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SIRT2 interacts with DDX24 to promote nasopharyngeal carcinoma growth

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BIOCELL 2023年第11期47卷 2445-2452页

作者： HAIYING YUE CHUNHUI WANG HUIJUN ZHU QINGHUA DU JIAN li XUE OU xiangde li QIULU ZHONG YITING XIE DANJING LUO YIHE li CHUNXIAO liANG XUEMEI XU SONGNAN DU WENQI liU Department of Radiotherapy The Second Affiliated Hospital of Guangxi Medical UniversityNanningChina

Background:Nasopharyngeal carcinoma(NPC)is one of the most prevalent cancers in Southeast *** 2(SIRT2)is a member of the NAD+-dependent deacetylase family and has been shown to play important roles in numerous biological ***,Its function in NPC remains *** primary aim of this study is to clarify the role of SIRT2 in ***:In this research,we examined the effect of SIRT2 silencing on NPC cell proliferation and colony formation using vitro NPC cell ***-immunoprecipitation and mass spectrometry was applied to identify SIRT2-interacting proteins in NPC ***:In comparison to nasopharyngeal epithelial NP69 cells,SIRT2 was up-regulated in multiple NPC cell lines,particularly in CNE2 ***2 knockdown abrogated CNE2 cell proliferation and colony formation,whereas SIRT2 overexpression promoted HNE1 cell proliferation and colony *** SIRT2-interacting proteins were gathered in gene expression and regulation processes including RNA processing and *** the SIRT2-interacting proteins,there were multiple DEAD-box(DDX)family *** note,silencing of DDX24 phenocopied the effect of SIRT2 knockdown on NPC *** of DDX24 restored SIRT2-depleted CNE2 cells to proliferative and colony ***:Our study indicates that SIRT2 can interact with DDX24 to enhance NPC *** clinical relevance of SIRT2 and DDX24 in NPC warrants further investigation.

关键词： Nasopharyngeal carcinoma Sirtuin 2 DDX24 Proliferation

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光伏组件雷电冲击损伤特性实验研究

安全、健康和环境 2024年第5期24卷 18-22页

作者：刘璇黄彬臧秋莉李祥德许万红毕晓蕾张英杰化学品安全全国重点实验室山东青岛266104 中石化安全工程研究院有限公司山东青岛266104 中国石化销售股份有限公司广东石油分公司广东广州510000

采用高电压及大电流冲击模拟实验,对光伏组件雷击损伤特性进行了分析,获取了雷击对光伏组件的损伤形貌、雷电路径、损伤阈值、电学特性变化等关键损伤特征。研究结果表明:在自然界雷电情况下,多数为光伏边框或支架接闪,20 kA的雷电流即... 详细信息

采用高电压及大电流冲击模拟实验,对光伏组件雷击损伤特性进行了分析,获取了雷击对光伏组件的损伤形貌、雷电路径、损伤阈值、电学特性变化等关键损伤特征。研究结果表明:在自然界雷电情况下,多数为光伏边框或支架接闪,20 kA的雷电流即可引起边框烧蚀;雷击会影响组件的功能和寿命,随着雷电冲击电压的增大,最大输出功率逐渐减小,冲击电压为300 kV时,最大输出功率变化率达到10.02%。基于雷击损伤实验模拟结果,可以为光伏系统的雷击防护提供数据支撑和参考依据。

关键词：光伏发电系统雷击损伤光伏组件雷电流分量烧蚀损伤雷击防护

TP-PROFILE: Monitoring the Thermodynamic Structure of the Troposphere over the Third Pole

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Advances in Atmospheric Sciences 2024年第6期41卷 1264-1277页

作者： Xuelong CHEN Yajing liU Yaoming MA Weiqiang MA xiangde XU Xinghong CHENG Luhan li Xin XU Binbin WANG Land-Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Atmospheric Science Lanzhou UniversityLanzhou 730000China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Disastrous Weather China Academy of Meteorological SciencesBeijing 100081China

Ground-based microwave radiometers(MWRs)operating in the K-and V-bands(20–60 GHz)can help us obtain temperature and humidity profiles in the *** from some soundings from local meteorological observatories,the tropospheric atmosphere over the Tibetan Plateau(TP)has never been continuously *** part of the Chinese Second Tibetan Plateau Scientific Expedition and Research Program(STEP),the Tibetan Plateau Atmospheric Profile(TPPROFILE)project aims to construct a comprehensive MWR troposphere observation network to study the synoptic processes and environmental changes on the *** initiative has collected three years of data from the MWR *** paper introduces the data information,the data quality,and data *** applications of the data obtained from these MWRs were also *** comparisons of MWR against the nearest radiosonde observation demonstrate that the TP-PROFILE MWR system is adequate for monitoring the thermal and moisture variability of the troposphere over the *** continuous temperature and moisture profiles derived from the MWR data provide a unique perspective on the evolution of the thermodynamic structure associated with the heating of the *** TP-PROFILE project reveals that the low-temporal resolution instruments are prone to large uncertainties in their vapor estimation in the mountain valleys on the TP.

