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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 530-534页

作者： Ying Wang Xin-Yi Zhou xiang-yun Lu Ke-Da Chen Hang-Ping Yao Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Hepatocellular carcinoma(HCC)is the third most common cause of cancer-related death worldwide with high *** incidence of HCC is increasing in *** activation of glucose-6-phosphate dehydrogenase(G6 PD)exists in all malignant tumors,including HCC,and is closely related to the development of *** addition,the differential expression of non-coding RNAs is closely related to the development of *** systematic review focuses on the relationship between G6 PD,HCC,and noncoding RNA,which form the basis for the circ RNA/mi RNA/G6 PD axis in *** circular RNA(circ RNA)/micro RNA(mi RNA)/G6 PD axis is involved in development of *** proposed that non-coding RNA molecules of the circ RNA/mi RNA/G6 PD axis may be novel biomarkers for the pathological diagnosis,prognosis,and targeted therapy of HCC.

关键词： Hepatocellular carcinoma Glucose-6-phosphate dehydrogenase Non-coding RNA

Achieving High Strength and High Electrical Conductivity in a CuCrZr Alloy Using Equal-Channel Angular Pressing

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Acta Metallurgica Sinica(English Letters) 2018年第10期31卷 1084-1088页

作者： yun-xiang Tong Yu Wang Zhi-Min Qian Dian-Tao Zhang Li Li Yu-Feng Zheng Institute of Materials Processing and Intelligent Manufacturing College of Materials Science and Chemical Engineering Harbin Engineering University Department of Materials Science and Engineering College of Engineering Peking University

In the present work, a CuCrZr alloy characterized by ultrafine grains and nanoscale particles was prepared by equalchannel angular pressing （ECAP） at 450℃. A desired combination of a tensile strength （580 MPa） and an electrical conductivity （81% International Annealed Copper Standard） is simultaneously obtained in the as-ECAP-processed CuCrZr alloy without additional aging treatment. The improved properties can be mainly attributed to the ultrafine grains and nanoscale precipitates. This processing may pave a way to develop the CuCrZr alloys having high strength and high electrical conductivity for engineering applications.

关键词： Microstructure CuCrZr Equal-channel angular pressing Strengthening

Carbon Sequestration in Soil Humic Substances Under Long-Term Fertilization in a Wheat-Maize System from North China

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Journal of Integrative Agriculture 2014年第3期13卷 562-569页

作者： SONG xiang-yun LIU Shu-tang LIU Qing-hua ZHANG Wen-ju HU Chun-guang College of Resources and Environment Qingdao Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

The changes in humic substances （HS） is fundamental in detecting soil carbon sequestration mechanisms in natural and cultivated environments. Based on a long-term trial, the amounts of water dissolved substances （WSS）, humic acid （HA）, fulvic acid （FA） and humin （HU） were determined to explore the impact of long-term fertilization on HS. Increases in the amounts of WSS, HA, FA and HU were significant different among the treatments with manure. A significant correlation was found between the increased soil organic carbon （SOC） and HS （R^2=0.98, P〈0.01）. The change in the E4/E6 ratio was significantly correlated with the increased SOC （R2=0.88, P〈0.01）, HA （R^2=0.91, P〈0.01）, FA （R^2=0.91, P〈0.01） and HU （R^2=0.88, P〈0.01）. The cluster was mainly divided into two parts as manure fertilization and inorganic fertilization, based on the increases in HA, FA and HU. These results suggest that long term fertilization with manure favours carbon sequestration in HS and is mainly stabilized as HU, while the HA becomes more aliphatic. We conclude that increases in SOC can be linked to changes in the molecular characteristics of HS fractions under long term fertilization.

关键词： carbon sequestration humic acid humin long term fertilization E4/E6 ratio

Galvanic Corrosion Behavior of Copper-Drawn Steel for Grounding Grids in the Acidic Red Soil Simulated Solution

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Acta Metallurgica Sinica(English Letters) 2020年第11期33卷 1571-1582页

作者： Xiao-Lei Fan yun-xiang Chen Jun-Xi Zhang De-Yuan Lin Xuan-Xuan Liu Xiao-Jian Xia Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric PowerShanghai 200090China Electric Power Research Institute of State Grid Fujian Electric Power Company Limited Fuzhou 350007China

The influence of pH and metallographic structure on the corrosion behavior of copper-drawn steel is studied with the simulated *** effect of pH on the corrosion behavior of copper-drawn steel has been investigated using open-circuit potential,potentiodynamic polarization,galvanic current measurement,scanning electron microscopy and scanning vibrating electrode technique *** steel is corroded as anode,while the corrosion of copper plate is protected as *** the results revealed that pH and metallographic structure had a significant influence on the corrosion behavior of copper-drawn *** the decrease in pH value from 6 to 2.4,the corrosion rate of copper-drawn steel galvanic couple(Cu-Fe GC)obviously increased in the simulated solution of acidic red *** electric field formed by the Cu-Fe GC changes the direction of ion migration between the copper and drawn steel electrodes,which impacts the composition and microstructure of corrosion products formed on the electrode surface.

