检索结果-南通市图书馆

LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第3期48卷 501-511页

作者： YAN LI HUZHI CAI XIAOlinG PENG YOUHUI LIU QINGYANG CHEN xiangdong lin XINYU CHEN Department of Vascular and Tumor Intervention The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensive Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Nursing Research The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensivie Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Endocrinology The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Preventive Treatment Center The First Hospital of Hunan University of Chinese MedicineChangsha410007China

Background:Renalﬁbrosis is an important process in the development of chronic kidney *** the pathogenesis andﬁnding effective treatments for renalﬁbrosis is *** study aims to investigate whether a newly discovered long non-coding RNA(lncRNA)called LOC103694972 could be a potential target for treatingﬁbrosis of NRK-49F ***:LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal *** dual-luciferase assay conﬁrmed the binding between miR-29c-3p and signal transducer and activator of transcription(STAT3),as well as between miR-29c-3p and lncRNA ***-LOC103694972 and miR-29c-3p mimic were then transfected into TGF-β1-induced NRK-49F ***:The study found that LOC103694972 was highly expressed in TGF-β1-induced NRK-49F *** cells exhibited increased cell length and activity compared to the control *** expression levels of Collagen I,α-Smooth muscle actin(α-SMA),and tissue inhibitor of metalloproteinase(TIMP-1)were increased,while matrix Metalloproteinase 2(MMP2)and matrix Metalloproteinase 9(MMP9)expression was ***,transfection with si-LOC103694972 and miR-29c-3p mimics restored cell morphology and reduced cell *** led to a decrease in the levels of Collagen I,α-SMA,and TIMP-1,as well as an increase in MMP2 and MMP9 ***,TGF-β1-induced NRK-49F cells transfected with miR-29c-3p mimics activated the STAT3-Smad3/CTGF ***:Based on theseﬁndings,lncRNA LOC103694972 shows promise as a target for treating renalﬁ*** negatively regulates miR-29c-3p and activates the STAT3-Smad3/CTGF pathway.

关键词： Renal fibrosis lncRNA LOC103694972 lncRNA Chip miR-29c-3p STAT3-Smad3/CTGF

Seismic comprehensive forecast based on modified project pursuit regression

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Science 2009年第5期22卷 563-574页

作者： Anxu Wu xiangdong lin Changsheng Jiang Yongxian Zhang Xiaodong Zhang Mingxiao Li Ping'an Li Earthquake Administration of Beijing Municipality Beijing 100080 China Institute of Geophysics China Earthquake Administration Beijing 100081 China China Earthquake Networks Center Beijing 100045 China

In the research of projection pursuit for seismic comprehensive forecast, the algorithm of projection pursuit regression （PPR） is one of most applicable methods. But generally, the algorithm structure of the PPR is very complicated. By partial smooth regressions for many times, it has a large amount of calculation and complicated extrapolation, so it is easily trapped in partial solution. On the basis of the algorithm features of the PPR method, some solutions are given as below to aim at some shortcomings in the PPR calculation： to optimize project direction by using particle swarm optimization instead of Gauss-Newton algorithm, to simplify the optimal process with fitting ridge function by using Hermitian polynomial instead of piecewise linear regression. The overall optimal ridge function can be obtained without grouping the parameter optimization. The modeling capability and calculating accuracy of projection pursuit method are tested by means of numerical emulation technique on the basis of particle swarm optimization and Hermitian polynomial, and then applied to the seismic comprehensive forecasting models of poly-dimensional seismic time series and general disorder seismic samples. The calculation and analysis show that the projection pursuit model in this paper is characterized by simplicity, celerity and effectiveness. And this model is approved to have satisfactory effects in the real seismic comprehensive forecasting, which can be regarded as a comprehensive analysis method in seismic comprehensive forecast.

关键词： particle swarm optimization Hermitian polynomial projection pursuit numerical modeling forecasting regression model

在线全文

学校读者我要写书评

暂无评论

用VB编制AutoCAD阀门绘制程序

热能动力工程 2000年第1期15卷 62-64页

作者：林向东哈尔滨.第七三研究所

着重讨论在用ＡｕｔｏＣＡＤ进行热力系统制图设计中，如何采用ＶＢ编制绘制阀门的应用程序，以提高设计绘图的工作效率。

关键词： AutoCAD VB语言阀门绘制制图

Inversion of Stress Fields in the Middle Section of the Xiaojiang Fault and Its Adjacent Area

在线全文

学校读者我要写书评

暂无评论

Earthquake Research in China 2011年第1期25卷 82-91页

作者： lin xiangdong Xu Ping Wu Minjie Gao ling Wu Anxu Lanzhou Institute of Seismology CEA Lanzhou 73000 China Earthquake Administration of Beijing Municipality Beijing 100080 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

