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Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： yifeng Nie Dong Han xiang Li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising *** ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and *** micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative ***,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing ***,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are *** also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

Controllable optofluidic assembly of biological cells using an all-dielectric one-dimensional photonic crystal

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Photonics Research 2022年第1期10卷 14-20页

作者： FENGYA LU LEI GONG YAN KUAI XI TANG yifeng xiang PEI WANG DOUGUO ZHANG Advanced Laser Technology Laboratory of Anhui Province Department of Optics and Optical EngineeringUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Fujian Provincial Key Laboratory of Photonics Technology College of Photonic and Electronic EngineeringFujian Normal UniversityFuzhou 350117China

Opto-thermophoretic manipulation is emerging as an effective way for versatile trapping,guiding,and assembly of biological nanoparticles and *** we report a new opto-thermophoretic tweezer based on an all-dielectric one-dimensional photonic crystal(1 DPC)for reversible assembly of biological cells with a controllable *** reveal its ability of long-range optofluidic manipulation,we demonstrate the reversible assembly of many yeast cells as well as *** cells that are dispersed in water *** 1 DPC-based tweezer can also exert short-range optical gradient forces associated with focused Bloch surface waves excited on the 1 DPC,which can optically trap single *** combining both the optical and thermophoretic manipulation,the optically trapped single polystyrene particle can work as a controllable origin of the reversible cellular *** simulations are performed to calculate the temperature distribution and convective flow velocity on the 1 DPC,which are consistent with the experimental observations and theoretically confirm the long-range manipulations on the alldielectric 1 DPC *** opto-thermophoretic tweezers based on all-dielectric 1 DPC endow the microma-nipulation toolbox for potential applications in biomedical sciences.

关键词： solution dielectric reversible

^(3)He极化系统中FID NMR线圈的优化分析及实验验证

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波谱学杂志 2024年第3期41卷 266-275页

作者：罗庆金吴良勇王雨婷闫海洋向一峰陈思宇中子物理重点实验室核物理与化学研究所中国工程物理研究院四川绵阳621900

超极化^(3)He气体在中子极化、基础物理和诊断医学等领域广泛应用.测量其极化率对于^(3)He极化系统至关重要.通常使用自由感应衰减核磁共振(FID NMR)线圈来检测^(3)He原子的FID信号.线圈的测量信噪比与直径、匝数、以及其与气室的相对... 详细信息

超极化^(3)He气体在中子极化、基础物理和诊断医学等领域广泛应用.测量其极化率对于^(3)He极化系统至关重要.通常使用自由感应衰减核磁共振(FID NMR)线圈来检测^(3)He原子的FID信号.线圈的测量信噪比与直径、匝数、以及其与气室的相对位置等因素相关.关于FID NMR线圈的优化分析,目前仅有少量的文献提及且缺乏详细的实验验证.本文通过对FID信号和线圈噪声的理论分析,建立了线圈测量信噪比模型,并且在基于亚稳态交换光泵(Metastability-Exchange Optical Pumping,MEOP)极化技术的^(3)He极化系统中对FID NMR线圈进行了实验验证.实验结果显示,在半径和高度均为r_(cell)的柱形气室中,线圈的测量信噪比在半径为r_(cell)/2时达到最优值,此结论与理论分析结果相符.该信噪比模型的相对误差不超过10%,证明了理论模型的有效性.这些研究结果对于优化设计^(3)He极化系统具有重要的指导意义.

关键词：自由感应衰减线圈设计极化率测量极化^(3)He 亚稳态交换光泵

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Identification of a novel MYO1D variant associated with laterality defects,congenital heart diseases,and sperm defects in humans

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Frontiers of Medicine 2024年第3期18卷 558-564页

作者： Zhuangzhuang Yuan Xin Zhu Xiaohui Xie Chenyu Wang Heng Gu Junlin Yang Liangliang Fan Rong xiang yifeng Yang Zhiping Tan Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityChangsha410011China Clinical Center for Gene Diagnosis and Therapy The Second Xiangya Hospital of Central South UniversityChangsha410011China Department of Cell Biology School of Life SciencesCentral South UniversityChangsha410013China Department of Gynecology and Obstetrics Xiangya Hospital of Central South UniversityChangsha410008China

