m^(3),F(000)=792.andμ=0.2.9 mm^(–1).X-ray analysis indicated C–H....O intermolecular H-bonds in this crystal *** target compound exhibited 53%curative activity against TMV.

关键词： 1,2.3-thiadiazole cinnamic amide synthesis crystal structure anti-TMV activity

The IH-RFQ for HIRFL-CSR injector

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2018年第6期29卷 119-127页

作者： Zhong-Shan Li Xue-Jun Yin Heng Du Jia-Wen Xia You-jin Yuan Jian-Cheng Yang Peng Li jie Li {2.-Ni Li Guo-Dong Shen Wen-Wen Ge Wen-Heng Zheng {2.-Hu {4. Ke-Dong Wang Yun-Zhe Gao Qi-Yu Kong institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China University of chinese academy of sciences Beijing 100049China

A new linac injector CSR-LINAC for the Cooler Storage Ring of the Heavy Ion Research Facility in Lanzhou(HIRFL-CSR) is proposed to improve the performance of the HIRFL. As a key component of the CSRLINAC, the 108.4.-MHz radio frequency quadrupole(RFQ) is under design at the institute of Modern *** ions with mass-to-charge ratios of 3–7 will be accelerated from 4.to 300 keV/u by the RFQ. In the beam dynamics design, the New Four-Section Procedure is adopted to improve the transmission efficiency and obtain a compact structure. In this paper, a transmission efficiency of 98.0% in the 3.07-m-long cavity was obtained. The Interdigital H-type structure is employed because of its mechanical stability and high shunt impedance. The RF performance of the cavity is investigated by the electromagnetic simulation. The optimized results of the electric field to meet the beam dynamics requirements are presented in this paper.

关键词： HIRFL-CSR 注射线性加速器动力学设计机械稳定性关键部件现代物理重离子

4.园林绿化植物凋落物混合对其持水特性的影响

在线全文

学校读者我要写书评

暂无评论

西北林学院学报 2024年第4期39卷 178-188页

作者：张晓曦胡嘉伟刘凯旋李世强陈灵素董雨欣王子泉陈锦强延安大学生命科学学院陕西延安716000 陕西省红枣重点实验室(延安大学) 陕西延安716000

适当保留凋落物层有助于改善城市绿地的水文效应,但不同树种凋落物混合对凋落物层的持水特性有何影响尚不清楚。以丁香、垂柳、日本晚樱和五角枫的凋落叶以及上述凋落叶5种形式的混合物为对象,基于室内浸泡试验检测混合形式及其比例对... 详细信息

适当保留凋落物层有助于改善城市绿地的水文效应,但不同树种凋落物混合对凋落物层的持水特性有何影响尚不清楚。以丁香、垂柳、日本晚樱和五角枫的凋落叶以及上述凋落叶5种形式的混合物为对象,基于室内浸泡试验检测混合形式及其比例对凋落物持水特征参数(含吸水和失水过程)的非加和性影响。结果表明,1)丁香-晚樱凋落叶以7∶3和5∶5(质量比,后同)混合使其最大持水量较预期显著降低,以3∶7混合则使其持水在叶片间隙中的分配比例显著提高;五角枫-垂柳凋落叶混合使其最大持水量(5∶5和4.6)、间隙分配比例(4.6)和最大吸水速率(5∶5和3∶7)均较预期显著降低;五角枫-晚樱凋落叶以3∶7混合使其间隙分配比例较预期显著降低;丁香-五角枫凋落叶以4.6混合使其吸水速率较预期显著提高;而丁香-垂柳凋落叶以7∶3、4.6或3∶7混合分别使其间隙分配比例和最大吸水速率较预期显著提高(P2.丁香-晚樱凋落叶以7∶3和5∶5、五角枫-垂柳凋落叶以6∶4.3∶7、五角枫-晚樱凋落叶以7∶3、4.6以及丁香-五角枫凋落叶以4.6、3∶7混合均使其最大失水率较预期显著降低,而丁香-垂柳凋落叶以除6∶4.的质量比混合则产生相反作用;丁香-晚樱以6∶4.3∶7、丁香-五角枫和丁香-垂柳凋落叶以任一质量比混合均使其最大失水速率较预测显著提高(P<0.05)。

关键词：凋落物混合比例持水性能失水特征城市绿地

维普期刊数据库博看期刊

Antitumor Compound Identification from Zanthoxylum bungeanum Essential Oil Based on Composition-activity Relationship

在线全文

学校读者我要写书评

暂无评论

Chemical Research in chinese Universities 2013年第6期29卷 1068-1071页

作者： LI Zi-dan HAN Sheng-nan JIANG Jian-lan zhang xiao-hang LI Yan CHEN Hao YUAN Ying-{2. Key Laboratory of Systems Bioengineering Ministry of Education Tianjin Key Laboratory of Biological and Pharmaceutical Engineering Department of Pharmaceutical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P.R.China

