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The rapid and efficient strategy for SARS-CoV-2 Omicron transmission control: analysis of outbreaks at the city level

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Infectious Diseases of Poverty 2022年第6期11卷 38-49页

作者： jin‑Xin Zheng Shan Lv li‑Guang Tian Zhao‑Yu Guo Pei‑Yong Zheng yue‑Lai Chen Shi‑yang Guan Wei‑ming Wang Shun‑xian zhang Department of Nephrology Ruijin HospitalInstitute of NephrologyShanghai Jiao Tong University School of MedicineShanghai 200025People’s Republic of China Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research On Tropical DiseasesNational Institute of Parasitic DiseasesShanghai 200025People’s Republic of China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032Peo‑ple’s Republic of China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032People’s Republic of China School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025People’s Republic of China One Health Center Shanghai Jiao Tong Univer‑sity–The University of EdinburghShanghai 200025People’s Republic of China

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant is highly transmissible with potential immune escape. Hence, control measures are continuously being optimized to guard against large-scale coronavirus disease 2019 (COVID-19) outbreaks. This study aimed to explore the relationship between the intensity of control measures in response to different SARS-CoV-2 variants and the degree of outbreak control at city ***: A retrospective study was conducted in 49 cities with COVID-19 outbreaks between January 2020 and June 2022. Epidemiological data on COVID-19 were extracted from the National Health Commission, People’s Republic of China, and the population flow data were sourced from the Baidu migration data provided by the Baidu platform. Outbreak control was quantified by calculating the degree of infection growth and the time-varying reproduction number (Rt). The intensity of the outbreak response was quantified by calculating the reduction in population mobility during the outbreak period. Correlation and regression analyses of the intensity of the control measures and the degree of outbreak control for the Omicron variant and non-Omicron mutants were conducted, ***: Overall, 65 outbreaks occurred in 49 cities in China from January 2020 to June 2022. Of them, 66.2% were Omicron outbreaks and 33.8% were non-Omicron outbreaks. The intensity of the control measures was positively correlated with the degree of outbreak control (r = 0.351,P = 0.03). The degree of reduction in population mobility was negatively correlated with the R_(t) value (r = - 0.612,P < 0.01). Therefore, under the same control measure intensity, the number of new daily Omicron infections was 6.04 times higher than those attributed to non-Omicron variants, and theRt value of Omicron outbreaks was 2.6 times higher than that of non-Omicron variants. In addition, the duration of non-Omicron variant outbreaks was shorter than that

关键词： COVID-19 SARS-CoV-2 Outbreak Population flow Time-varying reproduction number

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头颈部血管瘤及脉管畸形手术治疗专家共识

中国口腔颌面外科杂志 2024年第2期22卷 105-117页

作者：王延安秦中平郑家伟李春洁刘少华杨耀武陈刚陈伟良刘学键杜仲张雷王业飞王德明苏立新谢峰董长宪郭磊李凯顾松何悦张志愿上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海200011 山东省临沂市肿瘤医院血管瘤脉管畸形专科山东临沂276001 四川大学华西口腔医院头颈肿瘤外科四川成都610041 山东大学齐鲁医院口腔颌面外科山东济南250012 空军军医大学口腔医院口腔颌面-头颈肿瘤外科陕西西安710032 武汉大学口腔医院口腔颌面-头颈肿瘤外科湖北武汉430079 中山大学孙逸仙纪念医院口腔颌面外科广东广州510120 山东省第一康复医院血管瘤中心山东临沂276029 北京大学口腔医院口腔颌面外科北京100081 上海交通大学医学院附属第九人民医院眼科上海200011 上海交通大学医学院附属第九人民医院介入科上海200011 上海交通大学医学院附属第九人民医院整复外科上海200011 河南省人民医院血管瘤科河南郑州450003 山东大学附属儿童医院血管瘤与介入血管外科山东济南250022 复旦大学附属儿科医院外科上海201102 上海交通大学医学院附属上海儿童医学中心普通外科上海200127

血管瘤及脉管畸形是头颈部常见的良性脉管源性疾病,随着对非手术治疗方案的深入研究与广泛应用,大量患者在微创或无创情况下得以改善或治愈疾病,但在特定情况下,手术依然是血管瘤及脉管畸形综合序列治疗中不可替代的治疗手段。然而,针... 详细信息