The establishment of left–right asymmetry is a fundamental process in animal *** with this process leads to a range of disorders collectively known as laterality defects,which manifest as abnormal arrangements of visceral *** patients with laterality defects,congenital heart diseases(CHD)are *** multiple model organisms,extant research has established that myosin-Id(MYO1D)deficiency causes laterality *** study investigated over a hundred cases and identified a novel biallelic variant of MYO1D(NM_015194:c.1531G>A;p.D511N)in a consanguineous family with complex CHD and laterality *** examination of the proband revealed asthenoteratozoospermia and shortened ***,the effects of the D511N variant and another known MYO1D variant(NM_015194:c.2293C>T;p.P765S)were *** assessment showed that both enhance the interaction withβ-actin and ***,this study revealed the genetic heterogeneity of this rare disease and found that MYO1D variants are correlated with laterality defects and CHD in ***,this research established a connection between sperm defects and MYO1D *** offers guidance for exploring infertility and reproductive health *** findings provide a critical basis for advancing personalized medicine and genetic counseling.

关键词： MYO1D laterality defect congenital heart disease sperm defect β-actin SPAG6

Fu-Zheng-Yi-Liu Formula inhibits the stem cells and metastasis of prostate cancer via tumor-associated macrophages/C-C motif chemokine ligand 5 pathway in tumor microenvironment

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Chinese Journal of Natural Medicines 2024年第6期22卷 501-514页

作者： CHEN Chiwei HUANG Renlun WANG Neng ZHENG yifeng ZHOU Jianfu YANG Bowen WANG Xuan ZHANG Juping PAN Bo CHEN Zhiqiang WANG Shengqi WANG Zhiyu xiang Songtao The Research Center of Integrative Cancer Medicine Discipline of Integrated Chinese and Western Medicinethe Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510000China The First Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510000China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangdong Provincial Academy of Chinese Medical SciencesGuangdong Provincial Hospital of Chinese MedicineGuangzhou 510000China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou 510000China The Research Center for Integrative Medicine School of Basic Medical SciencesGuangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000China

Prostate cancer(PCa)is the second most common malignancy among men *** Fu-Zheng-Yi-Liu(FZYL)Formula has been widely utilized in the treatment of *** study investigates whether the FZYL Formula can inhibit PCa by tar-geting the TAMs/CCL5 *** conducted in vitro co-cultures and in vivo co-injections of PCa cells and TAMs to mimic their *** showed that the FZYL Formula significantly reduced the proliferation,colony formation,subpopulations of PCSCs,and sphere-formation efficacy of PCa cells,even in the presence of TAM ***,the Formula markedly decreased the migration,invasion,and epithelial-mesenchymal transition(EMT)of PCa cells induced by *** FZYL Formula also reversed M2 phenotype polarization in TAMs and dose-dependently reduced their CCL5 expression and secretion,with minimal cytotoxicity *** studies confirmed that the TAMs/CCL5 axis is a critical target of the FZYL Formula,as the addition of exogen-ous CCL5 partially reversed the formula’s inhibitory effects on PCSCs self-renewal in the co-culture ***,the Formula also significantly inhibited the growth of PCa xenografts,bone metastasis,and PCSCs activity in vivo by targeting the TAMs/CCL5 ***,this study not only elucidates the immunomodulatory mechanism of the FZYL Formula in PCa therapy but also highlights the TAMs/CCL5 axis as a promising therapeutic target.

关键词： Traditional Chinese medicine Tumor-associated macrophages Prostate cancer stem cells CCL5 Tumor microenvironment

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麦积山石窟《法华经》变相及其弘法思想

敦煌学辑刊 2009年第4期4卷 76-92页

作者：项一峰刘莉麦积山石窟艺术研究所甘肃天水741020

本文从以下三方面,即:一、《法华经》在中国的弘传及其变相;二、麦积山《法华经》变相;三、麦积山《法华经》变相所弘思想,分别辨析《法华经》在中国,尤其在麦积山石窟的弘传及其变相情况,剖析了麦积山《法华经》变相所示教的内容及思想... 详细信息

本文从以下三方面,即:一、《法华经》在中国的弘传及其变相;二、麦积山《法华经》变相;三、麦积山《法华经》变相所弘思想,分别辨析《法华经》在中国,尤其在麦积山石窟的弘传及其变相情况,剖析了麦积山《法华经》变相所示教的内容及思想,认为麦积山具有与其它石窟的不同之处,为中国佛教、佛教艺术的弘传,起到重要的作用。它与长安佛教集团及汉民族文化艺术有一定的关系。