关键词： microwave radiometer thermodynamic structure vertical profile Tibetan Plateau

Research progress on the water vapor channel within the Yarlung Zsangbo Grand Canyon, China

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Atmospheric and Oceanic Science Letters 2024年第5期17卷 10-15页

作者： Xuelong Chen Yajing liu Yaoming Ma xiangde Xu Xin Xu Luhan li Dianbin Cao Qiang Zhang Gaili Wang Maoshan li Siqiong Luo Xin Wang Land–Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijingChina State Key Laboratory of Disastrous Weather China Academy of Meteorological SciencesBeijingChina The Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina College of Atmospheric Sciences Plateau Atmosphere and Environment Key Laboratory of Sichuan ProvinceChengdu University of Information TechnologyChengduChina

The Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team with the“Investigation of the water vapor channel of the Yarlung Zsangbo Grand Canyon(INVC)”in the southeastern Tibetan Plateau(TP).This paper summarizes the scientific achievements obtained from the data collected by the INVC observation network and highlights the progress in investigating the development of heavy rainfall events associated with water vapor *** rain gauge network of the INVC can represent the impacts of the Yarlung Zsangbo Grand Canyon(YGC)topography on precipitation at the hourly *** microphysical characteristics of the precipitation in the YGC are different than those in the lowland *** GPM-IMERG(Integrated MultisatellitE Retrievals for Global Precipitation Measurement)satellite precipitation data for the YGC region should be calibrated before they are *** meridional water vapor flux through the YGC is more important than the zonal flux for the precipitation over the southeastern *** decreased precipitation around the YGC region is partly due to the decreased meridional water vapor flux passing through the ***-resolution numerical models can benefit precipitation forecasting in this region by using a combination of specific schemes that capture the valley wind and water vapor flux along the valley floor.

关键词： Water vapor channel Land-air interaction Mountian meteorology Extreme rainfall Observation network

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长江经济带生态效率测度及分析

生态经济 2018年第8期34卷 174-179页

作者：曹俊文李湘德江西财经大学统计学院

基于PCA-DEA组合模型,对长江经济带11省市2005—2015年的生态效率进行评价,并测算生态效率收敛性以及对其影响因素进行分析。实证结果显示：长江经济带平均生态效率处于中等水平,下游水平高于整体平均水平;各省市之间追赶效应较弱,生态... 详细信息

基于PCA-DEA组合模型,对长江经济带11省市2005—2015年的生态效率进行评价,并测算生态效率收敛性以及对其影响因素进行分析。实证结果显示：长江经济带平均生态效率处于中等水平,下游水平高于整体平均水平;各省市之间追赶效应较弱,生态效率水平没有趋同,差距可能扩大;经济发展水平、外商投资、环境污染治理投资、技术进步与生态效率是正相关关系,而产业结构、地区就业人口总数与生态效率是负相关关系;促进产业结构的转型有利于生态效率的提升。

关键词： PCA-DEA组合模型长江经济带生态效率收敛性 Tobit模型

lncRNA介导ceRNA调控网络作用于缺血性脑卒中的研究进展

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中华神经医学杂志 2021年第11期20卷 1160-1166页

作者：郑继青刘云龙耀斌廖世杰李波香李相德广西医科大学第二附属医院康复医学科南宁530007 广西医科大学第一附属医院骨科南宁530021 广西医科大学第二附属医院放疗科南宁530007

缺血性脑卒中(IS)是由短暂或永久性的局部脑血流减少引起的脑血管病,从细胞和分子层面揭示其的病理生理过程以及探寻新的治疗靶点一直是该病研究的热点。近年来,长链非编码RNA(lncRNA)介导竞争性内源RNA(ceRNA)调控网络已经被证实在IS... 详细信息

缺血性脑卒中(IS)是由短暂或永久性的局部脑血流减少引起的脑血管病,从细胞和分子层面揭示其的病理生理过程以及探寻新的治疗靶点一直是该病研究的热点。近年来,长链非编码RNA(lncRNA)介导竞争性内源RNA(ceRNA)调控网络已经被证实在IS后的病理生理过程中发挥关键作用,能够有效改善IS的诊断、治疗和预后。本文旨在阐述微小RNA(miRNA)、lncRNA在IS中的作用机制及lncRNA作为miRNA的ceRNA对IS的细胞凋亡、细胞活性、血管生成、炎症反应、氧化应激及神经保护等生物学过程的作用,以期拓宽对IS发生发展机制的认知视野,为其诊断和治疗提供新思路。

关键词：缺血性脑卒中长链非编码RNA 竞争性内源RNA 微小RNA