血管瘤及脉管畸形是头颈部常见的良性脉管源性疾病,随着对非手术治疗方案的深入研究与广泛应用,大量患者在微创或无创情况下得以改善或治愈疾病,但在特定情况下,手术依然是血管瘤及脉管畸形综合序列治疗中不可替代的治疗手段。然而,针对头颈部血管瘤及脉管畸形,如何选择和应用手术诊疗技术,学术界尚未形成规范和共识。为进一步提高国内同行对头颈部血管瘤及脉管畸形的治疗水平,规范和统一手术治疗策略,本文汇集全国多所医学院校及附属医院相关专家的讨论意见,借鉴和参考国内外相关最新成果与诊治经验,从头颈部血管瘤及脉管畸形的临床诊断及术前准备、手术适应证及策略、术后护理及观察、术后常见并发症及处理、随访及社会心理支持等方面,制定此专家共识,以帮助和指导相关专业的医师开展规范化手术治疗。

关键词：头颈部血管瘤脉管畸形手术治疗专家共识

Loss of Hrh2 on dopaminergic neurons leads to mania-like behavior in mice

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中国药理学与毒理学杂志 2021年第9期35卷 684-684页

作者： MA Shi-jia zhang Xing-xian li yue HU Wei-wei CHEN zhong zhang xiang-nan Institute of Pharmacology&Toxicology College of Pharmaceutical SciencesKey Laboratory of Medical Neurobiology of the Ministry of Health of ChinaZhejiang UniversityHangzhou 310058China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province College of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310058China

OBJECTIVE Dysfunction of the dopaminergic(DA)neurons is implicated in the pathogenesis of bipolar disorder(BPD).Hista⁃mine receptor 2(Hrh2)is highly expressed in DA neurons,and its antagonists have been reported to induce mania phase of ***,whether Hrh2 on DA neurons contributes to BPD patho⁃genesis is *** present study aims to explore the role of hrh2 on DA neurons in the pathology of *** AAV-FLEX-shHrh2 was injected into a targeted brain area of DAT-Cre mice,leading to a selective brain-regional loss of Hrh2 on DA neurons.A series of behavior tests were used to measure the sponta⁃neous activity,anxiety and depression level of Hrh2-deficient ***①In the open field test and home-cage activity test,Hrh2-defi⁃cient mice displayed increased spontaneous activity.②Hrh2-deficient mice showed reduced depression level in the tail suspension test,forced swimming test and sucrose preference test.③The anxiety level of Hrh2-deficient mice was decreased in the open field ***⁃SION Hrh2 on DA neurons is closely related with mania-like behavior.

关键词： bipolar disorder mania histamine receptor 2 dopaminergic neurons

CD155/SRC complex promotes hepatocellular carcinoma progression via inhibiting the p38 MAPK signaling pathway and correlates with poor prognosis

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CD155/SRC complex promotes hepatocellular carcinoma progress...

Lung-protective Ventilation in Patients with Brain Injury： A Multicenter Cross-sectional Study and Questionnaire Survey in China

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Anli jin CHUN-YAN zhang wen-jing ZHENG jinG-RONG xian wen-jinG yang TE liU WEI CHEN tong li BEI-li WANG BAI-SHEN PAN QIAN li JIAN-wen CHENG PENG-xiang WANG BO HU JIAN ZHOU JIA FAN XIN-RONG yang WEI GUO Department of Laboratory Medicine Zhongshan HospitalFudan University 上海中医药大学上海老年医学研究所

Background:Hepatocellular carcinoma(HCC) is a prevalent malignancy with poor *** a cell adhesion molecule,poliovirus receptor(PVR/CD155) is abnormally overexpressed in tumor cells and related to tumor proliferation and ***,the potential role and mechanism of CD155 have not yet been elucidated in ***:Immunohistochemistry,RT-PCR and western blot assays were used to determine CD155 expression in HCC cell lines and *** Counting Kit-8 and colony formation assays were used to examine cell *** and wound healing assays were used to evaluate cell migration and *** apoptosis and cycle distribution were assessed by flow *** regression and Kaplan-Meier analyses were performed to explore the clinical significance of *** role of CD155 in vivo was evaluated by establishing liver orthotropic xenograft mice ***-sequencing,bioinformatics analysis and co-immunoprecipitation assay were used to explore the downstream signaling pathway of ***:CD155 was up-regulated in HCC tissues and represented a promising prognostic indicator for HCC patients(n=189) undergoing curative *** CD155 expression enhanced cell proliferation,migration and invasion,and contributed to cell survival in ***155 overexpression also induced epithelial-mesenchymal transition in HCC ***155function in HCC involved SRC/p38 MAPK signaling ***155 interacted with SRC homology-2 domain of SRC and promoted SRC activation,further inhibiting the downstream p38 MAPK signaling pathway in ***:CD155 promotes HCC progression via the SRC/p38 MAPK signaling ***155 may represent a predictor for poor post-surgery prognosis in HCC patients.

