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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Oxidation behavior and microstructural evolution of FeCoNiTiCu five-element high-entropy alloy nanoparticles

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Journal of Materials Science & Technology 2024年第10期177卷 133-141页

作者： H.Bai R.Su R.Z.Zhao C.l.Hu l.Z.Ji y.J.liao y.N.Zhang y.x.li x.F.Zhang Key laboratory for Anisotropy and Texture of Materials(MOE) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China Institute of Advanced Magnetic Materials College of Materials and Environmental EngineeringHangzhou Dianzi UniversityHangzhou310012China

High-entropy alloys(HEAs)have attracted extensive attention ascribed to their unique physical and chemical properties induced by the cocktail ***,their oxidation behaviors,in particular at nanoscale,are still lack because of multi-element complexity,which could also be completely differ-ent from the bulk *** this work,we synthesized FeCoNiTiCu five-element HEA nanopar-ticles(NPs)with uniform elemental distribution by arc-discharging approach,and further investigated their oxidation behaviors at 250 ℃,and 350 ℃.The morphology,structure and element distribution of NPs were analyzed by transmission electron microscopy(TEM),energy dispersive spectroscopy(EDS)and electron energy loss spectroscopy(EElS).The surface oxidation in FeCoNiTiCu NPs during the high-temperature process can induce nanoscale pores at core/shell interfaces by Kirkendall effect,and even the eventual coalescence into a single ***,the oxidation states of NPs with diameters(d)varying from 60 to 350 nm were analyzed in detail,revealing two typical configurations:hollow(dyolk-shell structures(d>150 nm).The experimental results were complemented by first-principles calculations to investigate the diffusion behaviors of five elements,evidencing that the surface oxidation strongly alters the surface segregation preferences:(1)in the initial stage,Cu and Ni appear to prefer segregating on the surface,while Co,Ti and Fe tend to stay in the bulk;(2)in the oxidation process,Cu prefers to stay in the center,while Ti segregates to the surface ascribed to the reduced po-tential *** study gives new insights into oxidation of nanoscale HEA,and also provides a way for fabrication of high-entropy oxides with controllable architectures.

关键词： High-entropy alloy Nanoparticles Oxidation Kirkendall effect Exchange bias effect

Eutectic-reaction brazing of Al_(0.3)CoCrFeNi high-entropy alloys using Ni/Nb/Ni interlayers

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Journal of Materials Science & Technology 2022年第26期121卷 245-255页

作者： y.lei J.Sun x.G.Song M.x.yang T.l.yang J.yin State Key laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Beijing Power Machinery Institute Beijing 100074China Sichuan Aerospace Changzheng Equipment Manufacturing Co. Ltd.Chengdu 610100China

In this study,a novel eutectic-reaction brazing of Al_(0.3)CoCrFeNi high-entropy alloys(HEAs)^(1)was investigated with a design of laminated Ni/Nb/Ni *** typical Al_(0.3)CoCrFeNi brazing seam consisted of proeutecticγ,the lamellar eutectic structure composed of face-centered cubic(FCC)phase(eutecticγ)and C14 laves,as well as a few amounts of Nb based solid solution.A high density of nanoscale ordered l1_(2)(γ)phase was precipitated withinγphase *** the brazing temperature raised from 1200 to 1320℃,the dissolution volume of Al_(0.3)CoCrFeNi alloy into Ni-Nb liquid was *** microstructure of the brazing seam changed from hypereutectic(blocky laves+γphase)to eutectic(laves+eutecticγ)to hypoeutectic structures(proeutecticγ+laves/γeutectic structure).The shear strength of joints was increased gradually due to the formation of eutectic lamellae and the cellular growth of proeutecticγ*** maximum shear strength of the joint brazed at 1320℃for 10 min was up to 592 MPa,reaching 95%of the base *** joint mainly ruptured in the soft proeutecticγphase in a ductile fracture mode.

关键词： High-entropy alloys Brazing Eutectic structure Shear strength

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Early Paleozoic granulite-facies metamorphism and anatexis in the northern West Qinling orogen： Monazite and zircon u-Pb geochronological constraints

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Science China Earth Sciences 2017年第5期60卷 943-957页

作者： MAO xiaoHong ZHANG Jianxin yu Shengyao lI yunShuai yu xingxing lu Zenglong Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China School of Earth and Space Sciences Peking UniversityBeijing 100871China Submarine Geosciences and Prospecting Techniques MOE and College of Marine GeosciencesOcean University of ChinaQingdao 266100China laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266235China Institute of Surface-Earth System Science Tianjin UniversityTianjin 300072China

In the northern West Qinling orogen(WQO), granulite-facies metamorphic rocks are recognized within the Qinling Complex. These rocks are composed of amphibole-bearing two-pyroxene granulite and garnet-sillimanite gneiss with widespread migmatitization. We investigate three granulite-facies samples and one leucosome sample from the Qinling Complex, which are suitable for u-Pb analyses of zircon and monazite. SHRIMP and lA-ICPMS u-Pb age dating of zircon and monazite from two pelitic granulites provides weighted mean ages of 430±4 Ma(MSWD=0.88) and 433±4 Ma(MSWD=0.27), *** on the petrographic characteristics and zircon Cl imagery, we postulated a ca. 430 Ma metamorphic timing for the pelitic granulites. lA-ICPMS zircon u-Pb data from an amphibole two-pyroxene granulite sample reports two weighted mean age groups:424±3 Ma(MSWD=0.45) and 402±3 Ma(MSWD=1.4), which were interpreted as granulite-facies metamorphic and retrograde ages, respectively. lA-ICPMS u-Pb dating of zircons from the leucosome sample yields a weighted mean age of 426±2 Ma(MSWD=0.3), which is interpreted as the crystallization age of the leucosome. These data indicate that the West QOB experienced early Paleozoic granulite-facies metamorphism and anatexis similar to the East QOB. However, it remains unclear whether the early Paleozoic granulite facies metamorphism resulted from an arc setting created by the northward subduction of the Shangdan ocean or from a continental collisional orogenic event.

