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Multiple well-differentiated retroperitoneal liposarcomas with different patterns of appearance on computed tomography:A case report

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World Journal of Clinical Cases 2021年第7期9卷 1661-1667页

作者： Tian-Hao Xie Xiang-Xiang Ren Yan Fu Si-Ning Ha Li-Tao Liu xiao-shi jin Department of General Surgery Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Ophthalmology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Primary retroperitoneal liposarcoma(PRPLS)is a rare soft tissue tumor with nonspecific clinical symptoms;it has different computed tomography(CT)image features according to pathological *** patients with a single tumor have been previously reported in the *** present an exceptional case of a PRPLS patient with multiple large tumors exhibiting different patterns of appearance on CT and confirmed as atypical lipomatous tumor/welldifferentiated liposarcoma by postoperative *** SUMMARY A 64-year-old man presented with abdominal distension for 1 *** patient was diagnosed with PRPLS based on physical examination,laparotomy,ultrasonography,CT scan,and *** of the tumors were completely resected through surgery and confirmed as atypical lipomatous tumor/welldifferentiated liposarcoma by postoperative *** postoperative course was uneventful without recurrence or metastasis,as demonstrated by abdominalpelvic CT during an 18 mo *** Multiple large Well-differentiated liposarcomas with different patterns of appearance on CT image can occur simultaneously in the same patient,to which more attention should be paid to make an effective differential diagnosis.

关键词： Retroperitoneal liposarcoma Soft tissue tumor Complete resection Recurrence Case report

Mesh plug erosion into the small intestine after inguinal hernia repair: A case report

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World Journal of Clinical Cases 2022年第12期10卷 3944-3950页

作者： Tian-Hao Xie Qiang Wang Si-Ning Ha Shu-Jie Cheng Zheng Niu Xiang-Xiang Ren Qian Sun xiao-shi jin Department of General Surgery the Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Mesh plug(MP)erosion into the intra-abdominal organs is a rare but serious long-term complication after inguinal hernia repair(IHR),and may lead to aggravation of symptoms if not treated *** is difficult to diagnose MP erosion as there are no obvious specific clinical manifestations,and surgery is often needed for *** recent years,with the increased understanding of postoperative complications,MP eroding into the intra-abdominal organs has been a cause for concern among *** SUMMARY A 50-year-old man was referred to the Department of General Surgery with the complaint of abdominal pain in the right lower quadrant for 2 *** had a surgical history of right open IHR and partial thyroidectomy performed 20 years and 15 years ago,*** tomography revealed a circinate highdensity image with short segmental thickening of the ileum stuck to the abdominal wall,and no evidence of recurrent inguinal *** abdominal exploration confirmed adhesion of the middle segmental portion of the ileal loop to the right inguinal abdominal wall;the rest of the small intestine was *** exploration revealed migration of the polypropylene MP into the intraperitoneal cavity and formation of granulation tissue around the plug,which eroded the *** resection of the ileum,including the MP and end-to-side anastomosis with an anastomat,was *** Surgeons should aim to improve their ability to predict patients at high risk for MP erosion after IHR.

关键词： Mesh plug Inguinal hernia repair Migration Erosion Complication Case report

Expression of chemokine receptors CCR3, CCR5 and CXCR3 on CD4^＋ T cells in CBA/J×DBA/2 mouse model, selectively induced by IL-4 and IL-10, regulates the embryo resorption rate

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Chinese Medical Journal 2009年第16期122卷 1917-1921页

作者： JIANG Pei-juan ZHAO Ai-min BAO shi-min xiao shi-jin XIONG Miao Department of Obstetrics and Gynecology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Laboratory Animal Center of Shanghai Chinese Academy of Science Shanghai 201615 China Department of Obstetrics and Gynecology Shanghai Pudong New Area Gongli Hospital Shanghai 200135 China

