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Indirect Measurement Methods forQuality and Process Control in Nanomanufacturing

Nanomanufacturing and Metrology 2022年第3期5卷 209-229页

作者： Zhaoyan Fan xiaochen Hu Robert x.gao School of Mechanical Industrialand Manufacturing EngineeringOregon State UniversityCorvallisOR97331USA Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOH44106USA

Rapid advancement over the past decades in nanomanufacturing has led to the realization of a broad range of nanostructures such as nanoparticles,nanotubes,and *** unique mechanical,chemical,and electrical properties of these nanostructures have made them increasingly desired as key components in industrial and commercial *** the geometric dimension of nano-manufactured products is on the sub-micron to nanometer scale,different mechanisms and effects are involved in the nanomanufacturing process as compared to those for macro-scale *** direct measurement methods using atomic force microscopy and electron beam microscopy can determine the dimensions of the nano structure with high accuracy,these methods are not suited for online process control and quality *** comparison,indirect measurement methods analyze in-process parameters as the basis for inferring the dimensional variations in the nano products,thereby enabling online feedback for process control and quality *** paper provides a comprehensive review of relevant indirect measurement methods,starting with their respective working principles,and subsequently discussing their characteristics and applications in terms of two different approaches:data-based and physicsbased *** mathematical and physics models for each of the methods are summarized,together with the associated effect of key process parameters on the quality of the final *** on the comprehensive literature conducted,it was found that:(1)indirect measurement,especially the data-based method,plays a critical role when it comes to online process control and quality assurance in nanomanufacturing,because of the short processing time compared to the direct method,and(2)physics-based method is providing a way to optimize the process set up for desired geometrical dimensions.

关键词： Measurement Modeling Nanomanufacturing Quality control

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Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： xiaoxue Wang lulu Jin Jinke Wang Rongqiao Wang xiuchun liu Kai gao Jingli Sun Yong Yuan lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress

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World Journal of Diabetes 2025年第1期16卷 91-103页

作者： Zhi-Min lin Han-Yuan gao Shu-Han Shi Yue-Ting li Department of Nephrology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGlT1)originally developed as a medication for *** To explore the impact of MIZ on diabetic nephropathy(DN).METHODS Diabetic mice were created using db/db *** were administered either a low dose(0.5 mg/kg)or a high dose(1.0 mg/kg)of the SGlT1 inhibitor MIZ via stomach gavage for 8 ***,mesangial cells(MCs)were isolated and subjected to high glucose conditions in culture to assess the effects of MIZ on *** The results showed that low doses of MIZ significantly reduced albuminuria to a level comparable to that achieved with high doses in db/db *** doses of MIZ led to a substantial increase in body weight in mice,along with decreased blood glucose levels and food ***,the intervention with high-dose MIZ notably decreased the expression of extracellular matrix genes,such as collagen type 1 alpha 1 mRNA *** the expression of SGlT1 increased after exposure to high glucose,it decreased following treatment with ***,MIZ intervention was more effective in improving lactate dehydrogenase levels in MCs induced by high glucose compared to *** also significantly elevated levels of antioxidant enzymes superoxide dismutase,catalase,and glutathione,while reducing malondialdehyde *** These findings indicate that MIZ can ameliorate DN by inhibiting SGlT1,inflammation,and oxidative stress.

关键词： Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi liang Wenbo Ji Jianhua Zhuang Yan liu Jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Tracing the origin of large respiratory droplets by their deposition characteristics inside the respiratory tract during speech

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Building Simulation 2023年第5期16卷 781-794页

作者： Yihan Wang Jianjian Wei Caroline x.gao Tao Jin li liu Institute of Refrigeration and Cryogenics Key Laboratory of Refrigeration and Cryogenic Technology of Zhejiang ProvinceZhejiang UniversityHangzhou 310000China Public Health and Preventive Medicine Monash UniversityMelbourneVIC3004Australia Department of Building Science Tsinghua UniversityBeijing 100084China

Origin of differently sized respiratory droplets is fundamental for clarifying their viral loads and the sequential transmission mechanism of SARS-CoV-2 in indoor *** talking activities characterized by low(0.2 l/s),medium(0.9 l/s),and high(1.6 l/s)airflow rates of monosyllabic and successive syllabic vocalizations were investigated by computational fluid dynamics(CFD)simulations based on a real human airway *** k-ωmodel was chosen to predict the airflow field,and the discrete phase model(DPM)was used to calculate the trajectories of droplets within the respiratory *** results showed that flow field in the respiratory tract during speech is characterized by a significant laryngeal jet,and bronchi,larynx,and pharynx-larynx junction were main deposition sites for droplets released from the lower respiratory tract or around the vocal cords,and among which,over 90%of droplets over 5μm released from vocal cords deposited at the larynx and pharynx-larynx ***,droplets’deposition fraction increased with their size,and the maximum size of droplets that were able to escape into external environment decreased with the airflow *** threshold size for droplets released from the vocal folds was 10-20μm,while that for droplets released from the bronchi was 5-20μm under various airflow ***,successive syllables pronounced at low airflow rates promoted the escape of small droplets,but do not significantly affect the droplet threshold *** study indicates that droplets larger than 20μm may entirely originate from the oral cavity,where viral loads are lower;it provides a reference for evaluating the relative importance of large-droplet spray and airborne transmission route of COVID-19 and other respiratory infections.