关键词： West Qinling Granulite Migmatite u-Pb age dating Metamorphism Early Paleozoic

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In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels

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Regenerative Biomaterials 2019年第5期6卷 249-258页

作者： u.D’Amora A.Ronca M.G.Raucci S.M.Dozio H.lin y.Fan x.Zhang l.Ambrosio Institute of Polymers Composites and BiomaterialsNational Research CouncilNaplesItaly Institute of Science and Technology for Ceramics National Research CouncilFaenzaItaly School of Advanced Study“G.D’Annunzio” University of Chieti-PescaraChieti Italy National Engineering Research Center for Biomaterials Sichuan UniversityChengduChina

The main driving idea of the present study was the comparison between two different chemical modifications of hyaluronic acid(HA)followed by the development of nanocomposite hydrogels directly in situ by biomineralization of photocrosslinkable HA polymers through sol-gel *** this way,it has been possible to overcome some limitations due to classical approaches based on the physical blending of inorganic fillers into polymer *** this aim,methacrylated and maleated HA,synthesized with similar degree of substitution(DS)were compared in terms of mechanical and physico-chemical *** success of in situ biomineralization was highlighted by reflect Fourier transform infrared spectroscopy and thermogravimetric ***,mechanical characterization demonstrated the reinforcing effect of inorganic fillers evidencing a strong correlation with *** swelling behavior resulted to be correlated with filler ***,the cytotoxicity tests revealed the absence of toxic components and an increase of cell proliferation over culture time was observed,highlighting these bio-nanocomposite hyaluronan derivatives as biocompatible hydrogel with tunable properties.

关键词： hyaluronic acid derivatives photocrosslinking sol-gel nanocomposites

Inhibiting effect of I-phase formation on the plastic instability of the duplex structured Mg-8li-6Zn-1.2y(in wt.%)alloy

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Journal of Magnesium and Alloys 2023年第6期11卷 2196-2204页

作者： B.J.Wang D.K.xu x.Q.Zhuang l.y.Sheng School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Key laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Peking university Shenzhen InstituteShenzhen Key Lab Human Tissue Regenerate&RepairShenzhen 518057China

In this work,the tensile behaviors of Mg-8%li and Mg-8%li-6%Zn-1.2%y alloys at ambient temperature were investigated and *** revealed that the plastic instability of Mg-8%li alloy was quite remarkable and the variation range of serrated flowing stress can reach5 *** the Mg-8%li-6%Zn-1.2%y alloy,the formation of I-phase(Mg_(3)Zn_(6)y)can simultaneously enhance the tensile strength and eliminate the plastic instability phenomenon,whilst its ductility was *** in-situ tensile tests revealed that for the Mg-8%li alloy,the severity and number of slip traces present in bothα-Mg andβ-li matrix phases increased remarkably with the applied tensile ***,slip traces were quite fine inβ-li matrix phase and could be clearly observed when the applied tensile strain exceeded 18%.Due to the incompatibility of plastic deformation occurred in two matrix phases,the induced strain concentration atα-Mg/β-li interfaces caused their subsequent *** the Mg-8%-6%Zn-1.2%y alloy,the I-phase distributed atα-Mg/β-li interfaces suppressed the plastic deformation ofα-Mg matrix phase and the tensile strain was dominated by theβ-li matrix phase,resulting in the disappearance of plastic ***,the plastic strain would preferentially concentrate at I-phase/β-li interfaces and subsequently induced the cracking of I-phase.

关键词： Mg-li alloys Microstructure Plastic deformation Basal slip Cracking

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： yan lu Kang Wang yuanhong Peng Meng Chen lin Zhong luji Huang F u Cheng xindan Sheng xin yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-l1), and cytotoxic T-lymphocyte antigen-4 (CTlA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ElISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' uTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Structures and formation mechanisms of dislocation-induced precipitates in relation to the age-hardening responses of Al-Mg-Si alloys

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Journal of Materials Science & Technology 2020年第6期41卷 127-138页

作者： y.x.lai W.Fan M.J.yin C.l.Wu J.H.Chen Center for High-Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha 410082China Electron Microscopy Center Shenzhen UniversityShenzhen 518060China

In the slightly deformed Al-Mg-Si alloys,dislocation-induced precipitates are frequently observed,and they usually line up,forming sophisticated precipitation *** atomic-resolution electron microscopy in association with hardness measurements,we systematically investigated these precipitates in relation to the age-hardening responses of the *** study reveals that the majority of dislocation-induced complex precipitates are actually short-range ordered while long-range disordered polycrystalline precipitates and multiphase composite precipitates,including polycrystalline u2 precipitates,B’/u2,B’-2/u2,B’/B’-2/u2 and’/u2 composite *** is suggested that the formation of these complex precipitates is mainly owing to a high nucleation rate and rapid growth of different precipitate phases parallel to the associated dislocation *** dislocation-induced precipitates consume more Mg than Si from the matrix and have a high formation kinetics,they will have different impacts on the matrix precipitation in different types of Al-Mg-Si *** results further demonstrate that for the"normally-β"-hardened"alloy,their formation leads to a coarser precipitate microstructure in the matrix,whereas for the"normally-β’-hardened"alloy,their formation reverses the precipitation pathway in the matrix,resulting in a reduced age-hardening potential of the former alloy and an improved age-hardening potential of the latter alloy.

关键词： Al-Mg-Si alloys Precipitation Dislocation Age-hardening Electron microscopy