关键词：

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Chinese Medical Journal 2016年第14期129卷 1643-1651页

作者： Xu-ying luo ying-Hong Hu xiang-Yuan Cao Yan Kang li-Ping liu Shou-Hong Wang Rong-Guo Yu xiang-You Yu Xia zhang Bao-Shan li Zeng-xiang Ma Yi-Bing weng Heng zhang De-Chang Chen Wei Chen wen-jin Chen Xiu-Mei Chen Bin Du Mei-li Duan jin Hu Yun-Feng Hoang Gui-Jun Jia li-Hong li Yu-min liang Bing-Yu Qin xian-Dong Wang Jian Xiong li-Mei Yan Zheng-Ping yang Chen-ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-lin FU lin Zhao Qi-Bing Huang ying-Guang Xie Xiao-Bo Huang Guo-Bin zhang Wang-Bin Xu Yuan Xu Yaling liu He-ling Zhao Rong-Qing Sun ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng yang ming Xu zhong-Hua Shi Han Chen Xuan He Yan-lin yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou Department of Critical Care Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Neurological Intensive Care Unit Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510000 China Surgical Intensive Care Unit Fujian Province Hospital Fuzhou Fujian 350000 China Department of Critical Care Medicine First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Critical Care Medicine Bethune International Peace Hospital Shijiazhuang Hebei 050000 China Department of Critical Care Medicine Yuncheng Central Hospital Yuncheng Shanxi 044000 China Department of Emergency and Critical Care Medicine Cangzhou People's Hospital Cangzhou Hebei 061000 China Department of Critical Care Medicine Beijing Luhe Hospital Capital Medical University Beijing 101100 China Department of Critical Care Medicine First Hospital of China Medical University Shenyang Liaoning 110000 China Department of Critical Care Medicine Shanghai Changzheng Hospital Shanghai 200000 China Department of Critical Care Medicine Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Critical Care Medicine Miyun County Hospital Beijing 100038 China Medical Intensive Care Unit Peking Union Medical College Hospital Beijing 101500 China Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 Chin

Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in China. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across China. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in China, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.

关键词： Brain Injury Epidemiology Lung-protective Ventilation Mechanical Ventilation

2019 Chinese expert consensus statement on diagnosis and treatment of syphilis

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Chinese Medical Journal 2020年第19期133卷 2335-2337页

作者：无 Qian-Qiu Wang Rui-li zhang yue-Ping Yin Quan-zhong liu Shu-Zhen Qi Dong-Mei Xu Yu-Ye li Xiao-Fang li Xiao-Hong Su min-Zhi Wu xian-Biao Zou li-Gang yang xiang-Sheng Chen Ping-Yu Zhou jin-Hua Xu xiang-Dong Gong Guo-Jun liang Juan Jiang Hao Cheng Feng-Qin Ge National Center for Sexually Transmitted Disease Control China Centers for Disease Control and Prevention Committee of Sexually Transmitted Disease Branch of DermatovenereologyChinese Medical Association Committee of Sexually Transmitted Disease Branch of DermatologistsChinese Medical Doctor Association Institute of Dermatology Chinese Academy of Medical Science&Peking Union Medical CollegeNational Center for Sexually Transmitted Disease ControlChina Centers for Disease Control and PreventionNanjingJiangsu 210042China Department of Dermatology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China Department of Dermatology General Hospital of Tianjin Medical UniversityTianjin 300052China Department of Neurology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Dermatology The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Dermatology The 5th People’s Hospital of SuzhouSuzhouJiangsu 215131China Department of Dermatology The First Affiliated Hospital of General Hospital of People’s Liberation ArmyBeijing 100037China Department of Dermatology Dermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China Department of Sexually Transmitted Disease Institute Shanghai Skin Disease HospitalShanghai 200071China Department of Dermatology Huashan Hospital of Fudan UniversityShanghai 200040China Department of Dermatology Sir Run Run Shaw Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310016China

Syphilis,caused by Treponema pallidum subsp pallidum(***),is a chronic,systemic human disease transmitted through sexual *** incidence and prevalence of syphilis is still high in China.[1]To guide the prevention measures and management of this disease,we renew the guidelines on diagnosis and treatment of syphilis[Supplementary file,http://***/CM9/A292].Manifestations and diagnosis of all stages of syphilis are presented in Table 1,and management in Table 2.

