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High-Confidence Computing 2024年第3期4卷 64-74页

作者： Chao Wang Xueqiao Xu Ke xiao Yunhua He Guangcan Yang School of Information Science and Technology North China University of TechnologyBeijing 100144North China University of TechnologyBeijing 100144

Recently,vehicles have experienced a rise in networking and informatization,leading to increased security *** the most widely used automotive bus network,the Controller Area Network(CAN)bus is vulnerable to attacks,as security was not considered in its original *** paper proposes SIDuBzip2,a traffic anomaly detection method for the CAN bus based on the bzip2 compression *** proposed method utilizes the pseudo-periodic characteristics of CAN bus traffic,constructing time series of CAN IDs and calculating the similarity between adjacent time series to identify abnormal *** method consists of three parts:the conversion of CAN ID values to characters,the calculation of similarity based on bzip2 compression,and the optimal solution of model *** experimental results demonstrate that the proposed SIDuBzip2 method effectively detects various attacks,including Denial of Service,replay,basic injection,mixed injection,and suppression *** addition,existing CAN bus traffic anomaly detection methods are compared with the proposed method in terms of performance and delay,demonstrating the feasibility of the proposed method.

关键词： Automotive safety CAN bus Anomaly detection

Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location

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World Journal of Gastroenterology 2024年第33期30卷 3823-3836页

作者： Qian-Yu Wang Wen-Tao Zhong Yi xiao Guo-Le Lin Jun-Yang Lu lai Xu Guan-Nan Zhang Jun-Feng Du Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Medical Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers(LCC)and right-sided colon cancers(RCC).Pan-immune-inflammation value(PIV)is a systemic immune response marker that can predict the prognosis of patients with colon ***,the specific distinction between PIV of LCC and RCC remains *** To investigate the prognostic and clinical significance of PIV in LCC and RCC *** This multicenter retrospective cohort study included 1510 patients with colon cancer,comprising 801 with LCC and 709 with *** used generalized lifting regression analysis to evaluate the relative impact of PIV on disease-free survival(DFS)in these ***-Meier analysis,as well as univariate and multivariate analyses,were used to examine the risk factors for *** correlation between PIV and the clinical characteristics was statistically analyzed in these *** A total of 1510 patients{872 female patients(58%);median age 63 years[interquartile ranges(IQR):54-71];patients with LCC 801(53%);median follow-up 44.17 months(IQR 29.67-62.32)}were *** was significantly higher in patients with RCC[median(IQR):214.34(121.78-386.72)vs 175.87(111.92-286.84),P227.84)was associated with worse DFS in LCC[PIV-high:Adjusted hazard ratio(aHR)=2.39;95%confidence interval:1.70-3.38;P<0.001]but not in RCC(PIV-high:aHR=0.72;95%confidence interval:0.48-1.08;P=0.114).CONCLUSION These findings suggest that PIV may predict recurrence in patients with LCC but not RCC,underscoring the importance of tumor location when using PIV as a colon cancer biomarker.

关键词： Colon cancer Left-sided colon cancer Right-sided colon cancer Pan-immune-inflammation value Systemic inflammatory biomarkers Prognosis

Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第4期30卷 291-298页

作者： lai Yuan-yuan LIU Li-ying WU Yong-na HUANG Lei ZHENG xiao-yan GAN Di YU Si-yi ZHONG Ying LIANG Fan-rong ZHOU Ying YANG Jie Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu(610032)China Sichuan Jinxin Xi'nan Women's and Children's Hospital Chengdu(610032)China Yuan TCM Wellness Pte.Ltd.(999002) Pulse TCM SingaporeSingapore

Objective To investigate the immediate effects of electro-acupuncture(EA)on endometrial blood flow among recurrent implantation failure(RIF)*** Eighty RIF patients,enrolled from March 2022 to December 2022,were randomly allocated into either the EA group(40 cases)or the waiting-list(WL)group(40 cases)by using a random number *** EA group underwent acupuncture at points of Shenting(GV 24),Baihui(GV 4),Benshen(GB 13),bilateral Zigong(EX-CA 1),Huangshu(KI 16),Sanyinjiao(SP 6)and Xuehai(SP10),and electric acupuncture apparatus was connected to EX-CA 1,KI 16,SP 6,and SP 10 with disperse-dense waves at 4/20 Hz frequencies for 30 min after transvaginal ultrasound,while the WL group received no *** primary outcome measured was the endometrial volume blood *** secondary outcomes included the bilateral uterine artery index,endometrial volume,endometrial blood flow type,vascular distribution index(VI^(MV))for endometrial and ovary,clinical pregnancy rate,and embryo implantation *** In the EA group,there was a notable decrease in the bilateral pulsatility index and a significant improvement in the endometrial blood flow type post-EA(P0.05).Besides,no adverse events related to EA were *** EA can promptly ameliorate VI^(MV) for the endometrial and right ovary,and endometrial blood flow *** randomized controlled trials are warranted to investigate the long-term effects of EA on blood flow of RIF patients and its implications for pregnancy outcomes.(Trial registration ***2200057377

