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Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review

World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić Srdjan M Stefanović Milošn Milosavljević Vladimir S Janjić Marko M Folić nevena d Folić Jovana Z Milosavljević department of Pharmacology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Clinical Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharmaceutical and Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia department of Anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUnd Women with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAI antipsychotics during *** To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAI antipsychotic use in *** A literature search was performed through november 11,2023,using three online databases:PubMed/MEdLInE,Scopus,and Web of *** reports or case series that reported information about the outcomes of pregnancy in women who used LAI antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative summation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcomes of LAI antipsychotic use in 74 women and 77 *** use of secondgeneration LAI antipsychotics was reported in the majority(n=47;61.0%)of ***-generation LAI antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in ***,there were no reports of negative long-term developmental *** Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcome Review

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Structural changes in the obese brain

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neural Regeneration Research 2024年第12期19卷 2561-2562页

作者： Anna R.R.da Conceicao Marcelo n.n.Vieira Fernanda G.de Felice d’Or Institute for Research and Education Rio de JaneiroBrazil Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).

关键词： diseases consequences prevalence

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High strength Al-Cu-Mg based alloy with synchronous improved tensile properties and hot-cracking resistance suitable for laser powder b e d fusion

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Journal of Materials Science & Technology 2023年第10期141卷 155-170页

作者： q.Z.Wang n.Kang x.Lin M.EL Mansori W.d.Huang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Arts et Metiers Institute of Technology MSMPHESAM UniversitéChâlons-en-Champagne F-51006France Key Laboratory of Metal High Performance Additive Manufacturing and Innovative design MIIT ChinaNorthwestern Polytechnical UniversityXi’an 710072China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843USA

In present work,a novel crack-free Al-Cu-Mg-Si-Ti alloy with synchronous improved tensile properties and hot-cracking resistance was proposed and successfully manufactured by laser powder bed fusion(LPBF).The microstructure evolution behaviors and the corresponding strengthening mechanisms were investigated in *** LPBF-processed Al-Cu-Mg-Si-Ti alloy presents a heterogeneous microstructure consisting of ultrafine equiaxed grains(UFGs)at the boundary and coarse columnar grains(CGs)at the center of the single molten ***-precipitated d022-Al 3 Ti particles were found to act as the nuclei to refine the grains at the boundary of the molten pool during solidification process,which is attributed to the low cooling rate providing the sufficient incubation time for the precipitation of d022-Al 3 *** are two orientation relationships(ORs)betweenα-Al and d022-Al 3 Ti,i.e.[001]α-Al//[001]d022-Al3Ti,(200)α-Al//(200)d022-Al3Ti and[1¯1¯2]α-Al//[¯111]d022-Al3Ti,(1¯11)α-Al//(¯11¯2)d022-Al3Ti,which are two of the eight ORs predicted with the E2EM *** grains in present alloy,no matter for UFGs or CG,exhibited high critical hot-cracking stress,which means a strong hot-cracking ***-nanoprecipitation of Cu-,Mg-,and Si-rich q’and S’phases was introduced to enhance the mechanical performance ofα-Al *** as-built sample exhibits superior tensile properties,with the yield strength(YS)of 473±8 MPa,ultimate tensile strength(UTS)of 541±2 MPa and elongation(EI)of 10.9%±1.2%.

关键词： Laser powder bed fusion High strength Al-Cu-Mg alloys duplex microstructure Precipitation Tensile properties

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Influence of cardiorespiratory fitness and body composition on resting and post-exercise indices of vascular health in young adults

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Sports Medicine and Health Science 2024年第1期6卷 54-62页

作者： Rian q.Landers-Ramos Kathleen dondero Ian Imery nicholas Reveille Hannah A.Zabriskie devon A.dobrosielski Towson University Department of KinesiologyTowsonMDUSA University of Maryland School of Medicine Department of Physical Therapy and Rehabilitation SciencesBaltimoreMDUSA Johns Hopkins University Department of Cell BiologyBaltimoreMDUSA University of Florida Department of Applied Physiology and KinesiologyGainesvilleFLUSA

Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy *** study aimed to compare flow mediated dilation(FMd)and vascular augmentation index(AIx75)between young adults with low,moderate,and high levels of cardiorespiratory fitness before and after an acute bout of aerobic ***-three participants(22 men;21 women)between 18 and 29 years of age completed the *** were classified into low,moderate,and high health-related cardiorespiratory fitness groups according to age-and sex-based relative maximal oxygen consumption(V_O2 max)percentile *** was performed using doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70%V_O2 max.A significant interaction(p=0.047;ηp 2=0.142)was observed,with the moderate fitness group exhibiting a higher FMd post-exercise compared with baseline([6.7%3.1%]vs.[8.5%2.8%],p=0.028;d=0.598).We found a significant main effect of group for AIx75(p=0.023;ηp 2=0.168),with the high fitness group exhibiting lower AIx75 compared to low fitness group([10%10%]vs.[2%10%],respectively,p=0.019;g=1.07).This was eliminated after covarying for body fat percentage(p=0.489).Our findings suggest that resting FMd and AIx75 responses are not significantly influenced by cardiorespiratory fitness,but FMd recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels.

关键词： Cardiorespiratory fitness Flow mediated dilation Augmentation index Vascular Acute exercise Body composition

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A Learning-based Control Framework for Fast and Accurate Manipulation of a Flexible Object

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Journal of Bionic Engineering 2024年第4期21卷 1761-1774页

作者： Junyi Wang xiaofeng xiong Silvia Tolu Stanislav n.Gorb department of Electrical and Photonics Engineering Technical University of DenmarkAnker Engelunds Vej 101Kongens LyngbyZealand2800Denmark SdU Biorobotics Mærsk Mc-Kinney Møller InstituteUniversity of Southern Denmark(SDU)Campusvej 55Odense MFunen5230Denmark department Functional Morphology and Biomechanics Zoological InstituteUniversity of KielAm Botanischen Garten 1–9D-24118KielSchleswig-HolsteinGermany

This paper presents a learning-based control framework for fast(3 times of others).Besides,motion tracking errors are greatly reduced to 13.29 and 22.36 of constant impedance control by the OIAC of the proposed *** ad... 详细信息

This paper presents a learning-based control framework for fast(nd accurate manipulation of a flexible object,i.e.,whip *** framework consists of a motion planner learned or optimized by an algorithm,Online Impedance Adaptation Control(OIAC),a sim2real mechanism,and a visual feedback *** experimental results show that a soft actor-critic algorithm outperforms three deep Reinforcement Learning(dRL),a nonlinear optimization,and a genetic algorithm in learning generalization of motion *** can greatly reduce average learning trials(tond maximize average rewards(to>3 times of others).Besides,motion tracking errors are greatly reduced to 13.29 and 22.36 of constant impedance control by the OIAC of the proposed *** addition,the trajectory similarity between simulated and physical whips is *** presented framework provides a new method integrating data-driven and physics-based algorithms for controlling fast and accurate arm manipulation of a flexible object.

关键词： deep reinforcement learning deformable object manipulation Variable impedance control Sim2real Visual tracking

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Two-dimensional magnetic materials for spintronic applications

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nano Research 2024年第2期17卷 743-762页

作者： Shivam n.Kajale Jad Hanna Kyuho Jang deblina Sarkar MIT Media Lab Massachusetts Institute of TechnologyCambridgeMA 02139USA department of Information Technology and Electrical Engineering ETH ZürichZürich8092Switzerland

Spintronic devices are driving new paradigms of bio-inspired,energy efficient computation like neuromorphic stochastic computing and in-memory *** have also emerged as key candidates for non-volatile memories for embedded systems as well as alternatives to persistent *** meet the growing demands from such diverse applications,there is need for innovation in materials and device designs which can be scaled and adapted according to the ***-dimensional(2d)magnetic materials address challenges facing bulk magnet systems by offering scalability while maintaining device integrity and allowing efficient control of *** this review,we highlight the progress made in experimental studies on 2d magnetic materials towards their integration into spintronic *** provide an account of the various relevant material discoveries,demonstrations of current and voltage-based control of magnetism and reported device systems,while also discussing the challenges and opportunities towards integration of 2d magnetic materials in commercial spintronic devices.