关键词：麦积山石窟法华经变相弘法思想

基于EMD-CNN-LSTM混合模型的短期电力负荷预测

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华北电力大学学报（自然科学版） 2022年第2期49卷 81-89页

作者：徐岩向益锋马天祥华北电力大学电气与电子工程学院河北保定071003 新能源电力系统国家重点实验室(华北电力大学) 河北保定071003 国网河北省电力有限公司电力科学研究院河北石家庄050021

为了更有效地提取电力负荷数据中的潜藏特征与隐藏信息,提高电力负荷预测精度,针对负荷具有较强非线性、非平稳性和时序性特点,提出一种基于经验模态分解(empirical mode decomposition,EMD)、卷积神经网络(convolutional neural networ... 详细信息

为了更有效地提取电力负荷数据中的潜藏特征与隐藏信息,提高电力负荷预测精度,针对负荷具有较强非线性、非平稳性和时序性特点,提出一种基于经验模态分解(empirical mode decomposition,EMD)、卷积神经网络(convolutional neural network,CNN)和长短期记忆网络(long-term and short-term memory network,LSTM)的混合模型短期电力负荷预测方法,将海量过往负荷数据、温度和历史电价信息以滑动窗口方式构造串联特征向量作为输入,先利用EMD将数据重构成多个分量,将高、中和低频分量各自叠加组合,再运用CNN提取高、中分量的潜藏特征,减少权值数量,并以特征向量的方式输入LSTM网络进行负荷预测,最后叠加各分量预测结果得到最终负荷预测值。实验结果表明,相对于BP神经网络(Back Propagation Neural Network)、支持向量机(support vector machine,SVM)、LSTM模型和EMD-LSTM模型,此模型具有更高的负荷预测精度。

关键词：短期负荷预测经验模态分解卷积神经网络长短期记忆网络经验模态分解-卷积网络-长短期记忆网络混合模型

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试论龙门与麦积山石窟造像艺术之间的关系

敦煌学辑刊 2006年第2期2卷 135-140页

作者：刘晓毅项一峰天水师范学院美术系甘肃天水741000 麦积山石窟艺术研究所甘肃天水741000

本文主要从佛教造像艺术的渊源、中国化造像艺术的流布、历史文献资料等三方面,对麦积山与龙门石窟造像艺术之间的关系进行了初步探讨。通过比较研究,我们发现两处石窟中造像样式非常一致,相互传播影响的关系很密切。

关键词：龙门麦积山造像艺术

基于粒子群算法优化参数的VMD-GRU短期电力负荷预测模型

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华北电力大学学报（自然科学版） 2023年第1期50卷 38-47页

作者：徐岩向益锋马天祥华北电力大学电气与电子工程学院河北保定071003 国网河北省电力有限公司电力科学研究院河北石家庄050021

为了更有效提取电力负荷数据中的特征信息,从原始含噪声较多的负荷序列中提取包含丰富特征信息的信号分量,提高电力负荷预测精度。针对变分模态分解(variational mode decomposition,VMD)参数设定经验与主观性较强,提出一种基于粒子群算... 详细信息

为了更有效提取电力负荷数据中的特征信息,从原始含噪声较多的负荷序列中提取包含丰富特征信息的信号分量,提高电力负荷预测精度。针对变分模态分解(variational mode decomposition,VMD)参数设定经验与主观性较强,提出一种基于粒子群算法(particle swarm algorithm,PSO)优化参数的变分模态分解和门控循环单元(gated recurrent unit,GRU)的组合模型短期电力负荷预测方法,先通过粒子群算法对VMD最佳影响参数组合进行搜寻,得到最佳效果的分解子序列,减少不同趋势信息对预测精度影响。然后运用GRU网络,针对各子序列分量建立基于GRU的预测模型。最后叠加各子序列预测结果得到短期电力负荷的最终预测值。实验结果表明,相对于相对于BP神经网络(Back Propagation Neural Network)、支持向量机(support vector machine,SVM)、GRU模型和EMD-GRU模型以及未经优化VMD-GRU模型,此模型具有更高的负荷预测精度。

关键词：短期负荷预测变分模态分解粒子群算法门控循环单元