Background Chemokines and their receptors have been a research focus in transplantation immunology. Chemokines and their receptors play a role in lymphocyte recruitment and differentiation process. This study aimed to observe whether IL-4 and IL-10 may regulate the expression of chemokine receptors CCR3, CCR5 and CXCR3 on CD4^＋ T cells in CBA/J×DBA/2 mouse model and to explore the role of CCR3, CCR5, CXCR3 in immune tolerance in pregnancy. Methods The mouse model of spontaneous abortion （CBA/J×DBA/2） and the normal pregnant mouse model （CBA/J×BALB/c） were used. CBA/J×DBA/2 mice were injected with IL-4 （CBA/J×DBA/2-IL-4）, IL-4 and IL-10 （CBA/J×DBA/2-IL-4＋IL-10）, or normal saline （CBA/J×DBA/2-NS） as a control. The expression of CCR3, CCR5 and CXCR3 on CD4^＋ T cells from mouse peripheral blood was measured by the double-labelled FCM method, and the embryo resorption rate was also examined. Results The embryo resorption rate in the CBA/J×DBA/2 group without any treatment was significantly higher than that in the CBA/J×BALB/c group （17.9% vs 3.7%, P 〈0.01）. The embryo resorption rate in the CBA/J×DBA/2 group immunized with IL-4 or IL-4 together with IL-10 was significantly decreased, compared with that in the control and NS groups respectively. CCR3 expression on CD4^＋ T cells in the CBA/J×DBA/2 group without any treatment was significantly lower than that in the CBA/J×BALB/c group （0.3738±0.3575 vs 1.2190±0.2772, P 〈0.01）; both CCR5 （3.0900±1.5603 vs 1.2390±0.6361, P〈0.01） and CXCR3 （2.4715±0.9074 vs 0.9200±0.5585, P 〈0.01） expressions on CD4^＋ T cells of the CBA/J×DBA/2 group without any treatment were significantly higher than those of the CBA/J×BALB/c group. Significant up-regulation of CCR3 and down-regulation of CXCR3 were found in the CBA/J×DBA/2 group treated with IL-4 （CCR3： 2.0360±0.6944, CXCR3： 1.3510±0.5263, P〈0.01） or IL-4 and IL-10 （CCR3： 1.8160±1.0947, CXCR3：1.0940±0.7168, P〈0.01）. Because of the CCR5, IL-4 and IL-10 （1.9400±0.8504 vs 3.0900±1.5603, P 〈0.0

关键词： chemokine receptors CD4-positive T-lymphocytes abortion, spontaneous interleukin-4 interleukin-10

Relationship between expression of chemokine receptors CCR3, CCR5 and CXCR3 on CD4^＋ T cells and spontaneous abortion in mice

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Chinese Medical Journal 2009年第4期122卷 390-395页

作者： JIANG Pei-juan LIN Qi-de BAO shi-min ZHAO Ai-min ZHANG Yu xiao shi-jin Department of Obstetrics and Gynecology Renji Hospital Schoolof Medicine Shanghai Jiao Tong University Shanghai 200127China Laboratory Animal Center of Shanghai Chinese Academy ofScience Shanghai 201615 China

Background Previous studies have shown that local immune cells in the feto-maternal interface are recruited from peripheral blood, and that chemokines and their receptors play an initial and key role in this recruitment process. In this study, we aimed to determine whether spontaneous abortion is associated with the expression of chemokine receptors CCR3, CCR5, and CXCR3 on CD4^＋ T cells. Methods Peripheral blood, spleen, and thymus were collected from the spontaneous abortion mouse model CBA/JxDBA/2 （SA group, n=14）, the normal pregnant mouse model CBA/JxBALB/c （NP group, n=13）, and normal non-pregnant CBA/J mice （NNP group, n=11）. The number of chemokine receptors CCR3, CCR5, and CXCR3 expressed on CD4^＋ T cells was measured by double-label flow cytometry （FCM） method. Results In peripheral blood, the SA group had significantly lower CCR3 expression （P 〈0.01） and higher CCR5 and CXCR3 expression （P 〈0.01） on CD4^＋ T cells than did the NP group. But comparing these chemokines between the SA and NNP groups, there was no significant difference （P 〉0.05）. In spleen, the SA group expressed significantly lower CCR3 expression （P 〈0.01） and higher CCR5 and CXCR3 expression （P 〈0.05） on CD4^＋ T cells than did the NP group. When compared with the NNP group, the SA group had significantly higher CCR3 expression （P 〈0.01）, but was not statistically different with regards to the other two chemokines （P 〉0.05）. In thymus, the SA group had significantly lower CCR3 expression （P 〈0.05） and higher CXCR3 expression （P 〈0.05） on CD4^＋ T cells than the NP group, with no significant difference in CCR5 expression （P 〉0.05）. Compared with the NNP group, the SA group had higher CCR3 expression （P 〈0.01）, but there was no statistical difference in CXCR3 and CCR5 expression （P 〉0.05） between the two groups. Conclusion The abnormal expression of CCR3, CCR5 and CXCR3 on CD4^＋ T cells may play an important role in the pathogenesis of spontaneous abortion.

