Synthesis, Crystal Structure and Anti-TMV Activity of(Z)-4-[3-(4-Methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine

作     者：SUN Su-Su LI Qing GAO Wei LI Xiao-Tian CHEN Lai ZHANG Jin-Lin 孙素素;李晴;高卫;李晓天;陈来;张金林

作者机构：College of Plant ProtectionHebei Agricultural UniversityBaoding 071001China 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2021年第40卷第1期

页      面：109-113,4页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 09[农学] 0904[农学-植物保护] 0703[理学-化学] 

基　　金：supported in part by Youth Natural Science Foundation of Hebei Province(No.B2019204030) the starting Scientific Research Foundation for the introduced talents of Hebei Agricultural University(Nos.201842) by the National Natural Science Foundation of China(Nos.31871981) Modern Agriculture Industry Technology System Innovation Team of Phase II of Hebei Province(Nos.HB2018020205) 

主　　题：1,2,3-thiadiazole cinnamic amide synthesis crystal structure anti-TMV activity 

摘      要：The target compound(Z)-4-[3-(4-methyl-1,2,3-thiadiazol-5-yl)-3-(4-trifluoromethylphenyl)acryloyl]morpholine was synthesized by the nucleophilic substitution,Horner-Emmons reaction,ester hydrolysis,and *** structure was characterized by NMR,H RMS and single-crystal X-ray *** crystal of the target compound belongs to monoclinic system,space group P2_(1) with a=11.5058(15),b=6.6626(10),c=23.184(3)Å,V=1777.3(4)Å^(3),Z=8,D_(c)=1.496 Mg/m^(3),F(000)=792 andμ=0.229 mm^(–1).X-ray analysis indicated C–H....O intermolecular H-bonds in this crystal *** target compound exhibited 53%curative activity against TMV.