关键词： diagnosis prevention treatment

固相萃取-高效液相色谱法分析香辛料对酱卤肉中β-咔啉类杂环胺形成的影响

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现代食品科技 2019年第3期35卷 234-240页

作者：李进李凯凯高悦项贤统李春美华中农业大学食品科技学院华中农业大学环境食品学教育部重点实验室湖北武汉430070

建立了固相萃取-高效液相色谱分析卤肉中β-咔啉类杂环胺含量的方法,并研究六种中国传统香辛料对卤鸡肉中β-咔啉类杂环胺形成的影响。样品经二氯甲烷萃取,离心和混合阳离子萃取小柱净化后,采用荧光检测器检测杂环胺含量。结果表明,2种... 详细信息

建立了固相萃取-高效液相色谱分析卤肉中β-咔啉类杂环胺含量的方法,并研究六种中国传统香辛料对卤鸡肉中β-咔啉类杂环胺形成的影响。样品经二氯甲烷萃取,离心和混合阳离子萃取小柱净化后,采用荧光检测器检测杂环胺含量。结果表明,2种杂环胺在线性范围内线性关系良好,相关系数r>0.999,检出限为0.17～0.30ng/g。杂环胺的加标回收率为81.92%～93.37%,相对标准偏差(RSD)为3.66%～7.49%。该方法操作简单,净化效果好,可满足实际样品分析的需求。在不添加香辛料的对照组中检测到Harman和Norharman两种杂环胺,6种香辛料对杂环胺抑制能力不同,5%添加剂量下,干姜、青花椒和桂皮抑制率最强达到42%～60%,红花椒、陈皮和黑胡椒的抑制效果较弱。拟合了香辛料的抗氧化能力与抑制能力之间的相关性,结果表明香辛料的抑制能力与羟基自由基的清除能力相关,为研究抑制机理提供线索。

关键词：固相萃取酱卤肉制品 β-咔啉类杂环胺香辛料

受限空间内油水界面动态特性及粘附行为的荧光原位观测

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物理化学学报 2016年第5期32卷 1257-1266页

作者：刘翔王金涛张跃李占宏许常红佟林中国计量科学研究院力声所容量密度室北京100013

水污染作为润滑油污染的常见形式,对润滑油本身以及机械系统都有巨大的危害。为了模拟实际非均匀多相系统中的界面行为,本文搭建了高精度点接触实验台来研究传统的不溶相替换问题。将目前静态平行受限空间内油水界面行为的研究推广到动... 详细信息

水污染作为润滑油污染的常见形式,对润滑油本身以及机械系统都有巨大的危害。为了模拟实际非均匀多相系统中的界面行为,本文搭建了高精度点接触实验台来研究传统的不溶相替换问题。将目前静态平行受限空间内油水界面行为的研究推广到动态点接触楔形受限空间内,探究了游离水滴穿过点接触狭缝间毛细油池过程中的界面特性。重点关注固壁润湿性以及固壁的分离运动对整个侵入过程中液滴动态行为的影响。实验发现了铺展系数是决定油水界面融合和分离特性的关键因素,揭示了固壁润湿性和球盘间的相对分离运动会影响游离水滴穿过毛细油池之后的粘附行为。表面张力和液体与壁面之间的粘附功能够解释观测的实验现象。

关键词：受限空间油水两相界面行为液滴融合固壁润湿性粘附液滴分配

Determination of Double Beta Decay Half-life of 136Xe with the PandaX-4T Natural Xenon Detector

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Research 2023年第2期2022卷 33-41页

作者： lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng xiangyi Cui yingjie Fan Deqing Fang Changbo Fu Mengting Fu lisheng Geng Karl Giboni linhui Gu Xuyuan Guo Ke Han Changda He jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou xiangdong Ji Yonglin Ju Chenxiang li Jiafu li mingchuan li Shu li Shuaijie li Qing lin Jianglai liu Xiaoying Lu lingyin luo Yunyang luo wenbo Ma Yugang Ma Yujun Mao yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian xiangxiang Ren Changsong Shang Guofang Shen wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang yuehuan Wei Mengmeng Wu Weihao Wu jingkai Xia Mengjiao Xiao xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong yang Chunxu Yu Jumin Yuan ying Yuan Zhe Yuan Dan zhang minzhen zhang Peng zhang Shibo zhang Shu zhang Tao zhang li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou IMOE Key Laboratory for Particle Astrophysics and Cosmology Shanghai Key Laboratory for Particle Physics and Cosmology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Sichuan Research Institute Shanghai Jiao Tong UniversityChengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao266237 ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of ministry of Education Shandong UniversityQingdao266237 ShandongChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory NuclearPyics and Ionampplication(MOE)Instituteof ModenPysics Fun Universty Shanghai 200433China School of Physics Peking UniversityBeijing 100871China Schol of Physics Beihang UniversityBejing 100191China International Research Center for Nuclei and Particles in the Cosmos Beijing key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Physics University of MarylandCollge ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratoryof Particle Detetion and Electronics University of Scienceand Technology of ChinaHefei230026China Department of Modern Physics University of Science and Technology of ChinaHefei230026China SJTU ParisElite Instute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta *** report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release.

关键词： decay double Determination