关键词： respiratory droplets deposition viral load airborne transmission COVID-19

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STRAIN RATE SENSITIVITY OF UlTRAFINE-GRAINED Cu WITH NANOSIZED TWINS

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Acta Metallurgica Sinica(English letters) 2006年第5期19卷 313-318页

作者： l.x. liu x.H. Chen l. lu Shenyang National laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

An ultrafine-grained Cu sample with a high density of growth twins was synthesized by means of pulsed electrodeposition technique. The strain rate sensitivity of the Cu sample was measured by strain rate cycling tests under tension. The effects of grain size as well as twin density on the strength and strain rate sensitivity were discussed.

关键词： copper nanosized twin strain rate sensitivity deformation mechanism

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Canonical transient receptor potential 4 and its small molecule modulators

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Science China(life Sciences) 2015年第1期58卷 39-47页

作者： FU Jie gao ZhaoBing SHEN Bing ZHU Michael x. Department of Physiology Anhui Medical University International Scientist Workstation of Neuropharmacology Shanghai Institute of Materia MedicaChinese Academy of Sciences Department of Integrative Biology and Pharmacology the University of Texas Health Science Center at Houston

Canonical transient receptor potential 4(TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca2+ entry into cells following stimulation of G protein coupled receptors and receptor tyrosine ***,the channels are regulated by pertussis toxin-sensitive Gi/o proteins,lipids,and various other signaling ***4-containing channels participate in the regulation of a variety of physiological functions,including excitability of both gastrointestinal smooth muscles and brain *** review is to present recent advances in the understanding of physiology and development of small molecular modulators of TRPC4 channels.

关键词： TRPC4 channel non-selective cation channel G protein coupled receptors small molecular modulators G proteins excitation contraction Ca2+ signaling

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng lulu liu xu gao Dayong Wang Qing xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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AI-Enabled Monitoring, Diagnosis & Prognosis

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Chinese Journal of Mechanical Engineering 2021年第3期34卷 1-2页

作者： Ruqiang Yan xuefeng Chen Weihua li Robert x.gao School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China SHIEN-MING WU School of Intelligent Engineering South China University of TechnologyGuangzhou 510641China Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhio 44106-7222USA

The emerging and development of Artificial Intelligence(AI),especially deep learning,has stimulated its application in various engineering ***,diagnosis and prognosis,as the key elements of intelligence maintenance of manufacturing systems in the era of Industry 4.0,has also benefited from the advancement of AI *** main objective of this special issue aims at bringing scholars to show their research findings in the field of monitoring,diagnosis and prognosis driven by AI,and promote its application in intelligent maintenance of manufacturing system in *** papers have been selected in this special issue after rigorous review and they represent the latest research outcomes in this active area.

关键词： diagnosis prognosis bringing

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Optimizing surface-engineered ultra-small gold nanoparticles for highly efficient miRNA delivery to enhance osteogenic differentiation of bone mesenchymal stromal cells

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Nano Research 2017年第1期10卷 49-63页

作者： Meng Yu Bo lei Chuanbo gao Jin Yan Peter x. Ma Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an 710054 China State Key laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an 710054 China State Key laboratory for Mechanical Behavior of Materials Xi'an Jiootong University Xi'an 710054 China Department of Biomedical Engineering University of Michigan Ann Arbor M148109-2009 USA Macromolecular Science and Engineering Center University of Michigan Ann Arbor M148109-1055 USA Department of Materials Science and Engineering University of Michigan Ann Arbor M148109-1078 USA

Regulation of osteogenic differentiation of bone mesenchymal stromal cells （BMSCs） plays a critical role in bone regeneration. As small non-coding RNAs, microRNAs （miRNAs） play an important role in stem cell differentiation through regulating target-mRNA expression. Unfortunately, highly efficient and safe delivery of miRNAs to BMSCs to regulate their osteogenic differentiation remains challenging. Conventional inorganic nanocrystals have shown increased toxicity owing to their larger size precluding renal clearance. Here, we developed novel, surface-engineered, ultra-small gold nanoparticles （USAuNPs, 〈10 nm） for use as highly efficient miR-5106-delivery systems to enable regulation of BMSC differentiation. We exploited the effects of AuNPs coated layer-by-layer with polyethylenimine （PEI） and liposomes （lipo） to enhance miR-5106-delivery activity and subsequent BMSC differentiation capacity. The PEI- and lipo-coated AuNPs （Au@PEI@lipo） showed negligible cytotoxicity, good miRNA-5106-binding affinity, highly efficient delivery of miRNAs to BMSCs, and long-term miRNA expression （21 days）. Additionally, compared with commercial lipofectamine 3000 and 25 kD PEI, the optimized Au@PEI@lipo-miR-5106 nanocomplexes significantly enhanced BMSC differentiation into osteoblast-like cells through activation of the Sox9 transcription factor. Our findings reveal a promising strategy for the rational design of ultra-small inorganic nanoparticles as highly efficient miRNA-delivery platforms for tissue regeneration and disease therapy.

关键词： ultra-small goldnanoparticles surface engineering microRNA (miRNA)delivery bone mesenchymalstromal cells osteogenic differentiation

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