关键词： Cu-Fe galvanic couple Electrochemical test Scanning vibrating electrode technique(SVET)measurement Soil corrosion

Unsymmetric Side Chains of Indacenodithiophene Copolymers Lead to Improved Packing and Device Performance

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Chinese Journal of Polymer Science 2020年第4期38卷 342-348,I0005页

作者： Ying Yang Tong Shan Jian Cao Hua-Chun Wang Ji-Kang Wang Hong-Liang Zhong yun-xiang Xu College of Polymer Science&Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China

Two conjugated polymers(PulDTBD and PulDTQ)with un symmetric side chai ns have been prepared for polymer solar cells using two other polymers(PIDTBD and PIDTQ)with symmetric side chains as control *** combi nation of methyl a nd 4-hexylphenyl side chai ns on the same bridged carb on can en sure good solubility,decrease tt-tt stacking dista nces,and bring proper miscibility with PC71BM ***,the corresp on ding polymer solar cells(PSCs)based on donor polymers with un symmetric side chains exhibited enhanced short-circuit current density(■)and power conversion efficiency(PCE)compared with those of control *** PIDTBD and PIDTQ based devices possessed low PCE of 2.13%and 1.48%,while PCEs of devices based on PulDTBD and PulDTQ were improved to 3.93%and 4.12%,*** results demonstrate that unsymmetric side chain engineering of conjugated polymers is an effective approach to achieve high performance PSCs.

关键词： Polymer solar cell Indacenodithiophene Side-chain engineering Unsymmetric

Rapid discovery and identification of the anti-inflammatory constituents in Zhi-Shi-Zhi-Zi-Chi-Tang

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Chinese Journal of Natural Medicines 2019年第4期17卷 308-320页

作者： WANG Hai-Qiang ZHU yun-xiang LIU Yi-Ning WANG Ruo-Liu WANG Shu-Fang College of Pharmaceutical Sciences Zhejiang University

The anti-inflammatory active ingredients of Zhi-Shi-Zhi-Zi-Chi-Tang(ZSZZCT), a traditional Chinese medicine formula, were predicted and identified using an approach based on activity index, LC-MS, semi-preparative LC and NMR. Firstly, the whole extract of ZSZZCT was analyzed using liquid chromatography-quadrupole time of flight-mass spectrometry(LC-QTOF-MS) and liquid chromatography-ion trap mass spectrometry(LC-IT-MS), 79 constituents were detected and 39 constituents were identified unambiguously or tentatively. Subsequently, the whole extract of the formula was separated into multiple components and the activity index method was used to calculate index values of the 79 constituents by integrating the chemical and pharmacological information of multiple components. Four polymethoxyl flavones were predicted as the major active constituents according to the activity index values. Furthermore, three polymethoxyl flavones were prepared using the strategy with semipreparative LC guided by LC-MS, and their anti-inflammatory activities were validated. The results show that three polymethoxyl flavones with higher positive index values, i.e., 3, 5, 6, 7, 8, 3', 4'-heptamethoxyflavone, 3-hydroxynobiletein and tangeretin had significant anti-inflammatory effects. In conclusion, the predicted results indicated that the activity index method is feasible for the accurate prediction of active constituents in TCM formulae.

关键词： Zhi-Shi-Zhi-Zi-Chi-Tang LC-MS Semi-preparative LC NMR Activity index Anti-inflammatory activity

ABP41 is Involved in the Pollen Tube Development via Fragmenting Actin Filaments

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Molecular Plant 2008年第6期1卷 1048-1055页

作者： Ting Wang yun xiang Jian Hou Hai-yun Ren Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education Beijing Normal University Beijing 100875 People's Republic of China

ABP41 is identified as a novel member of plant villin/gelsolin/fragmin superfamily proteins from lily pollen, which binds stoichiometrically to actin filaments and severs them in vitro. To further understand its in-vivo function and the potential molecular mechanisms, biochemical analysis, fluorescence microscopic observation and microinjection assays were performed. Different biochemical measurements showed that ABP41 maintained actin filaments in forms of short F-actin in vitro. Microinjection of ABP41 into pollen tubes could fragment the pre-existing actin filaments, inhibit the velocity of cytoplasmic streaming, and shorten the length of the clear zone of pollen tube. In addition, it was found that the endogenous ABP41 expressing level was dynamically corresponding to the short actin filament structure in pollen at different stages of pollen germination. Our results suggest that ABP41 is involved in the regulation of actin dynamics during the pollen germination process via maintenance of short dynamic actin filaments.

关键词： ABP41 actin filament fragmentation pollen germination actin-binding protein.