With waveform data of 613 earthquakes with ML ≥ 2. 5 in the middle section of the Xiaojiang fault and its adjacent area which occurred during January,1998 to September 2007,focal mechanisms were calculated by the direct wave amplitude ratio of S /P in the vertical component and their characteristics were analyzed. According to regional tectonic features of the middle section of the Xiaojiang fault and its adjacent area,the study region was partitioned into two zones with the Xiaojiang fault as the boundary,e. g. zone A and zone B (including the Xiaojiang fault). In order to research the faults stress in detail,the Xiaojiang fault zone was picked out for independent analysis. The study region was also partitioned into 1°× 1° cells with a 0. 5° step. The stress fields of zone A,B and the fault zone were inverted with the FMSI method (Gephart,1990). The results show that first, the faults are mainly of strike-slip in the middle section and its adjacent area,amounting to 81. 28%,69. 23% and 72. 97% in the A,B and fault zones,respectively. Secondly,the stress inversion also indicates that the directions of maximum principal stress σ1 in the A, B,and fault zones are approximately NNW,NWW and NWW,the stress action is mainly horizontal,and strike-slip faulting is dominant in the study area. On the other hand,the direction of the principal stress field in the central Yunnan block changed from NNW to NWW,however,in the region between the Yuanmou and Pudu River faults,the azimuth of the main compressive stress shows that the north-south slip is obvious. While the direction of the main compressive stress of the Xiaojiang fault zone is nearly NW; in the east of the Xiaojiang fault,the direction of principal compressive stress is NW to NNW in the eastern Yunnan block.

关键词： Middle section of the Xiaojiang fault Focal mechanism Stress field inversion

Comprehensive Research on Focal Mechanism Solutions in the Capital Circle Area of China

在线全文

学校读者我要写书评

暂无评论

Earthquake Research in China 2014年第1期28卷 79-90页

作者： Wu Minjie Wu Anxu Xu Ping lin xiangdong Dong Hongyan Xin Xuexia Li Layue Earthquake Administration of Beijing Municipality First Crust Monitoring and Application Center CEA

Comprehensive statistical analysis was performed on the basic features of focal mechanisms of 619 ML≥2. 0 earthquakes which occurred in the capital circle area from January 2002 to June 2010. By dividing the capital area into three studying regions based on regional tectonic characteristics,cluster analysis was conducted on the focal mechanisms of all subregions using the longest distance method in the statistical cluster analysis to study the characteristics of tectonic stress tensors. The result shows that dominant P-axis azimuth distribution is NNE-NEE and that of T-axis is NNW-NWW,most of the focal areas are controlled by a horizontal stress field and rupture is mainly of horizontal strike-slip. The maximum principal compression stress orientation is NE75° in the west,NE62° in the middle,and near EW in the east of the capital area. The regional tectonic stress field is characterized by horizontal compression.

关键词： Focal mechanism solution Systematic cluster Stress tensor Capital circlearea

在线全文

学校读者我要写书评

暂无评论

黄连素对肥胖小鼠肠道菌群的影响及其机制

基因组学与应用生物学 2019年第2期38卷 810-814页

作者：黄娟胡维林湘东湖南中医药大学第一附属医院长沙410007

为了探索黄连素对肥胖小鼠肠道菌群的影响和作用机制,本研究将40只雄性昆明种小鼠随机分为空白组、模型组、黄连素高剂量组、黄连素中剂量组和黄连素低剂量组,每组8只,除空白组外,其余4组给予高脂饮食,建立实验性肥胖小鼠模型。造模14 d... 详细信息

为了探索黄连素对肥胖小鼠肠道菌群的影响和作用机制,本研究将40只雄性昆明种小鼠随机分为空白组、模型组、黄连素高剂量组、黄连素中剂量组和黄连素低剂量组,每组8只,除空白组外,其余4组给予高脂饮食,建立实验性肥胖小鼠模型。造模14 d后,全部给予正常饮食,黄连素高、中、低剂量组灌胃给予每天0.1～0.3 mL/10 g的药物干预,空白组和模型组给予等剂量的生理盐水,给药持续14 d。每周称量两次体质量,并分别于实验第0、14、28天从眼眶取血测定血脂和炎性因子的含量,收集小鼠粪便测定乳酸杆菌和双歧杆菌的数量。研究结果表明:空白组和模型组小鼠的体质量在第14天时有明显差异,造模成功;实验第28天,黄连素各给药组小鼠的体质量与模型组相比有显著性差异。模型组双歧杆菌、乳酸菌的数量和血脂水平与空白组比较有显著性差异,黄连素给药组能显著改善肥胖小鼠的血脂水平和双歧杆菌、乳酸杆菌的数量。本研究结果初步得出结论认为:黄连素改善肥胖小鼠的作用机制可能与脂质代谢、炎性反应和肠道微环境的改变密切相关。