The chemical composition of Zanthoxylum bungeanum（Z bungeanum） essential oi1（39 batches） was analyzed by gas chromatography-mass spectrometry（GC-MS） analysis（2. ingredients）, and the antitumor activity against HeLa cells was detected via the MTT[3-（4.5-dimethylthiazol-2.yl）-2.5-diphenyltetrazolium bromide] assay. Two composition-activity relationship（CAR） models, generalized regression neural network（GRNN） and support vector regression（SVR） were respectively used to calculate the mean impact value（MIV） so as to identify bioactive com- pounds. Among them 9 ingredients（peaks 4. 15, 7, 8, 13, 3, 16, 9 and 11） were selected due to their high absolute MIVs. All of them have been confirmed with potential antitumor activity by previous researches. The CAR model combined with MIV was expected to be a credible tool for the active compound identification from herbs.

关键词： Zanthoxylum bungeanum essential oil HeLa cell Composition-activity relationship model Active compound identification

Postprandial glucagon-like peptide 1 secretion is associated with urinary albumin excretion in newly diagnosed type 2.diabetes patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2023年第3期14卷 279-289页

作者： Lu-Lu Song Na Wang jin-Ping zhang Li-Ping Yu {2.-Ping Chen Bo zhang Wen-Ying Yang Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Microalbuminuria is an early and informative marker of diabetic *** study found that microalbuminuria developed in patients with newly diagnosed type 2.diabetes mellitus(T2.M).AIM To investigate the association between glucagon-like peptide 1(GLP-1)and microalbuminuria in newly diagnosed T2.M *** In total,760 patients were recruited for this cross-sectional *** GLP-1 levels during a standard meal test and urinary albumin-creatinine ratio(UACR)were *** Patients with microalbuminuria exhibited lower GLP-1 levels at 30 min and 12. min during a standard meal test than patients with normal albuminuria(30 min GLP-1,16.7±13.3 pmol vs 19.9±15.6 pmol,P=0.007;12. min GLP-1,16.0±14.1 pmol vs 18.4.13.8 pmol,P=0.037).The corresponding area under the curve for active GLP-1(AUCGLP-1)was also lower in microalbuminuria patients(2.57,1585 to 3506 vs 2.96,1763 to 4.2.,pmol×min,P=0.003).Postprandial GLP-1 levels at 30 min and 12. min and AUCGLP-1 were negatively correlated with the UACR(r=0.159,r=0.132.r=0.2.6,respectively,P1).The prevalence of microalbuminuria in patients with newly diagnosed T2.M was 2..7%,which decreased with increasing quartiles of AUCGLP-1 levels(2..4.,2..3%,18.9%and 15.8%).After logistic regression analysis adjusted for sex,age,hemoglobin A1c,body mass index,systolic blood pressure,estimated glomerular filtration rate,homeostasis model assessment of insulin resistance,AUC_(glucose)and AUC_(glucagon)patients in quartile 4.of the AUCGLP-1 presented a lower risk of microalbuminuria compared with the patients in quartile 1(odds ratio=0.54.,95%confidence interval:0.32.-0.92.,P=0.01).A consistent association was also found between 30 min GLP-1 or 12. min GLP-1 and *** Postprandial GLP-1 levels were independently associated with microalbuminuria in newly diagnosed {2. T2.M patients.

关键词： Microalbuminuria Glucagon-like peptide 1 Type 2.diabetes Nephropathy

加替沙星与左氧氟沙星随机双盲对照治疗泌尿系统感染98例

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国新药与临床杂志 2004年第11期23卷 753-757页

作者：袁喆肖永红张唯力王长征金欢胜重庆医科大学附属第一医院感染科重庆400016 重庆医科大学附属第二医院泌尿科重庆400010 中国人民解放军第三军医大学新桥医院泌尿科重庆400037 西安交通大学第一医院泌尿科陕西西安710061

目的 :评价国产加替沙星治疗泌尿道感染的有效性和安全性。方法 :采用多中心随机对照双盲试验。左氧氟沙星为对照药 ,试验组和对照组剂量均为 2.0 0mg ,静脉滴注 ,bid ,疗程 7～ 14.。结果 :试验组与对照组可进行安全性评价者分别有 4.8... 详细信息