Surfactant Mediated Microphase Separation in Miscible Block Copolymer of Poly(4-vinyl pyridine-b-hydroxybutylacrylate)

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Chinese Journal of Polymer Science 2023年第6期41卷 897-904,I0007页

作者： xiang-yun Xu Yu-Tong Gao Ying-Ying Wang You-Shuang Zhou Bi-Jin Xiong Jin-Tao Zhu Key Laboratory of Materials Chemistry for Energy Conversion and Storage(HUST)of Ministry of Education School of Chemistry and Chemical Engineering.Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory of Optoelectronic Chemical Materials and Devices(Ministry of Education) Jianghan UniversityWuhan 430056China Key Laboratory of Green Preparation and Application of Functional Materials(Ministry of Education) Hubei Key Laboratory of Polymer MaterialsFaculty of Materials Science and EngineeringHubei UniversityWuhan 430062China

Miscible disordered block copolymers(BCPs)are rarely studied due to the limits in self-assembly into ordered ***,we proposed a facile method for the transformation of disordered miscible BCPs to comb-like BCPs with well-ordered microphase separation structures via blending with amphiphilic *** this work,poly(4-vinyl pyridine-b-hydroxybutylacrylate)(P4VP-b-P4HBA)was applied as a model of miscible disordered BCPs and the microphase separation was induced via blending with surfactants of dodecylbenzene sulfonic acid(DBSA)and 3-pentadecylphenol(PDP).The ordered microstructures including spherical and cylindrical morphologies were confirmed by transmission electron microscopy(TEM)and small angle X-ray scattering(SAXS)*** ordered microstructures thermal sensitive,in which ordered and disordered transformation(ODT)was observed in the blend of P4VP-b-P4HBA and PDP whereas it disappeared in the blend of P4VP-b-P4HBA and *** results show that the thermal stability of the ordered microstructures are strongly depends on the interactions between the miscible BCPs and surfactants,which investigated by in situ SAXS and Fourier transform infrared spectrometer(FTIR).The combination of miscible BCPs and surfactant creates a feasible strategy to fabricate ordered nanostructures,which could be employed to develop complicated nanomaterials.

关键词： ordered disordered vinyl

New progress in development of ferroelectric and piezoelectric nanoceramics

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Journal of Advanced Ceramics 2015年第1期4卷 1-21页

作者： Xiao-Hui WANG I-Wei CHEN xiang-yun DENG Yu-Di WANG Long-Tu LI State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPA 19104-6272USA

There has been great progress in the last decade in the synthesis of nanopowders with highly controlled size and size ***,the development of an unconventional pressureless two-step sintering strategy enabling densification without grain growth provides a novel technology suitable for commercial production of nanograin *** particular interest concerning bulk dense nanograin ceramics is the manifestation of ferroelectricity,which remains a fundamental issue to be understood and *** the best powder synthesis and optimized two-step sintering,high-density barium titanate(BT)and related nanograin ceramics have been fabricated to allow for a detailed determination of the size effect on nanometer-scale ferroelectricity and piezoelectricity of fundamental and industrial *** include dense ceramics of undoped BT with an average grain size down to 5 nm,and of(1x)BiScO_(3)xPbTiO_(3)(BSPT)solid solutions with an average grain size down to 10 *** we review the fabrication methods of high-density BT and BSPT nanoceramics and the major findings of the size effect on their microstructure,phase transition and electrical *** ferroelectricity is demonstrated for the first time in 5 nm BT nanoceramics,while strong local piezoelectricity is present in 10 nm BSPT nanoceramics.

关键词： nanoceramic ferroelectric piezoelectric barium titanate size effe

Target Recycling Transcription of Lighting-Up RNA Aptamers for Highly Sensitive and Label-Free Detection of ATP

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Journal of Analysis and Testing 2021年第2期5卷 174-180页

作者： Jia Lun He Bing Ying Jiang Wen Jiao Zhou Ruo Yuan yun xiang School of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing 400054China Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationSchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

We describe here a target recycling transcription of lighting-up aptamer strategy for detecting ATP in human serums in a label-free means with high *** molecules specifically recognize the binding aptamer and result in the structure switching of the DNA assembly probes to imitate the target ATP molecule recycling cycles through the toehold-mediated strand displacement reaction,which causes the formation of many dsDNAs containing the RNA promoter sequences for subsequent transcription generation of large amounts of lighting-up *** organic dye,malachite green,then associates with these lighting-up aptamers to produce significantly enhanced fluorescence signals,which can sensitively detect ATP within a dynamic range from 10 to 500 nM in a label-free *** sensing approach shows a detection limit of 7.3 nM and also has an excellent selectivity for ATP analogue *** addition,this method can detect ATP molecules in diluted human serum samples sensitively,which proves the promising potential to diagnose ATP-related diseases.

关键词： ATP Toehold strand displacement reaction Lighting-up aptamer RNA transcription Recycling amplification