关键词： electro-acupuncture recurrent implantation failure transvaginal ultrasound endometrial receptivityanalysis randomized controlledtrial

Optimal decision-making in relieving global high temperature-related disease burden by data-driven simulation

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Infectious Disease Modelling 2024年第2期9卷 618-633页

作者： Xin-Chen Li Hao-Ran Qian Yan-Yan Zhang Qi-Yu Zhang Jing-Shu Liu Hong-Yu lai Wei-Guo Zheng Jian Sun Bo Fu xiao-Nong Zhou xiao-Xi Zhang School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Institute of One Health Shanghai Jiao Tong UniversityShanghaiPeople's Republic of China School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China School of Data Science Fudan UniversityShanghaiPeople's Republic of China

The rapid acceleration of global warming has led to an increased burden of high temperature-related diseases(HTDs),highlighting the need for advanced evidence-based management *** have developed a conceptual framework aimed at alleviating the global burden of HTDs,grounded in the One Health *** framework refines the impact pathway and establishes systematic data-driven models to inform the adoption of evidence-based decision-making,tailored to distinct *** collected extensive national-level data from authoritative public databases for the years 2010–*** burdens of five categories of disease causes–cardiovascular diseases,infectious respiratory diseases,injuries,metabolic diseases,and non-infectious respiratory diseases–were designated as intermediate outcome *** cumulative burden of these five categories,referred to as the total HTD burden,was the final outcome *** evaluated the predictive performance of eight models and subsequently introduced twelve intervention measures,allowing us to explore optimal decision-making strategies and assess their corresponding *** model selection results demonstrated the superior performance of the Graph Neural Network(GNN)model across various *** simulations driven by the GNN model,we identified a set of optimal intervention strategies for reducing disease burden,specifically tailored to the seven major regions:East Asia and Pacific,Europe and Central Asia,Latin America and the Caribbean,Middle East and North Africa,North America,South Asia,and Sub-Saharan *** mitigation and adaptation measures,acting upon our categories of Infrastructure&Community,Ecosystem Resilience,and Health System Capacity,exhibited particularly strong performance for various regions and *** out of twelve interventions were included in the optimal intervention package for each region,including raising low-carbon energy use,increasing energy intensity,improving

关键词： High temperature-related diseases Data-driven simulation Optimal intervention Disease burden Graph neural network Global warming

Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun xiao Shi-lin LIN Ru-kun LI Chan CHEN Zhi-jie CHEN Yi-fei LUO Chao-hua MO Zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

Highly reversible photomodulated hydrosoluble stiff-stilbene supramolecular luminophor induced by cucurbituril

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Chinese Chemical Letters 2024年第8期35卷 235-239页

作者： Guoxing Liu Yixin Li Changming Tian Yongmei xiao Lijie Liu Zhanqi Cao Song Jiang Xin Zheng Caoyuan Niu Yun-lai Ren Liangru Yang Xianfu Zheng Yong Chen College of Science Henan Agricultural UniversityZhengzhou 450002China College of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China

A photochromic molecular rotor based on stiff-stilbene(SSB-FMR)was handily prepared through coupled reaction,and further self-assembled with cucurbit[8]uril(CB[8])to form a 2:2 quaternary supramolecu-lar complex(SSB-FMR/CB[8]).Significantly,the intervention of CB[8]on SSB-FMR achieved dual functions that assembly-induced emission enhancement and assembly-induced improvement of photoisomerized performance(especially reversibility)of stiff-stilbene molecular *** supramolecular strategy further facilitated the assembly as a photoresponsive fluorescence switch with outstanding fatigue resis-tance,which was expediently applied in high-security-level QR code anti-counterfeiting and controllable lysosome targeted *** study unprecedentedly provides a supramolecular method for highly effi-ciently improving photoisomerized performance especially reversibility of molecular photoswitches based on stiff-stilbene,and is of vital significance for the construction of intelligent materials with excellent ca-pability.