关键词： spintronics van der Waals magnetic tunnel junction(MTJ) spin-orbit torque magnetism

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Integrative Analysis of Transcriptome and Phenolic Compounds Profile Provides Insights into the quality of Soursop (Annona muricata L.) Fruit

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1717-1732页

作者： Yolotzin Apatzingán Palomino-Hermosillo Ángel Elpidio díaz-Jasso Rosendo Balois-Morales Verónica AlhelíOchoa-Jiménez Pedro Ulises Bautista-Rosales Guillermo Berumen-Varela Unidad de Tecnología de Alimentos-Secretaría de Investigación y Posgrado Universidad Autónoma de Nayarit.Ciudad de la Cultura SNTepic63000NayaritMéxico Programa Académico de Biología Unidad Académica de AgriculturaUniversidad Autónoma de NayaritKm.9.Carretera Tepic-CompostelaXalisco63780NayaritMéxico Estancias Posdoctorales-Consejo nacional de Humanidades Ciencias y TecnologíasCoordinación de Apoyos a Becarios e InvestigadoresDirección de PosgradoCiudad de México03940México

Soursop(Annona muricata L.)is a tropical fruit highly valued for its uniqueﬂavor,nutritional value,and health-promoting *** ripening process of soursop involves complex changes in gene expression and metabo-lite accumulation,which have been studied using various omics *** analysis has provided insights into the regulation of key genes involved in ripening,while metabolic compound analysis has revealed the presence of numerous bioactive compounds with potential health beneﬁ***,the integration of transcrip-tome and metabolite compound data has not been extensively explored in ***,in this paper,we present a comprehensive analysis of the transcriptome and phenolic compound proﬁles of soursop during *** integration analysis showed that the genes and phenolic compounds were mainly involved in the starch and sucrose metabolism pathways during soursop ***,the phenolic compounds Kaempferol 3-q-galactoside,Procyanidin C1,Procyanidin trimmer C1,and m-Coumaric,as well as the genes Ubiquitin-like protein 5(UBL5_ARATH),ATP-dependent zinc metalloprotease FTSH8(FTSH8_ORYSJ),Zinc transporter 4(ZIP4_AR-ATH),Thioredoxin-like 3-1(TRL31_ORYSJ),Mitogen-activated protein kinase YOdA(YOdA_ARATH),R-man-delonitrile lyase-like(MGL_ARATH),26s protease regulatory subunit 6A homolog(PRS6_SOLLC),Cytochrome P45072A13(C7A13ARATH),Cytochrome P45084A1(C84A1_ARATH)and Homoserine O-trans-acetylase(MET2-ORYSJ)were correlated and differentially accumulated and expressed,*** study provides new insights into the molecular mechanisms underlying soursop ripening and may contribute to the development of strategies for improving the nutritional quality and shelf life of this important fruit.

关键词： Bioinformatics data integration genes metabolites postharvest storage ripening

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Improvement of Fracture Toughness Lanthanum Zirconate

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材料工程 2006年第5期34卷 51-56,62页

作者： LI J dAI H LI q ZHOnG x H CAO x q Key Lab of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China GraduateSchool of the Chinese Academy of Sciences Beijing 100049 China

La2Zr2O7 （LZ） is a promising thermal barrier coating material for the high temperature applications. The fracture toughness and microhardness of nanocrystalline LZ （n-LZ）, microcrystalline LZ （m-LZ） and LZ-5mol%8YSZ （LZ-5-8YSZ） composite （8YSZ for zirconia stabilized by 8 mol% ytrria） were studied. The n-LZ had a thermal expansion coefficient of （9.6±0.4）×10 -6 K -1 （200～1000℃） and fracture toughness of （1.98±0.07） MPa·m 1/2 which are obviously higher than those of the m-LZ （（9.1±0.4）×10 -6 K -1 and （1.40±0.23） MPa·m 1/2, respectively）, indicating that nanofication was an efficient way to increase the toughness and thermal expansion coefficient of LZ. The composite LZ-5-8YSZ had a higher fracture toughness （（1.88±0.30） MPa·m 1/2） than LZ, which was close to that of 8YSZ densified by superhigh pressure （SHP）.