目的 :评价国产加替沙星治疗泌尿道感染的有效性和安全性。方法 :采用多中心随机对照双盲试验。左氧氟沙星为对照药 ,试验组和对照组剂量均为 2.0 0mg ,静脉滴注 ,bid ,疗程 7～ 14.。结果 :试验组与对照组可进行安全性评价者分别有 4.8,5 0例 ;可进行疗效评价者分别有 4.7,5 0例。试验组痊愈率 89%、临床有效率 10 0 %、细菌清除率 89% ;对照组分别为 90 % ,96 % ,85 %。加替沙星对革兰阳性菌体外抗菌活性优于其他几种抗菌药。不良事件的发生率分别为 10 %和 12.% ,2.比较差异均无显著意义 (P >0 .0 5 )。结论 :国产加替沙星对敏感菌引起的泌尿道感染疗效确切 ,安全性好。

关键词：左氧氟沙星泌尿道感染随机对照试验双盲法多中心研究加替沙星

Efficacy of one-day quadruple therapy for H pylori infection in chinese patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第19期12卷 3105-3107页

作者： xiao-Hui Huo Jian-Kun Chu Xiu-Fen Yang jing Wang Li-jing zhang jin-Cheng Ma Jun Yu Department of Gastroenterology First Affiliated Hospital of Hebei Medical University Shijiazhuang Hebei Province China Department of Medicine and Therapeutics Prince of Wales Hospital Chinese University of Hong Kong Hong Kong China

AIM： TO compare the efficacies of one-day quadruple therapy and seven-day triple therapy in chinese patients. METHODS： Sixty consecutive patients with nonulcer dyspepsia and confirmed H pylori infection were randomized to receive either omeprazole 4. mg, amoxycillin 1 g, and furazolidone 100 mg, all twice a day for 7 d or omeprazole 2. mg （at breakfast and dinner）, amoxicillin 1 g, furazolidone 2.0 mg, and colloidal bismuth subcitrate 2.0 mg four times for only one day. H pylori status was determined before and at least 5 weeks after therapy by endoscopy with antral and corpus biopsies for rapid urease test and histology. RESULTS： Hpyloi eradication was successful in 66.67% （2./30） patients in the 7-d group and in 36.67% （11/30） patients in the 1-day group （P = 0.037）. Side effects were induced by the treatment in 13.3% （4.30） patients of each group, but these were all self-limiting, shortlasting, and did not require any specific treatment. CONCLUSION： The one-day quadruple therapy is less effective than the one-week regimen in curing H pylori infection in chinese patients.

关键词： H pylori Quadruple therapy Antibiotics Gastritis Side effects

LEARN algorithm:a novel option for predicting non-alcoholic steatohepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2023年第4期12卷 507-522,I0017-I0022页

作者： Gang Li Tian-Lei Zheng xiao-Ling Chi Yong-Fen Zhu jin-Jun Chen Liang Xu Jun-Ping Shi xiao-Dong Wang Wei-Guo Zhao Christopher D.Byrne Giovanni Targher Rafael S.Rios Ou-Yang Huang Liang-jie Tang Shi-jin zhang Shi Geng Huan-Ming xiao Sui-Dan Chen Rui zhang Ming-Hua Zheng MAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Artificial Intelligence Unit Department of Medical EquipmentThe Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina Department of Hepatology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Department of Hepatology and Infection Sir Run Run Shaw HospitalAffiliated with School of MedicineZhejiang UniversityHangzhouChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Hepatology Unit Zengcheng BranchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Hepatology Tianjin Second People’s HospitalTianjinChina Department of Liver Diseases Hangzhou Normal University Affiliated HospitalHangzhouChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouChina Southampton National institute for Health and Care Research Biomedical Research Centre University Hospital Southampton&University of SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity of VeronaVeronaItaly Department of Pathology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Nutrition the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina institute of Hepatology Wenzhou Medical UniversityWenzhouChina

Background:There is an unmet need for accurate non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH).Since impedance-based measurements of body composition are simple,repeatable and have a strong association with non-alcoholic fatty liver disease(NAFLD)severity,we aimed to develop a novel and fully automatic machine learning algorithm,consisting of a deep neural network based on impedance-based measurements of body composition to identify NASH[the bioeLectrical impEdance Analysis foR Nash(LEARN)algorithm].Methods:A total of 1,2.9 consecutive subjects with suspected NAFLD were screened from six medical centers across China,of which 766 patients with biopsy-proven NAFLD were included in final *** patients were randomly subdivided into the training and validation groups,in a ratio of 4.*** LEARN algorithm was developed in the training group to identify NASH,and subsequently,tested in the validation ***:The LEARN algorithm utilizing impedance-based measurements of body composition along with age,sex,pre-existing hypertension and diabetes,was able to predict the likelihood of having *** algorithm showed good discriminatory ability for identifying NASH in both the training and validation groups[area under the receiver operating characteristics(AUROC):0.81,95%CI:0.77-0.84.and AUROC:0.80,95%CI:0.73-0.87,respectively].This algorithm also performed better than serum cytokeratin-18 neoepitope M30(CK-18 M30)level or other non-invasive NASH scores(including HAIR,ION,NICE)for identifying NASH(P value<0.001).Additionally,the LEARN algorithm performed well in identifying NASH in different patient subgroups,as well as in subjects with partial missing body composition ***:The LEARN algorithm,utilizing simple easily obtained measures,provides a fully automated,simple,non-invasive method for identifying NASH.