关键词：黄连素高脂饮食肥胖小鼠模型肠道菌群作用机制

在线全文

学校读者我要写书评

暂无评论

不同养殖模式斑石鲷的鱼肉品质特性分析

食品科学 2016年第3期37卷 17-21页

作者：熊铭吴祖亮林向东海南大学食品学院海南海口570228

对不同养殖模式斑石鲷的生长和鱼肉品质特性进行探究与分析。通过随机选取鲜活斑石鲷,运用质量长度指数K值、色差值、质构特性及感官评定等指标,研究不同养殖模式下斑石鲷的食用品质特性并分析鱼肉差异的成因。结果表明:网箱养殖的斑石... 详细信息

对不同养殖模式斑石鲷的生长和鱼肉品质特性进行探究与分析。通过随机选取鲜活斑石鲷,运用质量长度指数K值、色差值、质构特性及感官评定等指标,研究不同养殖模式下斑石鲷的食用品质特性并分析鱼肉差异的成因。结果表明:网箱养殖的斑石鲷质量长度指数K值为19.29 g/cm,稍高于池塘养殖模式,表明其运动能力更高,且影响极显著;在色差值指标上,池塘养殖的鱼肉肉色鲜亮饱和;在硬度、弹性、内聚性及恢复性等参数上,网箱养殖模式下的斑石鲷鱼片均大于池塘养殖模式;而在咀嚼性这项参数上,池塘养殖的斑石鲷鱼片为2.457 m J,表现更好。养殖模式仅对硬度和恢复性影响显著。

关键词：斑石鲷养殖模式质构特性质量长度指数色差值感官评定

基于罗非鱼肌肉微结构分形维数表征的冻融过程品质变化分析

在线全文

学校读者我要写书评

暂无评论

食品科学 2021年第15期42卷 19-26页

作者：付仁豪汪春玲陈政林向东冯爱国海南大学食品科学与工程学院海南海口570228

为研究罗非鱼片经冻融过程后品质变化规律及机理,选用规格为(130±10)g的新鲜罗非鱼片为样品,分别在-4、-18、-30℃条件下进行不同次数的反复冻融处理,拟将样品品质指标与微结构分形维数建立关联,采用分形维数表征冷冻鱼肉中由因冰晶而... 详细信息

为研究罗非鱼片经冻融过程后品质变化规律及机理,选用规格为(130±10)g的新鲜罗非鱼片为样品,分别在-4、-18、-30℃条件下进行不同次数的反复冻融处理,拟将样品品质指标与微结构分形维数建立关联,采用分形维数表征冷冻鱼肉中由因冰晶而形成的多孔微结构,并测定相应的品质参数。结果表明:分形维数随冻融次数的增加而呈下降趋势。在-4、-18℃和-30℃下冻融4次后,鱼片的分形维数从初始的1.925分别下降到1.815、1.843和1.853,且伴随着总峰面积、弹性、硬度的降低以及电导率、总挥发性盐基氮含量和总色差ΔE的升高,这些参数的变化量总体随着冷冻温度的降低而降低。相关性分析结果表明,不同温度下分形维数与这些传统品质指标存在显著相关性(P<0.05,P<0.01)。综上,本研究证明了分形维数是一种评价冻融过程中罗非鱼片品质的新颖、可行的方法。

关键词：罗非鱼片分形维数微结构冻融循环品质变化

华北北部地区震源机制解及构造应力场特征分析

在线全文

学校读者我要写书评

暂无评论

大地测量与地球动力学 2011年第5期31卷 39-43页

作者：武敏捷林向东徐平北京市地震局北京100038

利用华北北部地区2002-01—2010-06月848个Ml≥2.0地震的震源机制解,根据区域构造活动特征将其划分为4个研究区,分析各研究区震源机制解特征,并采用1°×1°的网格,0.5°滑动分区的方法对华北北部地区各研究区和空间滑动进行应力场特征... 详细信息

利用华北北部地区2002-01—2010-06月848个Ml≥2.0地震的震源机制解,根据区域构造活动特征将其划分为4个研究区,分析各研究区震源机制解特征,并采用1°×1°的网格,0.5°滑动分区的方法对华北北部地区各研究区和空间滑动进行应力场特征研究。结果表明,各研究区的最大主应力的方位为NEE向,最小主应力方位为NNW向,与华北地区区域构造应力场方向较一致。各研究区的应力结构均为走滑型,水平应力作用为华北北部地区构造应力场的主要特征,震源错动方式以水平走滑为主。

关键词：华北地区震源机制解构造应力场最大主应力方位最小主应力方位