关键词： ceramics nanostructure fracture toughness thermal expansion

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MICROSTRUCTURE EVOLUTIOn And MECHAnICAL HARdEnInG OF HYPEREUTECTOId PEARLITIC STEEL dURInG COLd ROLLInG

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Acta Metallurgica Sinica(English Letters) 2007年第4期20卷 287-292页

作者： x. Zhang C.x. Wang x.M. Liu q.n. Shi Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and Technology Kunming 650093 China Institute for Structural Materials Central Iron and Steel Research InstituteBeijing 100081 China

The microstructure evolution of different cold rolling reductions （from 0 to 81.6%） was studied by SEM （scanning electron microscopy） and TEM （transmission electron microscope）. The study showed that the orientation multiplicity of pearlitic lamellas resulted in inhomogeneous deformation of different pearlitic lamellas, and with the increase of reduction, the microstructure underwent a course of ＂homogeneity → inhomogeneity → homogeneity＂. The result of xRd （x-ray diffraction） analysis indicated that cementite did not decompose and dissolve into ferrite; the results of the mechanical property test suggested that the relationship between Rp0.2 （yield strength） and ε （true strain） was in good agreement with Hollomon relationship. With the equation Rp0.2 = 1465ε^0.18, the yield strength of the steel in different reductions could be well predicted.

关键词： cold rolling hypereutectoid pearlitic steel microstructure evolution mechanical hardening

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青藏高原及其周边新近纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 1343-1378页

作者：邓涛方小敏李强王世骐吴飞翔侯素宽马姣江左其杲孙丹辉郑妍史勤勤孙博阳李录中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044 中国科学院生物演化与环境卓越创新中心北京100044 中国科学院大学地球与行星科学学院北京100049 中国科学院青藏高原研究所中国科学院青藏高原地球科学卓越创新中心北京100101 北京大学地球与空间科学学院造山带与地壳演化教育部重点实验室北京100871

青藏高原在新近纪的显著隆升对东亚乃至全球的气候环境产生了巨大的影响,因此,建立青藏高原新近纪地层框架对地球科学各领域的研究都有重要的意义.国际新近纪年代地层系统以海相为标准,分为中新统的6个阶和上新统的2个阶.新生代以来,陆... 详细信息

青藏高原在新近纪的显著隆升对东亚乃至全球的气候环境产生了巨大的影响,因此,建立青藏高原新近纪地层框架对地球科学各领域的研究都有重要的意义.国际新近纪年代地层系统以海相为标准,分为中新统的6个阶和上新统的2个阶.新生代以来,陆相地层在陆地上所占的比例迅速增加,到新近纪时已远远超过海相地层,在青藏高原及其周边地区几乎全部为陆相地层.中国的中新统包括5个阶,上新统包括2个阶,除中中新统的通古尔阶以15Ma为底界外,其余各阶都与对应的国际海相阶具有相同的古地磁定义和时限.哺乳动物化石在新生代陆相地层的划分对比中占有非常重要的地位,在新近系尤其倚重于啮齿类、食肉类、长鼻类、奇蹄类和偶蹄类化石.青藏高原有不少地层出露好且富含哺乳动物化石的盆地,新近系谢家阶和灞河阶的底界层型剖面分别位于西宁盆地和临夏盆地,并有精细的古地磁定年与哺乳动物化石相互配合,其余各阶的底界在青藏高原也可以有效确定.东亚地区许多哺乳动物首现属出现在青藏高原及其周边地区,在东北缘的临夏盆地和西南缘的西瓦立克地区尤为典型,其中,西瓦立克的原恐象Prodeinotherium首现于中新统底界,旧大陆最早的三趾马Hipparion首现于临夏盆地的灞河阶底界.对青藏高原及其周缘地区新生代沉积物及其所含的哺乳动物化石进行的牙釉质和古土壤碳氧同位素分析重建了气候环境背景及植被发育特征,发现其既与全球变化相关,又有地区性的特点.根据碳同位素变化得到的晚中新世C4植物扩张事件证据来自于青藏高原南缘,但形成鲜明对比的是,多个食草哺乳动物类群和古土壤碳酸盐及有机质的δ13C指示在青藏高原北缘直到新近纪末期仍然缺少明确或显著的C4植物信号.δ^(18)O分析显示在新生代存在几次重大的气候变化事件,尤其是晚中新世末期约7Ma的δ^(18)O正漂指示了青藏高原南北两侧向更干旱环境的转变.青藏高原在晚中新世的强烈隆升强化了海陆热力对比,由此加强了季风环流并导致C4植被在南亚扩张,但能够为中国北方带来大气降水和C4植物适宜气候的东亚夏季风还不足以影响到青藏高原北部地区.青藏高原在中新世整体上已上升至海拔3000m左右,成为阻碍大型哺乳动物交流的屏障;至上新世达到4000m以上的现代海拔高度,由此形成冰冻圈环境,导致冰期动物群祖先类型出现.

关键词：青藏高原新近系陆相地层哺乳动物化石古地磁

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