关键词： receptors, CCR3, CCR5, CXCR3 CD4-positive T-lymphocytes abortion, spontaneous

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一种基于粗集的目标识别信息提取算法

传感技术学报 2005年第2期18卷 272-276页

作者：肖金石邢昌风海军工程大学电子工程学院武汉430033

目标识别的原始信息往往很粗糙难以直接用于计算。粗集理论是一种对数据进行处理和挖掘的不确定性系统理论,基于此理论提出一种对原始数据进行信息提取的算法。采用关系表存储原始信息,通过简化关系表删去冗余信息,达到提取有用信息的... 详细信息

目标识别的原始信息往往很粗糙难以直接用于计算。粗集理论是一种对数据进行处理和挖掘的不确定性系统理论,基于此理论提出一种对原始数据进行信息提取的算法。采用关系表存储原始信息,通过简化关系表删去冗余信息,达到提取有用信息的目的。该方法运用粗集理论强大的属性约简和规则生成能力,生成的规则简单准确。与其它计算方法比较,粗集在处理粗糙信息方面有计算量小、抗扰性和传递性好的优点。

关键词：粗集理论信息提取目标识别约简

基于Fourier-Mellin变换和相干系数法的重复轨道干涉SAR图像配准新方法

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电子与信息学报 2009年第4期31卷 803-807页

作者：石晓进张云华中国科学院空间科学与应用研究中心北京100190 中国科学院研究生院北京100049

相对于单轨双天线InSAR系统,重复轨道InSAR系统由于轨道不能完全平行,导致InSAR图像对间存在夹角,使其配准更为困难。该文针对非平行重复轨道的InSAR问题,提出了一种结合Fourier-Mellin变换和相干系数法的InSAR图像配准算法,对存在夹角... 详细信息

相对于单轨双天线InSAR系统,重复轨道InSAR系统由于轨道不能完全平行,导致InSAR图像对间存在夹角,使其配准更为困难。该文针对非平行重复轨道的InSAR问题,提出了一种结合Fourier-Mellin变换和相干系数法的InSAR图像配准算法,对存在夹角的SAR复图像对进行精确配准。该方法用于粗配准时,通过引入非线性图像幅度变换预处理,克服了Fourier-Mellin变换无法直接处理SAR图像对幅度分布动态范围大且不均匀的问题,而用于精配准时,通过引入相干系数法,精确估计了复图像对之间存在的微小角度。以SIR-C/X重复轨道的X波段SAR数据为例,详细比较了传统相干系数配准算法和该文算法在配准精度和计算时间上的差异,从而验证了算法的有效性。

关键词：干涉合成孔径雷达重复轨道图像配准 Fourier-Mellin变换相干系数法

高效液相色谱法同时测定人血浆中6种抗癫痫药物及两种活性代谢物的浓度

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中国药学杂志 2006年第24期41卷 1899-1902页

作者：杨洁焦正施孝金复旦大学附属华山医院临床药学研究室

目的建立了同时测定人血浆中扑米酮（PRI）、拉莫三嗪（LTG）、苯巴比妥（PB）、苯妥英（PHT）、奥卡西平（OXC）、卡马西平（CBZ）压两种活性代谢物单羟奥卡西平（MHD）、环氧卡马西平（CBZE）浓度的HPLC方法。方法以盐酸普萘洛尔为内... 详细信息

目的建立了同时测定人血浆中扑米酮（PRI）、拉莫三嗪（LTG）、苯巴比妥（PB）、苯妥英（PHT）、奥卡西平（OXC）、卡马西平（CBZ）压两种活性代谢物单羟奥卡西平（MHD）、环氧卡马西平（CBZE）浓度的HPLC方法。方法以盐酸普萘洛尔为内标，血浆样品经蛋白沉淀法处理后直接进样测定。色谱柱采用Agilent RX—C8柱（4．6mm×250mm，5μm），流动相为甲醇-乙腈-体积分数0．1％三氟乙酸水溶液（20：13．5：66．5）。双波长双通道检测，在215nm测定PRI，LTG，MHD，PB和CBZE，235nm测定OXC，PHT和CBZ。结果PRI，LTG，MHD，PB，CBZE，OXC，PHT和CBZ的线性范围分别是5-50，1-25，1～50，5-100，1～10，0．5～25，1—50，1—25mg·L^-1。平均方法回收率分别为98．7％，97．0％，97．9％，102．9％，100．0％。99．2％，100．1％和101．7％。各待测组分的日内、日间RSD均小于11．6％。结论本法操作简便，结果准确，适用于临床治疗药物监测。

关键词：扑米酮拉莫三嗪单羟奥卡西平苯巴比妥环氧卡马西平奥卡西平苯妥英卡马西平高效液相色谱法

Effect of ZNRD1 gene antisense RNA on drug resistant gastric cancer cells

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World Journal of Gastroenterology 2003年第5期9卷 894-898页

作者： Yu-Mei Zhang Yan-Qiu Zhao Yang-Lin Pan Yong-Quan shi xiao-Hang jin Hui Yi Dai-Ming Fan Department of Gastroenterology,Xijing Hospital,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China Department of Gastroenterology Xijing Hospital Fourth Military Medical University Xi'an 710033 Shaanxi Province China.