关键词： Non-alcoholic fatty liver disease(NAFLD) non-alcoholic steatohepatitis(NASH) bioeLectrical impEdance Analysis foR Nash(LEARN)algorithm body composition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川巴中红层滑坡降雨阈值克里金插值法研究

中国地质灾害与防治学报 2024年第4期35卷 36-44页

作者：张群肖智林马志刚金圣杰李俊峰许钟元曾普张小琼四川省国土空间生态修复与地质灾害防治研究院四川成都610084 中国地质环境监测院(自然资源部地质灾害技术指导中心) 北京100081 西南交通大学地球科学与环境工程学院四川成都611756 雅安市自然资源和规划局四川雅安625099

降雨阈值是目前最常用的降雨型滑坡预警判据之一,然而目前经验性降雨阈值主要是针对滑坡的区域性预警,对于该区域内随空间变化的单个滑坡的降雨阈值还缺乏探讨。基于巴中2.14.2.2.年降雨型滑坡历史数据以及小时降雨数据,采用克里金插值... 详细信息

降雨阈值是目前最常用的降雨型滑坡预警判据之一,然而目前经验性降雨阈值主要是针对滑坡的区域性预警,对于该区域内随空间变化的单个滑坡的降雨阈值还缺乏探讨。基于巴中2.14.2.2.年降雨型滑坡历史数据以及小时降雨数据,采用克里金插值法,提取2.14.2.2.年各滑坡灾害的四类致灾短期雨量(1 h、12.h、2. h、72.h)和相应的长期雨量(滑坡发生前7 d),由此分成4.阈值模型进行分析,确定每组模型长期和短期致灾雨量阈值分布情况,并用2.2.年滑坡灾害数据验证所得的降雨阈值。研究结果显示4.阈值模型的预测准确率分布在4.%~65%,表明4.阈值都具有较好的应用前景。同时,预测准确率随短期降雨时长增加而提高,由72.h至7 d致灾雨量数据所计算的降雨阈值预测准确率最高,为62.;而1 h至7 d模型计算的降雨阈值预测准确率最低,为4.%。基于模型的最高预测准确率,研究计算得到4.模型的最佳短期与长期致灾雨量的划分比例,从而定量划分了短期降雨致灾滑坡和长期降雨致灾滑坡。研究通过对致灾雨量空间分布的计算,可提取滑坡隐患点位上的降雨阈值,实现了区域一点一阈值的目标,丰富了现有降雨阈值计算模型。

关键词：克里金插值滑坡短期降雨长期降雨降雨阈值

Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

chinese Medical Journal 2011年第12期124卷 1876-1884页

作者： WANG xiao-fang zhang {2.-ying LI Ling ZHAO xiao-yan Department of Cardiology First Affiliated Hospital College ofMedicine Zhengzhou University Zhengzhou Henan 450052China

Background Metformin has become a cornerstone in the treatment of patients with type-2.diabetes. Accumulated evidence suggests that metformin supports direct cardiovascular effects. The present study aimed to investigate if metformin has beneficial effects on primary cardiomyocytes damaged by H2.2. and reveal the potential mechanism of action of metformin. Methods Cardiomyocytes were incubated in the presence of 100μmol/L H2.2.for 12.hours. Cardiomyocytes were pretreated with metformin at different concentrations and time and with aminoimidazole carboxamide ribonucleotide （AICAR）（500μmol/L）, an adenosine monophophate （AMP）-activated protein kinase （AMPK） agonist for 60 minutes before the addition of H2.2. Other cells were preincubated with compound C （an AMPK antagonist, 2.μmol/L） for 4.hours. The viability and apoptosis of cells were analyzed. AMPK, endothelial nitric oxide synthase （eNOS）, and transforming growth factor （TGF）-β1 were analyzed using immunblotting. Results Metformin had antagonistic effects on the influences of H2.2.on cell viability and attenuated oxidative stress-induced apoptosis. Metformin also increased phosphorylation of AMPK and eNOS, and reduced the expression of TGF-β1, basic fibroblast growth factor （bFGF）, and tumor necrosis factor （TNF）-α. Conclusions Metformin has beneficial effects on cardiomyocytes, and this effect involves activation of the AMPK-eNOS pathway. Metformin may be potentially beneficial for the treatment of heart disease.

关键词： adenosine monophosphate-activated protein kinase cardiomyocyte, endothelial nitric oxide synthase metformin transforming growth factor