关键词： Host-guest complexation Cucurbituril Fluorescence switch Stiff-stilbene Fluorescence enhancement

Triboelectric nanogenerators for self-powered neurostimulation

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Nano Research 2024年第10期17卷 8926-8941页

作者： Shumao Xu Farid Manshaii xiao xiao Junyi Yin Jun Chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The burgeoning field of soft bioelectronics heralds a new dawn in medical treatment for neurological and psychiatric conditions,presenting innovative methods for the stimulation,inhibition,and precise sensing of neuronal *** to these advancements is the challenge of power supply;devices dependent on traditional batteries face limitations regarding miniaturization and require invasive surgeries for battery *** nanogenerators(TENGs),which generate power from biomechanical movements,offer a promising solution for developing self-powered neurostimulation devices without the need for an external power *** review delves into recent progress in TENGs,with a focus on their application in selfpowered neurostimulation *** utility of TENGs across various nervous systems—including the center,autonomic,and somatic nervous systems—is explored and presented,highlighting the potential for these devices to facilitate neurological *** summarizing TENGs’operational details and the potential for clinical translation,this review also identifies challenges associated with the implantation and integration of neural electrodes and presents recent advances in solutions,aiming to reshape electric treatments for neurological diseases.

关键词： triboelectric nanogenerators neurostimulation self-powered soft bioelectronics biomechanical energy harvesting

Navigation Finsler metrics on a gradient Ricci soliton

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 266-275页

作者： LI Ying MO xiao-huan WANG xiao-yang Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Pure and Applied Mathematics School of Mathematical SciencesPeking UniversityBeijing 100871China School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China

In this paper,we study a class of Finsler metrics defined by a vector field on a gradient Ricci *** obtain a necessary and sufficient condition for these Finsler metrics on a compact gradient Ricci soliton to be of isotropic S-curvature by establishing a new integral *** we determine the Ricci curvature of navigation Finsler metrics of isotropic S-curvature on a gradient Ricci soliton generalizing result only known in the case when such soliton is of Einstein *** its application,we obtain the Ricci curvature of all navigation Finsler metrics of isotropic S-curvature on Gaussian shrinking soliton.

关键词： gradient Ricci soliton navigation Finsler metric isotropic S-curvature Ricci curvature Gaussian shrinking soliton

Design and commissioning of a wideband RF system for CSNS-Ⅱ rapid-cycling synchrotron

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Nuclear Science and Techniques 2024年第1期35卷 35-44页

作者： Jian Wu Xiang Li Bin Wu chun-Lin Zhang Yang Liu Wei Long xiao Li University of Chinese Academy of Sciences Beijing 100049China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China

The China Spallation Neutron Source(CSNS) upgrade project(CSNS-Ⅱ) aims to enhance the beam power from 100 to 500 kW. A dual-harmonic accelerating method has been adopted to alleviate the stronger space-charge effect in rapid-cycling synchrotrons owing to the increased beam intensity. To satisfy the requirements of dual-harmonic acceleration, a new radiofrequency(RF) system based on a magnetic alloy-loaded cavity is proposed. This paper presents design considerations and experimental results regarding the performance evaluation of the proposed RF system through high-power tests and beam commissioning. The test results demonstrate that the RF system satisfies the desired specifications and affords significant benefits for CSNS-Ⅱ.

关键词： Dual-harmonic acceleration Magnetic alloy-loaded cavity RF system

Metal-organic polyhedra as dynamic cross-linker for recyclable mixed matrix membranes with promising dimension stability

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Science China Chemistry 2024年

作者： Linjie Lan Mingxin Zhang Haiyan xiao Liufu Wei Yuyan lai Jiadong Chen Jiafu Yin Panchao Yin State Key Laboratory of Luminescent Materials and Devices&South China Advanced Institute for Soft Matter Science and Technology Guangdong Basic Research Center of Excellence for Energy and Information Polymer MaterialsSouth China University of Technology State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan University

Mixed matrix membranes （MMMs） are designed by incorporating microporous inorganic fillers into polymer matrix for the integration of inorganics’excellent gas separation performance with polymers’promising ***,due to the complex interphase interaction,the prevention of long-term aging is still challenging and the poor processability/recyclability of MMMs hinders their extensive ***,a coordination assembly protocol is developed for the fabrication of MMMs with both excellent processability/recyclability upon thermal annealing and promising dimension stability even under high gas *** bearing isophthalic acid （IPA） as side chains are applied to coordinate with Cu2+and the assembled 2.5 nm microporous metal-organic polyhedra （MOP）,{Cu24IPA24},serves as multi-functional cross-linkers for the polymer network *** MOPs’well-defined microporosity grants MMMs the capability for O2/N2separation while their activated dynamics at high temperatures （>120°C） endows polymer networks with excellent *** contrast to conventional supramolecular units,the MOPs possess unique logarithmic ligand-exchange kinetics and they show nearly frozen bonding dynamics at room temperature,ensuring promising dimensional stability to overcome the long-term aging and high gas pressure *** work not only provides fundamental understanding of the unique relaxation dynamics of complex systems with intertwined dynamics of supramolecular bonds and polymer chains,but also paves new avenues for the fabrication of robust and recyclable MMMs and elastomers.

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