AIM: To investigate the expression level of ZNRD1 gene in gastric cancer cells SGC7901 and gastric cancer MDR (multidrug resistant) cells SGC7901/VCR, and to observe the drug sensitizing and proliferation effect of ZNRD1 antisense nucleic acid transduction on SGC7901/VCR ***: Amplification of sequences encoding ZNRD1 from SGC7901/VCR cDNA by PCR. The levels of ZNRD1 mRNA expression were demonstrated using semiquantitative reverse transcription polymerase chain reaction (RT-PCR).Eukaryotic expression vector pcDNA3.1-anti ZNRD1 was constructed and transfected into SGC7901/VCR cells by lipofectamine. Immunochemical method was used to detect the expression of protein in SGC7901/VCR cells and transfectants. The cell cycle alteration and the intracellular adriamycin (ADM) accumulation were observed by *** curve and drug sensitization of cells for vincristine (VCR) were analyzed with MTT ***: We cloned the open reading frame of full-length ZNRD1. The expression of ZNRD1 showed higher in SGC7901/VCR than in SGC7901 cells. The antisense ZNRD1 drug-resistant clones were selected after gene *** results showed that the expression level of ZNRD1 protein was lower in anti ZNRD1-SGC7901/VCR cells than that in non-transfectants. Comparing to SGC7901/VCR and pcDNA3.1-SGC7901/VCR, anti ZNRD1-SGC7901/VCR showed gradually accumulated in G1 phase, with aconcomitant decrease of cell population in S phase. FACSalso suggested intracellular ADM accumulation increased2fold in SGC7901/VCR cells after transfected with *** assay showed that transfectant cells proliferationwas lagged and more sensitive to vcr than ***: ZNRD1 gene displayed highly expression in VCR resistant gastric cancer *** of ZNRD1 protein was effectively blockde in anti ZzNRD1-SGC7901/VCR cells by gene ***1 antisense nucleic acid transfection sensitized drug resistant gastric cancer cells to VCR,increased AD

关键词： ZNRD1基因胃癌耐药反义RNA 癌细胞聚合酶链反应 RT-PCR

COX-2及其信号转导通路的表达与自身免疫型复发性流产的关系

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上海交通大学学报（医学版） 2011年第7期31卷 895-899页

作者：肖世金赵爱民鲍世民上海交通大学医学院附属仁济医院妇产科上海200127 中国科学院上海实验动物中心上海201615

目的探讨环氧化酶2(COX-2)及其信号转导通路相关分子在自身免疫型复发性流产(RSA)发病机制中的作用。方法 83只BALB/c近交系小鼠分为实验组、子宫腔注射对照组和正常妊娠对照组。实验组包括子宫腔人β2糖蛋白1(β2GP1)注射组(n=15)、腹... 详细信息

目的探讨环氧化酶2(COX-2)及其信号转导通路相关分子在自身免疫型复发性流产(RSA)发病机制中的作用。方法 83只BALB/c近交系小鼠分为实验组、子宫腔注射对照组和正常妊娠对照组。实验组包括子宫腔人β2糖蛋白1(β2GP1)注射组(n=15)、腹腔β2GP1注射组(n=10)和皮下β2GP1注射组(n=14);子宫腔注射对照组包括子宫腔生理盐水(NS)注射组(n=10)、子宫腔无关蛋白注射组(n=6)和子宫腔佐剂注射组(n=13);正常妊娠对照组(n=15)为未行任何干预的雌雄BALB/c合笼小鼠。比较各组小鼠的胚胎丢失率、流产率和胎盘平均质量。采用RT-PCR技术检测各组小鼠胎盘组织中COX-2及其信号转导通路相关分子前列腺素D2(PGD2)、干扰素诱导蛋白(IP)、过氧化物酶体增殖物激活型受体α(PPARα)和PPARγ的mRNA表达。结果实验组各亚组小鼠胚胎丢失率均显著高于正常妊娠对照组(P<0.001),胎盘平均质量均显著低于正常妊娠对照组(P<0.05)。子宫腔β2GP1注射组小鼠流产率显著高于其余各组(P<0.05)。胎盘组织中COX-2、PGD2、IP、PPARα、PPARγmRNA表达检测结果显示:实验组各亚组均显著低于正常妊娠对照组(P<0.05),其中子宫腔β2GP1注射组明显低于子宫腔注射对照组(P<0.05)。结论子宫腔注射人β2GP1可诱导建立符合自身免疫型RSA临床特征的小鼠模型,COX-2及其信号转导通路相关分子可能在自身免疫型RSA的发病中发挥重要作用。

关键词：复发性流产自身免疫动物模型 β2糖蛋白1 环氧化酶2